Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICB7_LEIDO

TriTrypDb:

LdBPK_310100.1 , LdCL_310005800 , LDHU3_31.0120

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.473
CLV_C14_Caspase3-7	333	337	PF00656	0.753
CLV_C14_Caspase3-7	405	409	PF00656	0.576
CLV_NRD_NRD_1	132	134	PF00675	0.413
CLV_NRD_NRD_1	168	170	PF00675	0.392
CLV_NRD_NRD_1	177	179	PF00675	0.473
CLV_NRD_NRD_1	393	395	PF00675	0.638
CLV_NRD_NRD_1	469	471	PF00675	0.474
CLV_NRD_NRD_1	70	72	PF00675	0.472
CLV_PCSK_KEX2_1	168	170	PF00082	0.359
CLV_PCSK_KEX2_1	179	181	PF00082	0.401
CLV_PCSK_KEX2_1	31	33	PF00082	0.430
CLV_PCSK_KEX2_1	311	313	PF00082	0.616
CLV_PCSK_KEX2_1	393	395	PF00082	0.545
CLV_PCSK_KEX2_1	469	471	PF00082	0.491
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.442
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.430
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.616
CLV_PCSK_SKI1_1	133	137	PF00082	0.452
CLV_PCSK_SKI1_1	143	147	PF00082	0.328
CLV_PCSK_SKI1_1	229	233	PF00082	0.383
CLV_PCSK_SKI1_1	35	39	PF00082	0.440
CLV_PCSK_SKI1_1	367	371	PF00082	0.564
CLV_Separin_Metazoa	287	291	PF03568	0.536
CLV_Separin_Metazoa	68	72	PF03568	0.457
DEG_APCC_DBOX_1	242	250	PF00400	0.483
DEG_APCC_DBOX_1	445	453	PF00400	0.550
DEG_SPOP_SBC_1	330	334	PF00917	0.684
DOC_CYCLIN_yCln2_LP_2	422	428	PF00134	0.473
DOC_MAPK_gen_1	178	190	PF00069	0.324
DOC_MAPK_gen_1	35	45	PF00069	0.437
DOC_MAPK_MEF2A_6	156	165	PF00069	0.437
DOC_MAPK_MEF2A_6	229	238	PF00069	0.328
DOC_MAPK_RevD_3	358	373	PF00069	0.500
DOC_PP1_RVXF_1	154	160	PF00149	0.429
DOC_PP2B_LxvP_1	422	425	PF13499	0.522
DOC_PP4_FxxP_1	144	147	PF00568	0.329
DOC_PP4_FxxP_1	273	276	PF00568	0.515
DOC_USP7_MATH_1	330	334	PF00917	0.793
DOC_USP7_MATH_1	484	488	PF00917	0.588
DOC_USP7_UBL2_3	31	35	PF12436	0.448
DOC_WW_Pin1_4	157	162	PF00397	0.369
DOC_WW_Pin1_4	258	263	PF00397	0.594
DOC_WW_Pin1_4	91	96	PF00397	0.520
LIG_14-3-3_CanoR_1	255	262	PF00244	0.500
LIG_14-3-3_CanoR_1	298	306	PF00244	0.377
LIG_14-3-3_CanoR_1	32	38	PF00244	0.515
LIG_Actin_WH2_2	242	257	PF00022	0.362
LIG_AP2alpha_1	379	383	PF02296	0.414
LIG_AP2alpha_2	184	186	PF02296	0.442
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_CSL_BTD_1	158	161	PF09270	0.363
LIG_deltaCOP1_diTrp_1	244	250	PF00928	0.372
LIG_FHA_1	230	236	PF00498	0.332
LIG_FHA_1	419	425	PF00498	0.485
LIG_FHA_1	85	91	PF00498	0.493
LIG_FHA_2	105	111	PF00498	0.540
LIG_FHA_2	115	121	PF00498	0.427
LIG_FHA_2	259	265	PF00498	0.613
LIG_FHA_2	298	304	PF00498	0.586
LIG_FHA_2	460	466	PF00498	0.436
LIG_GBD_Chelix_1	21	29	PF00786	0.488
LIG_HCF-1_HBM_1	227	230	PF13415	0.365
LIG_LIR_Apic_2	189	195	PF02991	0.406
LIG_LIR_Apic_2	271	276	PF02991	0.601
LIG_LIR_Gen_1	293	304	PF02991	0.587
LIG_LIR_Nem_3	170	176	PF02991	0.520
LIG_LIR_Nem_3	293	299	PF02991	0.508
LIG_LIR_Nem_3	303	309	PF02991	0.497
LIG_LIR_Nem_3	353	357	PF02991	0.526
LIG_PCNA_yPIPBox_3	148	158	PF02747	0.405
LIG_Pex14_1	459	463	PF04695	0.494
LIG_Pex14_2	379	383	PF04695	0.414
LIG_Pex14_2	51	55	PF04695	0.403
LIG_SH2_CRK	192	196	PF00017	0.526
LIG_SH2_CRK	26	30	PF00017	0.399
