Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICB6_LEIDO

TriTrypDb:

LdBPK_251080.1 , LdCL_250016200 , LDHU3_25.1400

Length:

732

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	542	546	PF00656	0.709
CLV_C14_Caspase3-7	573	577	PF00656	0.738
CLV_C14_Caspase3-7	653	657	PF00656	0.761
CLV_C14_Caspase3-7	707	711	PF00656	0.608
CLV_C14_Caspase3-7	98	102	PF00656	0.562
CLV_MEL_PAP_1	194	200	PF00089	0.657
CLV_NRD_NRD_1	321	323	PF00675	0.613
CLV_NRD_NRD_1	336	338	PF00675	0.551
CLV_NRD_NRD_1	379	381	PF00675	0.714
CLV_NRD_NRD_1	460	462	PF00675	0.756
CLV_NRD_NRD_1	494	496	PF00675	0.764
CLV_NRD_NRD_1	523	525	PF00675	0.705
CLV_NRD_NRD_1	526	528	PF00675	0.710
CLV_NRD_NRD_1	561	563	PF00675	0.611
CLV_NRD_NRD_1	579	581	PF00675	0.713
CLV_NRD_NRD_1	595	597	PF00675	0.679
CLV_NRD_NRD_1	614	616	PF00675	0.741
CLV_NRD_NRD_1	667	669	PF00675	0.739
CLV_PCSK_FUR_1	523	527	PF00082	0.719
CLV_PCSK_KEX2_1	112	114	PF00082	0.566
CLV_PCSK_KEX2_1	321	323	PF00082	0.613
CLV_PCSK_KEX2_1	336	338	PF00082	0.551
CLV_PCSK_KEX2_1	378	380	PF00082	0.607
CLV_PCSK_KEX2_1	493	495	PF00082	0.764
CLV_PCSK_KEX2_1	523	525	PF00082	0.714
CLV_PCSK_KEX2_1	526	528	PF00082	0.716
CLV_PCSK_KEX2_1	561	563	PF00082	0.611
CLV_PCSK_KEX2_1	579	581	PF00082	0.713
CLV_PCSK_KEX2_1	595	597	PF00082	0.679
CLV_PCSK_KEX2_1	614	616	PF00082	0.741
CLV_PCSK_KEX2_1	667	669	PF00082	0.842
CLV_PCSK_KEX2_1	700	702	PF00082	0.846
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.655
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.711
CLV_PCSK_PC1ET2_1	700	702	PF00082	0.846
CLV_PCSK_PC7_1	490	496	PF00082	0.725
CLV_PCSK_PC7_1	575	581	PF00082	0.614
CLV_PCSK_PC7_1	663	669	PF00082	0.767
CLV_PCSK_SKI1_1	134	138	PF00082	0.518
CLV_PCSK_SKI1_1	141	145	PF00082	0.522
CLV_PCSK_SKI1_1	223	227	PF00082	0.743
CLV_PCSK_SKI1_1	366	370	PF00082	0.577
CLV_PCSK_SKI1_1	526	530	PF00082	0.667
CLV_PCSK_SKI1_1	567	571	PF00082	0.639
DEG_APCC_DBOX_1	525	533	PF00400	0.712
DEG_SPOP_SBC_1	13	17	PF00917	0.633
DEG_SPOP_SBC_1	586	590	PF00917	0.782
DOC_ANK_TNKS_1	540	547	PF00023	0.761
DOC_CYCLIN_yCln2_LP_2	405	411	PF00134	0.765
DOC_MAPK_gen_1	134	142	PF00069	0.517
DOC_MAPK_gen_1	55	62	PF00069	0.536
DOC_MAPK_RevD_3	365	380	PF00069	0.457
DOC_PP2B_LxvP_1	291	294	PF13499	0.744
