SLY1 protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sec1 family transport protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICD5_LEIDO

TriTrypDb:

LdBPK_262380.1 , LdCL_260029500 , LDHU3_26.3100

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICD5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0016192	vesicle-mediated transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.411
CLV_C14_Caspase3-7	382	386	PF00656	0.286
CLV_NRD_NRD_1	255	257	PF00675	0.267
CLV_NRD_NRD_1	359	361	PF00675	0.345
CLV_NRD_NRD_1	401	403	PF00675	0.405
CLV_NRD_NRD_1	614	616	PF00675	0.232
CLV_NRD_NRD_1	652	654	PF00675	0.287
CLV_PCSK_KEX2_1	255	257	PF00082	0.267
CLV_PCSK_KEX2_1	359	361	PF00082	0.311
CLV_PCSK_KEX2_1	403	405	PF00082	0.279
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.267
CLV_PCSK_SKI1_1	136	140	PF00082	0.296
CLV_PCSK_SKI1_1	268	272	PF00082	0.322
CLV_PCSK_SKI1_1	280	284	PF00082	0.203
CLV_PCSK_SKI1_1	303	307	PF00082	0.267
CLV_PCSK_SKI1_1	411	415	PF00082	0.396
CLV_PCSK_SKI1_1	671	675	PF00082	0.453
DEG_APCC_DBOX_1	158	166	PF00400	0.295
DEG_APCC_DBOX_1	279	287	PF00400	0.267
DEG_APCC_DBOX_1	302	310	PF00400	0.267
DEG_APCC_DBOX_1	459	467	PF00400	0.267
DEG_SCF_FBW7_1	270	275	PF00400	0.357
DOC_ANK_TNKS_1	114	121	PF00023	0.267
DOC_CDC14_PxL_1	236	244	PF14671	0.357
DOC_CDC14_PxL_1	393	401	PF14671	0.267
DOC_CKS1_1	269	274	PF01111	0.357
DOC_CKS1_1	319	324	PF01111	0.357
DOC_CYCLIN_RxL_1	277	287	PF00134	0.267
DOC_CYCLIN_RxL_1	297	308	PF00134	0.396
DOC_CYCLIN_RxL_1	76	85	PF00134	0.396
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.281
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.239
DOC_MAPK_gen_1	255	261	PF00069	0.273
DOC_MAPK_gen_1	613	620	PF00069	0.267
DOC_MAPK_JIP1_4	280	286	PF00069	0.267
DOC_MAPK_MEF2A_6	101	109	PF00069	0.267
DOC_MAPK_MEF2A_6	88	97	PF00069	0.267
DOC_PP1_RVXF_1	409	415	PF00149	0.396
DOC_PP1_RVXF_1	77	84	PF00149	0.396
DOC_PP4_FxxP_1	126	129	PF00568	0.267
DOC_USP7_MATH_1	173	177	PF00917	0.414
DOC_USP7_MATH_1	272	276	PF00917	0.324
DOC_USP7_MATH_1	518	522	PF00917	0.428
DOC_USP7_MATH_1	589	593	PF00917	0.352
DOC_USP7_MATH_1	595	599	PF00917	0.342
DOC_USP7_MATH_1	652	656	PF00917	0.345
DOC_USP7_MATH_1	67	71	PF00917	0.577
DOC_USP7_UBL2_3	210	214	PF12436	0.372
DOC_WW_Pin1_4	16	21	PF00397	0.716
DOC_WW_Pin1_4	169	174	PF00397	0.396
DOC_WW_Pin1_4	25	30	PF00397	0.473
DOC_WW_Pin1_4	268	273	PF00397	0.345
DOC_WW_Pin1_4	318	323	PF00397	0.357
DOC_WW_Pin1_4	509	514	PF00397	0.361
DOC_WW_Pin1_4	580	585	PF00397	0.473
LIG_14-3-3_CanoR_1	185	190	PF00244	0.463
LIG_14-3-3_CanoR_1	255	260	PF00244	0.311
LIG_14-3-3_CanoR_1	288	296	PF00244	0.267
