Peroxisomal membrane protein PEX16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisomal membrane protein (Pex16), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICA1_LEIDO

TriTrypDb:

LdBPK_150850.1 , LdCL_150014000 , LDHU3_15.1100

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0031903	microbody membrane	5	10
GO:0042579	microbody	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0098588	bounding membrane of organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1

Expansion

Sequence features

A0A3Q8ICA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICA1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	10
GO:0007031	peroxisome organization	5	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0071840	cellular component organization or biogenesis	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	461	465	PF00656	0.791
CLV_NRD_NRD_1	100	102	PF00675	0.309
CLV_NRD_NRD_1	133	135	PF00675	0.312
CLV_NRD_NRD_1	172	174	PF00675	0.417
CLV_NRD_NRD_1	185	187	PF00675	0.480
CLV_NRD_NRD_1	24	26	PF00675	0.570
CLV_NRD_NRD_1	257	259	PF00675	0.500
CLV_PCSK_KEX2_1	100	102	PF00082	0.331
CLV_PCSK_KEX2_1	133	135	PF00082	0.328
CLV_PCSK_KEX2_1	172	174	PF00082	0.418
CLV_PCSK_KEX2_1	184	186	PF00082	0.484
CLV_PCSK_KEX2_1	24	26	PF00082	0.570
CLV_PCSK_KEX2_1	257	259	PF00082	0.500
CLV_PCSK_SKI1_1	155	159	PF00082	0.415
CLV_PCSK_SKI1_1	172	176	PF00082	0.359
CLV_PCSK_SKI1_1	317	321	PF00082	0.536
CLV_PCSK_SKI1_1	326	330	PF00082	0.546
CLV_PCSK_SKI1_1	62	66	PF00082	0.361
DEG_APCC_DBOX_1	171	179	PF00400	0.639
DEG_APCC_DBOX_1	29	37	PF00400	0.676
DEG_SPOP_SBC_1	467	471	PF00917	0.707
DOC_ANK_TNKS_1	47	54	PF00023	0.536
DOC_CDC14_PxL_1	157	165	PF14671	0.667
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.427
DOC_MAPK_DCC_7	422	431	PF00069	0.642
DOC_MAPK_gen_1	100	110	PF00069	0.595
DOC_MAPK_gen_1	133	141	PF00069	0.597
DOC_MAPK_gen_1	419	428	PF00069	0.580
DOC_MAPK_MEF2A_6	104	112	PF00069	0.583
DOC_MAPK_MEF2A_6	317	324	PF00069	0.374
DOC_MAPK_MEF2A_6	422	431	PF00069	0.642
DOC_MAPK_RevD_3	158	173	PF00069	0.667
DOC_PP2B_LxvP_1	248	251	PF13499	0.629
DOC_PP2B_LxvP_1	330	333	PF13499	0.450
DOC_PP2B_LxvP_1	343	346	PF13499	0.509
DOC_PP4_FxxP_1	158	161	PF00568	0.606
DOC_PP4_MxPP_1	486	489	PF00568	0.682
DOC_USP7_MATH_1	13	17	PF00917	0.770
DOC_USP7_MATH_1	199	203	PF00917	0.770
DOC_USP7_MATH_1	209	213	PF00917	0.684
DOC_USP7_MATH_1	267	271	PF00917	0.743
DOC_USP7_MATH_1	467	471	PF00917	0.707
DOC_USP7_MATH_1	476	480	PF00917	0.767
