Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8ICA4_LEIDO

TriTrypDb:

LdBPK_220890.1 , LdCL_220016300 , LDHU3_22.1400

Length:

793

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.510
CLV_NRD_NRD_1	199	201	PF00675	0.525
CLV_NRD_NRD_1	205	207	PF00675	0.516
CLV_NRD_NRD_1	217	219	PF00675	0.497
CLV_NRD_NRD_1	558	560	PF00675	0.482
CLV_NRD_NRD_1	606	608	PF00675	0.520
CLV_NRD_NRD_1	703	705	PF00675	0.363
CLV_PCSK_FUR_1	215	219	PF00082	0.504
CLV_PCSK_KEX2_1	139	141	PF00082	0.510
CLV_PCSK_KEX2_1	199	201	PF00082	0.525
CLV_PCSK_KEX2_1	207	209	PF00082	0.531
CLV_PCSK_KEX2_1	215	217	PF00082	0.509
CLV_PCSK_KEX2_1	557	559	PF00082	0.480
CLV_PCSK_KEX2_1	606	608	PF00082	0.520
CLV_PCSK_KEX2_1	703	705	PF00082	0.363
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.531
CLV_PCSK_PC7_1	135	141	PF00082	0.502
CLV_PCSK_PC7_1	211	217	PF00082	0.521
CLV_PCSK_SKI1_1	140	144	PF00082	0.510
CLV_PCSK_SKI1_1	330	334	PF00082	0.531
CLV_PCSK_SKI1_1	487	491	PF00082	0.358
CLV_PCSK_SKI1_1	533	537	PF00082	0.351
CLV_PCSK_SKI1_1	664	668	PF00082	0.394
CLV_Separin_Metazoa	661	665	PF03568	0.408
DEG_APCC_DBOX_1	532	540	PF00400	0.352
DEG_SCF_FBW7_1	2	9	PF00400	0.525
DEG_SCF_FBW7_2	279	285	PF00400	0.512
DEG_SPOP_SBC_1	53	57	PF00917	0.502
DEG_SPOP_SBC_1	6	10	PF00917	0.527
DEG_SPOP_SBC_1	634	638	PF00917	0.503
DOC_CKS1_1	276	281	PF01111	0.495
DOC_CKS1_1	3	8	PF01111	0.526
DOC_CKS1_1	459	464	PF01111	0.509
DOC_CKS1_1	687	692	PF01111	0.496
DOC_CYCLIN_yCln2_LP_2	619	625	PF00134	0.478
DOC_MAPK_gen_1	530	539	PF00069	0.356
DOC_PP2B_LxvP_1	322	325	PF13499	0.498
DOC_PP2B_LxvP_1	593	596	PF13499	0.512
DOC_PP2B_LxvP_1	619	622	PF13499	0.465
DOC_PP2B_LxvP_1	744	747	PF13499	0.415
DOC_USP7_MATH_1	147	151	PF00917	0.501
DOC_USP7_MATH_1	164	168	PF00917	0.483
DOC_USP7_MATH_1	186	190	PF00917	0.477
DOC_USP7_MATH_1	230	234	PF00917	0.490
DOC_USP7_MATH_1	251	255	PF00917	0.492
DOC_USP7_MATH_1	31	35	PF00917	0.359
DOC_USP7_MATH_1	332	336	PF00917	0.531
DOC_USP7_MATH_1	352	356	PF00917	0.488
DOC_USP7_MATH_1	361	365	PF00917	0.485
DOC_USP7_MATH_1	370	374	PF00917	0.488
DOC_USP7_MATH_1	380	384	PF00917	0.497
DOC_USP7_MATH_1	390	394	PF00917	0.504
DOC_USP7_MATH_1	399	403	PF00917	0.498
DOC_USP7_MATH_1	409	413	PF00917	0.500
DOC_USP7_MATH_1	418	422	PF00917	0.491
DOC_USP7_MATH_1	426	430	PF00917	0.499
DOC_USP7_MATH_1	445	449	PF00917	0.515
DOC_USP7_MATH_1	469	473	PF00917	0.507
DOC_USP7_MATH_1	478	482	PF00917	0.425
