Pre-mRNA-splicing factor 18

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Prp18 domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICC8_LEIDO

TriTrypDb:

LdBPK_220740.1 , LdCL_220014700 , LDHU3_22.1190

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7
GO:0005682	U5 snRNP	5	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0071020	post-spliceosomal complex	4	1
GO:0071021	U2-type post-spliceosomal complex	5	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0120114	Sm-like protein family complex	2	1

Expansion

Sequence features

A0A3Q8ICC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICC8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006396	RNA processing	6	6
GO:0006397	mRNA processing	7	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0008380	RNA splicing	7	6
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	6
GO:0016071	mRNA metabolic process	6	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0000350	generation of catalytic spliceosome for second transesterification step	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.570
CLV_C14_Caspase3-7	303	307	PF00656	0.666
CLV_NRD_NRD_1	447	449	PF00675	0.352
CLV_NRD_NRD_1	495	497	PF00675	0.277
CLV_PCSK_KEX2_1	113	115	PF00082	0.590
CLV_PCSK_KEX2_1	495	497	PF00082	0.277
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.590
CLV_PCSK_SKI1_1	51	55	PF00082	0.633
CLV_PCSK_SKI1_1	523	527	PF00082	0.283
DEG_APCC_DBOX_1	447	455	PF00400	0.489
DEG_ODPH_VHL_1	366	379	PF01847	0.511
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.587
DOC_MAPK_gen_1	409	417	PF00069	0.396
DOC_MAPK_gen_1	448	456	PF00069	0.565
DOC_MAPK_MEF2A_6	469	477	PF00069	0.535
DOC_PP2B_LxvP_1	160	163	PF13499	0.516
DOC_PP2B_LxvP_1	249	252	PF13499	0.444
DOC_PP4_FxxP_1	263	266	PF00568	0.483
DOC_PP4_FxxP_1	441	444	PF00568	0.490
DOC_PP4_FxxP_1	540	543	PF00568	0.422
DOC_USP7_MATH_1	138	142	PF00917	0.674
DOC_USP7_MATH_1	150	154	PF00917	0.572
DOC_USP7_MATH_1	156	160	PF00917	0.477
DOC_USP7_MATH_1	205	209	PF00917	0.517
DOC_USP7_MATH_1	244	248	PF00917	0.555
DOC_USP7_MATH_1	304	308	PF00917	0.655
DOC_USP7_MATH_1	33	37	PF00917	0.646
DOC_USP7_MATH_1	429	433	PF00917	0.545
DOC_USP7_MATH_1	49	53	PF00917	0.565
DOC_USP7_MATH_1	86	90	PF00917	0.563
DOC_WW_Pin1_4	151	156	PF00397	0.635
DOC_WW_Pin1_4	371	376	PF00397	0.396
DOC_WW_Pin1_4	430	435	PF00397	0.569
DOC_WW_Pin1_4	51	56	PF00397	0.730
DOC_WW_Pin1_4	535	540	PF00397	0.494
LIG_14-3-3_CanoR_1	147	156	PF00244	0.695
LIG_14-3-3_CanoR_1	200	206	PF00244	0.475
LIG_14-3-3_CanoR_1	495	499	PF00244	0.477
LIG_APCC_ABBA_1	525	530	PF00400	0.535
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BRCT_BRCA1_1	537	541	PF00533	0.490
LIG_FHA_1	155	161	PF00498	0.570
LIG_FHA_1	214	220	PF00498	0.623
LIG_FHA_1	37	43	PF00498	0.621
LIG_FHA_1	451	457	PF00498	0.559
LIG_FHA_1	514	520	PF00498	0.520
LIG_FHA_1	524	530	PF00498	0.441
LIG_FHA_2	188	194	PF00498	0.472
LIG_FHA_2	278	284	PF00498	0.496
LIG_FHA_2	76	82	PF00498	0.591
LIG_Integrin_isoDGR_2	350	352	PF01839	0.632
LIG_LIR_Apic_2	537	543	PF02991	0.429
LIG_LIR_Gen_1	283	294	PF02991	0.405
LIG_LIR_Gen_1	462	473	PF02991	0.482
LIG_LIR_Nem_3	2	6	PF02991	0.590
LIG_LIR_Nem_3	283	289	PF02991	0.389
LIG_LIR_Nem_3	402	407	PF02991	0.489
LIG_LIR_Nem_3	462	468	PF02991	0.482
LIG_LIR_Nem_3	471	475	PF02991	0.535
LIG_LIR_Nem_3	77	83	PF02991	0.583
LIG_MLH1_MIPbox_1	537	541	PF16413	0.490
LIG_NRBOX	244	250	PF00104	0.444
LIG_NRBOX	324	330	PF00104	0.404
LIG_NRBOX	5	11	PF00104	0.569