DOC_USP7_MATH_1	489	493	PF00917	0.608
DOC_USP7_UBL2_3	146	150	PF12436	0.561
DOC_WW_Pin1_4	11	16	PF00397	0.777
DOC_WW_Pin1_4	179	184	PF00397	0.759
DOC_WW_Pin1_4	368	373	PF00397	0.551
DOC_WW_Pin1_4	439	444	PF00397	0.808
LIG_14-3-3_CanoR_1	100	108	PF00244	0.545
LIG_14-3-3_CanoR_1	133	137	PF00244	0.535
LIG_14-3-3_CanoR_1	176	182	PF00244	0.671
LIG_14-3-3_CanoR_1	62	67	PF00244	0.514
LIG_Actin_RPEL_3	18	37	PF02755	0.715
LIG_Actin_WH2_2	301	319	PF00022	0.272
LIG_AP2alpha_2	512	514	PF02296	0.584
LIG_Clathr_ClatBox_1	139	143	PF01394	0.561
LIG_FHA_1	103	109	PF00498	0.520
LIG_FHA_1	244	250	PF00498	0.641
LIG_FHA_1	334	340	PF00498	0.485
LIG_FHA_1	514	520	PF00498	0.678
LIG_FHA_1	545	551	PF00498	0.539
LIG_FHA_1	70	76	PF00498	0.533
LIG_FHA_2	223	229	PF00498	0.781
LIG_FHA_2	299	305	PF00498	0.490
LIG_FHA_2	406	412	PF00498	0.459
LIG_LIR_Apic_2	219	223	PF02991	0.704
LIG_LIR_Apic_2	65	71	PF02991	0.591
LIG_LIR_Gen_1	135	144	PF02991	0.535
LIG_LIR_Gen_1	301	310	PF02991	0.380
LIG_LIR_Gen_1	311	321	PF02991	0.336
LIG_LIR_Gen_1	512	523	PF02991	0.615
LIG_LIR_Gen_1	547	557	PF02991	0.544
LIG_LIR_Gen_1	88	95	PF02991	0.553
LIG_LIR_Nem_3	135	139	PF02991	0.512
LIG_LIR_Nem_3	301	305	PF02991	0.380
LIG_LIR_Nem_3	311	316	PF02991	0.329
LIG_LIR_Nem_3	512	518	PF02991	0.581
LIG_LIR_Nem_3	551	557	PF02991	0.414
LIG_LIR_Nem_3	88	92	PF02991	0.553
LIG_NRBOX	412	418	PF00104	0.485
LIG_Pex14_2	158	162	PF04695	0.605
LIG_Pex14_2	527	531	PF04695	0.642
LIG_PTB_Apo_2	501	508	PF02174	0.595
LIG_PTB_Phospho_1	501	507	PF10480	0.629
LIG_SH2_CRK	220	224	PF00017	0.784
LIG_SH2_CRK	555	559	PF00017	0.399
LIG_SH2_STAP1	545	549	PF00017	0.431
LIG_SH2_STAP1	555	559	PF00017	0.349
LIG_SH2_STAT5	313	316	PF00017	0.405
LIG_SH2_STAT5	43	46	PF00017	0.547
LIG_SH2_STAT5	430	433	PF00017	0.715
LIG_SH2_STAT5	549	552	PF00017	0.355
LIG_SH2_STAT5	559	562	PF00017	0.374
LIG_SH3_3	237	243	PF00018	0.683
LIG_SH3_3	339	345	PF00018	0.457
LIG_SH3_3	369	375	PF00018	0.553
LIG_SUMO_SIM_anti_2	105	112	PF11976	0.513
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.349
LIG_SUMO_SIM_anti_2	442	448	PF11976	0.680
LIG_SUMO_SIM_par_1	138	143	PF11976	0.509
LIG_SUMO_SIM_par_1	442	448	PF11976	0.677
LIG_TRAF2_1	348	351	PF00917	0.480
LIG_TRAF2_1	362	365	PF00917	0.397
LIG_UBA3_1	139	146	PF00899	0.452
LIG_UBA3_1	36	45	PF00899	0.641
LIG_WRC_WIRS_1	554	559	PF05994	0.415
LIG_WRC_WIRS_1	86	91	PF05994	0.551
MOD_CDK_SPK_2	179	184	PF00069	0.759
MOD_CDK_SPxK_1	179	185	PF00069	0.764
MOD_CDK_SPxK_1	368	374	PF00069	0.577
