Tetratricopeptide repeat protein 39B

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3808), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICA6_LEIDO

TriTrypDb:

LdBPK_303750.1 , LdCL_300042900 , LDHU3_30.4980

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8ICA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.456
CLV_C14_Caspase3-7	496	500	PF00656	0.590
CLV_NRD_NRD_1	117	119	PF00675	0.277
CLV_NRD_NRD_1	134	136	PF00675	0.205
CLV_NRD_NRD_1	182	184	PF00675	0.269
CLV_NRD_NRD_1	290	292	PF00675	0.333
CLV_NRD_NRD_1	314	316	PF00675	0.256
CLV_NRD_NRD_1	366	368	PF00675	0.358
CLV_NRD_NRD_1	535	537	PF00675	0.343
CLV_NRD_NRD_1	572	574	PF00675	0.381
CLV_PCSK_FUR_1	288	292	PF00082	0.333
CLV_PCSK_KEX2_1	136	138	PF00082	0.274
CLV_PCSK_KEX2_1	290	292	PF00082	0.279
CLV_PCSK_KEX2_1	366	368	PF00082	0.305
CLV_PCSK_KEX2_1	467	469	PF00082	0.369
CLV_PCSK_KEX2_1	535	537	PF00082	0.343
CLV_PCSK_KEX2_1	572	574	PF00082	0.360
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.350
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.392
CLV_PCSK_SKI1_1	119	123	PF00082	0.311
CLV_PCSK_SKI1_1	129	133	PF00082	0.298
CLV_PCSK_SKI1_1	137	141	PF00082	0.234
CLV_PCSK_SKI1_1	290	294	PF00082	0.256
CLV_PCSK_SKI1_1	325	329	PF00082	0.348
CLV_PCSK_SKI1_1	366	370	PF00082	0.361
CLV_PCSK_SKI1_1	400	404	PF00082	0.305
CLV_PCSK_SKI1_1	467	471	PF00082	0.363
CLV_PCSK_SKI1_1	506	510	PF00082	0.389
CLV_PCSK_SKI1_1	543	547	PF00082	0.333
CLV_PCSK_SKI1_1	57	61	PF00082	0.247
CLV_Separin_Metazoa	46	50	PF03568	0.533
DEG_APCC_DBOX_1	289	297	PF00400	0.542
DEG_APCC_DBOX_1	365	373	PF00400	0.561
DEG_APCC_DBOX_1	78	86	PF00400	0.481
DOC_CYCLIN_RxL_1	540	550	PF00134	0.566
DOC_CYCLIN_yClb5_NLxxxL_5	225	234	PF00134	0.343
DOC_MAPK_DCC_7	336	344	PF00069	0.467
DOC_MAPK_MEF2A_6	336	344	PF00069	0.467
DOC_PP2B_LxvP_1	273	276	PF13499	0.308
DOC_USP7_MATH_1	323	327	PF00917	0.542
DOC_USP7_MATH_1	516	520	PF00917	0.530
DOC_USP7_MATH_1	63	67	PF00917	0.542
DOC_USP7_UBL2_3	112	116	PF12436	0.567
DOC_USP7_UBL2_3	119	123	PF12436	0.477
DOC_USP7_UBL2_3	125	129	PF12436	0.467
DOC_USP7_UBL2_3	209	213	PF12436	0.467
DOC_USP7_UBL2_3	374	378	PF12436	0.524
DOC_USP7_UBL2_3	467	471	PF12436	0.608
DOC_WW_Pin1_4	258	263	PF00397	0.248
DOC_WW_Pin1_4	420	425	PF00397	0.456
LIG_14-3-3_CanoR_1	325	330	PF00244	0.561
LIG_Actin_WH2_2	163	179	PF00022	0.481
LIG_BIR_II_1	1	5	PF00653	0.745
LIG_BRCT_BRCA1_1	422	426	PF00533	0.467
LIG_CtBP_PxDLS_1	179	184	PF00389	0.517
LIG_eIF4E_1	158	164	PF01652	0.481
LIG_eIF4E_1	220	226	PF01652	0.324
LIG_FHA_1	147	153	PF00498	0.542
LIG_FHA_1	268	274	PF00498	0.308
LIG_FHA_1	380	386	PF00498	0.465
LIG_FHA_1	5	11	PF00498	0.645
LIG_FHA_2	16	22	PF00498	0.728
LIG_FHA_2	523	529	PF00498	0.566
LIG_FHA_2	73	79	PF00498	0.534
LIG_LIR_Apic_2	95	101	PF02991	0.517
LIG_LIR_Gen_1	218	228	PF02991	0.343