DOC_USP7_MATH_1	53	57	PF00917	0.502
DOC_USP7_MATH_1	585	589	PF00917	0.523
DOC_USP7_MATH_1	611	615	PF00917	0.450
DOC_USP7_MATH_1	629	633	PF00917	0.510
DOC_USP7_MATH_1	635	639	PF00917	0.503
DOC_USP7_MATH_1	673	677	PF00917	0.468
DOC_USP7_MATH_1	678	682	PF00917	0.505
DOC_USP7_MATH_1	735	739	PF00917	0.468
DOC_USP7_MATH_1	82	86	PF00917	0.495
DOC_WW_Pin1_4	105	110	PF00397	0.449
DOC_WW_Pin1_4	165	170	PF00397	0.472
DOC_WW_Pin1_4	2	7	PF00397	0.522
DOC_WW_Pin1_4	226	231	PF00397	0.487
DOC_WW_Pin1_4	254	259	PF00397	0.493
DOC_WW_Pin1_4	275	280	PF00397	0.486
DOC_WW_Pin1_4	333	338	PF00397	0.528
DOC_WW_Pin1_4	458	463	PF00397	0.506
DOC_WW_Pin1_4	471	476	PF00397	0.495
DOC_WW_Pin1_4	578	583	PF00397	0.510
DOC_WW_Pin1_4	63	68	PF00397	0.499
DOC_WW_Pin1_4	674	679	PF00397	0.481
DOC_WW_Pin1_4	686	691	PF00397	0.499
DOC_WW_Pin1_4	83	88	PF00397	0.503
DOC_WW_Pin1_4	96	101	PF00397	0.501
LIG_14-3-3_CanoR_1	139	149	PF00244	0.512
LIG_14-3-3_CanoR_1	4	13	PF00244	0.523
LIG_14-3-3_CanoR_1	454	463	PF00244	0.514
LIG_14-3-3_CanoR_1	655	663	PF00244	0.439
LIG_14-3-3_CanoR_1	721	726	PF00244	0.448
LIG_14-3-3_CanoR_1	754	763	PF00244	0.338
LIG_CaM_IQ_9	656	672	PF13499	0.419
LIG_CaM_IQ_9	748	764	PF13499	0.345
LIG_CSL_BTD_1	106	109	PF09270	0.443
LIG_FHA_1	141	147	PF00498	0.512
LIG_FHA_1	238	244	PF00498	0.496
LIG_FHA_1	657	663	PF00498	0.426
LIG_FHA_1	7	13	PF00498	0.524
LIG_LIR_Gen_1	613	623	PF02991	0.458
LIG_LIR_Nem_3	613	619	PF02991	0.451
LIG_LIR_Nem_3	692	698	PF02991	0.457
LIG_PCNA_yPIPBox_3	655	667	PF02747	0.425
LIG_PTAP_UEV_1	474	479	PF05743	0.471
LIG_SH2_CRK	276	280	PF00017	0.492
LIG_SH2_CRK	512	516	PF00017	0.348
LIG_SH2_CRK	616	620	PF00017	0.455
LIG_SH2_NCK_1	316	320	PF00017	0.499
LIG_SH2_SRC	641	644	PF00017	0.503
LIG_SH2_SRC	710	713	PF00017	0.374
LIG_SH2_STAP1	316	320	PF00017	0.499
LIG_SH2_STAP1	698	702	PF00017	0.393
LIG_SH2_STAT3	497	500	PF00017	0.345
LIG_SH2_STAT3	749	752	PF00017	0.356
LIG_SH2_STAT3	784	787	PF00017	0.321
LIG_SH2_STAT5	131	134	PF00017	0.492
LIG_SH2_STAT5	24	27	PF00017	0.415
LIG_SH2_STAT5	497	500	PF00017	0.345
LIG_SH2_STAT5	549	552	PF00017	0.410
LIG_SH2_STAT5	641	644	PF00017	0.503
LIG_SH2_STAT5	705	708	PF00017	0.351
LIG_SH2_STAT5	784	787	PF00017	0.321
LIG_SH3_1	276	282	PF00018	0.495
LIG_SH3_2	84	89	PF14604	0.506
LIG_SH3_3	224	230	PF00018	0.491
LIG_SH3_3	256	262	PF00018	0.486
LIG_SH3_3	276	282	PF00018	0.495
LIG_SH3_3	344	350	PF00018	0.491
LIG_SH3_3	351	357	PF00018	0.480
