LeishMANIAdb
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Putative endoribonuclease family protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative endoribonuclease family protein
Gene product:
endoribonuclease L-PSP (pb5), putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ICF3_LEIDO
TriTrypDb:
LdBPK_230220.1 , LdCL_230007100 , LDHU3_23.0270
Length:
163

Annotations

Annotations by Jardim et al.

Nucleases, endoribonuclease L-PSP (Pb5)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. yes yes: 2
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 1
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 60
Promastigote/Amastigote: 58

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8ICF3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICF3

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_PCSK_KEX2_1 91 93 PF00082 0.405
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.405
CLV_PCSK_SKI1_1 133 137 PF00082 0.431
DOC_CYCLIN_yCln2_LP_2 16 22 PF00134 0.344
DOC_MAPK_gen_1 89 96 PF00069 0.319
DOC_MAPK_MEF2A_6 11 18 PF00069 0.385
DOC_MAPK_NFAT4_5 11 19 PF00069 0.385
DOC_PP2B_LxvP_1 16 19 PF13499 0.501
DOC_USP7_MATH_1 142 146 PF00917 0.401
DOC_USP7_MATH_1 22 26 PF00917 0.495
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PDF0 Leptomonas seymouri 74% 100%
A0A0S4JNW3 Bodo saltans 54% 100%
A0A1X0NI09 Trypanosomatidae 51% 100%
A0A3R7NPU0 Trypanosoma rangeli 53% 100%
A4HCN4 Leishmania braziliensis 83% 100%
A4I058 Leishmania infantum 100% 100%
E9AW21 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O96876 Trypanosoma cruzi 55% 100%
Q4QBF5 Leishmania major 97% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS