C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICD1_LEIDO

TriTrypDb:

LdBPK_221400.1 , LdCL_220021200 , LDHU3_22.2000

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.523
CLV_NRD_NRD_1	534	536	PF00675	0.430
CLV_PCSK_SKI1_1	132	136	PF00082	0.433
CLV_PCSK_SKI1_1	333	337	PF00082	0.523
CLV_PCSK_SKI1_1	40	44	PF00082	0.339
CLV_PCSK_SKI1_1	65	69	PF00082	0.490
CLV_PCSK_SKI1_1	85	89	PF00082	0.535
DEG_APCC_DBOX_1	458	466	PF00400	0.572
DEG_APCC_DBOX_1	546	554	PF00400	0.360
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.560
DOC_MAPK_DCC_7	105	114	PF00069	0.360
DOC_MAPK_FxFP_2	209	212	PF00069	0.304
DOC_MAPK_gen_1	128	137	PF00069	0.507
DOC_MAPK_gen_1	372	380	PF00069	0.469
DOC_MAPK_HePTP_8	102	114	PF00069	0.443
DOC_MAPK_MEF2A_6	105	114	PF00069	0.590
DOC_MAPK_MEF2A_6	131	139	PF00069	0.497
DOC_MAPK_MEF2A_6	284	292	PF00069	0.371
DOC_MAPK_MEF2A_6	297	306	PF00069	0.391
DOC_MAPK_MEF2A_6	381	389	PF00069	0.562
DOC_MAPK_NFAT4_5	132	140	PF00069	0.490
DOC_PP1_RVXF_1	266	272	PF00149	0.357
DOC_PP1_RVXF_1	33	40	PF00149	0.372
DOC_PP1_RVXF_1	83	89	PF00149	0.530
DOC_PP4_FxxP_1	209	212	PF00568	0.353
DOC_PP4_FxxP_1	88	91	PF00568	0.615
DOC_USP7_MATH_1	11	15	PF00917	0.662
DOC_USP7_MATH_1	245	249	PF00917	0.489
DOC_USP7_MATH_1	311	315	PF00917	0.446
DOC_USP7_MATH_1	455	459	PF00917	0.661
DOC_USP7_MATH_1	47	51	PF00917	0.481
DOC_USP7_MATH_1	5	9	PF00917	0.718
DOC_USP7_MATH_1	522	526	PF00917	0.420
DOC_USP7_MATH_1	91	95	PF00917	0.636
DOC_USP7_UBL2_3	31	35	PF12436	0.374
DOC_WW_Pin1_4	184	189	PF00397	0.433
DOC_WW_Pin1_4	190	195	PF00397	0.564
DOC_WW_Pin1_4	20	25	PF00397	0.613
DOC_WW_Pin1_4	400	405	PF00397	0.726
DOC_WW_Pin1_4	432	437	PF00397	0.759
DOC_WW_Pin1_4	490	495	PF00397	0.420
DOC_WW_Pin1_4	558	563	PF00397	0.436
LIG_14-3-3_CanoR_1	203	208	PF00244	0.298
LIG_14-3-3_CanoR_1	268	277	PF00244	0.349
LIG_14-3-3_CanoR_1	406	410	PF00244	0.530
LIG_14-3-3_CanoR_1	547	555	PF00244	0.439
LIG_14-3-3_CanoR_1	575	584	PF00244	0.420
LIG_Actin_WH2_2	115	130	PF00022	0.397
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	492	496	PF00533	0.377
LIG_BRCT_BRCA1_1	541	545	PF00533	0.464
LIG_BRCT_BRCA1_1	582	586	PF00533	0.469
LIG_BRCT_BRCA1_1	71	75	PF00533	0.532
LIG_Clathr_ClatBox_1	41	45	PF01394	0.346
LIG_EH_1	453	457	PF12763	0.669
LIG_FHA_1	154	160	PF00498	0.495
LIG_FHA_1	199	205	PF00498	0.429
LIG_FHA_1	272	278	PF00498	0.334
LIG_FHA_1	31	37	PF00498	0.371
LIG_FHA_1	325	331	PF00498	0.356
LIG_FHA_1	471	477	PF00498	0.405
LIG_FHA_1	487	493	PF00498	0.584
LIG_FHA_1	589	595	PF00498	0.412
LIG_FHA_2	162	168	PF00498	0.411
LIG_FHA_2	191	197	PF00498	0.496
LIG_FHA_2	44	50	PF00498	0.416
LIG_FHA_2	499	505	PF00498	0.385
LIG_LIR_Apic_2	206	212	PF02991	0.354
LIG_LIR_Gen_1	149	160	PF02991	0.317
