WASH_WAHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICB4_LEIDO

TriTrypDb:

LdBPK_262050.1 , LdCL_260026100 , LDHU3_26.2680

Length:

1018

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	464	468	PF00656	0.714
CLV_C14_Caspase3-7	485	489	PF00656	0.714
CLV_C14_Caspase3-7	527	531	PF00656	0.662
CLV_C14_Caspase3-7	813	817	PF00656	0.697
CLV_C14_Caspase3-7	832	836	PF00656	0.583
CLV_C14_Caspase3-7	885	889	PF00656	0.708
CLV_NRD_NRD_1	345	347	PF00675	0.693
CLV_NRD_NRD_1	352	354	PF00675	0.650
CLV_NRD_NRD_1	372	374	PF00675	0.491
CLV_NRD_NRD_1	44	46	PF00675	0.502
CLV_NRD_NRD_1	584	586	PF00675	0.798
CLV_NRD_NRD_1	625	627	PF00675	0.735
CLV_NRD_NRD_1	767	769	PF00675	0.754
CLV_NRD_NRD_1	845	847	PF00675	0.683
CLV_NRD_NRD_1	99	101	PF00675	0.529
CLV_PCSK_KEX2_1	345	347	PF00082	0.693
CLV_PCSK_KEX2_1	352	354	PF00082	0.650
CLV_PCSK_KEX2_1	372	374	PF00082	0.495
CLV_PCSK_KEX2_1	44	46	PF00082	0.502
CLV_PCSK_KEX2_1	583	585	PF00082	0.667
CLV_PCSK_KEX2_1	625	627	PF00082	0.735
CLV_PCSK_KEX2_1	766	768	PF00082	0.801
CLV_PCSK_KEX2_1	845	847	PF00082	0.683
CLV_PCSK_KEX2_1	99	101	PF00082	0.529
CLV_PCSK_KEX2_1	996	998	PF00082	0.678
CLV_PCSK_PC1ET2_1	766	768	PF00082	0.801
CLV_PCSK_PC1ET2_1	996	998	PF00082	0.678
CLV_PCSK_SKI1_1	142	146	PF00082	0.713
CLV_PCSK_SKI1_1	154	158	PF00082	0.543
CLV_PCSK_SKI1_1	159	163	PF00082	0.454
CLV_PCSK_SKI1_1	166	170	PF00082	0.532
CLV_PCSK_SKI1_1	330	334	PF00082	0.694
CLV_PCSK_SKI1_1	353	357	PF00082	0.599
CLV_PCSK_SKI1_1	626	630	PF00082	0.724
CLV_PCSK_SKI1_1	840	844	PF00082	0.673
CLV_PCSK_SKI1_1	884	888	PF00082	0.639
DEG_APCC_DBOX_1	141	149	PF00400	0.708
DEG_MDM2_SWIB_1	843	850	PF02201	0.658
DEG_SCF_FBW7_2	861	868	PF00400	0.602
DEG_SIAH_1	52	60	PF03145	0.479
DEG_SPOP_SBC_1	912	916	PF00917	0.659
DOC_CDC14_PxL_1	750	758	PF14671	0.734
DOC_CKS1_1	200	205	PF01111	0.694
DOC_CKS1_1	30	35	PF01111	0.470
DOC_CKS1_1	509	514	PF01111	0.844
DOC_CKS1_1	680	685	PF01111	0.797
DOC_CKS1_1	862	867	PF01111	0.585
DOC_CYCLIN_RxL_1	346	357	PF00134	0.634
DOC_CYCLIN_RxL_1	840	853	PF00134	0.677
DOC_CYCLIN_RxL_1	878	891	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	1011	1017	PF00134	0.696
DOC_CYCLIN_yCln2_LP_2	588	594	PF00134	0.745
DOC_MAPK_gen_1	345	356	PF00069	0.747
DOC_MAPK_gen_1	583	592	PF00069	0.603
DOC_MAPK_MEF2A_6	171	179	PF00069	0.659
