Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ICA7_LEIDO

TriTrypDb:

LdBPK_250930.1 , LdCL_250014600 , LDHU3_25.1200

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8ICA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.818
CLV_NRD_NRD_1	171	173	PF00675	0.791
CLV_NRD_NRD_1	252	254	PF00675	0.346
CLV_PCSK_KEX2_1	171	173	PF00082	0.787
CLV_PCSK_KEX2_1	252	254	PF00082	0.346
CLV_PCSK_KEX2_1	45	47	PF00082	0.743
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.680
CLV_PCSK_PC7_1	167	173	PF00082	0.734
CLV_PCSK_SKI1_1	93	97	PF00082	0.336
DEG_APCC_DBOX_1	252	260	PF00400	0.546
DEG_SCF_FBW7_1	237	244	PF00400	0.767
DOC_ANK_TNKS_1	233	240	PF00023	0.777
DOC_CKS1_1	286	291	PF01111	0.474
DOC_CYCLIN_yCln2_LP_2	286	292	PF00134	0.474
DOC_MAPK_gen_1	252	259	PF00069	0.546
DOC_MAPK_MEF2A_6	252	261	PF00069	0.563
DOC_PP4_FxxP_1	127	130	PF00568	0.524
DOC_USP7_MATH_1	241	245	PF00917	0.757
DOC_USP7_MATH_1	290	294	PF00917	0.569
DOC_USP7_MATH_1	313	317	PF00917	0.522
DOC_USP7_UBL2_3	89	93	PF12436	0.738
DOC_WW_Pin1_4	126	131	PF00397	0.577
DOC_WW_Pin1_4	162	167	PF00397	0.471
DOC_WW_Pin1_4	223	228	PF00397	0.812
DOC_WW_Pin1_4	237	242	PF00397	0.615
DOC_WW_Pin1_4	274	279	PF00397	0.486
DOC_WW_Pin1_4	285	290	PF00397	0.390
LIG_14-3-3_CanoR_1	252	257	PF00244	0.617
LIG_14-3-3_CanoR_1	310	319	PF00244	0.482
LIG_14-3-3_CanoR_1	46	54	PF00244	0.560
LIG_14-3-3_CanoR_1	9	19	PF00244	0.626
LIG_APCC_ABBA_1	233	238	PF00400	0.783
LIG_DLG_GKlike_1	252	259	PF00625	0.563
LIG_EH1_1	72	80	PF00400	0.299
LIG_eIF4E_1	67	73	PF01652	0.389
LIG_FHA_1	186	192	PF00498	0.568
LIG_FHA_1	80	86	PF00498	0.406
LIG_FHA_2	226	232	PF00498	0.684
LIG_GBD_Chelix_1	75	83	PF00786	0.299
LIG_LIR_Apic_2	126	130	PF02991	0.452
LIG_LIR_Gen_1	13	22	PF02991	0.459
LIG_LIR_Gen_1	201	210	PF02991	0.337
LIG_LIR_Gen_1	36	41	PF02991	0.497
LIG_LIR_Gen_1	66	75	PF02991	0.298
LIG_LIR_Nem_3	13	18	PF02991	0.443
LIG_LIR_Nem_3	201	205	PF02991	0.481
LIG_LIR_Nem_3	245	251	PF02991	0.709
LIG_LIR_Nem_3	36	40	PF02991	0.439
LIG_LIR_Nem_3	66	70	PF02991	0.309
LIG_SH2_CRK	112	116	PF00017	0.375
LIG_SH2_CRK	15	19	PF00017	0.343
LIG_SH2_PTP2	108	111	PF00017	0.436
LIG_SH2_PTP2	202	205	PF00017	0.534
LIG_SH2_PTP2	67	70	PF00017	0.436
LIG_SH2_STAP1	15	19	PF00017	0.400
LIG_SH2_STAP1	152	156	PF00017	0.515
LIG_SH2_STAT5	108	111	PF00017	0.355
LIG_SH2_STAT5	152	155	PF00017	0.531
LIG_SH2_STAT5	202	205	PF00017	0.438
LIG_SH2_STAT5	26	29	PF00017	0.420
LIG_SH2_STAT5	67	70	PF00017	0.389
LIG_SH3_3	221	227	PF00018	0.666