LIG_SH2_GRB2like	150	153	PF00017	0.416
LIG_SH2_NCK_1	320	324	PF00017	0.578
LIG_SH2_SRC	150	153	PF00017	0.475
LIG_SH2_STAP1	306	310	PF00017	0.507
LIG_SH2_STAP1	320	324	PF00017	0.636
LIG_SH2_STAP1	60	64	PF00017	0.399
LIG_SH2_STAT5	100	103	PF00017	0.435
LIG_SH2_STAT5	225	228	PF00017	0.380
LIG_SH2_STAT5	230	233	PF00017	0.352
LIG_SH2_STAT5	237	240	PF00017	0.319
LIG_SH2_STAT5	296	299	PF00017	0.494
LIG_SH2_STAT5	439	442	PF00017	0.446
LIG_SH2_STAT5	463	466	PF00017	0.491
LIG_SH2_STAT5	60	63	PF00017	0.355
LIG_SH3_3	155	161	PF00018	0.390
LIG_SUMO_SIM_par_1	117	123	PF11976	0.395
LIG_UBA3_1	418	427	PF00899	0.387
MOD_CDK_SPK_2	157	162	PF00069	0.418
MOD_CK1_1	331	337	PF00069	0.698
MOD_CK1_1	431	437	PF00069	0.680
MOD_CK2_1	114	120	PF00069	0.445
MOD_CK2_1	258	264	PF00069	0.610
MOD_CK2_1	288	294	PF00069	0.604
MOD_CK2_1	297	303	PF00069	0.543
MOD_CMANNOS	247	250	PF00535	0.325
MOD_GlcNHglycan	204	207	PF01048	0.462
MOD_GlcNHglycan	290	293	PF01048	0.647
MOD_GlcNHglycan	333	336	PF01048	0.721
MOD_GlcNHglycan	344	347	PF01048	0.469
MOD_GlcNHglycan	353	357	PF01048	0.615
MOD_GlcNHglycan	433	436	PF01048	0.537
MOD_GSK3_1	110	117	PF00069	0.413
MOD_GSK3_1	184	191	PF00069	0.490
MOD_GSK3_1	196	203	PF00069	0.453
MOD_GSK3_1	250	257	PF00069	0.364
MOD_GSK3_1	352	359	PF00069	0.517
MOD_GSK3_1	459	466	PF00069	0.546
MOD_GSK3_1	96	103	PF00069	0.422
MOD_NEK2_1	186	191	PF00069	0.405
MOD_NEK2_1	305	310	PF00069	0.520
MOD_NEK2_1	352	357	PF00069	0.566
MOD_NEK2_1	418	423	PF00069	0.488
MOD_NEK2_2	250	255	PF00069	0.320
MOD_PIKK_1	447	453	PF00454	0.525
MOD_PIKK_1	84	90	PF00454	0.506
MOD_PKA_2	123	129	PF00069	0.498
MOD_PKA_2	167	173	PF00069	0.405
MOD_PKA_2	254	260	PF00069	0.416
MOD_PKA_2	297	303	PF00069	0.578
MOD_PKA_2	341	347	PF00069	0.587
MOD_Plk_1	6	12	PF00069	0.612
MOD_Plk_2-3	105	111	PF00069	0.540
MOD_Plk_2-3	114	120	PF00069	0.379
MOD_Plk_2-3	78	84	PF00069	0.425
MOD_Plk_4	114	120	PF00069	0.442
MOD_Plk_4	150	156	PF00069	0.384
MOD_Plk_4	193	199	PF00069	0.450
MOD_Plk_4	305	311	PF00069	0.522
MOD_Plk_4	45	51	PF00069	0.327
MOD_Plk_4	459	465	PF00069	0.516
MOD_Plk_4	6	12	PF00069	0.635
MOD_Plk_4	96	102	PF00069	0.358
MOD_ProDKin_1	157	163	PF00069	0.374
MOD_ProDKin_1	258	264	PF00069	0.598
MOD_ProDKin_1	91	97	PF00069	0.510
MOD_SUMO_rev_2	205	215	PF00179	0.424
MOD_SUMO_rev_2	366	375	PF00179	0.528
TRG_DiLeu_BaEn_1	114	119	PF01217	0.496
TRG_ENDOCYTIC_2	173	176	PF00928	0.545
TRG_ENDOCYTIC_2	26	29	PF00928	0.350
TRG_ENDOCYTIC_2	296	299	PF00928	0.480
TRG_ER_diArg_1	468	470	PF00400	0.458
TRG_NLS_MonoExtC_3	132	137	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U9	Leptomonas seymouri	71%	100%
A0A0S4JY56	Bodo saltans	43%	96%
A0A1X0P2D9	Trypanosomatidae	34%	83%
A0A3S5IRH4	Trypanosoma rangeli	37%	89%
A4HIX3	Leishmania braziliensis	82%	100%
A4I6A2	Leishmania infantum	99%	100%
C9ZM74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	83%
C9ZWU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	91%
E9B1F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6Q5	Leishmania major	94%	100%
V5BLG2	Trypanosoma cruzi	38%	88%