LIG_LIR_Gen_1	234	244	PF02991	0.388
LIG_LIR_Gen_1	542	553	PF02991	0.415
LIG_LIR_Gen_1	593	603	PF02991	0.417
LIG_LIR_Nem_3	149	155	PF02991	0.506
LIG_LIR_Nem_3	189	195	PF02991	0.454
LIG_LIR_Nem_3	196	202	PF02991	0.336
LIG_LIR_Nem_3	208	214	PF02991	0.322
LIG_LIR_Nem_3	234	239	PF02991	0.492
LIG_LIR_Nem_3	32	37	PF02991	0.373
LIG_LIR_Nem_3	542	548	PF02991	0.476
LIG_LIR_Nem_3	583	589	PF02991	0.388
LIG_LIR_Nem_3	590	595	PF02991	0.389
LIG_LIR_Nem_3	98	102	PF02991	0.542
LIG_Pex14_2	271	275	PF04695	0.300
LIG_PTAP_UEV_1	297	302	PF05743	0.404
LIG_SH2_CRK	199	203	PF00017	0.465
LIG_SH2_CRK	351	355	PF00017	0.565
LIG_SH2_CRK	595	599	PF00017	0.435
LIG_SH2_STAT5	152	155	PF00017	0.374
LIG_SH2_STAT5	222	225	PF00017	0.361
LIG_SH2_STAT5	252	255	PF00017	0.348
LIG_SH2_STAT5	270	273	PF00017	0.315
LIG_SH2_STAT5	577	580	PF00017	0.479
LIG_SH2_STAT5	587	590	PF00017	0.400
LIG_SH3_3	295	301	PF00018	0.438
LIG_SH3_3	449	455	PF00018	0.657
LIG_SUMO_SIM_anti_2	499	504	PF11976	0.398
LIG_SUMO_SIM_par_1	115	123	PF11976	0.371
LIG_SUMO_SIM_par_1	40	46	PF11976	0.467
LIG_SUMO_SIM_par_1	566	572	PF11976	0.436
LIG_TRAF2_1	337	340	PF00917	0.549
LIG_UBA3_1	462	468	PF00899	0.533
LIG_WRC_WIRS_1	211	216	PF05994	0.349
MOD_CDC14_SPxK_1	403	406	PF00782	0.703
MOD_CDK_SPxK_1	400	406	PF00069	0.703
MOD_CK1_1	14	20	PF00069	0.563
MOD_CK1_1	248	254	PF00069	0.477
MOD_CK1_1	314	320	PF00069	0.464
MOD_CK1_1	4	10	PF00069	0.649
MOD_CK1_1	417	423	PF00069	0.546
MOD_CK1_1	431	437	PF00069	0.551
MOD_CK1_1	466	472	PF00069	0.431
MOD_CK1_1	51	57	PF00069	0.579
MOD_CK1_1	518	524	PF00069	0.446
MOD_CK1_1	569	575	PF00069	0.466
MOD_CK1_1	80	86	PF00069	0.601
MOD_CK2_1	190	196	PF00069	0.535
MOD_CK2_1	417	423	PF00069	0.652
MOD_CK2_1	97	103	PF00069	0.570
MOD_Cter_Amidation	129	132	PF01082	0.452
MOD_GlcNHglycan	14	17	PF01048	0.525
MOD_GlcNHglycan	247	250	PF01048	0.483
MOD_GlcNHglycan	271	274	PF01048	0.393
MOD_GlcNHglycan	298	301	PF01048	0.400
MOD_GlcNHglycan	3	6	PF01048	0.649
MOD_GlcNHglycan	313	316	PF01048	0.484
MOD_GlcNHglycan	356	359	PF01048	0.620
MOD_GlcNHglycan	414	417	PF01048	0.616
MOD_GlcNHglycan	520	523	PF01048	0.431
MOD_GlcNHglycan	99	102	PF01048	0.454
MOD_GSK3_1	1	8	PF00069	0.665
MOD_GSK3_1	14	21	PF00069	0.539
MOD_GSK3_1	146	153	PF00069	0.533
MOD_GSK3_1	198	205	PF00069	0.333
MOD_GSK3_1	210	217	PF00069	0.340
MOD_GSK3_1	231	238	PF00069	0.485
MOD_GSK3_1	248	255	PF00069	0.444
MOD_GSK3_1	271	278	PF00069	0.364
MOD_GSK3_1	292	299	PF00069	0.426
MOD_GSK3_1	310	317	PF00069	0.598
MOD_GSK3_1	324	331	PF00069	0.317
MOD_GSK3_1	417	424	PF00069	0.630
MOD_GSK3_1	428	435	PF00069	0.483
MOD_GSK3_1	43	50	PF00069	0.409
MOD_GSK3_1	466	473	PF00069	0.400
MOD_GSK3_1	486	493	PF00069	0.476
MOD_GSK3_1	518	525	PF00069	0.410
MOD_GSK3_1	91	98	PF00069	0.657