LIG_SH3_3	362	368	PF00018	0.477
LIG_SH3_3	369	375	PF00018	0.480
LIG_SH3_3	379	385	PF00018	0.490
LIG_SH3_3	391	397	PF00018	0.491
LIG_SH3_3	398	404	PF00018	0.490
LIG_SH3_3	410	416	PF00018	0.489
LIG_SH3_3	417	423	PF00018	0.486
LIG_SH3_3	425	431	PF00018	0.493
LIG_SH3_3	437	443	PF00018	0.505
LIG_SH3_3	446	452	PF00018	0.507
LIG_SH3_3	472	478	PF00018	0.485
LIG_SH3_3	61	67	PF00018	0.506
LIG_SH3_3	81	87	PF00018	0.492
LIG_SH3_3	94	100	PF00018	0.506
LIG_SUMO_SIM_anti_2	245	252	PF11976	0.489
LIG_SxIP_EBH_1	721	735	PF03271	0.463
LIG_TRAF2_1	189	192	PF00917	0.499
LIG_TRAF2_1	520	523	PF00917	0.345
LIG_TRAF2_1	658	661	PF00917	0.435
LIG_TYR_ITIM	510	515	PF00017	0.348
LIG_WW_3	451	455	PF00397	0.511
MOD_CDC14_SPxK_1	261	264	PF00782	0.465
MOD_CDC14_SPxK_1	86	89	PF00782	0.513
MOD_CDK_SPK_2	674	679	PF00069	0.481
MOD_CDK_SPxK_1	258	264	PF00069	0.476
MOD_CDK_SPxK_1	83	89	PF00069	0.507
MOD_CK1_1	105	111	PF00069	0.443
MOD_CK1_1	20	26	PF00069	0.429
MOD_CK1_1	221	227	PF00069	0.496
MOD_CK1_1	245	251	PF00069	0.488
MOD_CK1_1	254	260	PF00069	0.493
MOD_CK1_1	318	324	PF00069	0.501
MOD_CK1_1	340	346	PF00069	0.513
MOD_CK1_1	436	442	PF00069	0.508
MOD_CK1_1	54	60	PF00069	0.516
MOD_CK1_1	553	559	PF00069	0.462
MOD_CK1_1	565	571	PF00069	0.511
MOD_CK1_1	645	651	PF00069	0.519
MOD_CK1_1	724	730	PF00069	0.463
MOD_CK1_1	85	91	PF00069	0.512
MOD_CK2_1	186	192	PF00069	0.485
MOD_CK2_1	569	575	PF00069	0.516
MOD_CK2_1	755	761	PF00069	0.335
MOD_Cter_Amidation	213	216	PF01082	0.518
MOD_DYRK1A_RPxSP_1	471	475	PF00069	0.497
MOD_GlcNHglycan	212	215	PF01048	0.524
MOD_GlcNHglycan	234	237	PF01048	0.514
MOD_GlcNHglycan	244	247	PF01048	0.480
MOD_GlcNHglycan	317	320	PF01048	0.499
MOD_GlcNHglycan	342	345	PF01048	0.515
MOD_GlcNHglycan	435	438	PF01048	0.511
MOD_GlcNHglycan	454	457	PF01048	0.526
MOD_GlcNHglycan	480	483	PF01048	0.404
MOD_GlcNHglycan	525	528	PF01048	0.344
MOD_GlcNHglycan	631	634	PF01048	0.505
MOD_GlcNHglycan	637	640	PF01048	0.511
MOD_GlcNHglycan	656	659	PF01048	0.443
MOD_GSK3_1	130	137	PF00069	0.492
MOD_GSK3_1	147	154	PF00069	0.506
MOD_GSK3_1	2	9	PF00069	0.525
MOD_GSK3_1	221	228	PF00069	0.498
MOD_GSK3_1	245	252	PF00069	0.489
MOD_GSK3_1	254	261	PF00069	0.490
MOD_GSK3_1	27	34	PF00069	0.369
MOD_GSK3_1	328	335	PF00069	0.527
MOD_GSK3_1	336	343	PF00069	0.520
MOD_GSK3_1	454	461	PF00069	0.520
MOD_GSK3_1	467	474	PF00069	0.505
MOD_GSK3_1	48	55	PF00069	0.484
MOD_GSK3_1	543	550	PF00069	0.371
