Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8ICF7_LEIDO

TriTrypDb:

LdBPK_310850.1 , LdBPK_342900.1 , LdCL_310014400 , LDHU3_31.1260

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.588
CLV_NRD_NRD_1	121	123	PF00675	0.703
CLV_NRD_NRD_1	136	138	PF00675	0.521
CLV_NRD_NRD_1	175	177	PF00675	0.470
CLV_NRD_NRD_1	231	233	PF00675	0.523
CLV_PCSK_KEX2_1	121	123	PF00082	0.703
CLV_PCSK_KEX2_1	175	177	PF00082	0.470
CLV_PCSK_KEX2_1	233	235	PF00082	0.528
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.528
CLV_PCSK_PC7_1	171	177	PF00082	0.481
CLV_PCSK_SKI1_1	98	102	PF00082	0.567
DEG_Nend_UBRbox_1	1	4	PF02207	0.502
DOC_CYCLIN_RxL_1	95	103	PF00134	0.561
DOC_MAPK_gen_1	137	145	PF00069	0.552
DOC_PP4_FxxP_1	157	160	PF00568	0.539
DOC_USP7_MATH_1	19	23	PF00917	0.592
DOC_USP7_MATH_1	63	67	PF00917	0.551
LIG_14-3-3_CanoR_1	246	250	PF00244	0.516
LIG_BIR_III_4	62	66	PF00653	0.557
LIG_FHA_1	217	223	PF00498	0.447
LIG_FHA_1	246	252	PF00498	0.544
LIG_FHA_1	79	85	PF00498	0.594
LIG_FHA_2	73	79	PF00498	0.731
LIG_LIR_Apic_2	155	160	PF02991	0.532
LIG_LIR_Apic_2	245	250	PF02991	0.544
LIG_LIR_Nem_3	25	30	PF02991	0.737
LIG_PCNA_PIPBox_1	189	198	PF02747	0.481
LIG_PCNA_yPIPBox_3	188	196	PF02747	0.485
LIG_Pex14_2	153	157	PF04695	0.528
LIG_SH2_CRK	193	197	PF00017	0.463
LIG_SH2_STAT5	132	135	PF00017	0.552
LIG_SH2_STAT5	177	180	PF00017	0.620
LIG_SH3_2	69	74	PF14604	0.507
LIG_SH3_3	28	34	PF00018	0.613
LIG_SH3_3	66	72	PF00018	0.758
LIG_TRAF2_1	237	240	PF00917	0.542
LIG_WRC_WIRS_1	132	137	PF05994	0.554
MOD_CK1_1	22	28	PF00069	0.759
MOD_CK1_1	245	251	PF00069	0.544
MOD_CK2_1	72	78	PF00069	0.579
MOD_GlcNHglycan	10	13	PF01048	0.556
MOD_GlcNHglycan	123	126	PF01048	0.626
MOD_GlcNHglycan	16	20	PF01048	0.741
MOD_GlcNHglycan	21	24	PF01048	0.789
MOD_GSK3_1	15	22	PF00069	0.586
MOD_NEK2_1	123	128	PF00069	0.623
MOD_NEK2_2	194	199	PF00069	0.417
MOD_PIKK_1	17	23	PF00454	0.527
MOD_PK_1	47	53	PF00069	0.561
MOD_PKA_1	121	127	PF00069	0.551
MOD_PKA_2	121	127	PF00069	0.551
MOD_PKA_2	245	251	PF00069	0.523
MOD_Plk_1	216	222	PF00069	0.413
MOD_Plk_4	131	137	PF00069	0.706
MOD_Plk_4	152	158	PF00069	0.561
MOD_Plk_4	22	28	PF00069	0.642
TRG_DiLeu_BaEn_1	217	222	PF01217	0.464
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.497
TRG_ENDOCYTIC_2	132	135	PF00928	0.552
TRG_ENDOCYTIC_2	154	157	PF00928	0.526
TRG_ENDOCYTIC_2	193	196	PF00928	0.542
TRG_ER_diArg_1	115	118	PF00400	0.693
TRG_ER_diArg_1	120	122	PF00400	0.742
TRG_ER_diArg_1	174	176	PF00400	0.469
TRG_NLS_MonoCore_2	232	237	PF00514	0.434
TRG_NLS_MonoExtC_3	233	238	PF00514	0.434
TRG_NLS_MonoExtN_4	232	238	PF00514	0.434
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I6H6	Leishmania infantum	98%	100%
Q4Q6I1	Leishmania major	88%	100%