Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICE6_LEIDO

TriTrypDb:

LdBPK_251570.1 , LdCL_250021400 , LDHU3_25.1940

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.503
CLV_C14_Caspase3-7	333	337	PF00656	0.799
CLV_NRD_NRD_1	227	229	PF00675	0.667
CLV_NRD_NRD_1	428	430	PF00675	0.729
CLV_NRD_NRD_1	431	433	PF00675	0.726
CLV_NRD_NRD_1	46	48	PF00675	0.589
CLV_NRD_NRD_1	516	518	PF00675	0.571
CLV_PCSK_KEX2_1	229	231	PF00082	0.693
CLV_PCSK_KEX2_1	316	318	PF00082	0.649
CLV_PCSK_KEX2_1	46	48	PF00082	0.589
CLV_PCSK_KEX2_1	516	518	PF00082	0.543
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.619
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.649
CLV_PCSK_PC7_1	225	231	PF00082	0.677
CLV_PCSK_SKI1_1	47	51	PF00082	0.582
DEG_APCC_DBOX_1	123	131	PF00400	0.759
DEG_COP1_1	493	501	PF00400	0.696
DEG_Nend_UBRbox_2	1	3	PF02207	0.643
DEG_SCF_FBW7_1	346	353	PF00400	0.780
DEG_SCF_TRCP1_1	489	494	PF00400	0.666
DEG_SPOP_SBC_1	320	324	PF00917	0.840
DEG_SPOP_SBC_1	370	374	PF00917	0.662
DEG_SPOP_SBC_1	403	407	PF00917	0.821
DEG_SPOP_SBC_1	501	505	PF00917	0.717
DOC_CDC14_PxL_1	71	79	PF14671	0.464
DOC_CKS1_1	465	470	PF01111	0.606
DOC_MAPK_gen_1	429	439	PF00069	0.718
DOC_MAPK_MEF2A_6	9	18	PF00069	0.583
DOC_PP2B_LxvP_1	72	75	PF13499	0.496
DOC_PP2B_PxIxI_1	391	397	PF00149	0.713
DOC_PP4_FxxP_1	11	14	PF00568	0.500
DOC_PP4_MxPP_1	348	351	PF00568	0.821
DOC_USP7_MATH_1	206	210	PF00917	0.651
DOC_USP7_MATH_1	299	303	PF00917	0.737
DOC_USP7_MATH_1	370	374	PF00917	0.733
DOC_USP7_MATH_1	402	406	PF00917	0.818
DOC_USP7_MATH_1	471	475	PF00917	0.815
DOC_USP7_MATH_1	487	491	PF00917	0.605
DOC_USP7_MATH_1	501	505	PF00917	0.531
DOC_USP7_MATH_1	61	65	PF00917	0.481
DOC_WW_Pin1_4	122	127	PF00397	0.693
DOC_WW_Pin1_4	284	289	PF00397	0.801
DOC_WW_Pin1_4	303	308	PF00397	0.564
DOC_WW_Pin1_4	346	351	PF00397	0.708
DOC_WW_Pin1_4	388	393	PF00397	0.819
DOC_WW_Pin1_4	464	469	PF00397	0.706
LIG_14-3-3_CanoR_1	329	335	PF00244	0.733
LIG_14-3-3_CanoR_1	381	385	PF00244	0.777
LIG_14-3-3_CanoR_1	46	55	PF00244	0.581
LIG_AP2alpha_2	397	399	PF02296	0.727
LIG_BH_BH3_1	80	96	PF00452	0.562
LIG_BIR_III_2	523	527	PF00653	0.710
LIG_FHA_1	434	440	PF00498	0.746
LIG_FHA_1	442	448	PF00498	0.630
LIG_FHA_1	477	483	PF00498	0.838
LIG_FHA_2	142	148	PF00498	0.585
LIG_FHA_2	156	162	PF00498	0.402
LIG_FHA_2	254	260	PF00498	0.591
LIG_FHA_2	408	414	PF00498	0.802
LIG_FHA_2	92	98	PF00498	0.620
LIG_LIR_Apic_2	10	14	PF02991	0.514
LIG_LIR_Gen_1	259	270	PF02991	0.707
LIG_LIR_Nem_3	259	265	PF02991	0.699
LIG_LIR_Nem_3	510	515	PF02991	0.609
LIG_MAD2	47	55	PF02301	0.619
LIG_MYND_1	388	392	PF01753	0.741
LIG_RPA_C_Fungi	77	89	PF08784	0.387
LIG_SH2_NCK_1	262	266	PF00017	0.725
LIG_SH2_SRC	194	197	PF00017	0.517
LIG_SH2_STAT5	140	143	PF00017	0.521
LIG_SH2_STAT5	194	197	PF00017	0.556
LIG_SH2_STAT5	529	532	PF00017	0.555
LIG_SH2_STAT5	65	68	PF00017	0.448
LIG_SH2_STAT5	70	73	PF00017	0.487
LIG_SH3_3	278	284	PF00018	0.699
LIG_SH3_3	301	307	PF00018	0.730
LIG_SH3_3	382	388	PF00018	0.775
LIG_SH3_3	392	398	PF00018	0.653
LIG_SUMO_SIM_par_1	266	275	PF11976	0.801
LIG_TRAF2_1	234	237	PF00917	0.588
LIG_TRAF2_1	416	419	PF00917	0.768
LIG_WRC_WIRS_1	8	13	PF05994	0.524
MOD_CK1_1	287	293	PF00069	0.802
