2OG-Fe(II)_oxygenase_superfamily_putative/Pfam:PF 13661/Pfam:PF13640

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICC7_LEIDO

TriTrypDb:

LdBPK_310290.1 , LdCL_310008000 , LDHU3_31.0350

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICC7

Function

Biological processes
Term	Name	Level	Count
GO:0001666	response to hypoxia	3	1
GO:0006950	response to stress	2	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0036293	response to decreased oxygen levels	4	1
GO:0036294	cellular response to decreased oxygen levels	5	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0070482	response to oxygen levels	3	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071453	cellular response to oxygen levels	4	1
GO:0071456	cellular response to hypoxia	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0005506	iron ion binding	6	5
GO:0016491	oxidoreductase activity	2	5
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	5
GO:0019842	vitamin binding	3	5
GO:0030246	carbohydrate binding	2	5
GO:0031406	carboxylic acid binding	4	5
GO:0031418	L-ascorbic acid binding	3	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0043169	cation binding	3	5
GO:0043177	organic acid binding	3	5
GO:0046872	metal ion binding	4	5
GO:0046914	transition metal ion binding	5	5
GO:0048029	monosaccharide binding	3	5
GO:0051213	dioxygenase activity	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5
GO:0008198	ferrous iron binding	7	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0031543	peptidyl-proline dioxygenase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.345
CLV_NRD_NRD_1	160	162	PF00675	0.273
CLV_NRD_NRD_1	218	220	PF00675	0.251
CLV_NRD_NRD_1	256	258	PF00675	0.416
CLV_PCSK_KEX2_1	12	14	PF00082	0.406
CLV_PCSK_KEX2_1	159	161	PF00082	0.273
CLV_PCSK_KEX2_1	256	258	PF00082	0.416
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.406
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.273
CLV_PCSK_SKI1_1	12	16	PF00082	0.401
CLV_PCSK_SKI1_1	133	137	PF00082	0.446
CLV_PCSK_SKI1_1	160	164	PF00082	0.273
CLV_PCSK_SKI1_1	212	216	PF00082	0.357
CLV_PCSK_SKI1_1	309	313	PF00082	0.350
CLV_PCSK_SKI1_1	42	46	PF00082	0.349
CLV_Separin_Metazoa	110	114	PF03568	0.394
DEG_APCC_DBOX_1	211	219	PF00400	0.281
DEG_APCC_DBOX_1	308	316	PF00400	0.379
DEG_Nend_UBRbox_2	1	3	PF02207	0.524
DOC_CYCLIN_RxL_1	39	47	PF00134	0.379
DOC_CYCLIN_RxL_1	9	18	PF00134	0.406
DOC_CYCLIN_yClb5_NLxxxL_5	4	11	PF00134	0.348
DOC_MAPK_gen_1	156	166	PF00069	0.279
DOC_MAPK_gen_1	17	25	PF00069	0.400
DOC_MAPK_gen_1	219	229	PF00069	0.333
DOC_MAPK_gen_1	304	314	PF00069	0.393
DOC_MAPK_MEF2A_6	159	168	PF00069	0.273
DOC_PP4_FxxP_1	185	188	PF00568	0.297
