Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICE3_LEIDO

TriTrypDb:

LdBPK_151560.1 , LdCL_150020900 , LDHU3_15.1880

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.605
CLV_C14_Caspase3-7	631	635	PF00656	0.657
CLV_NRD_NRD_1	179	181	PF00675	0.663
CLV_NRD_NRD_1	242	244	PF00675	0.588
CLV_NRD_NRD_1	290	292	PF00675	0.468
CLV_NRD_NRD_1	34	36	PF00675	0.605
CLV_NRD_NRD_1	415	417	PF00675	0.618
CLV_NRD_NRD_1	437	439	PF00675	0.644
CLV_NRD_NRD_1	500	502	PF00675	0.639
CLV_NRD_NRD_1	571	573	PF00675	0.679
CLV_NRD_NRD_1	577	579	PF00675	0.611
CLV_NRD_NRD_1	608	610	PF00675	0.661
CLV_NRD_NRD_1	627	629	PF00675	0.783
CLV_PCSK_FUR_1	288	292	PF00082	0.471
CLV_PCSK_KEX2_1	206	208	PF00082	0.536
CLV_PCSK_KEX2_1	244	246	PF00082	0.586
CLV_PCSK_KEX2_1	290	292	PF00082	0.468
CLV_PCSK_KEX2_1	310	312	PF00082	0.503
CLV_PCSK_KEX2_1	439	441	PF00082	0.662
CLV_PCSK_KEX2_1	474	476	PF00082	0.626
CLV_PCSK_KEX2_1	513	515	PF00082	0.609
CLV_PCSK_KEX2_1	571	573	PF00082	0.690
CLV_PCSK_KEX2_1	577	579	PF00082	0.640
CLV_PCSK_KEX2_1	627	629	PF00082	0.783
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.536
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.586
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.696
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.662
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.711
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.609
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.804
CLV_PCSK_SKI1_1	101	105	PF00082	0.556
CLV_PCSK_SKI1_1	181	185	PF00082	0.614
CLV_PCSK_SKI1_1	216	220	PF00082	0.490
CLV_PCSK_SKI1_1	35	39	PF00082	0.578
CLV_PCSK_SKI1_1	41	45	PF00082	0.546
CLV_PCSK_SKI1_1	502	506	PF00082	0.712
CLV_PCSK_SKI1_1	509	513	PF00082	0.762
CLV_PCSK_SKI1_1	75	79	PF00082	0.570
DEG_APCC_DBOX_1	289	297	PF00400	0.473
DEG_APCC_DBOX_1	636	644	PF00400	0.551
DOC_CYCLIN_yCln2_LP_2	421	427	PF00134	0.661
DOC_MAPK_DCC_7	417	427	PF00069	0.576
DOC_MAPK_DCC_7	461	469	PF00069	0.711
DOC_MAPK_gen_1	243	251	PF00069	0.615
DOC_MAPK_gen_1	280	287	PF00069	0.677
DOC_MAPK_gen_1	310	318	PF00069	0.615
DOC_MAPK_gen_1	361	369	PF00069	0.604
DOC_MAPK_gen_1	438	444	PF00069	0.662
DOC_MAPK_gen_1	44	52	PF00069	0.493
DOC_MAPK_MEF2A_6	461	469	PF00069	0.711
DOC_MAPK_RevD_3	559	572	PF00069	0.598
DOC_PP2B_LxvP_1	218	221	PF13499	0.559