DOC_MAPK_MEF2A_6	583	592	PF00069	0.603
DOC_MAPK_NFAT4_5	585	593	PF00069	0.606
DOC_PP2B_LxvP_1	1011	1014	PF13499	0.741
DOC_PP2B_LxvP_1	186	189	PF13499	0.680
DOC_PP2B_LxvP_1	446	449	PF13499	0.775
DOC_PP2B_LxvP_1	588	591	PF13499	0.827
DOC_PP2B_LxvP_1	859	862	PF13499	0.733
DOC_SPAK_OSR1_1	807	811	PF12202	0.607
DOC_USP7_MATH_1	181	185	PF00917	0.741
DOC_USP7_MATH_1	187	191	PF00917	0.732
DOC_USP7_MATH_1	215	219	PF00917	0.702
DOC_USP7_MATH_1	273	277	PF00917	0.672
DOC_USP7_MATH_1	472	476	PF00917	0.597
DOC_USP7_MATH_1	53	57	PF00917	0.471
DOC_USP7_MATH_1	548	552	PF00917	0.720
DOC_USP7_MATH_1	59	63	PF00917	0.479
DOC_USP7_MATH_1	594	598	PF00917	0.824
DOC_USP7_MATH_1	7	11	PF00917	0.428
DOC_USP7_MATH_1	793	797	PF00917	0.632
DOC_USP7_MATH_1	923	927	PF00917	0.803
DOC_USP7_MATH_1	951	955	PF00917	0.630
DOC_USP7_MATH_1	998	1002	PF00917	0.576
DOC_USP7_UBL2_3	305	309	PF12436	0.490
DOC_WW_Pin1_4	171	176	PF00397	0.727
DOC_WW_Pin1_4	189	194	PF00397	0.511
DOC_WW_Pin1_4	199	204	PF00397	0.601
DOC_WW_Pin1_4	216	221	PF00397	0.593
DOC_WW_Pin1_4	265	270	PF00397	0.630
DOC_WW_Pin1_4	29	34	PF00397	0.470
DOC_WW_Pin1_4	500	505	PF00397	0.812
DOC_WW_Pin1_4	508	513	PF00397	0.666
DOC_WW_Pin1_4	639	644	PF00397	0.822
DOC_WW_Pin1_4	66	71	PF00397	0.479
DOC_WW_Pin1_4	679	684	PF00397	0.796
DOC_WW_Pin1_4	861	866	PF00397	0.661
DOC_WW_Pin1_4	908	913	PF00397	0.838
DOC_WW_Pin1_4	99	104	PF00397	0.516
LIG_14-3-3_CanoR_1	147	155	PF00244	0.716
LIG_14-3-3_CanoR_1	206	211	PF00244	0.694
LIG_14-3-3_CanoR_1	24	33	PF00244	0.465
LIG_14-3-3_CanoR_1	391	401	PF00244	0.604
LIG_14-3-3_CanoR_1	455	463	PF00244	0.797
LIG_14-3-3_CanoR_1	510	516	PF00244	0.834
LIG_14-3-3_CanoR_1	583	589	PF00244	0.678
LIG_14-3-3_CanoR_1	726	732	PF00244	0.794
LIG_14-3-3_CanoR_1	845	851	PF00244	0.674
LIG_14-3-3_CanoR_1	938	946	PF00244	0.707
LIG_14-3-3_CanoR_1	962	967	PF00244	0.752
LIG_Actin_WH2_2	862	880	PF00022	0.749
LIG_Actin_WH2_2	983	998	PF00022	0.683
LIG_BIR_III_4	619	623	PF00653	0.758
LIG_BRCT_BRCA1_1	109	113	PF00533	0.491
LIG_DLG_GKlike_1	846	854	PF00625	0.680
LIG_DLG_GKlike_1	878	886	PF00625	0.618
LIG_EVH1_1	590	594	PF00568	0.606
LIG_EVH1_2	105	109	PF00568	0.483
LIG_EVH1_2	87	91	PF00568	0.508
LIG_FHA_1	17	23	PF00498	0.435
LIG_FHA_1	200	206	PF00498	0.685
LIG_FHA_1	236	242	PF00498	0.718
LIG_FHA_1	25	31	PF00498	0.457
LIG_FHA_1	287	293	PF00498	0.717