LIG_14-3-3_CanoR_1	478	487	PF00244	0.343
LIG_14-3-3_CanoR_1	504	509	PF00244	0.275
LIG_14-3-3_CanoR_1	653	657	PF00244	0.267
LIG_Actin_WH2_2	193	211	PF00022	0.372
LIG_APCC_ABBA_1	80	85	PF00400	0.267
LIG_APCC_ABBAyCdc20_2	335	341	PF00400	0.393
LIG_APCC_ABBAyCdc20_2	79	85	PF00400	0.267
LIG_BIR_III_4	53	57	PF00653	0.505
LIG_BRCT_BRCA1_1	520	524	PF00533	0.433
LIG_Clathr_ClatBox_1	283	287	PF01394	0.267
LIG_Clathr_ClatBox_1	80	84	PF01394	0.396
LIG_CtBP_PxDLS_1	617	621	PF00389	0.287
LIG_deltaCOP1_diTrp_1	147	153	PF00928	0.267
LIG_DLG_GKlike_1	185	192	PF00625	0.396
LIG_eIF4E_1	464	470	PF01652	0.286
LIG_FHA_1	104	110	PF00498	0.396
LIG_FHA_1	152	158	PF00498	0.311
LIG_FHA_1	449	455	PF00498	0.352
LIG_FHA_1	549	555	PF00498	0.267
LIG_FHA_1	583	589	PF00498	0.440
LIG_FHA_1	659	665	PF00498	0.273
LIG_FHA_1	75	81	PF00498	0.381
LIG_FHA_2	111	117	PF00498	0.396
LIG_FHA_2	318	324	PF00498	0.366
LIG_FHA_2	454	460	PF00498	0.267
LIG_GBD_Chelix_1	253	261	PF00786	0.267
LIG_GBD_Chelix_1	532	540	PF00786	0.267
LIG_IRF3_LxIS_1	225	230	PF10401	0.345
LIG_LIR_Apic_2	580	584	PF02991	0.303
LIG_LIR_Gen_1	106	112	PF02991	0.396
LIG_LIR_Gen_1	144	153	PF02991	0.260
LIG_LIR_Gen_1	186	197	PF02991	0.267
LIG_LIR_Gen_1	363	373	PF02991	0.339
LIG_LIR_Gen_1	443	454	PF02991	0.290
LIG_LIR_Gen_1	640	649	PF02991	0.283
LIG_LIR_Nem_3	106	111	PF02991	0.311
LIG_LIR_Nem_3	144	149	PF02991	0.297
LIG_LIR_Nem_3	186	192	PF02991	0.267
LIG_LIR_Nem_3	204	208	PF02991	0.267
LIG_LIR_Nem_3	301	305	PF02991	0.267
LIG_LIR_Nem_3	346	350	PF02991	0.286
LIG_LIR_Nem_3	363	368	PF02991	0.278
LIG_LIR_Nem_3	426	431	PF02991	0.290
LIG_LIR_Nem_3	443	449	PF02991	0.267
LIG_LIR_Nem_3	640	644	PF02991	0.303
LIG_LIR_Nem_3	76	81	PF02991	0.367
LIG_Pex14_2	524	528	PF04695	0.399
LIG_PTB_Apo_2	199	206	PF02174	0.362
LIG_SH2_CRK	302	306	PF00017	0.267
LIG_SH2_CRK	365	369	PF00017	0.286
LIG_SH2_CRK	581	585	PF00017	0.444
LIG_SH2_CRK	641	645	PF00017	0.396
LIG_SH2_GRB2like	150	153	PF00017	0.267
LIG_SH2_GRB2like	641	644	PF00017	0.396
LIG_SH2_NCK_1	581	585	PF00017	0.303
LIG_SH2_NCK_1	63	67	PF00017	0.602
LIG_SH2_PTP2	189	192	PF00017	0.267
LIG_SH2_SRC	108	111	PF00017	0.396
LIG_SH2_SRC	464	467	PF00017	0.286
LIG_SH2_STAP1	146	150	PF00017	0.267
LIG_SH2_STAP1	183	187	PF00017	0.390
LIG_SH2_STAP1	365	369	PF00017	0.400
LIG_SH2_STAP1	63	67	PF00017	0.602
LIG_SH2_STAT5	108	111	PF00017	0.368
LIG_SH2_STAT5	125	128	PF00017	0.236
LIG_SH2_STAT5	150	153	PF00017	0.282
LIG_SH2_STAT5	189	192	PF00017	0.267
LIG_SH2_STAT5	464	467	PF00017	0.270
LIG_SH2_STAT5	468	471	PF00017	0.262
LIG_SH2_STAT5	479	482	PF00017	0.247
LIG_SH2_STAT5	499	502	PF00017	0.291
LIG_SH3_3	116	122	PF00018	0.267