DOC_PP2B_LxvP_1	4	7	PF13499	0.696
DOC_PP2B_LxvP_1	548	551	PF13499	0.737
DOC_USP7_MATH_1	11	15	PF00917	0.668
DOC_USP7_MATH_1	178	182	PF00917	0.622
DOC_USP7_MATH_1	317	321	PF00917	0.732
DOC_USP7_MATH_1	35	39	PF00917	0.812
DOC_USP7_MATH_1	501	505	PF00917	0.800
DOC_USP7_MATH_1	531	535	PF00917	0.766
DOC_USP7_MATH_1	586	590	PF00917	0.782
DOC_USP7_MATH_1	661	665	PF00917	0.671
DOC_USP7_MATH_1	704	708	PF00917	0.763
DOC_USP7_UBL2_3	137	141	PF12436	0.507
DOC_WW_Pin1_4	215	220	PF00397	0.727
DOC_WW_Pin1_4	246	251	PF00397	0.642
DOC_WW_Pin1_4	252	257	PF00397	0.704
DOC_WW_Pin1_4	289	294	PF00397	0.751
DOC_WW_Pin1_4	404	409	PF00397	0.781
DOC_WW_Pin1_4	437	442	PF00397	0.778
DOC_WW_Pin1_4	455	460	PF00397	0.529
DOC_WW_Pin1_4	47	52	PF00397	0.693
DOC_WW_Pin1_4	552	557	PF00397	0.667
LIG_14-3-3_CanoR_1	105	114	PF00244	0.366
LIG_14-3-3_CanoR_1	206	211	PF00244	0.768
LIG_14-3-3_CanoR_1	24	30	PF00244	0.799
LIG_14-3-3_CanoR_1	282	291	PF00244	0.809
LIG_14-3-3_CanoR_1	55	63	PF00244	0.728
LIG_14-3-3_CanoR_1	614	618	PF00244	0.728
LIG_14-3-3_CanoR_1	648	653	PF00244	0.768
LIG_14-3-3_CanoR_1	663	669	PF00244	0.632
LIG_14-3-3_CanoR_1	703	709	PF00244	0.741
LIG_14-3-3_CanoR_1	89	94	PF00244	0.560
LIG_BRCT_BRCA1_1	150	154	PF00533	0.527
LIG_FHA_1	178	184	PF00498	0.631
LIG_FHA_1	608	614	PF00498	0.733
LIG_FHA_2	283	289	PF00498	0.806
LIG_FHA_2	367	373	PF00498	0.622
LIG_FHA_2	47	53	PF00498	0.611
LIG_FHA_2	484	490	PF00498	0.711
LIG_FHA_2	540	546	PF00498	0.757
LIG_FHA_2	75	81	PF00498	0.553
LIG_HCF-1_HBM_1	420	423	PF13415	0.685
LIG_Integrin_isoDGR_2	278	280	PF01839	0.608
LIG_LIR_Apic_2	420	426	PF02991	0.779
LIG_LIR_Gen_1	177	187	PF02991	0.635
LIG_LIR_Gen_1	242	253	PF02991	0.755
LIG_LIR_Nem_3	177	182	PF02991	0.626
LIG_LIR_Nem_3	242	247	PF02991	0.659
LIG_LYPXL_SIV_4	323	331	PF13949	0.568
LIG_NRBOX	413	419	PF00104	0.602
LIG_PDZ_Class_1	727	732	PF00595	0.559
LIG_Rb_pABgroove_1	91	99	PF01858	0.517
LIG_SH2_CRK	130	134	PF00017	0.625
LIG_SH2_CRK	179	183	PF00017	0.633
LIG_SH2_CRK	423	427	PF00017	0.804
LIG_SH2_GRB2like	352	355	PF00017	0.688
LIG_SH2_PTP2	146	149	PF00017	0.518
LIG_SH2_STAP1	179	183	PF00017	0.633
LIG_SH2_STAP1	239	243	PF00017	0.674
LIG_SH2_STAP1	352	356	PF00017	0.582
LIG_SH2_STAP1	619	623	PF00017	0.718