LIG_FHA_1	366	372	PF00498	0.760
LIG_FHA_1	409	415	PF00498	0.614
LIG_FHA_1	596	602	PF00498	0.839
LIG_FHA_1	627	633	PF00498	0.784
LIG_FHA_1	854	860	PF00498	0.635
LIG_FHA_1	913	919	PF00498	0.746
LIG_FHA_1	925	931	PF00498	0.668
LIG_FHA_1	958	964	PF00498	0.644
LIG_FHA_2	525	531	PF00498	0.754
LIG_FHA_2	830	836	PF00498	0.639
LIG_LIR_Apic_2	81	86	PF02991	0.498
LIG_LIR_Gen_1	871	879	PF02991	0.486
LIG_LIR_Nem_3	110	116	PF02991	0.478
LIG_LIR_Nem_3	276	281	PF02991	0.529
LIG_LIR_Nem_3	475	480	PF02991	0.785
LIG_LIR_Nem_3	871	876	PF02991	0.558
LIG_LIR_Nem_3	881	886	PF02991	0.568
LIG_NRBOX	651	657	PF00104	0.584
LIG_PCNA_yPIPBox_3	470	478	PF02747	0.575
LIG_Pex14_2	109	113	PF04695	0.491
LIG_Pex14_2	843	847	PF04695	0.757
LIG_RPA_C_Fungi	983	995	PF08784	0.675
LIG_SH2_CRK	750	754	PF00017	0.734
LIG_SH2_CRK	83	87	PF00017	0.497
LIG_SH2_CRK	873	877	PF00017	0.523
LIG_SH2_PTP2	680	683	PF00017	0.721
LIG_SH2_SRC	361	364	PF00017	0.714
LIG_SH2_STAP1	282	286	PF00017	0.722
LIG_SH2_STAP1	689	693	PF00017	0.601
LIG_SH2_STAP1	873	877	PF00017	0.698
LIG_SH2_STAT5	361	364	PF00017	0.716
LIG_SH2_STAT5	480	483	PF00017	0.782
LIG_SH2_STAT5	680	683	PF00017	0.721
LIG_SH2_STAT5	78	81	PF00017	0.506
LIG_SH3_1	100	106	PF00018	0.510
LIG_SH3_3	100	106	PF00018	0.510
LIG_SH3_3	249	255	PF00018	0.749
LIG_SH3_3	259	265	PF00018	0.692
LIG_SH3_3	481	487	PF00018	0.720
LIG_SH3_3	501	507	PF00018	0.542
LIG_SH3_3	588	594	PF00018	0.738
LIG_SH3_3	678	684	PF00018	0.718
LIG_SH3_3	714	720	PF00018	0.754
LIG_SH3_3	74	80	PF00018	0.502
LIG_SH3_3	859	865	PF00018	0.736
LIG_SH3_3	906	912	PF00018	0.804
LIG_SUMO_SIM_anti_2	1007	1012	PF11976	0.610
LIG_SUMO_SIM_anti_2	174	180	PF11976	0.716
LIG_SUMO_SIM_par_1	236	243	PF11976	0.681
LIG_SUMO_SIM_par_1	926	932	PF11976	0.592
LIG_SxIP_EBH_1	948	961	PF03271	0.556
LIG_TRAF2_1	497	500	PF00917	0.803
LIG_TRAF2_1	802	805	PF00917	0.645
MOD_CDK_SPK_2	216	221	PF00069	0.808
MOD_CDK_SPK_2	265	270	PF00069	0.630
MOD_CDK_SPK_2	508	513	PF00069	0.856
MOD_CDK_SPxxK_3	199	206	PF00069	0.724
MOD_CDK_SPxxK_3	503	510	PF00069	0.754
MOD_CK1_1	107	113	PF00069	0.493
MOD_CK1_1	125	131	PF00069	0.390
MOD_CK1_1	16	22	PF00069	0.432
MOD_CK1_1	209	215	PF00069	0.649
MOD_CK1_1	503	509	PF00069	0.863
MOD_CK1_1	61	67	PF00069	0.483
MOD_CK1_1	758	764	PF00069	0.579
MOD_CK1_1	849	855	PF00069	0.624
