Cytosol aminopeptidase family, catalytic domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MF, Family M17 (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8ICD9_LEIDO

TriTrypDb:

LdBPK_110630.1 , LdCL_110011700 , LDHU3_11.0830

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 2
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8ICD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICD9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0019538	protein metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004177	aminopeptidase activity	5	5
GO:0005488	binding	1	5
GO:0008233	peptidase activity	3	5
GO:0008235	metalloexopeptidase activity	5	5
GO:0008237	metallopeptidase activity	4	5
GO:0008238	exopeptidase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0030145	manganese ion binding	6	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0046914	transition metal ion binding	5	5
GO:0070006	metalloaminopeptidase activity	6	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	146	150	PF00082	0.586
CLV_PCSK_SKI1_1	91	95	PF00082	0.586
DEG_COP1_1	157	166	PF00400	0.528
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.586
DOC_MAPK_gen_1	257	265	PF00069	0.586
DOC_MAPK_MEF2A_6	257	265	PF00069	0.586
DOC_PP4_FxxP_1	258	261	PF00568	0.586
DOC_USP7_MATH_1	180	184	PF00917	0.586
DOC_USP7_MATH_1	241	245	PF00917	0.504
DOC_USP7_MATH_1	268	272	PF00917	0.411
DOC_WW_Pin1_4	223	228	PF00397	0.586
DOC_WW_Pin1_4	234	239	PF00397	0.469
LIG_14-3-3_CanoR_1	232	238	PF00244	0.411
LIG_14-3-3_CanoR_1	97	106	PF00244	0.528
LIG_BIR_III_4	142	146	PF00653	0.586
LIG_BRCT_BRCA1_1	254	258	PF00533	0.586
LIG_CtBP_PxDLS_1	6	12	PF00389	0.469
LIG_FHA_1	107	113	PF00498	0.484
LIG_FHA_2	139	145	PF00498	0.586
LIG_FHA_2	273	279	PF00498	0.626
LIG_LIR_Apic_2	221	227	PF02991	0.529
LIG_LIR_Apic_2	255	261	PF02991	0.586
LIG_LIR_Apic_2	32	38	PF02991	0.586
LIG_LIR_Gen_1	98	108	PF02991	0.586
LIG_LIR_Nem_3	11	17	PF02991	0.529
LIG_LIR_Nem_3	208	214	PF02991	0.586
LIG_LIR_Nem_3	98	103	PF02991	0.586
LIG_LYPXL_yS_3	211	214	PF13949	0.586
LIG_Pex14_2	258	262	PF04695	0.586
LIG_SH2_CRK	14	18	PF00017	0.586
LIG_SH2_CRK	224	228	PF00017	0.586
LIG_SH2_CRK	35	39	PF00017	0.586
LIG_SH2_STAP1	189	193	PF00017	0.528
LIG_SH2_STAT5	215	218	PF00017	0.586
LIG_SH2_STAT5	248	251	PF00017	0.586
LIG_Sin3_3	86	93	PF02671	0.586
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.586
LIG_SUMO_SIM_anti_2	135	142	PF11976	0.393
LIG_TYR_ITIM	209	214	PF00017	0.586
MOD_CK1_1	132	138	PF00069	0.586
MOD_CK1_1	237	243	PF00069	0.470
MOD_CK1_1	272	278	PF00069	0.578
MOD_CK2_1	138	144	PF00069	0.586
MOD_CK2_1	188	194	PF00069	0.586
MOD_GlcNHglycan	131	134	PF01048	0.492
MOD_GlcNHglycan	205	208	PF01048	0.557
MOD_GlcNHglycan	239	242	PF01048	0.437
MOD_GlcNHglycan	78	81	PF01048	0.424
MOD_GSK3_1	236	243	PF00069	0.586
MOD_GSK3_1	268	275	PF00069	0.430
MOD_GSK3_1	67	74	PF00069	0.586
MOD_N-GLC_1	104	109	PF02516	0.586
MOD_N-GLC_1	272	277	PF02516	0.551
MOD_NEK2_1	231	236	PF00069	0.502
MOD_NEK2_1	76	81	PF00069	0.500
MOD_NEK2_1	95	100	PF00069	0.493