DOC_PP2B_LxvP_1	421	424	PF13499	0.661
DOC_PP2B_LxvP_1	584	587	PF13499	0.762
DOC_PP4_FxxP_1	158	161	PF00568	0.522
DOC_SPAK_OSR1_1	245	249	PF12202	0.574
DOC_USP7_MATH_1	289	293	PF00917	0.525
DOC_USP7_MATH_1	477	481	PF00917	0.668
DOC_USP7_MATH_1	579	583	PF00917	0.793
DOC_USP7_MATH_1	619	623	PF00917	0.560
DOC_USP7_UBL2_3	101	105	PF12436	0.602
DOC_USP7_UBL2_3	134	138	PF12436	0.542
DOC_USP7_UBL2_3	361	365	PF12436	0.607
DOC_USP7_UBL2_3	509	513	PF12436	0.666
DOC_USP7_UBL2_3	55	59	PF12436	0.422
DOC_USP7_UBL2_3	569	573	PF12436	0.803
DOC_WW_Pin1_4	157	162	PF00397	0.678
DOC_WW_Pin1_4	209	214	PF00397	0.471
DOC_WW_Pin1_4	416	421	PF00397	0.581
DOC_WW_Pin1_4	445	450	PF00397	0.643
DOC_WW_Pin1_4	451	456	PF00397	0.657
DOC_WW_Pin1_4	602	607	PF00397	0.694
DOC_WW_Pin1_4	615	620	PF00397	0.779
DOC_WW_Pin1_4	621	626	PF00397	0.725
DOC_WW_Pin1_4	643	648	PF00397	0.544
LIG_14-3-3_CanoR_1	180	187	PF00244	0.507
LIG_14-3-3_CanoR_1	207	212	PF00244	0.588
LIG_14-3-3_CanoR_1	237	242	PF00244	0.605
LIG_14-3-3_CanoR_1	288	294	PF00244	0.648
LIG_14-3-3_CanoR_1	300	308	PF00244	0.469
LIG_14-3-3_CanoR_1	311	317	PF00244	0.587
LIG_14-3-3_CanoR_1	342	348	PF00244	0.558
LIG_14-3-3_CanoR_1	438	443	PF00244	0.634
LIG_14-3-3_CanoR_1	492	496	PF00244	0.718
LIG_14-3-3_CanoR_1	578	587	PF00244	0.620
LIG_14-3-3_CanoR_1	6	13	PF00244	0.621
LIG_14-3-3_CanoR_1	613	619	PF00244	0.799
LIG_14-3-3_CanoR_1	627	633	PF00244	0.695
LIG_Actin_WH2_2	89	107	PF00022	0.652
LIG_BRCT_BRCA1_1	619	623	PF00533	0.797
LIG_CaM_IQ_9	28	43	PF13499	0.531
LIG_EH1_1	369	377	PF00400	0.678
LIG_FHA_1	186	192	PF00498	0.601
LIG_FHA_1	439	445	PF00498	0.783
LIG_FHA_1	482	488	PF00498	0.693
LIG_FHA_1	563	569	PF00498	0.756
LIG_FHA_1	68	74	PF00498	0.672
LIG_FHA_1	87	93	PF00498	0.419
LIG_FHA_2	140	146	PF00498	0.708
LIG_FHA_2	521	527	PF00498	0.795
LIG_GBD_Chelix_1	632	640	PF00786	0.604
LIG_LIR_Gen_1	109	116	PF02991	0.459
LIG_LIR_Gen_1	167	177	PF02991	0.524
LIG_LIR_Gen_1	182	191	PF02991	0.506
LIG_LIR_Gen_1	22	31	PF02991	0.465
LIG_LIR_Gen_1	346	356	PF02991	0.711
LIG_LIR_Gen_1	89	97	PF02991	0.521
LIG_LIR_Nem_3	109	114	PF02991	0.464
LIG_LIR_Nem_3	152	158	PF02991	0.537
LIG_LIR_Nem_3	182	187	PF02991	0.499
LIG_LIR_Nem_3	22	27	PF02991	0.465
LIG_LIR_Nem_3	269	275	PF02991	0.616
LIG_LIR_Nem_3	346	351	PF02991	0.710