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.338
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.408
LIG_SUMO_SIM_anti_2	36	44	PF11976	0.302
LIG_SUMO_SIM_par_1	18	23	PF11976	0.418
LIG_TYR_ITIM	106	111	PF00017	0.394
LIG_TYR_ITIM	200	205	PF00017	0.557
MOD_CDK_SPK_2	126	131	PF00069	0.455
MOD_CDK_SPK_2	162	167	PF00069	0.461
MOD_CK1_1	126	132	PF00069	0.457
MOD_CK1_1	277	283	PF00069	0.604
MOD_CK1_1	48	54	PF00069	0.480
MOD_CK2_1	198	204	PF00069	0.504
MOD_CK2_1	33	39	PF00069	0.442
MOD_CMANNOS	28	31	PF00535	0.604
MOD_Cter_Amidation	169	172	PF01082	0.732
MOD_GlcNHglycan	103	106	PF01048	0.397
MOD_GlcNHglycan	15	18	PF01048	0.436
MOD_GlcNHglycan	182	185	PF01048	0.808
MOD_GlcNHglycan	192	195	PF01048	0.745
MOD_GlcNHglycan	279	282	PF01048	0.773
MOD_GlcNHglycan	292	295	PF01048	0.759
MOD_GlcNHglycan	313	316	PF01048	0.830
MOD_GlcNHglycan	329	332	PF01048	0.641
MOD_GlcNHglycan	49	53	PF01048	0.695
MOD_GlcNHglycan	61	64	PF01048	0.660
MOD_GlcNHglycan	89	92	PF01048	0.538
MOD_GSK3_1	237	244	PF00069	0.772
MOD_GSK3_1	311	318	PF00069	0.570
MOD_GSK3_1	41	48	PF00069	0.466
MOD_NEK2_1	1	6	PF00069	0.646
MOD_NEK2_1	101	106	PF00069	0.404
MOD_NEK2_1	264	269	PF00069	0.435
MOD_NEK2_1	41	46	PF00069	0.509
MOD_NEK2_1	59	64	PF00069	0.378
MOD_NEK2_2	292	297	PF00069	0.542
MOD_PIKK_1	140	146	PF00454	0.569
MOD_PKA_1	252	258	PF00069	0.530
MOD_PKA_1	45	51	PF00069	0.483
MOD_PKA_2	252	258	PF00069	0.534
MOD_PKA_2	311	317	PF00069	0.563
MOD_PKA_2	45	51	PF00069	0.566
MOD_Plk_1	148	154	PF00069	0.450
MOD_Plk_2-3	198	204	PF00069	0.479
MOD_Plk_4	198	204	PF00069	0.497
MOD_Plk_4	20	26	PF00069	0.366
MOD_Plk_4	252	258	PF00069	0.530
MOD_Plk_4	264	270	PF00069	0.389
MOD_Plk_4	79	85	PF00069	0.385
MOD_ProDKin_1	126	132	PF00069	0.579
MOD_ProDKin_1	162	168	PF00069	0.472
MOD_ProDKin_1	223	229	PF00069	0.815
MOD_ProDKin_1	237	243	PF00069	0.615
MOD_ProDKin_1	274	280	PF00069	0.488
MOD_ProDKin_1	285	291	PF00069	0.389
TRG_ENDOCYTIC_2	108	111	PF00928	0.355
TRG_ENDOCYTIC_2	112	115	PF00928	0.355
TRG_ENDOCYTIC_2	15	18	PF00928	0.408
TRG_ENDOCYTIC_2	202	205	PF00928	0.473
TRG_ENDOCYTIC_2	67	70	PF00928	0.353
TRG_ER_diArg_1	251	253	PF00400	0.701
TRG_ER_diArg_1	296	299	PF00400	0.599
TRG_ER_diLys_1	337	340	PF00400	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE40	Leptomonas seymouri	42%	100%
A4HE25	Leishmania braziliensis	58%	96%
A4I1D1	Leishmania infantum	99%	100%
E9AXG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QA04	Leishmania major	89%	100%