Translation initiation factor SUI1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor SUI1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICD2_LEIDO

TriTrypDb:

LdBPK_250420.1 , LdCL_250009300 , LDHU3_25.0490

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICD2

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	1
GO:0002183	cytoplasmic translational initiation	4	1
GO:0002188	translation reinitiation	5	1
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003743	translation initiation factor activity	4	10
GO:0005488	binding	1	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.476
CLV_NRD_NRD_1	173	175	PF00675	0.462
CLV_NRD_NRD_1	176	178	PF00675	0.497
CLV_NRD_NRD_1	212	214	PF00675	0.274
CLV_NRD_NRD_1	235	237	PF00675	0.327
CLV_NRD_NRD_1	94	96	PF00675	0.753
CLV_PCSK_FUR_1	174	178	PF00082	0.465
CLV_PCSK_FUR_1	3	7	PF00082	0.645
CLV_PCSK_KEX2_1	175	177	PF00082	0.472
CLV_PCSK_KEX2_1	208	210	PF00082	0.338
CLV_PCSK_KEX2_1	212	214	PF00082	0.314
CLV_PCSK_KEX2_1	237	239	PF00082	0.327
CLV_PCSK_KEX2_1	5	7	PF00082	0.683
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.453
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.338
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.327
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.683
CLV_PCSK_PC7_1	172	178	PF00082	0.458
CLV_PCSK_PC7_1	233	239	PF00082	0.312
CLV_PCSK_SKI1_1	176	180	PF00082	0.467
CLV_PCSK_SKI1_1	192	196	PF00082	0.481
CLV_PCSK_SKI1_1	213	217	PF00082	0.283
DOC_CKS1_1	54	59	PF01111	0.703
DOC_MAPK_gen_1	195	203	PF00069	0.464
DOC_MAPK_gen_1	276	284	PF00069	0.535
DOC_MAPK_gen_1	84	93	PF00069	0.565
DOC_USP7_MATH_1	278	282	PF00917	0.461
DOC_USP7_UBL2_3	77	81	PF12436	0.735
DOC_USP7_UBL2_3	97	101	PF12436	0.573
DOC_WW_Pin1_4	53	58	PF00397	0.717
LIG_14-3-3_CanoR_1	176	185	PF00244	0.461
LIG_14-3-3_CanoR_1	212	221	PF00244	0.477
LIG_14-3-3_CanoR_1	236	245	PF00244	0.532
LIG_14-3-3_CanoR_1	6	15	PF00244	0.560
LIG_Actin_RPEL_3	185	204	PF02755	0.506
LIG_Actin_WH2_2	214	231	PF00022	0.492
LIG_deltaCOP1_diTrp_1	234	239	PF00928	0.444
LIG_FHA_2	178	184	PF00498	0.458
LIG_GBD_Chelix_1	263	271	PF00786	0.244
LIG_LIR_Apic_2	273	278	PF02991	0.461
LIG_LIR_Nem_3	132	138	PF02991	0.410
LIG_LIR_Nem_3	147	151	PF02991	0.361
LIG_Pex14_1	158	162	PF04695	0.321
LIG_Pex14_1	235	239	PF04695	0.444
LIG_SH2_CRK	135	139	PF00017	0.387
LIG_SH2_CRK	275	279	PF00017	0.476
LIG_SH2_STAP1	162	166	PF00017	0.347
LIG_SH2_STAT5	135	138	PF00017	0.373
LIG_SH2_STAT5	283	286	PF00017	0.404
LIG_SH3_3	288	294	PF00018	0.540
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.279
LIG_SUMO_SIM_par_1	119	126	PF11976	0.575
LIG_SUMO_SIM_par_1	199	205	PF11976	0.303
LIG_TRAF2_1	118	121	PF00917	0.562
LIG_TRAF2_1	247	250	PF00917	0.444
LIG_TYR_ITIM	133	138	PF00017	0.403
MOD_CK1_1	4	10	PF00069	0.647
MOD_CK2_1	14	20	PF00069	0.670
MOD_Cter_Amidation	172	175	PF01082	0.449
MOD_Cter_Amidation	210	213	PF01082	0.261
MOD_Cter_Amidation	286	289	PF01082	0.525
MOD_GlcNHglycan	147	151	PF01048	0.419
MOD_GlcNHglycan	26	29	PF01048	0.546
MOD_GlcNHglycan	46	49	PF01048	0.779
MOD_GlcNHglycan	60	63	PF01048	0.672
MOD_GSK3_1	24	31	PF00069	0.739
MOD_GSK3_1	58	65	PF00069	0.712
MOD_NEK2_1	1	6	PF00069	0.719
MOD_NEK2_1	123	128	PF00069	0.582
MOD_NEK2_1	214	219	PF00069	0.472
MOD_NEK2_1	270	275	PF00069	0.544
MOD_NEK2_2	278	283	PF00069	0.458
MOD_PKA_1	237	243	PF00069	0.527
MOD_PKA_2	237	243	PF00069	0.527
MOD_PKA_2	62	68	PF00069	0.670
MOD_Plk_4	214	220	PF00069	0.527
MOD_Plk_4	278	284	PF00069	0.499
MOD_Plk_4	28	34	PF00069	0.547
MOD_ProDKin_1	53	59	PF00069	0.716
MOD_SUMO_rev_2	105	109	PF00179	0.665
TRG_DiLeu_BaEn_1	280	285	PF01217	0.545
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.647
TRG_ENDOCYTIC_2	135	138	PF00928	0.408
TRG_ER_diArg_1	174	177	PF00400	0.467
TRG_ER_diArg_1	212	214	PF00400	0.560
TRG_ER_diArg_1	235	238	PF00400	0.527
TRG_NLS_Bipartite_1	79	100	PF00514	0.662
TRG_NLS_MonoCore_2	173	178	PF00514	0.438
TRG_NLS_MonoExtC_3	287	292	PF00514	0.554
TRG_NLS_MonoExtC_3	94	99	PF00514	0.571
TRG_NLS_MonoExtN_4	172	179	PF00514	0.438
TRG_NLS_MonoExtN_4	233	240	PF00514	0.527
TRG_NLS_MonoExtN_4	3	9	PF00514	0.594
TRG_NLS_MonoExtN_4	95	100	PF00514	0.636
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAD2	Leptomonas seymouri	59%	100%
A0A3R7KWX6	Trypanosoma rangeli	53%	100%
A4HDY3	Leishmania braziliensis	80%	100%
A4I184	Leishmania infantum	99%	100%
D0A5G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AXB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QA54	Leishmania major	92%	100%
V5BN78	Trypanosoma cruzi	49%	100%