RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICC1_LEIDO

TriTrypDb:

LdBPK_221290.1 , LdCL_220020000 , LDHU3_22.1860

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICC1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.433
CLV_C14_Caspase3-7	440	444	PF00656	0.652
CLV_NRD_NRD_1	274	276	PF00675	0.412
CLV_NRD_NRD_1	282	284	PF00675	0.357
CLV_NRD_NRD_1	311	313	PF00675	0.506
CLV_PCSK_KEX2_1	274	276	PF00082	0.395
CLV_PCSK_KEX2_1	282	284	PF00082	0.369
CLV_PCSK_KEX2_1	311	313	PF00082	0.551
CLV_PCSK_KEX2_1	334	336	PF00082	0.496
CLV_PCSK_KEX2_1	50	52	PF00082	0.666
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.582
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.631
CLV_PCSK_SKI1_1	274	278	PF00082	0.457
CLV_PCSK_SKI1_1	295	299	PF00082	0.375
CLV_PCSK_SKI1_1	334	338	PF00082	0.425
CLV_PCSK_SKI1_1	342	346	PF00082	0.302
CLV_PCSK_SKI1_1	4	8	PF00082	0.686
CLV_PCSK_SKI1_1	426	430	PF00082	0.632
CLV_PCSK_SKI1_1	50	54	PF00082	0.712
DEG_APCC_DBOX_1	198	206	PF00400	0.467
DEG_APCC_DBOX_1	274	282	PF00400	0.468
DOC_CKS1_1	389	394	PF01111	0.466
DOC_MAPK_DCC_7	199	207	PF00069	0.436
DOC_MAPK_MEF2A_6	199	207	PF00069	0.427
DOC_PP1_RVXF_1	340	346	PF00149	0.383
DOC_PP2B_LxvP_1	158	161	PF13499	0.531
DOC_PP4_FxxP_1	492	495	PF00568	0.643
DOC_USP7_MATH_1	161	165	PF00917	0.610
DOC_USP7_MATH_1	304	308	PF00917	0.516
DOC_USP7_MATH_1	364	368	PF00917	0.569
DOC_USP7_MATH_1	405	409	PF00917	0.601
DOC_USP7_MATH_1	436	440	PF00917	0.688
DOC_USP7_MATH_1	45	49	PF00917	0.680
DOC_USP7_MATH_1	455	459	PF00917	0.688
DOC_USP7_UBL2_3	4	8	PF12436	0.598
DOC_WW_Pin1_4	14	19	PF00397	0.719
DOC_WW_Pin1_4	23	28	PF00397	0.667
DOC_WW_Pin1_4	240	245	PF00397	0.505
DOC_WW_Pin1_4	388	393	PF00397	0.490
DOC_WW_Pin1_4	448	453	PF00397	0.626
LIG_14-3-3_CanoR_1	153	162	PF00244	0.619
LIG_14-3-3_CanoR_1	163	168	PF00244	0.488
LIG_14-3-3_CanoR_1	199	203	PF00244	0.462
LIG_14-3-3_CanoR_1	204	208	PF00244	0.432
LIG_14-3-3_CanoR_1	424	433	PF00244	0.581
LIG_BRCT_BRCA1_1	135	139	PF00533	0.683
LIG_BRCT_BRCA1_1	392	396	PF00533	0.572
LIG_BRCT_BRCA1_1	87	91	PF00533	0.710
LIG_Clathr_ClatBox_1	305	309	PF01394	0.419
LIG_deltaCOP1_diTrp_1	172	181	PF00928	0.601
LIG_FHA_1	157	163	PF00498	0.534
LIG_FHA_1	282	288	PF00498	0.471
LIG_FHA_1	384	390	PF00498	0.428
LIG_FHA_1	415	421	PF00498	0.614
LIG_FHA_1	68	74	PF00498	0.666
LIG_FHA_1	80	86	PF00498	0.569
LIG_FHA_2	10	16	PF00498	0.737
LIG_FHA_2	167	173	PF00498	0.502
LIG_FHA_2	324	330	PF00498	0.416
LIG_FHA_2	467	473	PF00498	0.643
LIG_IBAR_NPY_1	501	503	PF08397	0.573
LIG_LIR_Apic_2	243	248	PF02991	0.465
LIG_LIR_Apic_2	352	358	PF02991	0.394
LIG_LIR_Apic_2	491	495	PF02991	0.677
LIG_LIR_Gen_1	172	183	PF02991	0.597
LIG_LIR_Nem_3	172	178	PF02991	0.578
LIG_LIR_Nem_3	472	476	PF02991	0.724
LIG_LIR_Nem_3	481	485	PF02991	0.559
LIG_Pex14_1	175	179	PF04695	0.464
LIG_SH2_CRK	485	489	PF00017	0.581
LIG_SH2_NCK_1	108	112	PF00017	0.772
LIG_SH2_NCK_1	433	437	PF00017	0.619
LIG_SH2_NCK_1	476	480	PF00017	0.535
LIG_SH2_STAP1	503	507	PF00017	0.608
LIG_SH2_STAT5	167	170	PF00017	0.594
LIG_SH2_STAT5	485	488	PF00017	0.526
LIG_SH2_STAT5	503	506	PF00017	0.636
LIG_SH3_3	386	392	PF00018	0.424
LIG_SH3_3	395	401	PF00018	0.576
