Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ICF2_LEIDO

TriTrypDb:

LdBPK_250800.1 , LdCL_250013300 , LDHU3_25.1010

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.412
CLV_C14_Caspase3-7	169	173	PF00656	0.620
CLV_C14_Caspase3-7	59	63	PF00656	0.788
CLV_NRD_NRD_1	115	117	PF00675	0.623
CLV_NRD_NRD_1	244	246	PF00675	0.706
CLV_NRD_NRD_1	269	271	PF00675	0.595
CLV_NRD_NRD_1	28	30	PF00675	0.775
CLV_PCSK_KEX2_1	244	246	PF00082	0.704
CLV_PCSK_KEX2_1	269	271	PF00082	0.595
CLV_PCSK_KEX2_1	28	30	PF00082	0.733
CLV_PCSK_SKI1_1	135	139	PF00082	0.638
CLV_PCSK_SKI1_1	269	273	PF00082	0.568
CLV_PCSK_SKI1_1	94	98	PF00082	0.553
DEG_APCC_DBOX_1	163	171	PF00400	0.591
DEG_APCC_DBOX_1	268	276	PF00400	0.562
DEG_APCC_DBOX_1	93	101	PF00400	0.528
DEG_SCF_TRCP1_1	152	157	PF00400	0.602
DEG_SPOP_SBC_1	140	144	PF00917	0.609
DOC_CYCLIN_RxL_1	267	277	PF00134	0.644
DOC_CYCLIN_yClb1_LxF_4	207	213	PF00134	0.447
DOC_MAPK_FxFP_2	211	214	PF00069	0.545
DOC_MAPK_gen_1	116	123	PF00069	0.613
DOC_MAPK_gen_1	269	275	PF00069	0.555
DOC_PP2B_LxvP_1	100	103	PF13499	0.677
DOC_PP2B_LxvP_1	123	126	PF13499	0.670
DOC_PP4_FxxP_1	211	214	PF00568	0.623
DOC_USP7_MATH_1	127	131	PF00917	0.555
DOC_USP7_MATH_1	185	189	PF00917	0.704
DOC_USP7_MATH_1	235	239	PF00917	0.776
DOC_USP7_MATH_1	254	258	PF00917	0.794
DOC_USP7_MATH_1	351	355	PF00917	0.567
DOC_USP7_MATH_1	405	409	PF00917	0.719
DOC_USP7_MATH_1	5	9	PF00917	0.804
DOC_USP7_MATH_1	51	55	PF00917	0.689
DOC_WW_Pin1_4	176	181	PF00397	0.683
DOC_WW_Pin1_4	32	37	PF00397	0.688
DOC_WW_Pin1_4	60	65	PF00397	0.735
LIG_FHA_1	155	161	PF00498	0.525
LIG_FHA_1	373	379	PF00498	0.588
LIG_FHA_1	63	69	PF00498	0.809
LIG_FHA_2	127	133	PF00498	0.518
LIG_GBD_Chelix_1	302	310	PF00786	0.586
LIG_LIR_Gen_1	237	248	PF02991	0.665
LIG_LIR_Nem_3	237	243	PF02991	0.665
LIG_PTAP_UEV_1	412	417	PF05743	0.698
LIG_PTB_Apo_2	205	212	PF02174	0.550
LIG_SH2_CRK	363	367	PF00017	0.718
LIG_SH2_GRB2like	337	340	PF00017	0.736
LIG_SH2_GRB2like	355	358	PF00017	0.798
LIG_SH2_GRB2like	370	373	PF00017	0.587
LIG_SH2_NCK_1	338	342	PF00017	0.664
LIG_SH2_SRC	411	414	PF00017	0.702
LIG_SH2_STAT3	346	349	PF00017	0.718
LIG_SH2_STAT3	392	395	PF00017	0.741
LIG_SH2_STAT5	276	279	PF00017	0.537
LIG_SH2_STAT5	411	414	PF00017	0.702
LIG_SH3_3	374	380	PF00018	0.721
LIG_SH3_3	410	416	PF00018	0.705
LIG_SH3_3	58	64	PF00018	0.735