LIG_LIR_Gen_1	261	271	PF02991	0.261
LIG_LIR_Gen_1	481	491	PF02991	0.492
LIG_LIR_Gen_1	61	68	PF02991	0.497
LIG_LIR_Nem_3	216	222	PF02991	0.456
LIG_LIR_Nem_3	261	266	PF02991	0.261
LIG_LIR_Nem_3	270	275	PF02991	0.297
LIG_LIR_Nem_3	304	309	PF02991	0.456
LIG_LIR_Nem_3	363	368	PF02991	0.522
LIG_LIR_Nem_3	440	446	PF02991	0.575
LIG_LIR_Nem_3	481	487	PF02991	0.494
LIG_LIR_Nem_3	61	65	PF02991	0.497
LIG_MYND_1	434	438	PF01753	0.525
LIG_PCNA_PIPBox_1	169	178	PF02747	0.450
LIG_PCNA_yPIPBox_3	165	176	PF02747	0.456
LIG_Pex14_1	186	190	PF04695	0.531
LIG_Pex14_1	37	41	PF04695	0.467
LIG_Pex14_2	146	150	PF04695	0.467
LIG_PTB_Apo_2	299	306	PF02174	0.556
LIG_PTB_Apo_2	308	315	PF02174	0.521
LIG_PTB_Apo_2	35	42	PF02174	0.517
LIG_PTB_Apo_2	52	59	PF02174	0.325
LIG_PTB_Phospho_1	299	305	PF10480	0.556
LIG_PTB_Phospho_1	35	41	PF10480	0.517
LIG_PTB_Phospho_1	52	58	PF10480	0.325
LIG_SH2_CRK	190	194	PF00017	0.449
LIG_SH2_CRK	220	224	PF00017	0.308
LIG_SH2_CRK	365	369	PF00017	0.481
LIG_SH2_GRB2like	305	308	PF00017	0.467
LIG_SH2_GRB2like	309	312	PF00017	0.444
LIG_SH2_GRB2like	446	449	PF00017	0.501
LIG_SH2_NCK_1	190	194	PF00017	0.491
LIG_SH2_PTP2	393	396	PF00017	0.514
LIG_SH2_SRC	158	161	PF00017	0.456
LIG_SH2_SRC	346	349	PF00017	0.467
LIG_SH2_STAP1	158	162	PF00017	0.456
LIG_SH2_STAP1	206	210	PF00017	0.513
LIG_SH2_STAP1	220	224	PF00017	0.243
LIG_SH2_STAP1	309	313	PF00017	0.456
LIG_SH2_STAP1	348	352	PF00017	0.522
LIG_SH2_STAP1	41	45	PF00017	0.538
LIG_SH2_STAP1	58	62	PF00017	0.376
LIG_SH2_STAT3	145	148	PF00017	0.561
LIG_SH2_STAT3	381	384	PF00017	0.456
LIG_SH2_STAT5	145	148	PF00017	0.561
LIG_SH2_STAT5	175	178	PF00017	0.456
LIG_SH2_STAT5	249	252	PF00017	0.256
LIG_SH2_STAT5	272	275	PF00017	0.308
LIG_SH2_STAT5	305	308	PF00017	0.458
LIG_SH2_STAT5	313	316	PF00017	0.452
LIG_SH2_STAT5	346	349	PF00017	0.456
LIG_SH2_STAT5	381	384	PF00017	0.475
LIG_SH2_STAT5	393	396	PF00017	0.456
LIG_SH2_STAT5	446	449	PF00017	0.504
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.504
LIG_UBA3_1	368	376	PF00899	0.493
LIG_UBA3_1	82	87	PF00899	0.456
MOD_CDK_SPK_2	420	425	PF00069	0.456
MOD_CK1_1	11	17	PF00069	0.660
MOD_CK1_1	4	10	PF00069	0.743
MOD_CK1_1	495	501	PF00069	0.626
MOD_CK1_1	88	94	PF00069	0.468
MOD_CK2_1	473	479	PF00069	0.529
MOD_CK2_1	522	528	PF00069	0.567
MOD_CK2_1	71	77	PF00069	0.464
MOD_GlcNHglycan	439	442	PF01048	0.369
MOD_GlcNHglycan	474	478	PF01048	0.358
MOD_GlcNHglycan	87	90	PF01048	0.317
MOD_GSK3_1	4	11	PF00069	0.764
MOD_GSK3_1	414	421	PF00069	0.508
MOD_GSK3_1	522	529	PF00069	0.567
MOD_GSK3_1	63	70	PF00069	0.504
MOD_GSK3_1	88	95	PF00069	0.517
MOD_N-GLC_1	301	306	PF02516	0.361
MOD_N-GLC_1	556	561	PF02516	0.383
MOD_N-GLC_1	63	68	PF02516	0.326
MOD_NEK2_1	1	6	PF00069	0.741
MOD_NEK2_1	12	17	PF00069	0.734
MOD_NEK2_1	146	151	PF00069	0.504