MOD_PKA_2	231	237	PF00069	0.455
MOD_Plk_1	104	110	PF00069	0.586
MOD_ProDKin_1	223	229	PF00069	0.586
MOD_ProDKin_1	234	240	PF00069	0.469
MOD_SUMO_for_1	4	7	PF00179	0.498
TRG_ENDOCYTIC_2	14	17	PF00928	0.437
TRG_ENDOCYTIC_2	211	214	PF00928	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A1AE61	Escherichia coli O1:K1 / APEC	35%	67%
A4HUX2	Leishmania infantum	100%	100%
A4WDA4	Enterobacter sp. (strain 638)	35%	66%
A6TCE4	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	36%	66%
A7MGW9	Cronobacter sakazakii (strain ATCC BAA-894)	35%	66%
A7ZPW6	Escherichia coli O139:H28 (strain E24377A / ETEC)	35%	67%
A8A329	Escherichia coli O9:H4 (strain HS)	35%	67%
A8AD60	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	34%	67%
A9MHK1	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	35%	67%
A9N1Y3	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	35%	67%
B1IWD8	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	35%	67%
B1LNH8	Escherichia coli (strain SMS-3-5 / SECEC)	34%	67%
B1XAZ8	Escherichia coli (strain K12 / DH10B)	35%	67%
B2TXU8	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	35%	67%
B4T0R5	Salmonella newport (strain SL254)	35%	67%
B5F1B3	Salmonella agona (strain SL483)	35%	67%
B5FR78	Salmonella dublin (strain CT_02021853)	35%	67%
B5R595	Salmonella enteritidis PT4 (strain P125109)	35%	67%
B5RD05	Salmonella gallinarum (strain 287/91 / NCTC 13346)	35%	67%
B5XNK4	Klebsiella pneumoniae (strain 342)	35%	66%
B5Z0Z6	Escherichia coli O157:H7 (strain EC4115 / EHEC)	35%	67%
B6I595	Escherichia coli (strain SE11)	35%	67%
B7LDB5	Escherichia coli (strain 55989 / EAEC)	35%	67%
B7LKB6	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	34%	67%
B7M7M6	Escherichia coli O8 (strain IAI1)	35%	67%
B7MI07	Escherichia coli O45:K1 (strain S88 / ExPEC)	35%	67%
B7MYF7	Escherichia coli O81 (strain ED1a)	35%	67%
B7N6B0	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	34%	67%
B7NRH2	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	34%	67%
B7UGW9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	35%	67%
C0PYL4	Salmonella paratyphi C (strain RKS4594)	35%	67%
C4ZX98	Escherichia coli (strain K12 / MC4100 / BW2952)	35%	67%
E9ANK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P37095	Escherichia coli (strain K12)	35%	67%
P58473	Escherichia coli O157:H7	35%	67%
Q0T1Z6	Shigella flexneri serotype 5b (strain 8401)	35%	67%
Q0TEW2	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	35%	67%
Q1R8K9	Escherichia coli (strain UTI89 / UPEC)	35%	67%
Q31XW7	Shigella boydii serotype 4 (strain Sb227)	35%	67%
Q32D41	Shigella dysenteriae serotype 1 (strain Sd197)	35%	67%
Q3YZ29	Shigella sonnei (strain Ss046)	35%	67%
Q4QH18	Leishmania major	96%	100%
Q57LH5	Salmonella choleraesuis (strain SC-B67)	35%	67%
Q83QK5	Shigella flexneri	35%	67%
Q8FF47	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	35%	67%
Q8Z4N3	Salmonella typhi	35%	67%
Q9KTX5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	34%	66%
Q9RF52	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	67%