MOD_CK1_1	911	917	PF00069	0.834
MOD_CK1_1	979	985	PF00069	0.757
MOD_CK2_1	125	131	PF00069	0.485
MOD_CK2_1	799	805	PF00069	0.676
MOD_CK2_1	998	1004	PF00069	0.581
MOD_Cter_Amidation	623	626	PF01082	0.727
MOD_DYRK1A_RPxSP_1	171	175	PF00069	0.645
MOD_GlcNHglycan	159	162	PF01048	0.694
MOD_GlcNHglycan	183	186	PF01048	0.715
MOD_GlcNHglycan	211	214	PF01048	0.684
MOD_GlcNHglycan	242	245	PF01048	0.564
MOD_GlcNHglycan	282	285	PF01048	0.576
MOD_GlcNHglycan	422	425	PF01048	0.828
MOD_GlcNHglycan	446	449	PF01048	0.852
MOD_GlcNHglycan	464	467	PF01048	0.537
MOD_GlcNHglycan	543	546	PF01048	0.664
MOD_GlcNHglycan	696	699	PF01048	0.738
MOD_GlcNHglycan	723	726	PF01048	0.628
MOD_GlcNHglycan	772	776	PF01048	0.715
MOD_GlcNHglycan	801	804	PF01048	0.808
MOD_GlcNHglycan	812	815	PF01048	0.684
MOD_GlcNHglycan	822	825	PF01048	0.639
MOD_GlcNHglycan	9	12	PF01048	0.432
MOD_GlcNHglycan	906	909	PF01048	0.712
MOD_GSK3_1	12	19	PF00069	0.431
MOD_GSK3_1	122	129	PF00069	0.499
MOD_GSK3_1	235	242	PF00069	0.731
MOD_GSK3_1	361	368	PF00069	0.758
MOD_GSK3_1	437	444	PF00069	0.791
MOD_GSK3_1	532	539	PF00069	0.818
MOD_GSK3_1	59	66	PF00069	0.483
MOD_GSK3_1	721	728	PF00069	0.796
MOD_GSK3_1	730	737	PF00069	0.692
MOD_GSK3_1	787	794	PF00069	0.757
MOD_GSK3_1	846	853	PF00069	0.591
MOD_GSK3_1	860	867	PF00069	0.567
MOD_GSK3_1	878	885	PF00069	0.442
MOD_GSK3_1	904	911	PF00069	0.735
MOD_GSK3_1	912	919	PF00069	0.667
MOD_GSK3_1	957	964	PF00069	0.748
MOD_GSK3_1	976	983	PF00069	0.448
MOD_N-GLC_1	576	581	PF02516	0.732
MOD_N-GLC_1	938	943	PF02516	0.639
MOD_NEK2_1	109	114	PF00069	0.488
MOD_NEK2_1	12	17	PF00069	0.432
MOD_NEK2_1	235	240	PF00069	0.575
MOD_NEK2_1	63	68	PF00069	0.483
MOD_NEK2_1	647	652	PF00069	0.592
MOD_NEK2_1	721	726	PF00069	0.628
MOD_NEK2_1	808	813	PF00069	0.705
MOD_NEK2_1	850	855	PF00069	0.690
MOD_NEK2_1	882	887	PF00069	0.702
MOD_NEK2_1	957	962	PF00069	0.716
MOD_NEK2_1	980	985	PF00069	0.581
MOD_NEK2_2	53	58	PF00069	0.475
MOD_OFUCOSY	21	28	PF10250	0.453
MOD_PIKK_1	13	19	PF00454	0.429
MOD_PIKK_1	154	160	PF00454	0.565
MOD_PIKK_1	286	292	PF00454	0.661
MOD_PIKK_1	392	398	PF00454	0.740
MOD_PIKK_1	448	454	PF00454	0.824
MOD_PIKK_1	482	488	PF00454	0.810
MOD_PIKK_1	755	761	PF00454	0.743
MOD_PK_1	206	212	PF00069	0.521
MOD_PKA_1	584	590	PF00069	0.679
MOD_PKA_2	146	152	PF00069	0.710
MOD_PKA_2	454	460	PF00069	0.791