MOD_NEK2_1	163	168	PF00069	0.383
MOD_NEK2_1	171	176	PF00069	0.467
MOD_NEK2_1	379	384	PF00069	0.466
MOD_NEK2_1	67	72	PF00069	0.462
MOD_NEK2_1	92	97	PF00069	0.500
MOD_NEK2_2	215	220	PF00069	0.481
MOD_NEK2_2	348	353	PF00069	0.542
MOD_PK_1	232	238	PF00069	0.393
MOD_PKA_1	467	473	PF00069	0.572
MOD_PKA_2	467	473	PF00069	0.531
MOD_PKA_2	78	84	PF00069	0.499
MOD_PKB_1	135	143	PF00069	0.505
MOD_Plk_1	12	18	PF00069	0.629
MOD_Plk_1	146	152	PF00069	0.497
MOD_Plk_1	282	288	PF00069	0.466
MOD_Plk_1	301	307	PF00069	0.377
MOD_Plk_1	556	562	PF00069	0.586
MOD_Plk_1	63	69	PF00069	0.518
MOD_Plk_2-3	78	84	PF00069	0.436
MOD_Plk_2-3	8	14	PF00069	0.688
MOD_Plk_4	171	177	PF00069	0.464
MOD_Plk_4	188	194	PF00069	0.420
MOD_Plk_4	215	221	PF00069	0.481
MOD_Plk_4	232	238	PF00069	0.343
MOD_Plk_4	267	273	PF00069	0.308
MOD_Plk_4	301	307	PF00069	0.480
MOD_Plk_4	348	354	PF00069	0.461
MOD_Plk_4	408	414	PF00069	0.464
MOD_Plk_4	516	522	PF00069	0.503
MOD_Plk_4	63	69	PF00069	0.504
MOD_Plk_4	78	84	PF00069	0.456
MOD_ProDKin_1	258	264	PF00069	0.248
MOD_ProDKin_1	420	426	PF00069	0.456
MOD_SUMO_for_1	121	124	PF00179	0.537
MOD_SUMO_rev_2	108	117	PF00179	0.567
MOD_SUMO_rev_2	201	210	PF00179	0.521
MOD_SUMO_rev_2	510	516	PF00179	0.603
TRG_DiLeu_BaEn_1	335	340	PF01217	0.456
TRG_DiLeu_BaEn_1	43	48	PF01217	0.533
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.497
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.522
TRG_ENDOCYTIC_2	189	192	PF00928	0.448
TRG_ENDOCYTIC_2	220	223	PF00928	0.308
TRG_ENDOCYTIC_2	272	275	PF00928	0.309
TRG_ENDOCYTIC_2	309	312	PF00928	0.456
TRG_ENDOCYTIC_2	365	368	PF00928	0.456
TRG_ENDOCYTIC_2	393	396	PF00928	0.517
TRG_ENDOCYTIC_2	484	487	PF00928	0.530
TRG_ER_diArg_1	288	291	PF00400	0.533
TRG_ER_diArg_1	365	367	PF00400	0.505
TRG_ER_diArg_1	534	536	PF00400	0.538
TRG_ER_diArg_1	571	573	PF00400	0.602
TRG_NLS_MonoExtC_3	125	130	PF00514	0.521
TRG_NLS_MonoExtN_4	123	130	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAD2	Leptomonas seymouri	82%	99%
A0A0S4JLL5	Bodo saltans	58%	100%
A0A1X0P173	Trypanosomatidae	65%	99%
A0A3S5IRG7	Trypanosoma rangeli	65%	100%
A1A5Y5	Danio rerio	23%	100%
A2ACP1	Mus musculus	22%	100%
A4HIV5	Leishmania braziliensis	86%	100%
A4I660	Leishmania infantum	100%	100%
C9ZRI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
D3ZC96	Rattus norvegicus	21%	94%
E9B1E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q0VGK2	Rattus norvegicus	23%	100%
Q1LXE6	Danio rerio	21%	100%
Q28D40	Xenopus tropicalis	21%	100%
Q28DB0	Xenopus tropicalis	21%	99%
Q4Q6R9	Leishmania major	95%	100%
Q5SRH9	Homo sapiens	23%	95%
Q5VTQ0	Homo sapiens	20%	85%
Q5XHH9	Xenopus laevis	22%	99%
Q8BYY4	Mus musculus	20%	94%
Q8N584	Homo sapiens	22%	100%
Q8VE09	Mus musculus	22%	100%
Q95LT8	Macaca fascicularis	20%	92%
V5BMN7	Trypanosoma cruzi	65%	100%