LIG_SH3_3	56	62	PF00018	0.513
LIG_SUMO_SIM_anti_2	432	437	PF11976	0.396
LIG_SUMO_SIM_par_1	239	245	PF11976	0.345
LIG_SUMO_SIM_par_1	281	287	PF11976	0.285
LIG_SUMO_SIM_par_1	326	332	PF11976	0.396
LIG_SUMO_SIM_par_1	616	622	PF11976	0.287
LIG_SxIP_EBH_1	150	159	PF03271	0.357
LIG_TRAF2_1	129	132	PF00917	0.345
LIG_TRAF2_1	472	475	PF00917	0.396
LIG_TYR_ITIM	187	192	PF00017	0.267
LIG_TYR_ITSM	104	111	PF00017	0.311
LIG_UBA3_1	305	313	PF00899	0.357
LIG_UBA3_1	465	473	PF00899	0.209
LIG_UBA3_1	547	552	PF00899	0.396
LIG_UBA3_1	90	96	PF00899	0.396
MOD_CDK_SPxxK_3	318	325	PF00069	0.357
MOD_CK1_1	415	421	PF00069	0.403
MOD_CK1_1	453	459	PF00069	0.292
MOD_CK1_1	507	513	PF00069	0.295
MOD_CK1_1	539	545	PF00069	0.402
MOD_CK1_1	568	574	PF00069	0.325
MOD_CK1_1	580	586	PF00069	0.178
MOD_CK1_1	593	599	PF00069	0.311
MOD_CK1_1	662	668	PF00069	0.396
MOD_CK2_1	141	147	PF00069	0.380
MOD_CK2_1	169	175	PF00069	0.363
MOD_CK2_1	539	545	PF00069	0.396
MOD_CK2_1	634	640	PF00069	0.396
MOD_GlcNHglycan	169	172	PF01048	0.357
MOD_GlcNHglycan	246	249	PF01048	0.404
MOD_GlcNHglycan	513	516	PF01048	0.320
MOD_GlcNHglycan	567	570	PF01048	0.316
MOD_GlcNHglycan	574	577	PF01048	0.350
MOD_GlcNHglycan	585	588	PF01048	0.344
MOD_GlcNHglycan	592	595	PF01048	0.266
MOD_GlcNHglycan	664	667	PF01048	0.396
MOD_GlcNHglycan	69	72	PF01048	0.480
MOD_GlcNHglycan	7	10	PF01048	0.706
MOD_GSK3_1	169	176	PF00069	0.415
MOD_GSK3_1	268	275	PF00069	0.409
MOD_GSK3_1	287	294	PF00069	0.298
MOD_GSK3_1	450	457	PF00069	0.229
MOD_GSK3_1	507	514	PF00069	0.288
MOD_GSK3_1	535	542	PF00069	0.405
MOD_GSK3_1	568	575	PF00069	0.296
MOD_GSK3_1	589	596	PF00069	0.294
MOD_GSK3_1	658	665	PF00069	0.274
MOD_LATS_1	502	508	PF00433	0.267
MOD_N-GLC_1	132	137	PF02516	0.384
MOD_N-GLC_1	151	156	PF02516	0.142
MOD_N-GLC_1	201	206	PF02516	0.420
MOD_N-GLC_1	208	213	PF02516	0.366
MOD_N-GLC_1	504	509	PF02516	0.263
MOD_N-GLC_2	315	317	PF02516	0.396
MOD_NEK2_1	103	108	PF00069	0.267
MOD_NEK2_1	151	156	PF00069	0.396
MOD_NEK2_1	201	206	PF00069	0.436
MOD_NEK2_1	208	213	PF00069	0.383
MOD_NEK2_1	227	232	PF00069	0.141
MOD_NEK2_1	242	247	PF00069	0.458
MOD_NEK2_1	412	417	PF00069	0.286
MOD_NEK2_1	450	455	PF00069	0.232
MOD_NEK2_1	676	681	PF00069	0.541
MOD_NEK2_2	141	146	PF00069	0.350
MOD_NEK2_2	173	178	PF00069	0.396
MOD_NEK2_2	595	600	PF00069	0.249
MOD_PIKK_1	152	158	PF00454	0.275
MOD_PIKK_1	27	33	PF00454	0.526
MOD_PIKK_1	507	513	PF00454	0.382
MOD_PIKK_1	518	524	PF00454	0.416
MOD_PIKK_1	623	629	PF00454	0.267
MOD_PIKK_1	676	682	PF00454	0.551
MOD_PK_1	255	261	PF00069	0.302
MOD_PKA_1	255	261	PF00069	0.267
MOD_PKA_2	255	261	PF00069	0.267
MOD_PKA_2	287	293	PF00069	0.282