LIG_SH2_STAP1	71	75	PF00017	0.535
LIG_SH2_STAT5	146	149	PF00017	0.511
LIG_SH2_STAT5	179	182	PF00017	0.613
LIG_SH3_1	429	435	PF00018	0.774
LIG_SH3_2	432	437	PF14604	0.735
LIG_SH3_2	658	663	PF14604	0.765
LIG_SH3_3	211	217	PF00018	0.619
LIG_SH3_3	244	250	PF00018	0.642
LIG_SH3_3	429	435	PF00018	0.774
LIG_SH3_3	453	459	PF00018	0.682
LIG_SH3_3	655	661	PF00018	0.763
LIG_SUMO_SIM_par_1	297	304	PF11976	0.681
LIG_SUMO_SIM_par_1	337	342	PF11976	0.559
MOD_CDC14_SPxK_1	458	461	PF00782	0.709
MOD_CDK_SPxK_1	455	461	PF00069	0.717
MOD_CDK_SPxxK_3	455	462	PF00069	0.713
MOD_CK1_1	12	18	PF00069	0.706
MOD_CK1_1	152	158	PF00069	0.536
MOD_CK1_1	255	261	PF00069	0.760
MOD_CK1_1	38	44	PF00069	0.718
MOD_CK1_1	436	442	PF00069	0.849
MOD_CK1_1	479	485	PF00069	0.770
MOD_CK1_1	50	56	PF00069	0.670
MOD_CK1_1	534	540	PF00069	0.768
MOD_CK1_1	588	594	PF00069	0.845
MOD_CK1_1	659	665	PF00069	0.728
MOD_CK2_1	282	288	PF00069	0.805
MOD_CK2_1	366	372	PF00069	0.622
MOD_CK2_1	46	52	PF00069	0.671
MOD_CK2_1	74	80	PF00069	0.552
MOD_GlcNHglycan	11	14	PF01048	0.747
MOD_GlcNHglycan	203	206	PF01048	0.693
MOD_GlcNHglycan	257	260	PF01048	0.809
MOD_GlcNHglycan	313	316	PF01048	0.695
MOD_GlcNHglycan	480	485	PF01048	0.774
MOD_GlcNHglycan	503	506	PF01048	0.833
MOD_GlcNHglycan	536	539	PF01048	0.728
MOD_GlcNHglycan	591	594	PF01048	0.791
MOD_GlcNHglycan	642	645	PF01048	0.721
MOD_GlcNHglycan	652	655	PF01048	0.759
MOD_GlcNHglycan	670	673	PF01048	0.621
MOD_GSK3_1	148	155	PF00069	0.490
MOD_GSK3_1	233	240	PF00069	0.769
MOD_GSK3_1	254	261	PF00069	0.733
MOD_GSK3_1	297	304	PF00069	0.771
MOD_GSK3_1	33	40	PF00069	0.719
MOD_GSK3_1	389	396	PF00069	0.788
MOD_GSK3_1	433	440	PF00069	0.847
MOD_GSK3_1	441	448	PF00069	0.715
MOD_GSK3_1	46	53	PF00069	0.668
MOD_GSK3_1	472	479	PF00069	0.838
MOD_GSK3_1	499	506	PF00069	0.817
MOD_GSK3_1	585	592	PF00069	0.828
MOD_GSK3_1	609	616	PF00069	0.775
MOD_GSK3_1	623	630	PF00069	0.613
MOD_GSK3_1	659	666	PF00069	0.696
MOD_GSK3_1	7	14	PF00069	0.726
MOD_GSK3_1	70	77	PF00069	0.559
MOD_LATS_1	625	631	PF00433	0.744
MOD_N-GLC_1	103	108	PF02516	0.641
MOD_NEK2_1	129	134	PF00069	0.628
MOD_NEK2_1	149	154	PF00069	0.277
MOD_NEK2_1	341	346	PF00069	0.571
MOD_NEK2_1	623	628	PF00069	0.817
MOD_NEK2_2	609	614	PF00069	0.696
