Ribosomal protein L14 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein L14, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICC3_LEIDO

TriTrypDb:

LdBPK_221370.1 , LdCL_220020900 , LdCL_220021300 , LDHU3_22.1970 , LDHU3_22.2010

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A0A3Q8ICC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICC3

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	15
GO:0006518	peptide metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009058	biosynthetic process	2	15
GO:0009059	macromolecule biosynthetic process	4	15
GO:0009987	cellular process	1	15
GO:0019538	protein metabolic process	3	15
GO:0034641	cellular nitrogen compound metabolic process	3	15
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	15
GO:0043043	peptide biosynthetic process	5	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043603	amide metabolic process	3	15
GO:0043604	amide biosynthetic process	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0044249	cellular biosynthetic process	3	15
GO:0044260	obsolete cellular macromolecule metabolic process	3	15
GO:0044271	cellular nitrogen compound biosynthetic process	4	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:1901566	organonitrogen compound biosynthetic process	4	15
GO:1901576	organic substance biosynthetic process	3	15
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003723	RNA binding	4	15
GO:0003735	structural constituent of ribosome	2	15
GO:0005198	structural molecule activity	1	15
GO:0005488	binding	1	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.618
CLV_C14_Caspase3-7	29	33	PF00656	0.434
CLV_NRD_NRD_1	117	119	PF00675	0.360
CLV_NRD_NRD_1	124	126	PF00675	0.435
CLV_NRD_NRD_1	162	164	PF00675	0.575
CLV_NRD_NRD_1	170	172	PF00675	0.488
CLV_PCSK_KEX2_1	117	119	PF00082	0.329
CLV_PCSK_KEX2_1	161	163	PF00082	0.521
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.521
CLV_PCSK_SKI1_1	125	129	PF00082	0.519
CLV_PCSK_SKI1_1	131	135	PF00082	0.556
CLV_PCSK_SKI1_1	141	145	PF00082	0.461
CLV_PCSK_SKI1_1	150	154	PF00082	0.413
CLV_PCSK_SKI1_1	171	175	PF00082	0.572
CLV_PCSK_SKI1_1	72	76	PF00082	0.353
CLV_PCSK_SKI1_1	86	90	PF00082	0.309
DOC_MAPK_gen_1	17	26	PF00069	0.396
DOC_MAPK_MEF2A_6	20	28	PF00069	0.388
DOC_USP7_MATH_1	116	120	PF00917	0.335
DOC_USP7_MATH_1	77	81	PF00917	0.433
DOC_USP7_UBL2_3	141	145	PF12436	0.463
DOC_USP7_UBL2_3	146	150	PF12436	0.487
DOC_USP7_UBL2_3	82	86	PF12436	0.329
DOC_WW_Pin1_4	132	137	PF00397	0.621
LIG_14-3-3_CanoR_1	67	74	PF00244	0.349
LIG_BRCT_BRCA1_1	104	108	PF00533	0.329
LIG_FHA_2	104	110	PF00498	0.335
LIG_LIR_Gen_1	138	147	PF02991	0.466
LIG_LIR_Nem_3	105	111	PF02991	0.375
LIG_LIR_Nem_3	138	142	PF02991	0.460
LIG_RPA_C_Fungi	62	74	PF08784	0.370
LIG_SH2_STAT5	6	9	PF00017	0.443
LIG_SH2_STAT5	61	64	PF00017	0.386
LIG_SH3_3	35	41	PF00018	0.386
LIG_SUMO_SIM_par_1	26	32	PF11976	0.408
MOD_CK2_1	103	109	PF00069	0.335
MOD_GlcNHglycan	69	72	PF01048	0.527
MOD_GSK3_1	63	70	PF00069	0.383
MOD_N-GLC_1	67	72	PF02516	0.349
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	78	83	PF00069	0.500
MOD_PKA_2	116	122	PF00069	0.480
MOD_ProDKin_1	132	138	PF00069	0.617
MOD_SUMO_rev_2	129	136	PF00179	0.455
MOD_SUMO_rev_2	39	46	PF00179	0.439
TRG_ER_diArg_1	117	120	PF00400	0.497
TRG_ER_diArg_1	162	164	PF00400	0.586
TRG_NLS_Bipartite_1	145	165	PF00514	0.607
TRG_NLS_MonoExtC_3	170	175	PF00514	0.703
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P212	Leptomonas seymouri	87%	100%
A0A0S4IV19	Bodo saltans	63%	70%
A0A1X0NR58	Trypanosomatidae	75%	97%
A0A1X0NTL1	Trypanosomatidae	75%	97%
A0A3R7RDB6	Trypanosoma rangeli	71%	98%
A0A422NG13	Trypanosoma rangeli	72%	98%
A1XQU3	Sus scrofa	29%	82%
A4HCJ1	Leishmania braziliensis	95%	100%
A4I011	Leishmania infantum	100%	100%
C9ZQ81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	93%
D0A8Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	93%
E9AVY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
P36105	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P38754	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P50914	Homo sapiens	28%	81%
P55841	Drosophila melanogaster	29%	100%
P55842	Trypanosoma brucei brucei	76%	93%
P55843	Trypanosoma congolense	75%	95%
P55844	Pisum sativum	30%	100%
Q24C27	Tetrahymena thermophila (strain SB210)	29%	100%
Q25278	Leishmania donovani	100%	100%
Q3T0U2	Bos taurus	29%	82%
Q4QBJ1	Leishmania major	99%	100%
Q54Z09	Dictyostelium discoideum	32%	100%
Q63507	Rattus norvegicus	28%	82%
Q7XYA7	Griffithsia japonica	29%	100%
Q95ZE8	Drosophila virilis	29%	100%
Q9CR57	Mus musculus	28%	81%
Q9SIM4	Arabidopsis thaliana	29%	100%
Q9T043	Arabidopsis thaliana	28%	100%
V5D9P7	Trypanosoma cruzi	72%	97%