LIG_SH2_PTP2	472	475	PF00017	0.535
LIG_SH2_SRC	472	475	PF00017	0.559
LIG_SH2_STAP1	211	215	PF00017	0.542
LIG_SH2_STAP1	425	429	PF00017	0.432
LIG_SH2_STAP1	83	87	PF00017	0.467
LIG_SH2_STAT5	258	261	PF00017	0.400
LIG_SH2_STAT5	334	337	PF00017	0.326
LIG_SH2_STAT5	378	381	PF00017	0.378
LIG_SH2_STAT5	420	423	PF00017	0.392
LIG_SH2_STAT5	472	475	PF00017	0.477
LIG_SH3_1	362	368	PF00018	0.605
LIG_SH3_3	160	166	PF00018	0.585
LIG_SH3_3	217	223	PF00018	0.651
LIG_SH3_3	362	368	PF00018	0.605
LIG_UBA3_1	288	293	PF00899	0.482
MOD_CK1_1	106	112	PF00069	0.593
MOD_CK1_1	132	138	PF00069	0.698
MOD_CK1_1	148	154	PF00069	0.538
MOD_CK1_1	167	173	PF00069	0.433
MOD_CK1_1	238	244	PF00069	0.510
MOD_CK1_1	247	253	PF00069	0.413
MOD_CK1_1	307	313	PF00069	0.565
MOD_CK1_1	36	42	PF00069	0.659
MOD_CK1_1	432	438	PF00069	0.595
MOD_CK1_1	75	81	PF00069	0.640
MOD_CK2_1	133	139	PF00069	0.652
MOD_CK2_1	187	193	PF00069	0.383
MOD_CK2_1	485	491	PF00069	0.493
MOD_GlcNHglycan	135	138	PF01048	0.759
MOD_GlcNHglycan	147	150	PF01048	0.605
MOD_GlcNHglycan	230	233	PF01048	0.658
MOD_GlcNHglycan	306	309	PF01048	0.724
MOD_GlcNHglycan	35	38	PF01048	0.664
MOD_GlcNHglycan	426	430	PF01048	0.431
MOD_GlcNHglycan	44	47	PF01048	0.626
MOD_GlcNHglycan	487	490	PF01048	0.277
MOD_GlcNHglycan	51	54	PF01048	0.595
MOD_GlcNHglycan	69	72	PF01048	0.594
MOD_GlcNHglycan	74	77	PF01048	0.601
MOD_GSK3_1	128	135	PF00069	0.691
MOD_GSK3_1	150	157	PF00069	0.609
MOD_GSK3_1	205	212	PF00069	0.559
MOD_GSK3_1	243	250	PF00069	0.605
MOD_GSK3_1	306	313	PF00069	0.770
MOD_GSK3_1	350	357	PF00069	0.573
MOD_GSK3_1	416	423	PF00069	0.440
MOD_GSK3_1	425	432	PF00069	0.404
MOD_GSK3_1	49	56	PF00069	0.716
MOD_GSK3_1	72	79	PF00069	0.658
MOD_N-GLC_1	132	137	PF02516	0.690
MOD_N-GLC_1	33	38	PF02516	0.647
MOD_NEK2_1	104	109	PF00069	0.614
MOD_NEK2_1	187	192	PF00069	0.452
MOD_NEK2_1	206	211	PF00069	0.415
MOD_NEK2_1	407	412	PF00069	0.457
MOD_NEK2_1	42	47	PF00069	0.717
MOD_NEK2_1	534	539	PF00069	0.542
MOD_PIKK_1	36	42	PF00454	0.649
MOD_PIKK_1	513	519	PF00454	0.499
MOD_PKA_2	199	205	PF00069	0.467
MOD_PKA_2	271	277	PF00069	0.563
MOD_PKA_2	494	500	PF00069	0.477
MOD_Plk_1	277	283	PF00069	0.505
MOD_Plk_1	473	479	PF00069	0.487
MOD_Plk_1	523	529	PF00069	0.462
MOD_Plk_4	244	250	PF00069	0.506
MOD_Plk_4	277	283	PF00069	0.505
MOD_Plk_4	416	422	PF00069	0.427
MOD_Plk_4	450	456	PF00069	0.559
MOD_Plk_4	523	529	PF00069	0.465
MOD_ProDKin_1	151	157	PF00069	0.634
MOD_ProDKin_1	371	377	PF00069	0.392
MOD_ProDKin_1	430	436	PF00069	0.572
MOD_ProDKin_1	51	57	PF00069	0.732
MOD_ProDKin_1	535	541	PF00069	0.487
MOD_SUMO_for_1	292	295	PF00179	0.508
MOD_SUMO_rev_2	285	294	PF00179	0.345
MOD_SUMO_rev_2	306	315	PF00179	0.575
TRG_DiLeu_BaEn_2	523	529	PF01217	0.477
TRG_DiLeu_BaEn_4	320	326	PF01217	0.432
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.409
TRG_ENDOCYTIC_2	378	381	PF00928	0.378
TRG_ENDOCYTIC_2	472	475	PF00928	0.477
TRG_ER_diArg_1	494	496	PF00400	0.477
TRG_ER_diArg_1	503	506	PF00400	0.477
TRG_NES_CRM1_1	179	193	PF08389	0.418
TRG_NES_CRM1_1	278	291	PF08389	0.485
TRG_NES_CRM1_1	327	341	PF08389	0.414
TRG_NES_CRM1_1	446	460	PF08389	0.462
TRG_NES_CRM1_1	517	530	PF08389	0.499
TRG_NLS_MonoCore_2	10	15	PF00514	0.528
TRG_NLS_MonoExtC_3	10	16	PF00514	0.599
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I883	Leptomonas seymouri	42%	100%
A4HCE1	Leishmania braziliensis	74%	99%
A4HZW5	Leishmania infantum	99%	100%
E9AVS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QBQ6	Leishmania major	90%	99%