MOD_PIKK_1	15	21	PF00454	0.751
MOD_PIKK_1	233	239	PF00454	0.773
MOD_PIKK_1	258	264	PF00454	0.718
MOD_PIKK_1	472	478	PF00454	0.636
MOD_PIKK_1	580	586	PF00454	0.752
MOD_PIKK_1	704	710	PF00454	0.776
MOD_PKA_2	196	202	PF00069	0.693
MOD_PKA_2	23	29	PF00069	0.792
MOD_PKA_2	281	287	PF00069	0.723
MOD_PKA_2	517	523	PF00069	0.704
MOD_PKA_2	613	619	PF00069	0.732
MOD_PKA_2	662	668	PF00069	0.845
MOD_PKB_1	113	121	PF00069	0.565
MOD_PKB_1	280	288	PF00069	0.664
MOD_PKB_1	646	654	PF00069	0.770
MOD_Plk_1	103	109	PF00069	0.641
MOD_Plk_1	301	307	PF00069	0.550
MOD_Plk_4	178	184	PF00069	0.664
MOD_ProDKin_1	215	221	PF00069	0.730
MOD_ProDKin_1	246	252	PF00069	0.648
MOD_ProDKin_1	289	295	PF00069	0.751
MOD_ProDKin_1	404	410	PF00069	0.769
MOD_ProDKin_1	437	443	PF00069	0.777
MOD_ProDKin_1	455	461	PF00069	0.529
MOD_ProDKin_1	47	53	PF00069	0.689
MOD_ProDKin_1	552	558	PF00069	0.659
MOD_SUMO_for_1	136	139	PF00179	0.512
MOD_SUMO_for_1	370	373	PF00179	0.669
MOD_SUMO_rev_2	109	114	PF00179	0.649
MOD_SUMO_rev_2	707	713	PF00179	0.732
TRG_DiLeu_BaEn_1	168	173	PF01217	0.601
TRG_DiLeu_BaEn_1	306	311	PF01217	0.679
TRG_DiLeu_LyEn_5	306	311	PF01217	0.582
TRG_ENDOCYTIC_2	130	133	PF00928	0.521
TRG_ENDOCYTIC_2	146	149	PF00928	0.518
TRG_ENDOCYTIC_2	179	182	PF00928	0.632
TRG_ENDOCYTIC_2	324	327	PF00928	0.578
TRG_ENDOCYTIC_2	97	100	PF00928	0.543
TRG_ER_diArg_1	336	338	PF00400	0.634
TRG_ER_diArg_1	378	380	PF00400	0.705
TRG_ER_diArg_1	493	495	PF00400	0.762
TRG_ER_diArg_1	523	526	PF00400	0.686
TRG_ER_diArg_1	561	563	PF00400	0.657
TRG_ER_diArg_1	595	598	PF00400	0.769
TRG_ER_diArg_1	613	615	PF00400	0.482
TRG_ER_diArg_1	646	649	PF00400	0.816
TRG_ER_diArg_1	667	669	PF00400	0.731
TRG_ER_diArg_1	701	704	PF00400	0.765
TRG_NES_CRM1_1	148	163	PF08389	0.622
TRG_NLS_MonoCore_2	523	528	PF00514	0.579
TRG_NLS_MonoExtC_3	699	704	PF00514	0.763
TRG_NLS_MonoExtN_4	523	529	PF00514	0.675
TRG_NLS_MonoExtN_4	697	704	PF00514	0.756
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	615	620	PF00026	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T6	Leptomonas seymouri	39%	92%
A4HE40	Leishmania braziliensis	61%	100%
A4I1E6	Leishmania infantum	99%	100%
E9AXI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q9Y9	Leishmania major	86%	98%