LIG_SH3_3	449	455	PF00018	0.643
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.583
LIG_SUMO_SIM_par_1	304	309	PF11976	0.420
LIG_SUMO_SIM_par_1	385	391	PF11976	0.423
LIG_TRAF2_1	458	461	PF00917	0.663
LIG_TRFH_1	498	502	PF08558	0.614
LIG_WRC_WIRS_1	178	183	PF05994	0.487
MOD_CDC14_SPxK_1	17	20	PF00782	0.592
MOD_CDC14_SPxK_1	26	29	PF00782	0.528
MOD_CDK_SPxK_1	14	20	PF00069	0.703
MOD_CDK_SPxK_1	23	29	PF00069	0.599
MOD_CK1_1	101	107	PF00069	0.654
MOD_CK1_1	109	115	PF00069	0.633
MOD_CK1_1	127	133	PF00069	0.454
MOD_CK1_1	156	162	PF00069	0.683
MOD_CK1_1	23	29	PF00069	0.662
MOD_CK1_1	367	373	PF00069	0.539
MOD_CK1_1	434	440	PF00069	0.726
MOD_CK1_1	442	448	PF00069	0.659
MOD_CK1_1	78	84	PF00069	0.598
MOD_CK2_1	166	172	PF00069	0.534
MOD_CK2_1	455	461	PF00069	0.813
MOD_CK2_1	466	472	PF00069	0.646
MOD_CK2_1	9	15	PF00069	0.736
MOD_Cter_Amidation	272	275	PF01082	0.367
MOD_GlcNHglycan	109	112	PF01048	0.651
MOD_GlcNHglycan	22	25	PF01048	0.687
MOD_GlcNHglycan	271	274	PF01048	0.548
MOD_GlcNHglycan	300	303	PF01048	0.351
MOD_GlcNHglycan	407	410	PF01048	0.607
MOD_GlcNHglycan	426	429	PF01048	0.753
MOD_GlcNHglycan	433	436	PF01048	0.664
MOD_GSK3_1	106	113	PF00069	0.594
MOD_GSK3_1	120	127	PF00069	0.546
MOD_GSK3_1	437	444	PF00069	0.715
MOD_GSK3_1	75	82	PF00069	0.591
MOD_GSK3_1	98	105	PF00069	0.636
MOD_N-GLC_1	298	303	PF02516	0.516
MOD_N-GLC_1	9	14	PF02516	0.657
MOD_N-GLC_1	98	103	PF02516	0.652
MOD_N-GLC_2	263	265	PF02516	0.490
MOD_NEK2_1	198	203	PF00069	0.458
MOD_NEK2_1	281	286	PF00069	0.462
MOD_NEK2_1	298	303	PF00069	0.375
MOD_NEK2_1	344	349	PF00069	0.440
MOD_NEK2_1	431	436	PF00069	0.651
MOD_NEK2_2	2	7	PF00069	0.614
MOD_PIKK_1	153	159	PF00454	0.674
MOD_PIKK_1	313	319	PF00454	0.629
MOD_PIKK_1	434	440	PF00454	0.643
MOD_PKA_1	311	317	PF00069	0.525
MOD_PKA_2	198	204	PF00069	0.499
MOD_PKA_2	281	287	PF00069	0.422
MOD_PKA_2	311	317	PF00069	0.571
MOD_PKA_2	383	389	PF00069	0.513
MOD_PKA_2	46	52	PF00069	0.682
MOD_PKA_2	93	99	PF00069	0.690
MOD_PKB_1	424	432	PF00069	0.549
MOD_Plk_1	329	335	PF00069	0.474
MOD_Plk_1	367	373	PF00069	0.505
MOD_Plk_1	442	448	PF00069	0.638
MOD_Plk_1	55	61	PF00069	0.559
MOD_Plk_1	9	15	PF00069	0.777
MOD_Plk_4	103	109	PF00069	0.723
MOD_Plk_4	163	169	PF00069	0.549
MOD_Plk_4	383	389	PF00069	0.455
MOD_Plk_4	478	484	PF00069	0.625
MOD_Plk_4	501	507	PF00069	0.577
MOD_Plk_4	75	81	PF00069	0.640
MOD_Plk_4	9	15	PF00069	0.680
MOD_ProDKin_1	14	20	PF00069	0.719
MOD_ProDKin_1	23	29	PF00069	0.667
MOD_ProDKin_1	240	246	PF00069	0.502
MOD_ProDKin_1	388	394	PF00069	0.502
MOD_ProDKin_1	448	454	PF00069	0.625
MOD_SUMO_for_1	97	100	PF00179	0.660
TRG_DiLeu_BaEn_1	352	357	PF01217	0.443
TRG_DiLeu_BaEn_1	56	61	PF01217	0.510
TRG_ENDOCYTIC_2	503	506	PF00928	0.670
TRG_ER_diArg_1	274	276	PF00400	0.409
TRG_ER_diArg_1	281	283	PF00400	0.349
TRG_ER_diArg_1	91	94	PF00400	0.746
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J803	Bodo saltans	35%	97%
A0A1X0NV61	Trypanosomatidae	38%	100%
A4HCI4	Leishmania braziliensis	84%	99%
A4I003	Leishmania infantum	100%	100%
E9AVX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBK3	Leishmania major	94%	100%
V5ANV0	Trypanosoma cruzi	34%	100%