MOD_PKA_2	584	590	PF00069	0.679
MOD_PKA_2	725	731	PF00069	0.795
MOD_PKA_2	937	943	PF00069	0.748
MOD_PKA_2	961	967	PF00069	0.719
MOD_PKB_1	152	160	PF00069	0.738
MOD_Plk_1	117	123	PF00069	0.536
MOD_Plk_1	126	132	PF00069	0.603
MOD_Plk_1	235	241	PF00069	0.712
MOD_Plk_1	441	447	PF00069	0.750
MOD_Plk_1	923	929	PF00069	0.700
MOD_Plk_1	980	986	PF00069	0.675
MOD_Plk_2-3	550	556	PF00069	0.662
MOD_Plk_4	117	123	PF00069	0.435
MOD_Plk_4	196	202	PF00069	0.743
MOD_Plk_4	235	241	PF00069	0.712
MOD_Plk_4	253	259	PF00069	0.769
MOD_Plk_4	295	301	PF00069	0.538
MOD_Plk_4	472	478	PF00069	0.785
MOD_Plk_4	53	59	PF00069	0.475
MOD_Plk_4	850	856	PF00069	0.692
MOD_Plk_4	868	874	PF00069	0.604
MOD_Plk_4	878	884	PF00069	0.501
MOD_ProDKin_1	171	177	PF00069	0.730
MOD_ProDKin_1	189	195	PF00069	0.511
MOD_ProDKin_1	199	205	PF00069	0.600
MOD_ProDKin_1	216	222	PF00069	0.593
MOD_ProDKin_1	265	271	PF00069	0.629
MOD_ProDKin_1	29	35	PF00069	0.469
MOD_ProDKin_1	500	506	PF00069	0.812
MOD_ProDKin_1	508	514	PF00069	0.658
MOD_ProDKin_1	639	645	PF00069	0.817
MOD_ProDKin_1	66	72	PF00069	0.481
MOD_ProDKin_1	679	685	PF00069	0.796
MOD_ProDKin_1	861	867	PF00069	0.661
MOD_ProDKin_1	908	914	PF00069	0.839
MOD_ProDKin_1	99	105	PF00069	0.514
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.730
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.722
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.831
TRG_DiLeu_BaLyEn_6	894	899	PF01217	0.683
TRG_ENDOCYTIC_2	278	281	PF00928	0.698
TRG_ENDOCYTIC_2	282	285	PF00928	0.699
TRG_ENDOCYTIC_2	480	483	PF00928	0.782
TRG_ENDOCYTIC_2	750	753	PF00928	0.734
TRG_ENDOCYTIC_2	873	876	PF00928	0.518
TRG_ER_diArg_1	152	155	PF00400	0.732
TRG_ER_diArg_1	345	347	PF00400	0.706
TRG_ER_diArg_1	352	354	PF00400	0.650
TRG_ER_diArg_1	371	373	PF00400	0.535
TRG_ER_diArg_1	582	585	PF00400	0.664
TRG_ER_diArg_1	844	846	PF00400	0.681
TRG_ER_diArg_1	99	101	PF00400	0.529
TRG_NES_CRM1_1	705	719	PF08389	0.753
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.712
TRG_Pf-PMV_PEXEL_1	352	357	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	884	888	PF00026	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HF49	Leishmania braziliensis	59%	100%
A4I2D3	Leishmania infantum	99%	100%
E9AYI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q8Y7	Leishmania major	84%	100%