LIG_LIR_Nem_3	551	556	PF02991	0.607
LIG_LIR_Nem_3	89	93	PF02991	0.529
LIG_NRBOX	639	645	PF00104	0.521
LIG_PCNA_PIPBox_1	50	59	PF02747	0.622
LIG_Pex14_2	229	233	PF04695	0.649
LIG_Pex14_2	532	536	PF04695	0.667
LIG_PTAP_UEV_1	563	568	PF05743	0.789
LIG_SH2_CRK	208	212	PF00017	0.614
LIG_SH2_SRC	348	351	PF00017	0.547
LIG_SH2_STAP1	348	352	PF00017	0.546
LIG_SH2_STAT5	203	206	PF00017	0.577
LIG_SH2_STAT5	286	289	PF00017	0.532
LIG_SH3_2	564	569	PF14604	0.794
LIG_SH3_3	313	319	PF00018	0.644
LIG_SH3_3	453	459	PF00018	0.643
LIG_SH3_3	484	490	PF00018	0.746
LIG_SH3_3	558	564	PF00018	0.778
LIG_SH3_3	608	614	PF00018	0.628
LIG_SUMO_SIM_par_1	188	194	PF11976	0.609
LIG_TRAF2_1	199	202	PF00917	0.494
LIG_UBA3_1	131	138	PF00899	0.486
LIG_UBA3_1	52	59	PF00899	0.493
LIG_UBA3_1	92	101	PF00899	0.544
LIG_WRC_WIRS_1	166	171	PF05994	0.528
MOD_CDC14_SPxK_1	458	461	PF00782	0.794
MOD_CDK_SPxK_1	455	461	PF00069	0.800
MOD_CDK_SPxK_1	621	627	PF00069	0.758
MOD_CDK_SPxxK_3	209	216	PF00069	0.438
MOD_CDK_SPxxK_3	445	452	PF00069	0.518
MOD_CDK_SPxxK_3	602	609	PF00069	0.708
MOD_CDK_SPxxK_3	621	628	PF00069	0.756
MOD_CK1_1	147	153	PF00069	0.642
MOD_CK1_1	167	173	PF00069	0.610
MOD_CK1_1	182	188	PF00069	0.468
MOD_CK1_1	194	200	PF00069	0.549
MOD_CK1_1	209	215	PF00069	0.450
MOD_CK1_1	274	280	PF00069	0.492
MOD_CK1_1	333	339	PF00069	0.621
MOD_CK1_1	519	525	PF00069	0.748
MOD_CK1_1	618	624	PF00069	0.730
MOD_CK1_1	8	14	PF00069	0.722
MOD_CK2_1	139	145	PF00069	0.710
MOD_CK2_1	165	171	PF00069	0.535
MOD_CK2_1	196	202	PF00069	0.507
MOD_CK2_1	220	226	PF00069	0.584
MOD_CK2_1	639	645	PF00069	0.547
MOD_Cter_Amidation	575	578	PF01082	0.685
MOD_GlcNHglycan	152	155	PF01048	0.584
MOD_GlcNHglycan	181	184	PF01048	0.511
MOD_GlcNHglycan	198	201	PF01048	0.524
MOD_GlcNHglycan	399	402	PF01048	0.682
MOD_GlcNHglycan	497	500	PF01048	0.723
MOD_GlcNHglycan	573	576	PF01048	0.663
MOD_GlcNHglycan	8	11	PF01048	0.622
MOD_GSK3_1	140	147	PF00069	0.627
MOD_GSK3_1	172	179	PF00069	0.528
MOD_GSK3_1	185	192	PF00069	0.508
MOD_GSK3_1	271	278	PF00069	0.503
MOD_GSK3_1	451	458	PF00069	0.605
MOD_GSK3_1	477	484	PF00069	0.793
MOD_GSK3_1	491	498	PF00069	0.724
MOD_GSK3_1	515	522	PF00069	0.705
MOD_GSK3_1	614	621	PF00069	0.759
MOD_GSK3_1	639	646	PF00069	0.525
MOD_LATS_1	4	10	PF00433	0.691
MOD_N-GLC_1	147	152	PF02516	0.573
MOD_N-GLC_1	194	199	PF02516	0.544
