Coiled-coil domain-containing protein 153

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICA5_LEIDO

TriTrypDb:

LdBPK_242400.1 , LdCL_240029600 , LDHU3_24.2960

Length:

163

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	50	52	PF00675	0.503
CLV_PCSK_KEX2_1	134	136	PF00082	0.546
CLV_PCSK_KEX2_1	38	40	PF00082	0.523
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.559
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.561
CLV_PCSK_SKI1_1	35	39	PF00082	0.526
CLV_PCSK_SKI1_1	7	11	PF00082	0.566
CLV_PCSK_SKI1_1	92	96	PF00082	0.546
DEG_APCC_DBOX_1	38	46	PF00400	0.517
DEG_APCC_DBOX_1	91	99	PF00400	0.544
DOC_MAPK_gen_1	33	42	PF00069	0.530
DOC_MAPK_gen_1	51	58	PF00069	0.568
DOC_MAPK_gen_1	72	79	PF00069	0.539
DOC_MAPK_gen_1	85	95	PF00069	0.457
DOC_USP7_MATH_1	71	75	PF00917	0.570
DOC_USP7_UBL2_3	72	76	PF12436	0.611
LIG_Actin_WH2_2	23	40	PF00022	0.515
LIG_CaM_IQ_9	105	120	PF13499	0.572
LIG_LIR_Gen_1	148	158	PF02991	0.559
LIG_LIR_Nem_3	148	154	PF02991	0.558
LIG_SH2_STAT3	18	21	PF00017	0.584
LIG_SH2_STAT5	41	44	PF00017	0.557
LIG_SUMO_SIM_anti_2	25	32	PF11976	0.589
LIG_SUMO_SIM_anti_2	74	82	PF11976	0.517
LIG_SUMO_SIM_par_1	25	32	PF11976	0.527
LIG_TRAF2_1	94	97	PF00917	0.551
LIG_UBA3_1	45	53	PF00899	0.512
MOD_CK2_1	136	142	PF00069	0.530
MOD_CK2_1	153	159	PF00069	0.620
MOD_GlcNHglycan	58	61	PF01048	0.551
MOD_GSK3_1	125	132	PF00069	0.602
MOD_NEK2_1	108	113	PF00069	0.496
MOD_PIKK_1	97	103	PF00454	0.601
MOD_Plk_2-3	136	142	PF00069	0.578
MOD_SUMO_rev_2	25	34	PF00179	0.510
TRG_DiLeu_BaEn_1	150	155	PF01217	0.561
TRG_NES_CRM1_1	32	43	PF08389	0.546
TRG_NLS_MonoExtC_3	111	117	PF00514	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM4	Leptomonas seymouri	58%	100%
A0A1X0NW82	Trypanosomatidae	33%	95%
A0A422N6N3	Trypanosoma rangeli	29%	94%
A4HDU2	Leishmania braziliensis	75%	100%
A4I139	Leishmania infantum	100%	100%
C9ZW69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9AX77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QA99	Leishmania major	93%	100%