MOD_CDK_SPxxK_3	179	186	PF00069	0.767
MOD_CK1_1	16	22	PF00069	0.786
MOD_CK1_1	230	236	PF00069	0.699
MOD_CK1_1	69	75	PF00069	0.553
MOD_CK2_1	100	106	PF00069	0.546
MOD_CK2_1	16	22	PF00069	0.755
MOD_CK2_1	345	351	PF00069	0.422
MOD_CK2_1	52	58	PF00069	0.591
MOD_CMANNOS	401	404	PF00535	0.508
MOD_Cter_Amidation	255	258	PF01082	0.545
MOD_Cter_Amidation	98	101	PF01082	0.308
MOD_GlcNHglycan	196	199	PF01048	0.546
MOD_GlcNHglycan	201	204	PF01048	0.553
MOD_GlcNHglycan	211	214	PF01048	0.440
MOD_GlcNHglycan	228	232	PF01048	0.476
MOD_GlcNHglycan	254	257	PF01048	0.480
MOD_GlcNHglycan	96	99	PF01048	0.361
MOD_GSK3_1	102	109	PF00069	0.575
MOD_GSK3_1	163	170	PF00069	0.666
MOD_GSK3_1	199	206	PF00069	0.741
MOD_GSK3_1	393	400	PF00069	0.437
MOD_GSK3_1	467	474	PF00069	0.727
MOD_GSK3_1	540	547	PF00069	0.418
MOD_GSK3_1	553	560	PF00069	0.303
MOD_GSK3_1	58	65	PF00069	0.531
MOD_GSK3_1	69	76	PF00069	0.520
MOD_GSK3_1	7	14	PF00069	0.776
MOD_NEK2_1	163	168	PF00069	0.661
MOD_NEK2_1	397	402	PF00069	0.399
MOD_NEK2_1	466	471	PF00069	0.737
MOD_NEK2_1	537	542	PF00069	0.369
MOD_NEK2_1	544	549	PF00069	0.369
MOD_NEK2_1	557	562	PF00069	0.209
MOD_NEK2_1	60	65	PF00069	0.558
MOD_NEK2_1	8	13	PF00069	0.777
MOD_PIKK_1	222	228	PF00454	0.781
MOD_PKA_1	100	106	PF00069	0.561
MOD_PKA_2	132	138	PF00069	0.561
MOD_PKA_2	99	105	PF00069	0.591
MOD_Plk_4	106	112	PF00069	0.537
MOD_Plk_4	393	399	PF00069	0.404
MOD_Plk_4	553	559	PF00069	0.403
MOD_Plk_4	62	68	PF00069	0.561
MOD_ProDKin_1	11	17	PF00069	0.778
MOD_ProDKin_1	179	185	PF00069	0.764
MOD_ProDKin_1	368	374	PF00069	0.555
MOD_ProDKin_1	439	445	PF00069	0.807
MOD_SUMO_rev_2	364	369	PF00179	0.528
TRG_DiLeu_BaEn_1	106	111	PF01217	0.560
TRG_DiLeu_BaEn_1	117	122	PF01217	0.499
TRG_DiLeu_BaEn_1	335	340	PF01217	0.345
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.432
TRG_ENDOCYTIC_2	313	316	PF00928	0.420
TRG_ENDOCYTIC_2	507	510	PF00928	0.611
TRG_ENDOCYTIC_2	524	527	PF00928	0.431
TRG_ENDOCYTIC_2	549	552	PF00928	0.352
TRG_ENDOCYTIC_2	554	557	PF00928	0.314
TRG_ER_diArg_1	171	173	PF00400	0.607
TRG_ER_diArg_1	183	186	PF00400	0.713
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R8	Leptomonas seymouri	58%	100%
A0A1X0NUI4	Trypanosomatidae	36%	100%
A4H843	Leishmania braziliensis	82%	99%
A4HWH7	Leishmania infantum	100%	100%
C9ZXX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AQ78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QFA4	Leishmania major	95%	100%
V5DL46	Trypanosoma cruzi	34%	100%