ADP-ribosylation_factor_family_putative/Pfam:PF00 025

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICC5_LEIDO

TriTrypDb:

LdBPK_262200.1 , LdCL_260027600 , LDHU3_26.2880

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICC5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006893	Golgi to plasma membrane transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034067	protein localization to Golgi apparatus	6	1
GO:0043001	Golgi to plasma membrane protein transport	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061951	establishment of protein localization to plasma membrane	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0072659	protein localization to plasma membrane	5	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1
GO:1990778	protein localization to cell periphery	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0003924	GTPase activity	7	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.415
CLV_MEL_PAP_1	121	127	PF00089	0.436
CLV_MEL_PAP_1	355	361	PF00089	0.566
CLV_NRD_NRD_1	88	90	PF00675	0.685
CLV_PCSK_FUR_1	86	90	PF00082	0.585
CLV_PCSK_KEX2_1	108	110	PF00082	0.400
CLV_PCSK_KEX2_1	88	90	PF00082	0.655
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.481
CLV_PCSK_SKI1_1	177	181	PF00082	0.429
CLV_PCSK_SKI1_1	248	252	PF00082	0.377
CLV_PCSK_SKI1_1	65	69	PF00082	0.588
DEG_APCC_DBOX_1	176	184	PF00400	0.360
DEG_APCC_DBOX_1	247	255	PF00400	0.430
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DOC_CDC14_PxL_1	260	268	PF14671	0.363
DOC_CKS1_1	13	18	PF01111	0.494
DOC_CKS1_1	40	45	PF01111	0.496
DOC_CKS1_1	78	83	PF01111	0.725
DOC_CKS1_1	94	99	PF01111	0.422
DOC_CYCLIN_yCln2_LP_2	255	261	PF00134	0.460
DOC_MAPK_gen_1	108	116	PF00069	0.483
DOC_MAPK_gen_1	136	142	PF00069	0.582
DOC_MAPK_MEF2A_6	108	116	PF00069	0.483
DOC_MAPK_MEF2A_6	351	359	PF00069	0.531
DOC_PP4_FxxP_1	125	128	PF00568	0.464
DOC_PP4_FxxP_1	13	16	PF00568	0.522
DOC_USP7_MATH_1	144	148	PF00917	0.554
DOC_USP7_MATH_1	218	222	PF00917	0.625
DOC_USP7_MATH_1	28	32	PF00917	0.383
DOC_USP7_MATH_1	55	59	PF00917	0.569
DOC_USP7_UBL2_3	237	241	PF12436	0.487
DOC_WW_Pin1_4	12	17	PF00397	0.532
DOC_WW_Pin1_4	123	128	PF00397	0.424
DOC_WW_Pin1_4	216	221	PF00397	0.566
DOC_WW_Pin1_4	336	341	PF00397	0.766
DOC_WW_Pin1_4	39	44	PF00397	0.486
DOC_WW_Pin1_4	77	82	PF00397	0.723
DOC_WW_Pin1_4	93	98	PF00397	0.439
LIG_14-3-3_CanoR_1	214	223	PF00244	0.485
LIG_14-3-3_CanoR_1	57	67	PF00244	0.592
LIG_FHA_1	111	117	PF00498	0.421
LIG_FHA_1	174	180	PF00498	0.409
LIG_FHA_1	270	276	PF00498	0.474
LIG_FHA_1	40	46	PF00498	0.425
LIG_FHA_1	68	74	PF00498	0.712
LIG_FHA_2	234	240	PF00498	0.520
LIG_FHA_2	280	286	PF00498	0.441
LIG_FHA_2	30	36	PF00498	0.363
LIG_FHA_2	348	354	PF00498	0.652
LIG_GBD_Chelix_1	203	211	PF00786	0.376
LIG_LIR_Apic_2	11	16	PF02991	0.529
LIG_LIR_Gen_1	17	23	PF02991	0.412
LIG_LIR_Gen_1	6	16	PF02991	0.540
LIG_LIR_Nem_3	15	21	PF02991	0.443
LIG_LIR_Nem_3	191	196	PF02991	0.338
LIG_LIR_Nem_3	295	301	PF02991	0.605
LIG_LIR_Nem_3	362	367	PF02991	0.473
LIG_LIR_Nem_3	6	12	PF02991	0.542
LIG_NRBOX	250	256	PF00104	0.430
LIG_PCNA_PIPBox_1	186	195	PF02747	0.360
LIG_PCNA_yPIPBox_3	181	193	PF02747	0.360
LIG_PDZ_Class_1	399	404	PF00595	0.547
LIG_Pex14_1	193	197	PF04695	0.300
LIG_PTB_Apo_2	7	14	PF02174	0.532
LIG_SH2_CRK	118	122	PF00017	0.458
LIG_SH2_CRK	18	22	PF00017	0.344