MOD_N-GLC_1	190	195	PF02516	0.570
MOD_N-GLC_1	231	236	PF02516	0.334
MOD_N-GLC_1	275	280	PF02516	0.503
MOD_N-GLC_1	292	297	PF02516	0.428
MOD_N-GLC_1	325	330	PF02516	0.388
MOD_N-GLC_1	360	365	PF02516	0.590
MOD_N-GLC_1	441	446	PF02516	0.599
MOD_N-GLC_1	463	468	PF02516	0.472
MOD_N-GLC_1	548	553	PF02516	0.417
MOD_N-GLC_1	598	603	PF02516	0.552
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	146	151	PF00069	0.382
MOD_NEK2_1	18	23	PF00069	0.449
MOD_NEK2_1	214	219	PF00069	0.402
MOD_NEK2_1	271	276	PF00069	0.327
MOD_NEK2_1	392	397	PF00069	0.596
MOD_NEK2_1	463	468	PF00069	0.480
MOD_NEK2_1	496	501	PF00069	0.328
MOD_NEK2_1	598	603	PF00069	0.477
MOD_NEK2_1	67	72	PF00069	0.405
MOD_NEK2_2	30	35	PF00069	0.334
MOD_NEK2_2	522	527	PF00069	0.449
MOD_PIKK_1	139	145	PF00454	0.557
MOD_PIKK_1	255	261	PF00454	0.457
MOD_PIKK_1	292	298	PF00454	0.420
MOD_PIKK_1	335	341	PF00454	0.424
MOD_PIKK_1	463	469	PF00454	0.467
MOD_PIKK_1	48	54	PF00454	0.535
MOD_PIKK_1	539	545	PF00454	0.515
MOD_PIKK_1	575	581	PF00454	0.434
MOD_PIKK_1	80	86	PF00454	0.402
MOD_PIKK_1	91	97	PF00454	0.522
MOD_PKA_2	104	110	PF00069	0.501
MOD_PKA_2	202	208	PF00069	0.296
MOD_PKA_2	405	411	PF00069	0.587
MOD_PKA_2	447	453	PF00069	0.651
MOD_Plk_1	234	240	PF00069	0.359
MOD_Plk_1	325	331	PF00069	0.392
MOD_Plk_1	441	447	PF00069	0.569
MOD_Plk_1	48	54	PF00069	0.409
MOD_Plk_1	598	604	PF00069	0.558
MOD_Plk_2-3	590	596	PF00069	0.416
MOD_Plk_4	141	147	PF00069	0.459
MOD_Plk_4	179	185	PF00069	0.446
MOD_Plk_4	210	216	PF00069	0.368
MOD_Plk_4	248	254	PF00069	0.492
MOD_Plk_4	441	447	PF00069	0.576
MOD_Plk_4	498	504	PF00069	0.489
MOD_Plk_4	590	596	PF00069	0.431
MOD_Plk_4	599	605	PF00069	0.463
MOD_ProDKin_1	184	190	PF00069	0.439
MOD_ProDKin_1	20	26	PF00069	0.609
MOD_ProDKin_1	400	406	PF00069	0.727
MOD_ProDKin_1	432	438	PF00069	0.757
MOD_ProDKin_1	490	496	PF00069	0.410
MOD_ProDKin_1	558	564	PF00069	0.430
TRG_DiLeu_BaEn_1	32	37	PF01217	0.400
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.450
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.602
TRG_ENDOCYTIC_2	152	155	PF00928	0.410
TRG_ENDOCYTIC_2	199	202	PF00928	0.463
TRG_ENDOCYTIC_2	211	214	PF00928	0.466
TRG_ENDOCYTIC_2	351	354	PF00928	0.593
TRG_ENDOCYTIC_2	595	598	PF00928	0.423
TRG_ER_diArg_1	553	556	PF00400	0.455
TRG_ER_FFAT_2	514	525	PF00635	0.530
TRG_NES_CRM1_1	221	235	PF08389	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRF1	Leptomonas seymouri	78%	100%
A0A0S4J7N2	Bodo saltans	29%	74%
A0A1X0NTT4	Trypanosomatidae	52%	100%
A0A3R7K4C8	Trypanosoma rangeli	54%	100%
A4HCJ4	Leishmania braziliensis	88%	100%
A4I014	Leishmania infantum	100%	100%
C9ZQ83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QBJ2	Leishmania major	96%	100%
V5BGJ4	Trypanosoma cruzi	53%	100%