DOC_USP7_MATH_1	131	135	PF00917	0.450
DOC_USP7_MATH_1	69	73	PF00917	0.530
DOC_WW_Pin1_4	57	62	PF00397	0.501
LIG_14-3-3_CanoR_1	133	138	PF00244	0.397
LIG_14-3-3_CanoR_1	160	165	PF00244	0.273
LIG_14-3-3_CanoR_1	256	264	PF00244	0.387
LIG_Actin_WH2_2	240	258	PF00022	0.403
LIG_Actin_WH2_2	308	325	PF00022	0.418
LIG_FHA_1	125	131	PF00498	0.489
LIG_FHA_1	134	140	PF00498	0.377
LIG_FHA_1	161	167	PF00498	0.273
LIG_FHA_1	196	202	PF00498	0.334
LIG_FHA_2	232	238	PF00498	0.299
LIG_GBD_Chelix_1	108	116	PF00786	0.379
LIG_GBD_Chelix_1	7	15	PF00786	0.329
LIG_IRF3_LxIS_1	286	291	PF10401	0.381
LIG_LIR_Gen_1	238	247	PF02991	0.407
LIG_LIR_Gen_1	26	36	PF02991	0.380
LIG_LIR_Nem_3	238	244	PF02991	0.419
LIG_LIR_Nem_3	26	31	PF02991	0.353
LIG_MYND_1	184	188	PF01753	0.273
LIG_NRBOX	10	16	PF00104	0.339
LIG_NRBOX	298	304	PF00104	0.407
LIG_PCNA_PIPBox_1	22	31	PF02747	0.380
LIG_PCNA_yPIPBox_3	17	29	PF02747	0.390
LIG_Pex14_2	225	229	PF04695	0.273
LIG_Pex14_2	97	101	PF04695	0.378
LIG_PTB_Apo_2	95	102	PF02174	0.386
LIG_Rb_LxCxE_1	114	132	PF01857	0.436
LIG_SH2_CRK	151	155	PF00017	0.273
LIG_SH2_GRB2like	151	154	PF00017	0.273
LIG_SH2_NCK_1	151	155	PF00017	0.273
LIG_SH2_SRC	151	154	PF00017	0.273
LIG_SH2_SRC	273	276	PF00017	0.372
LIG_SH2_STAP1	269	273	PF00017	0.317
LIG_SH2_STAP1	81	85	PF00017	0.384
LIG_SH2_STAT5	167	170	PF00017	0.283
LIG_SH2_STAT5	223	226	PF00017	0.358
LIG_SH2_STAT5	28	31	PF00017	0.372
LIG_SH2_STAT5	50	53	PF00017	0.450
LIG_SH3_1	151	157	PF00018	0.273
LIG_SH3_2	154	159	PF14604	0.273
LIG_SH3_3	151	157	PF00018	0.273
LIG_SUMO_SIM_anti_2	107	114	PF11976	0.387
LIG_UBA3_1	214	220	PF00899	0.251
MOD_CK2_1	288	294	PF00069	0.400
MOD_GlcNHglycan	257	260	PF01048	0.403
MOD_GSK3_1	129	136	PF00069	0.507
MOD_GSK3_1	65	72	PF00069	0.441
MOD_N-GLC_2	117	119	PF02516	0.385
MOD_NEK2_1	218	223	PF00069	0.331
MOD_NEK2_1	255	260	PF00069	0.322
MOD_NEK2_1	288	293	PF00069	0.363
MOD_NEK2_1	7	12	PF00069	0.348
MOD_NEK2_2	69	74	PF00069	0.381
MOD_PKA_1	160	166	PF00069	0.273
MOD_PKA_2	160	166	PF00069	0.273
MOD_PKA_2	218	224	PF00069	0.251
MOD_PKA_2	255	261	PF00069	0.386
MOD_Plk_1	273	279	PF00069	0.406
MOD_Plk_4	195	201	PF00069	0.330
MOD_ProDKin_1	57	63	PF00069	0.507
MOD_SUMO_for_1	303	306	PF00179	0.378
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.383
TRG_ENDOCYTIC_2	28	31	PF00928	0.408
TRG_ER_diArg_1	160	162	PF00400	0.273
TRG_ER_diArg_1	210	213	PF00400	0.330
TRG_ER_diArg_1	255	257	PF00400	0.391
TRG_NLS_MonoExtN_4	156	163	PF00514	0.275
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P964	Leptomonas seymouri	79%	100%
A0A0S4KJQ7	Bodo saltans	46%	99%
A4I6C0	Leishmania infantum	100%	100%
Q4Q6N6	Leishmania major	94%	100%