Sedlin, N-terminal conserved region family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICA3_LEIDO

TriTrypDb:

LdBPK_261900.1 , LdCL_260024500 , LDHU3_26.2470

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.522
CLV_PCSK_SKI1_1	159	163	PF00082	0.410
CLV_PCSK_SKI1_1	30	34	PF00082	0.475
DOC_CYCLIN_yCln2_LP_2	33	39	PF00134	0.560
DOC_PP1_RVXF_1	51	57	PF00149	0.380
DOC_PP4_FxxP_1	199	202	PF00568	0.460
DOC_USP7_MATH_1	119	123	PF00917	0.668
DOC_USP7_MATH_1	228	232	PF00917	0.705
DOC_USP7_MATH_1	73	77	PF00917	0.686
DOC_USP7_MATH_1	80	84	PF00917	0.698
DOC_WW_Pin1_4	114	119	PF00397	0.768
DOC_WW_Pin1_4	133	138	PF00397	0.547
DOC_WW_Pin1_4	16	21	PF00397	0.422
DOC_WW_Pin1_4	198	203	PF00397	0.509
DOC_WW_Pin1_4	25	30	PF00397	0.415
DOC_WW_Pin1_4	32	37	PF00397	0.425
LIG_14-3-3_CanoR_1	152	157	PF00244	0.458
LIG_14-3-3_CanoR_1	24	29	PF00244	0.416
LIG_14-3-3_CanoR_1	260	265	PF00244	0.584
LIG_14-3-3_CanoR_1	294	304	PF00244	0.509
LIG_BRCT_BRCA1_1	154	158	PF00533	0.361
LIG_BRCT_BRCA1_1	242	246	PF00533	0.525
LIG_BRCT_BRCA1_1	292	296	PF00533	0.434
LIG_deltaCOP1_diTrp_1	270	273	PF00928	0.670
LIG_EH_1	196	200	PF12763	0.428
LIG_FHA_1	129	135	PF00498	0.487
LIG_FHA_1	164	170	PF00498	0.490
LIG_FHA_1	17	23	PF00498	0.443
LIG_FHA_1	228	234	PF00498	0.608
LIG_FHA_1	287	293	PF00498	0.555
LIG_FHA_1	3	9	PF00498	0.433
LIG_FHA_2	296	302	PF00498	0.451
LIG_LIR_Apic_2	25	29	PF02991	0.412
LIG_LIR_Apic_2	270	276	PF02991	0.665
LIG_NRBOX	143	149	PF00104	0.434
LIG_NRBOX	299	305	PF00104	0.445
LIG_PCNA_yPIPBox_3	294	304	PF02747	0.509
LIG_SH2_CRK	26	30	PF00017	0.525
LIG_SH2_NCK_1	188	192	PF00017	0.382
LIG_SH2_PTP2	45	48	PF00017	0.481
LIG_SH2_STAT3	241	244	PF00017	0.609
LIG_SH2_STAT5	26	29	PF00017	0.506
LIG_SH2_STAT5	45	48	PF00017	0.270
LIG_SH3_3	33	39	PF00018	0.560
LIG_SUMO_SIM_par_1	12	17	PF11976	0.388
LIG_SUMO_SIM_par_1	165	170	PF11976	0.487
LIG_SUMO_SIM_par_1	19	25	PF11976	0.388
LIG_SUMO_SIM_par_1	287	293	PF11976	0.569
LIG_WRC_WIRS_1	304	309	PF05994	0.528
MOD_CAAXbox	314	317	PF01239	0.646
MOD_CDK_SPK_2	25	30	PF00069	0.430
MOD_CK1_1	104	110	PF00069	0.639
MOD_CK1_1	136	142	PF00069	0.465
MOD_CK1_1	263	269	PF00069	0.749
MOD_CK1_1	305	311	PF00069	0.556
MOD_CK1_1	95	101	PF00069	0.678
MOD_CK2_1	102	108	PF00069	0.636
MOD_CK2_1	295	301	PF00069	0.485
MOD_GlcNHglycan	100	103	PF01048	0.768
MOD_GlcNHglycan	159	162	PF01048	0.411
MOD_GlcNHglycan	191	194	PF01048	0.377
MOD_GlcNHglycan	218	221	PF01048	0.741
MOD_GlcNHglycan	265	268	PF01048	0.678
MOD_GlcNHglycan	279	282	PF01048	0.637
MOD_GlcNHglycan	83	86	PF01048	0.599
MOD_GSK3_1	159	166	PF00069	0.371
MOD_GSK3_1	259	266	PF00069	0.741
MOD_GSK3_1	282	289	PF00069	0.502
MOD_GSK3_1	303	310	PF00069	0.507
MOD_GSK3_1	98	105	PF00069	0.713
MOD_N-GLC_1	98	103	PF02516	0.767
MOD_NEK2_1	147	152	PF00069	0.449
MOD_NEK2_1	167	172	PF00069	0.427
MOD_NEK2_1	22	27	PF00069	0.442
MOD_NEK2_1	269	274	PF00069	0.629
MOD_NEK2_1	290	295	PF00069	0.446
MOD_NEK2_1	303	308	PF00069	0.415
MOD_PIKK_1	228	234	PF00454	0.656
MOD_PIKK_1	240	246	PF00454	0.536
MOD_PIKK_1	247	253	PF00454	0.528
MOD_PIKK_1	295	301	PF00454	0.533
MOD_PK_1	260	266	PF00069	0.561
MOD_PKA_2	259	265	PF00069	0.585
MOD_Plk_1	102	108	PF00069	0.505
MOD_Plk_1	269	275	PF00069	0.665
MOD_Plk_1	92	98	PF00069	0.749
MOD_Plk_4	163	169	PF00069	0.419
MOD_Plk_4	92	98	PF00069	0.641
MOD_ProDKin_1	114	120	PF00069	0.770
MOD_ProDKin_1	133	139	PF00069	0.540
MOD_ProDKin_1	16	22	PF00069	0.417
MOD_ProDKin_1	198	204	PF00069	0.510
MOD_ProDKin_1	25	31	PF00069	0.424
MOD_ProDKin_1	32	38	PF00069	0.421
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.606
TRG_DiLeu_LyEn_5	17	22	PF01217	0.498
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P7	Leptomonas seymouri	57%	94%
A0A1X0P7Q6	Trypanosomatidae	38%	100%
A4HF34	Leishmania braziliensis	77%	99%
A4I2B8	Leishmania infantum	100%	100%
C9ZX95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AYG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q903	Leishmania major	91%	100%
V5AV59	Trypanosoma cruzi	36%	100%