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.711
LIG_SUMO_SIM_par_1	166	172	PF11976	0.635
LIG_SUMO_SIM_par_1	191	198	PF11976	0.653
LIG_SUMO_SIM_par_1	271	277	PF11976	0.502
LIG_TRAF2_1	110	113	PF00917	0.594
LIG_TRAF2_1	7	10	PF00917	0.742
MOD_CK1_1	144	150	PF00069	0.638
MOD_CK1_1	188	194	PF00069	0.632
MOD_CK1_1	202	208	PF00069	0.366
MOD_CK1_1	4	10	PF00069	0.723
MOD_CK2_1	4	10	PF00069	0.779
MOD_DYRK1A_RPxSP_1	32	36	PF00069	0.692
MOD_GlcNHglycan	118	121	PF01048	0.567
MOD_GlcNHglycan	144	147	PF01048	0.589
MOD_GlcNHglycan	152	155	PF01048	0.591
MOD_GlcNHglycan	20	23	PF01048	0.807
MOD_GlcNHglycan	3	6	PF01048	0.710
MOD_GlcNHglycan	357	360	PF01048	0.744
MOD_GlcNHglycan	407	410	PF01048	0.712
MOD_GlcNHglycan	413	416	PF01048	0.608
MOD_GlcNHglycan	51	54	PF01048	0.784
MOD_GlcNHglycan	69	72	PF01048	0.718
MOD_GlcNHglycan	74	77	PF01048	0.650
MOD_GlcNHglycan	87	91	PF01048	0.588
MOD_GSK3_1	1	8	PF00069	0.776
MOD_GSK3_1	112	119	PF00069	0.609
MOD_GSK3_1	140	147	PF00069	0.551
MOD_GSK3_1	150	157	PF00069	0.553
MOD_GSK3_1	195	202	PF00069	0.513
MOD_GSK3_1	351	358	PF00069	0.574
MOD_GSK3_1	39	46	PF00069	0.748
MOD_GSK3_1	407	414	PF00069	0.713
MOD_GSK3_1	60	67	PF00069	0.709
MOD_N-GLC_1	127	132	PF02516	0.552
MOD_N-GLC_1	72	77	PF02516	0.675
MOD_NEK2_1	1	6	PF00069	0.689
MOD_NEK2_1	139	144	PF00069	0.552
MOD_NEK2_1	18	23	PF00069	0.724
MOD_NEK2_1	43	48	PF00069	0.714
MOD_NEK2_1	86	91	PF00069	0.501
MOD_NEK2_2	154	159	PF00069	0.553
MOD_NMyristoyl	1	7	PF02799	0.722
MOD_PIKK_1	5	11	PF00454	0.822
MOD_PKA_1	116	122	PF00069	0.618
MOD_Plk_1	127	133	PF00069	0.556
MOD_Plk_1	202	208	PF00069	0.534
MOD_Plk_1	86	92	PF00069	0.553
MOD_Plk_4	188	194	PF00069	0.608
MOD_Plk_4	235	241	PF00069	0.701
MOD_Plk_4	351	357	PF00069	0.573
MOD_Plk_4	39	45	PF00069	0.780
MOD_Plk_4	407	413	PF00069	0.715
MOD_ProDKin_1	176	182	PF00069	0.684
MOD_ProDKin_1	32	38	PF00069	0.687
MOD_ProDKin_1	60	66	PF00069	0.733
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.566
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.567
TRG_ER_diArg_1	243	245	PF00400	0.706
TRG_NES_CRM1_1	92	106	PF08389	0.599
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V9	Leptomonas seymouri	34%	100%
A4HE12	Leishmania braziliensis	58%	99%
A4I1B9	Leishmania infantum	100%	100%
E9AXF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QA17	Leishmania major	91%	100%