MOD_GSK3_1	562	569	PF00069	0.502
MOD_GSK3_1	570	577	PF00069	0.517
MOD_GSK3_1	59	66	PF00069	0.515
MOD_GSK3_1	611	618	PF00069	0.451
MOD_GSK3_1	629	636	PF00069	0.506
MOD_GSK3_1	674	681	PF00069	0.489
MOD_GSK3_1	724	731	PF00069	0.467
MOD_GSK3_1	736	743	PF00069	0.456
MOD_GSK3_1	88	95	PF00069	0.522
MOD_LATS_1	198	204	PF00433	0.524
MOD_LATS_1	719	725	PF00433	0.439
MOD_N-GLC_1	186	191	PF02516	0.481
MOD_N-GLC_1	254	259	PF02516	0.493
MOD_N-GLC_1	27	32	PF02516	0.370
MOD_N-GLC_1	547	552	PF02516	0.399
MOD_NEK2_1	249	254	PF00069	0.492
MOD_NEK2_1	312	317	PF00069	0.499
MOD_NEK2_1	543	548	PF00069	0.359
MOD_NEK2_1	58	63	PF00069	0.525
MOD_NEK2_2	173	178	PF00069	0.444
MOD_NEK2_2	611	616	PF00069	0.453
MOD_OFUCOSY	172	177	PF10250	0.444
MOD_PIKK_1	11	17	PF00454	0.499
MOD_PIKK_1	656	662	PF00454	0.433
MOD_PK_1	218	224	PF00069	0.505
MOD_PKA_2	134	140	PF00069	0.499
MOD_PKA_2	201	207	PF00069	0.517
MOD_PKA_2	210	216	PF00069	0.525
MOD_PKA_2	654	660	PF00069	0.458
MOD_PKA_2	678	684	PF00069	0.512
MOD_PKA_2	755	761	PF00069	0.335
MOD_PKB_1	216	224	PF00069	0.504
MOD_PKB_1	471	479	PF00069	0.483
MOD_Plk_1	147	153	PF00069	0.505
MOD_Plk_1	218	224	PF00069	0.505
MOD_Plk_1	27	33	PF00069	0.371
MOD_Plk_1	307	313	PF00069	0.489
MOD_Plk_4	151	157	PF00069	0.510
MOD_Plk_4	20	26	PF00069	0.429
MOD_Plk_4	245	251	PF00069	0.488
MOD_Plk_4	318	324	PF00069	0.501
MOD_Plk_4	611	617	PF00069	0.451
MOD_Plk_4	637	643	PF00069	0.506
MOD_Plk_4	724	730	PF00069	0.463
MOD_ProDKin_1	105	111	PF00069	0.443
MOD_ProDKin_1	165	171	PF00069	0.469
MOD_ProDKin_1	2	8	PF00069	0.524
MOD_ProDKin_1	226	232	PF00069	0.483
MOD_ProDKin_1	254	260	PF00069	0.493
MOD_ProDKin_1	275	281	PF00069	0.489
MOD_ProDKin_1	333	339	PF00069	0.528
MOD_ProDKin_1	458	464	PF00069	0.508
MOD_ProDKin_1	471	477	PF00069	0.492
MOD_ProDKin_1	578	584	PF00069	0.511
MOD_ProDKin_1	63	69	PF00069	0.499
MOD_ProDKin_1	674	680	PF00069	0.485
MOD_ProDKin_1	686	692	PF00069	0.498
MOD_ProDKin_1	83	89	PF00069	0.507
MOD_ProDKin_1	96	102	PF00069	0.499
MOD_SUMO_rev_2	586	593	PF00179	0.529
TRG_DiLeu_BaEn_1	486	491	PF01217	0.362
TRG_ENDOCYTIC_2	512	515	PF00928	0.347
TRG_ENDOCYTIC_2	616	619	PF00928	0.456
TRG_ER_diArg_1	199	202	PF00400	0.525
TRG_ER_diArg_1	215	218	PF00400	0.506
TRG_ER_diArg_1	557	559	PF00400	0.480
TRG_ER_diArg_1	606	608	PF00400	0.520
TRG_ER_diArg_1	702	704	PF00400	0.369
TRG_NES_CRM1_1	759	772	PF08389	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
O42854	SCHPO	46%	49%