Putative endoribonuclease family protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endoribonuclease L-PSP (pb5), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICF3_LEIDO

TriTrypDb:

LdBPK_230220.1 , LdCL_230007100 , LDHU3_23.0270

Length:

163

Annotations

Annotations by Jardim et al.

Nucleases, endoribonuclease L-PSP (Pb5)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 2
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 60
Promastigote/Amastigote: 58

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8ICF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	91	93	PF00082	0.405
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.405
CLV_PCSK_SKI1_1	133	137	PF00082	0.431
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.344
DOC_MAPK_gen_1	89	96	PF00069	0.319
DOC_MAPK_MEF2A_6	11	18	PF00069	0.385
DOC_MAPK_NFAT4_5	11	19	PF00069	0.385
DOC_PP2B_LxvP_1	16	19	PF13499	0.501
DOC_USP7_MATH_1	142	146	PF00917	0.401
DOC_USP7_MATH_1	22	26	PF00917	0.495
DOC_USP7_MATH_1	67	71	PF00917	0.440
DOC_USP7_UBL2_3	156	160	PF12436	0.592
DOC_USP7_UBL2_3	65	69	PF12436	0.417
LIG_APCC_ABBA_1	121	126	PF00400	0.347
LIG_BIR_III_4	45	49	PF00653	0.417
LIG_FHA_1	13	19	PF00498	0.431
LIG_FHA_2	58	64	PF00498	0.322
LIG_LIR_Nem_3	25	29	PF02991	0.435
LIG_PTB_Apo_2	31	38	PF02174	0.385
LIG_PTB_Phospho_1	31	37	PF10480	0.385
LIG_SH2_GRB2like	99	102	PF00017	0.431
LIG_SH2_SRC	99	102	PF00017	0.431
LIG_SH2_STAT5	37	40	PF00017	0.379
LIG_SH2_STAT5	99	102	PF00017	0.431
LIG_SH3_3	16	22	PF00018	0.331
LIG_SUMO_SIM_par_1	145	150	PF11976	0.386
LIG_UBA3_1	75	80	PF00899	0.405
MOD_CK2_1	142	148	PF00069	0.401
MOD_GlcNHglycan	101	104	PF01048	0.434
MOD_GlcNHglycan	38	41	PF01048	0.365
MOD_N-GLC_2	114	116	PF02516	0.431
MOD_NEK2_1	119	124	PF00069	0.347
MOD_NEK2_1	12	17	PF00069	0.340
MOD_NEK2_1	55	60	PF00069	0.432
MOD_Plk_4	119	125	PF00069	0.405
MOD_Plk_4	142	148	PF00069	0.351
MOD_SUMO_rev_2	154	162	PF00179	0.589
MOD_SUMO_rev_2	45	51	PF00179	0.408
MOD_SUMO_rev_2	57	67	PF00179	0.310
TRG_ENDOCYTIC_2	26	29	PF00928	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF0	Leptomonas seymouri	74%	100%
A0A0S4JNW3	Bodo saltans	54%	100%
A0A1X0NI09	Trypanosomatidae	51%	100%
A0A3R7NPU0	Trypanosoma rangeli	53%	100%
A4HCN4	Leishmania braziliensis	83%	100%
A4I058	Leishmania infantum	100%	100%
E9AW21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O96876	Trypanosoma cruzi	55%	100%
Q4QBF5	Leishmania major	97%	100%