V-type proton ATPase subunit G

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

(H+)-ATPase G subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICF4_LEIDO

TriTrypDb:

LdBPK_230380.1 , LdCL_230009200 , LDHU3_23.0550

Length:

108

Annotations

Annotations by Jardim et al.

Acidocalcisome, (H+)-ATPase G subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016469	proton-transporting two-sector ATPase complex	3	10
GO:0016471	vacuolar proton-transporting V-type ATPase complex	5	10
GO:0032991	protein-containing complex	1	10
GO:0033176	proton-transporting V-type ATPase complex	4	10
GO:0098796	membrane protein complex	2	10

Expansion

Sequence features

A0A3Q8ICF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICF4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005215	transporter activity	1	10
GO:0008324	monoatomic cation transmembrane transporter activity	4	10
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	10
GO:0015075	monoatomic ion transmembrane transporter activity	3	10
GO:0015078	proton transmembrane transporter activity	5	10
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	10
GO:0015399	primary active transmembrane transporter activity	4	10
GO:0016787	hydrolase activity	2	8
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	10
GO:0022804	active transmembrane transporter activity	3	10
GO:0022853	active monoatomic ion transmembrane transporter activity	4	10
GO:0022857	transmembrane transporter activity	2	10
GO:0022890	inorganic cation transmembrane transporter activity	4	10
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	10
GO:0042626	ATPase-coupled transmembrane transporter activity	2	10
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	10
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	10
GO:0140657	ATP-dependent activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	27	29	PF00675	0.343
CLV_PCSK_KEX2_1	17	19	PF00082	0.320
CLV_PCSK_KEX2_1	85	87	PF00082	0.395
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.343
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.395
CLV_PCSK_SKI1_1	34	38	PF00082	0.317
CLV_PCSK_SKI1_1	85	89	PF00082	0.360
LIG_14-3-3_CanoR_1	101	107	PF00244	0.449
LIG_14-3-3_CanoR_1	86	92	PF00244	0.385
LIG_FHA_2	75	81	PF00498	0.397
LIG_LIR_Nem_3	52	58	PF02991	0.307
LIG_PCNA_yPIPBox_3	4	12	PF02747	0.375
LIG_SH2_STAT3	58	61	PF00017	0.318
LIG_SUMO_SIM_par_1	102	108	PF11976	0.392
LIG_TRAF2_1	13	16	PF00917	0.418
LIG_UBA3_1	98	107	PF00899	0.466
LIG_WRC_WIRS_1	44	49	PF05994	0.406
MOD_CK2_1	102	108	PF00069	0.458
MOD_CK2_1	74	80	PF00069	0.418
MOD_NEK2_1	102	107	PF00069	0.391
MOD_PKA_1	85	91	PF00069	0.392
MOD_PKA_2	74	80	PF00069	0.343
MOD_PKA_2	85	91	PF00069	0.283
MOD_SUMO_rev_2	23	27	PF00179	0.392
MOD_SUMO_rev_2	78	87	PF00179	0.458
TRG_DiLeu_BaEn_4	82	88	PF01217	0.458
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.392
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVY9	Leptomonas seymouri	76%	100%
A0A1X0NX64	Trypanosomatidae	64%	99%
A0A422NW25	Trypanosoma rangeli	68%	99%
A4HCP8	Leishmania braziliensis	83%	100%
A4I074	Leishmania infantum	100%	100%
C9ZUY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
E9AW37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O82629	Arabidopsis thaliana	31%	100%
O82702	Nicotiana tabacum	39%	98%
O82703	Nicotiana tabacum	35%	97%
P91303	Caenorhabditis elegans	28%	86%
Q25532	Manduca sexta	28%	92%
Q4QBE0	Leishmania major	98%	100%
Q54Z13	Dictyostelium discoideum	30%	100%
Q617N0	Caenorhabditis briggsae	28%	86%
Q96LB4	Homo sapiens	25%	92%
Q9SP55	Citrus limon	35%	98%
Q9SZH0	Arabidopsis thaliana	29%	100%