LIG_SH2_CRK	9	13	PF00017	0.479
LIG_SH2_NCK_1	118	122	PF00017	0.455
LIG_SH2_STAP1	157	161	PF00017	0.525
LIG_SH2_STAT3	299	302	PF00017	0.546
LIG_SH2_STAT5	205	208	PF00017	0.360
LIG_SH2_STAT5	41	44	PF00017	0.489
LIG_SH3_1	88	94	PF00018	0.642
LIG_SH3_3	146	152	PF00018	0.613
LIG_SH3_3	217	223	PF00018	0.629
LIG_SH3_3	75	81	PF00018	0.738
LIG_SH3_3	88	94	PF00018	0.572
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.590
LIG_SUMO_SIM_par_1	263	269	PF11976	0.351
LIG_SUMO_SIM_par_1	370	375	PF11976	0.413
LIG_TRAF2_1	236	239	PF00917	0.494
LIG_TRAF2_1	282	285	PF00917	0.415
LIG_TRAF2_1	310	313	PF00917	0.642
LIG_TYR_ITIM	116	121	PF00017	0.452
LIG_UBA3_1	33	38	PF00899	0.382
LIG_WW_3	229	233	PF00397	0.568
MOD_CK1_1	11	17	PF00069	0.642
MOD_CK1_1	130	136	PF00069	0.676
MOD_CK1_1	147	153	PF00069	0.479
MOD_CK1_1	216	222	PF00069	0.614
MOD_CK1_1	269	275	PF00069	0.448
MOD_CK1_1	328	334	PF00069	0.714
MOD_CK1_1	58	64	PF00069	0.570
MOD_CK2_1	11	17	PF00069	0.512
MOD_CK2_1	222	228	PF00069	0.708
MOD_CK2_1	233	239	PF00069	0.493
MOD_CK2_1	279	285	PF00069	0.452
MOD_CK2_1	29	35	PF00069	0.251
MOD_CK2_1	347	353	PF00069	0.654
MOD_CK2_1	58	64	PF00069	0.592
MOD_GlcNHglycan	129	132	PF01048	0.620
MOD_GlcNHglycan	216	219	PF01048	0.395
MOD_GlcNHglycan	224	227	PF01048	0.802
MOD_GlcNHglycan	327	330	PF01048	0.630
MOD_GlcNHglycan	361	364	PF01048	0.472
MOD_GlcNHglycan	373	377	PF01048	0.360
MOD_GlcNHglycan	60	63	PF01048	0.722
MOD_GSK3_1	123	130	PF00069	0.475
MOD_GSK3_1	169	176	PF00069	0.552
MOD_GSK3_1	214	221	PF00069	0.281
MOD_GSK3_1	269	276	PF00069	0.469
MOD_GSK3_1	343	350	PF00069	0.639
MOD_GSK3_1	68	75	PF00069	0.720
MOD_GSK3_1	8	15	PF00069	0.534
MOD_N-GLC_1	269	274	PF02516	0.435
MOD_N-GLC_1	302	307	PF02516	0.599
MOD_NEK2_1	213	218	PF00069	0.446
MOD_NEK2_1	266	271	PF00069	0.366
MOD_NEK2_2	365	370	PF00069	0.459
MOD_PIKK_1	100	106	PF00454	0.484
MOD_PIKK_1	135	141	PF00454	0.622
MOD_PIKK_1	197	203	PF00454	0.360
MOD_PIKK_1	313	319	PF00454	0.710
MOD_PIKK_1	328	334	PF00454	0.535
MOD_PKA_2	110	116	PF00069	0.430
MOD_PKA_2	213	219	PF00069	0.354
MOD_PKA_2	56	62	PF00069	0.586
MOD_Plk_1	207	213	PF00069	0.300
MOD_Plk_1	273	279	PF00069	0.492
MOD_Plk_1	365	371	PF00069	0.438
MOD_Plk_1	372	378	PF00069	0.357
MOD_Plk_4	130	136	PF00069	0.590
MOD_Plk_4	29	35	PF00069	0.406
MOD_Plk_4	294	300	PF00069	0.635
MOD_Plk_4	49	55	PF00069	0.525
MOD_Plk_4	8	14	PF00069	0.474
MOD_ProDKin_1	12	18	PF00069	0.517
MOD_ProDKin_1	123	129	PF00069	0.441
MOD_ProDKin_1	216	222	PF00069	0.572
MOD_ProDKin_1	336	342	PF00069	0.766
MOD_ProDKin_1	39	45	PF00069	0.490
MOD_ProDKin_1	77	83	PF00069	0.724
MOD_ProDKin_1	93	99	PF00069	0.430
MOD_SUMO_rev_2	233	243	PF00179	0.469
TRG_DiLeu_BaEn_1	17	22	PF01217	0.414
TRG_DiLeu_BaEn_2	34	40	PF01217	0.420
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.377
TRG_ENDOCYTIC_2	118	121	PF00928	0.456
TRG_ENDOCYTIC_2	18	21	PF00928	0.345
TRG_ENDOCYTIC_2	9	12	PF00928	0.493
TRG_ER_diArg_1	109	112	PF00400	0.480
TRG_ER_diArg_1	86	89	PF00400	0.675
TRG_NLS_MonoExtC_3	107	112	PF00514	0.431
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTD1	Leptomonas seymouri	58%	100%
A4HF63	Leishmania braziliensis	71%	98%
A4I2E6	Leishmania infantum	100%	100%
C9ZX62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AYJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8X3	Leishmania major	94%	100%