MOD_PKA_2	652	658	PF00069	0.345
MOD_Plk_1	132	138	PF00069	0.407
MOD_Plk_1	183	189	PF00069	0.267
MOD_Plk_1	201	207	PF00069	0.267
MOD_Plk_1	504	510	PF00069	0.263
MOD_Plk_4	103	109	PF00069	0.345
MOD_Plk_4	141	147	PF00069	0.392
MOD_Plk_4	185	191	PF00069	0.354
MOD_Plk_4	273	279	PF00069	0.339
MOD_Plk_4	543	549	PF00069	0.368
MOD_Plk_4	652	658	PF00069	0.399
MOD_Plk_4	659	665	PF00069	0.350
MOD_Plk_4	671	677	PF00069	0.288
MOD_ProDKin_1	16	22	PF00069	0.713
MOD_ProDKin_1	169	175	PF00069	0.396
MOD_ProDKin_1	25	31	PF00069	0.468
MOD_ProDKin_1	268	274	PF00069	0.345
MOD_ProDKin_1	318	324	PF00069	0.357
MOD_ProDKin_1	509	515	PF00069	0.361
MOD_ProDKin_1	580	586	PF00069	0.473
MOD_SUMO_for_1	213	216	PF00179	0.280
MOD_SUMO_for_1	472	475	PF00179	0.209
TRG_DiLeu_BaEn_1	445	450	PF01217	0.311
TRG_DiLeu_BaEn_4	363	369	PF01217	0.245
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.357
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.267
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.326
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.267
TRG_ENDOCYTIC_2	108	111	PF00928	0.313
TRG_ENDOCYTIC_2	146	149	PF00928	0.268
TRG_ENDOCYTIC_2	150	153	PF00928	0.267
TRG_ENDOCYTIC_2	189	192	PF00928	0.267
TRG_ENDOCYTIC_2	302	305	PF00928	0.296
TRG_ENDOCYTIC_2	365	368	PF00928	0.286
TRG_ENDOCYTIC_2	428	431	PF00928	0.356
TRG_ENDOCYTIC_2	641	644	PF00928	0.286
TRG_ER_diArg_1	255	257	PF00400	0.267
TRG_ER_diArg_1	34	37	PF00400	0.311
TRG_ER_diArg_1	358	360	PF00400	0.345
TRG_ER_diArg_1	420	423	PF00400	0.409
TRG_ER_diArg_1	460	463	PF00400	0.267
TRG_ER_diArg_1	612	615	PF00400	0.226
TRG_Pf-PMV_PEXEL_1	303	308	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.267

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P0	Leptomonas seymouri	79%	100%
A0A1X0P7J8	Trypanosomatidae	59%	100%
A0A3R7MBF0	Trypanosoma rangeli	57%	100%
A4HF81	Leishmania braziliensis	90%	100%
A4I2G4	Leishmania infantum	99%	100%
C9ZX33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AYL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	99%
O18637	Drosophila virilis	30%	100%
O74534	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P22213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q24179	Drosophila melanogaster	30%	100%
Q4Q8V5	Leishmania major	96%	100%
Q54IJ1	Dictyostelium discoideum	28%	100%
Q5VNU3	Oryza sativa subsp. japonica	21%	100%
Q62991	Rattus norvegicus	28%	100%
Q851W1	Oryza sativa subsp. japonica	31%	100%
Q8BRF7	Mus musculus	28%	100%
Q8SS97	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q8WVM8	Homo sapiens	28%	100%
Q9SL48	Arabidopsis thaliana	30%	100%
V5BI09	Trypanosoma cruzi	57%	100%