MOD_CK1_1	302	308	PF00069	0.570
MOD_CK1_1	4	10	PF00069	0.556
MOD_CK1_1	407	413	PF00069	0.771
MOD_CK1_1	442	448	PF00069	0.672
MOD_CK1_1	466	472	PF00069	0.720
MOD_CK1_1	474	480	PF00069	0.759
MOD_CK1_1	490	496	PF00069	0.680
MOD_CK1_1	500	506	PF00069	0.680
MOD_CK2_1	141	147	PF00069	0.511
MOD_CK2_1	155	161	PF00069	0.393
MOD_CK2_1	168	174	PF00069	0.485
MOD_CK2_1	217	223	PF00069	0.620
MOD_CK2_1	253	259	PF00069	0.588
MOD_CK2_1	334	340	PF00069	0.671
MOD_CK2_1	407	413	PF00069	0.725
MOD_CK2_1	53	59	PF00069	0.508
MOD_CK2_1	7	13	PF00069	0.610
MOD_CK2_1	91	97	PF00069	0.608
MOD_GlcNHglycan	107	110	PF01048	0.610
MOD_GlcNHglycan	136	139	PF01048	0.553
MOD_GlcNHglycan	144	147	PF01048	0.449
MOD_GlcNHglycan	219	222	PF01048	0.609
MOD_GlcNHglycan	274	277	PF01048	0.809
MOD_GlcNHglycan	367	370	PF01048	0.836
MOD_GlcNHglycan	382	385	PF01048	0.584
MOD_GlcNHglycan	469	472	PF01048	0.691
MOD_GlcNHglycan	489	492	PF01048	0.510
MOD_GlcNHglycan	499	502	PF01048	0.699
MOD_GlcNHglycan	55	58	PF01048	0.501
MOD_GSK3_1	155	162	PF00069	0.457
MOD_GSK3_1	196	203	PF00069	0.662
MOD_GSK3_1	287	294	PF00069	0.782
MOD_GSK3_1	299	306	PF00069	0.593
MOD_GSK3_1	3	10	PF00069	0.573
MOD_GSK3_1	319	326	PF00069	0.780
MOD_GSK3_1	330	337	PF00069	0.659
MOD_GSK3_1	346	353	PF00069	0.717
MOD_GSK3_1	360	367	PF00069	0.699
MOD_GSK3_1	403	410	PF00069	0.835
MOD_GSK3_1	463	470	PF00069	0.722
MOD_GSK3_1	471	478	PF00069	0.720
MOD_GSK3_1	487	494	PF00069	0.716
MOD_GSK3_1	497	504	PF00069	0.693
MOD_N-GLC_1	334	339	PF02516	0.775
MOD_NEK2_1	1	6	PF00069	0.508
MOD_NEK2_1	141	146	PF00069	0.473
MOD_NEK2_1	168	173	PF00069	0.557
MOD_NEK2_1	217	222	PF00069	0.510
MOD_NEK2_1	364	369	PF00069	0.634
MOD_NEK2_1	91	96	PF00069	0.514
MOD_NEK2_2	458	463	PF00069	0.746
MOD_PIKK_1	159	165	PF00454	0.511
MOD_PIKK_1	291	297	PF00454	0.621
MOD_PKA_2	272	278	PF00069	0.619
MOD_PKA_2	380	386	PF00069	0.779
MOD_Plk_1	334	340	PF00069	0.775
MOD_Plk_1	442	448	PF00069	0.672
MOD_Plk_4	360	366	PF00069	0.685
MOD_Plk_4	404	410	PF00069	0.788
MOD_Plk_4	433	439	PF00069	0.754
MOD_Plk_4	442	448	PF00069	0.622
MOD_Plk_4	7	13	PF00069	0.513
MOD_Plk_4	91	97	PF00069	0.528
MOD_ProDKin_1	122	128	PF00069	0.691
MOD_ProDKin_1	284	290	PF00069	0.798
MOD_ProDKin_1	303	309	PF00069	0.564
MOD_ProDKin_1	346	352	PF00069	0.713
MOD_ProDKin_1	388	394	PF00069	0.820
MOD_ProDKin_1	464	470	PF00069	0.705
TRG_DiLeu_BaEn_1	239	244	PF01217	0.661
TRG_DiLeu_BaEn_1	460	465	PF01217	0.738
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.463
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.481
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.738
TRG_ENDOCYTIC_2	262	265	PF00928	0.702
TRG_ER_diArg_1	327	330	PF00400	0.691
TRG_ER_diArg_1	45	47	PF00400	0.587
TRG_ER_diArg_1	515	517	PF00400	0.603
TRG_NES_CRM1_1	13	27	PF08389	0.464
TRG_NLS_MonoExtC_3	428	433	PF00514	0.829
TRG_NLS_MonoExtN_4	426	433	PF00514	0.830
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	517	522	PF00026	0.738

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYY1	Leptomonas seymouri	38%	100%
A4HEK1	Leishmania braziliensis	76%	99%
A4I1J7	Leishmania infantum	100%	100%
E9AXN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q9U0	Leishmania major	91%	100%