Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICF1_LEIDO

TriTrypDb:

LdBPK_160100.1 , LdCL_160005900 , LDHU3_16.0110

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	213	215	PF00675	0.477
CLV_NRD_NRD_1	252	254	PF00675	0.418
CLV_NRD_NRD_1	286	288	PF00675	0.526
CLV_NRD_NRD_1	319	321	PF00675	0.423
CLV_PCSK_KEX2_1	213	215	PF00082	0.477
CLV_PCSK_KEX2_1	252	254	PF00082	0.420
CLV_PCSK_KEX2_1	286	288	PF00082	0.502
CLV_PCSK_KEX2_1	319	321	PF00082	0.423
CLV_PCSK_PC7_1	315	321	PF00082	0.386
CLV_PCSK_SKI1_1	319	323	PF00082	0.587
DEG_APCC_DBOX_1	319	327	PF00400	0.463
DOC_CDC14_PxL_1	262	270	PF14671	0.492
DOC_CKS1_1	65	70	PF01111	0.507
DOC_CYCLIN_RxL_1	315	327	PF00134	0.617
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.530
DOC_MAPK_gen_1	223	231	PF00069	0.476
DOC_MAPK_gen_1	252	259	PF00069	0.457
DOC_MAPK_HePTP_8	249	261	PF00069	0.456
DOC_MAPK_MEF2A_6	223	231	PF00069	0.523
DOC_MAPK_MEF2A_6	252	261	PF00069	0.479
DOC_MAPK_MEF2A_6	46	53	PF00069	0.462
DOC_MAPK_NFAT4_5	252	260	PF00069	0.466
DOC_PP2B_LxvP_1	272	275	PF13499	0.533
DOC_PP2B_LxvP_1	310	313	PF13499	0.501
DOC_PP2B_LxvP_1	321	324	PF13499	0.429
DOC_PP4_FxxP_1	224	227	PF00568	0.573
DOC_PP4_FxxP_1	86	89	PF00568	0.521
DOC_USP7_MATH_1	15	19	PF00917	0.570
DOC_USP7_MATH_1	150	154	PF00917	0.371
DOC_USP7_MATH_1	202	206	PF00917	0.278
DOC_WW_Pin1_4	205	210	PF00397	0.591
DOC_WW_Pin1_4	292	297	PF00397	0.639
DOC_WW_Pin1_4	61	66	PF00397	0.571
LIG_14-3-3_CanoR_1	154	164	PF00244	0.420
LIG_14-3-3_CanoR_1	167	175	PF00244	0.443
LIG_14-3-3_CanoR_1	181	189	PF00244	0.282
LIG_14-3-3_CanoR_1	246	255	PF00244	0.412
LIG_14-3-3_CanoR_1	286	290	PF00244	0.621
LIG_14-3-3_CanoR_1	56	60	PF00244	0.501
LIG_14-3-3_CanoR_1	70	78	PF00244	0.495
LIG_ActinCP_TwfCPI_2	224	234	PF01115	0.552
LIG_BIR_II_1	1	5	PF00653	0.757
LIG_BIR_III_1	1	5	PF00653	0.659
LIG_BIR_III_2	123	127	PF00653	0.557
LIG_BIR_III_3	1	5	PF00653	0.659
LIG_BRCT_BRCA1_1	82	86	PF00533	0.533
LIG_CSL_BTD_1	47	50	PF09270	0.364
LIG_deltaCOP1_diTrp_1	161	170	PF00928	0.484
LIG_FHA_2	127	133	PF00498	0.349
LIG_FHA_2	156	162	PF00498	0.329
LIG_FHA_2	303	309	PF00498	0.673
LIG_GBD_Chelix_1	53	61	PF00786	0.369
LIG_LIR_Apic_2	83	89	PF02991	0.554
LIG_LIR_Nem_3	205	210	PF02991	0.574
LIG_SH2_CRK	166	170	PF00017	0.443
LIG_SH2_CRK	215	219	PF00017	0.393
LIG_SH2_CRK	240	244	PF00017	0.552
LIG_SH2_NCK_1	196	200	PF00017	0.447
LIG_SH2_NCK_1	215	219	PF00017	0.449
LIG_SH2_SRC	215	218	PF00017	0.419
LIG_SH3_2	65	70	PF14604	0.548
LIG_SH3_3	260	266	PF00018	0.501
LIG_SH3_3	44	50	PF00018	0.414
LIG_SH3_3	62	68	PF00018	0.490
LIG_SUMO_SIM_anti_2	88	95	PF11976	0.511
LIG_TRAF2_1	137	140	PF00917	0.446
LIG_TYR_ITIM	238	243	PF00017	0.542
MOD_CDK_SPxK_1	64	70	PF00069	0.511
MOD_CK1_1	205	211	PF00069	0.518
MOD_CK1_1	64	70	PF00069	0.539
MOD_CK1_1	74	80	PF00069	0.496
MOD_CK2_1	126	132	PF00069	0.332
MOD_CK2_1	133	139	PF00069	0.317
MOD_CK2_1	155	161	PF00069	0.344
MOD_GlcNHglycan	135	138	PF01048	0.449
MOD_GlcNHglycan	26	29	PF01048	0.578
MOD_GlcNHglycan	287	290	PF01048	0.668
MOD_GSK3_1	198	205	PF00069	0.427
MOD_GSK3_1	281	288	PF00069	0.552
MOD_GSK3_1	33	40	PF00069	0.318
MOD_GSK3_1	70	77	PF00069	0.556
MOD_N-GLC_1	150	155	PF02516	0.422
MOD_N-GLC_1	74	79	PF02516	0.497
MOD_NEK2_1	115	120	PF00069	0.652
MOD_NEK2_1	257	262	PF00069	0.453
MOD_NEK2_1	33	38	PF00069	0.366
MOD_NEK2_1	71	76	PF00069	0.512
MOD_PIKK_1	115	121	PF00454	0.645
MOD_PIKK_1	15	21	PF00454	0.544
MOD_PIKK_1	247	253	PF00454	0.488
MOD_PIKK_1	81	87	PF00454	0.426
MOD_PKA_2	285	291	PF00069	0.636
MOD_PKA_2	55	61	PF00069	0.550
MOD_Plk_1	150	156	PF00069	0.422
MOD_Plk_2-3	135	141	PF00069	0.443
MOD_Plk_4	257	263	PF00069	0.516
MOD_ProDKin_1	205	211	PF00069	0.587
MOD_ProDKin_1	292	298	PF00069	0.638
MOD_ProDKin_1	61	67	PF00069	0.571
MOD_SUMO_rev_2	159	165	PF00179	0.422
TRG_DiLeu_BaEn_1	318	323	PF01217	0.581
TRG_DiLeu_BaEn_2	28	34	PF01217	0.514
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.430
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.406
TRG_ENDOCYTIC_2	215	218	PF00928	0.394
TRG_ENDOCYTIC_2	240	243	PF00928	0.458
TRG_ER_diArg_1	213	215	PF00400	0.477
TRG_ER_diArg_1	319	321	PF00400	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA4	Leptomonas seymouri	49%	99%
A0A1X0P0E9	Trypanosomatidae	31%	100%
A4H8D6	Leishmania braziliensis	69%	100%
A4HWQ8	Leishmania infantum	99%	100%
C9ZPS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AQG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QF11	Leishmania major	94%	100%
V5ARD2	Trypanosoma cruzi	35%	100%