LeishMANIAdb
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Partitioning defective 3 B

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Partitioning defective 3 B
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8ICE4_LEIDO
TriTrypDb:
LdBPK_230260.1 * , LdCL_230007500 , LDHU3_23.0330
Length:
161

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A0A3Q8ICE4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICE4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 84 88 PF00656 0.620
CLV_NRD_NRD_1 71 73 PF00675 0.659
CLV_PCSK_KEX2_1 71 73 PF00082 0.659
CLV_PCSK_SKI1_1 90 94 PF00082 0.557
DEG_Nend_UBRbox_1 1 4 PF02207 0.563
DEG_SCF_FBW7_1 39 46 PF00400 0.644
DEG_SPOP_SBC_1 26 30 PF00917 0.588
DOC_CKS1_1 40 45 PF01111 0.624
DOC_PP2B_LxvP_1 92 95 PF13499 0.651
DOC_PP4_FxxP_1 119 122 PF00568 0.660
DOC_PP4_MxPP_1 129 132 PF00568 0.612
DOC_USP7_MATH_1 13 17 PF00917 0.577
DOC_WW_Pin1_4 39 44 PF00397 0.641
DOC_WW_Pin1_4 50 55 PF00397 0.590
LIG_FHA_1 145 151 PF00498 0.405
LIG_FHA_1 27 33 PF00498 0.598
LIG_FHA_1 34 40 PF00498 0.570
LIG_FHA_2 123 129 PF00498 0.604
LIG_FHA_2 44 50 PF00498 0.564
LIG_FHA_2 82 88 PF00498 0.637
LIG_LIR_Apic_2 75 81 PF02991 0.566
LIG_LIR_Nem_3 152 158 PF02991 0.392
LIG_PDZ_Class_1 156 161 PF00595 0.388
LIG_SH2_STAT3 115 118 PF00017 0.660
LIG_SH2_STAT3 41 44 PF00017 0.627
LIG_SH2_STAT5 35 38 PF00017 0.662
LIG_SH2_STAT5 41 44 PF00017 0.596
LIG_SH2_STAT5 50 53 PF00017 0.648
LIG_SH3_1 37 43 PF00018 0.562
LIG_SH3_3 128 134 PF00018 0.502
LIG_SH3_3 37 43 PF00018 0.620
LIG_SH3_3 88 94 PF00018 0.653
LIG_WW_1 112 115 PF00397 0.664
MOD_CDK_SPK_2 50 55 PF00069 0.650
MOD_GlcNHglycan 158 161 PF01048 0.385
MOD_GSK3_1 140 147 PF00069 0.449
MOD_GSK3_1 39 46 PF00069 0.608
MOD_N-GLC_1 26 31 PF02516 0.631
MOD_NEK2_1 149 154 PF00069 0.397
MOD_PIKK_1 144 150 PF00454 0.475
MOD_Plk_4 149 155 PF00069 0.406
MOD_ProDKin_1 39 45 PF00069 0.641
MOD_ProDKin_1 50 56 PF00069 0.584
TRG_Pf-PMV_PEXEL_1 139 144 PF00026 0.610

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHG6 Leptomonas seymouri 54% 76%
A0A1X0NGS3 Trypanosomatidae 44% 95%
A0A3S7WXM6 Leishmania donovani 100% 73%
E9AW25 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 71%
Q4QBF2 Leishmania major 96% 73%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS