ATP-binding cassette protein subfamily B, member 2, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily B, member 2, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICF5_LEIDO

TriTrypDb:

LdBPK_262700.1 , LdCL_260033000 , LDHU3_26.3520

Length:

1267

Annotations

LeishMANIAdb annotations

ABC transporters probably involved in multidrug resistance. A member of this family confers vinblastine resistance to Leishmania enriettii.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

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Expansion

Sequence features

A0A3Q8ICF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICF5

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0009987	cellular process	1	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	5
GO:0005215	transporter activity	1	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0015399	primary active transmembrane transporter activity	4	17
GO:0016787	hydrolase activity	2	5
GO:0017076	purine nucleotide binding	4	17
GO:0022804	active transmembrane transporter activity	3	17
GO:0022857	transmembrane transporter activity	2	17

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1117	1121	PF00656	0.493
CLV_C14_Caspase3-7	1125	1129	PF00656	0.474
CLV_C14_Caspase3-7	1193	1197	PF00656	0.562
CLV_C14_Caspase3-7	453	457	PF00656	0.472
CLV_C14_Caspase3-7	644	648	PF00656	0.712
CLV_NRD_NRD_1	1212	1214	PF00675	0.437
CLV_NRD_NRD_1	137	139	PF00675	0.266
CLV_NRD_NRD_1	215	217	PF00675	0.349
CLV_NRD_NRD_1	256	258	PF00675	0.331
CLV_NRD_NRD_1	387	389	PF00675	0.287

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A059JJ46	Trichophyton interdigitale (strain MR816)	32%	95%
A0A059JK44	Trichophyton interdigitale (strain MR816)	28%	92%
A0A095C325	Cryptococcus gattii serotype B (strain R265)	33%	90%
A0A0D1BUH6	Ustilago maydis (strain 521 / FGSC 9021)	29%	92%
A0A0D1CZ63	Ustilago maydis (strain 521 / FGSC 9021)	24%	95%
A0A0N0P6R0	Leptomonas seymouri	47%	92%
A0A0N1IM38	Leptomonas seymouri	72%	99%
A0A0S4IRS2	Bodo saltans	46%	100%
A0A0S4JDP8	Bodo saltans	46%	100%
A0A0S4JGM3	Bodo saltans	48%	100%

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