MOD_N-GLC_1	86	91	PF02516	0.541
MOD_NEK2_1	115	120	PF00069	0.683
MOD_NEK2_1	164	169	PF00069	0.622
MOD_NEK2_1	172	177	PF00069	0.549
MOD_NEK2_1	191	196	PF00069	0.366
MOD_NEK2_1	271	276	PF00069	0.626
MOD_NEK2_1	338	343	PF00069	0.551
MOD_NEK2_1	5	10	PF00069	0.612
MOD_NEK2_1	67	72	PF00069	0.622
MOD_NEK2_2	116	121	PF00069	0.691
MOD_NEK2_2	343	348	PF00069	0.622
MOD_NEK2_2	491	496	PF00069	0.592
MOD_PIKK_1	25	31	PF00454	0.460
MOD_PIKK_1	516	522	PF00454	0.733
MOD_PIKK_1	594	600	PF00454	0.720
MOD_PIKK_1	8	14	PF00454	0.722
MOD_PK_1	189	195	PF00069	0.552
MOD_PKA_1	206	212	PF00069	0.522
MOD_PKA_1	438	444	PF00069	0.653
MOD_PKA_1	513	519	PF00069	0.647
MOD_PKA_1	571	577	PF00069	0.667
MOD_PKA_1	628	634	PF00069	0.681
MOD_PKA_2	179	185	PF00069	0.511
MOD_PKA_2	206	212	PF00069	0.592
MOD_PKA_2	289	295	PF00069	0.544
MOD_PKA_2	299	305	PF00069	0.479
MOD_PKA_2	491	497	PF00069	0.728
MOD_PKA_2	5	11	PF00069	0.616
MOD_PKA_2	513	519	PF00069	0.606
MOD_PKA_2	571	577	PF00069	0.658
MOD_Plk_1	126	132	PF00069	0.565
MOD_Plk_1	147	153	PF00069	0.593
MOD_Plk_1	194	200	PF00069	0.692
MOD_Plk_1	325	331	PF00069	0.612
MOD_Plk_1	86	92	PF00069	0.539
MOD_Plk_4	333	339	PF00069	0.576
MOD_Plk_4	343	349	PF00069	0.499
MOD_Plk_4	586	592	PF00069	0.611
MOD_Plk_4	639	645	PF00069	0.521
MOD_ProDKin_1	157	163	PF00069	0.674
MOD_ProDKin_1	209	215	PF00069	0.475
MOD_ProDKin_1	416	422	PF00069	0.579
MOD_ProDKin_1	445	451	PF00069	0.647
MOD_ProDKin_1	455	461	PF00069	0.671
MOD_ProDKin_1	602	608	PF00069	0.695
MOD_ProDKin_1	615	621	PF00069	0.780
MOD_ProDKin_1	643	649	PF00069	0.550
MOD_SUMO_rev_2	236	246	PF00179	0.532
MOD_SUMO_rev_2	30	38	PF00179	0.562
MOD_SUMO_rev_2	400	408	PF00179	0.567
TRG_ENDOCYTIC_2	208	211	PF00928	0.616
TRG_ENDOCYTIC_2	348	351	PF00928	0.557
TRG_ER_diArg_1	243	246	PF00400	0.587
TRG_ER_diArg_1	287	290	PF00400	0.496
TRG_NLS_Bipartite_1	428	442	PF00514	0.674
TRG_NLS_MonoExtC_3	415	420	PF00514	0.616
TRG_NLS_MonoExtN_4	414	420	PF00514	0.677
TRG_NLS_MonoExtN_4	436	442	PF00514	0.615
TRG_NLS_MonoExtN_4	569	575	PF00514	0.754

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZB6	Leptomonas seymouri	43%	100%
A4H8B7	Leishmania braziliensis	69%	98%
A4HWN8	Leishmania infantum	99%	100%
E9AQE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QF30	Leishmania major	91%	100%