LeishMANIAdb
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ADP-ribosylation_factor_family_putative/Pfam:PF00 025

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ADP-ribosylation_factor_family_putative/Pfam:PF00 025
Gene product:
ADP-ribosylation factor family, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ICC5_LEIDO
TriTrypDb:
LdBPK_262200.1 , LdCL_260027600 , LDHU3_26.2880
Length:
404

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A3Q8ICC5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICC5

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006892 post-Golgi vesicle-mediated transport 6 1
GO:0006893 Golgi to plasma membrane transport 5 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016192 vesicle-mediated transport 4 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 8
GO:0003824 catalytic activity 1 8
GO:0003924 GTPase activity 7 8
GO:0005488 binding 1 8
GO:0005525 GTP binding 5 8
GO:0016462 pyrophosphatase activity 5 8
GO:0016787 hydrolase activity 2 8
GO:0016817 hydrolase activity, acting on acid anhydrides 3 8
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 8
GO:0017076 purine nucleotide binding 4 8
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 375 379 PF00656 0.415
CLV_MEL_PAP_1 121 127 PF00089 0.436
CLV_MEL_PAP_1 355 361 PF00089 0.566
CLV_NRD_NRD_1 88 90 PF00675 0.685
CLV_PCSK_FUR_1 86 90 PF00082 0.585
CLV_PCSK_KEX2_1 108 110 PF00082 0.400
CLV_PCSK_KEX2_1 88 90 PF00082 0.655
CLV_PCSK_PC1ET2_1 108 110 PF00082 0.481
CLV_PCSK_SKI1_1 177 181 PF00082 0.429
CLV_PCSK_SKI1_1 248 252 PF00082 0.377
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HTD1 Leptomonas seymouri 58% 100%
A4HF63 Leishmania braziliensis 71% 98%
A4I2E6 Leishmania infantum 100% 100%
C9ZX62 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AYJ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q8X3 Leishmania major 94% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS