LeishMANIAdb
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Testicular haploid expressed gene protein-like

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Testicular haploid expressed gene protein-like
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IC96_LEIDO
TriTrypDb:
LdBPK_250730.1 * , LdCL_250012600 , LDHU3_25.0910
Length:
279

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 130, 243

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IC96
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC96

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 209 211 PF00675 0.508
CLV_NRD_NRD_1 217 219 PF00675 0.472
CLV_NRD_NRD_1 259 261 PF00675 0.670
CLV_PCSK_KEX2_1 209 211 PF00082 0.508
CLV_PCSK_PC1ET2_1 209 211 PF00082 0.516
CLV_PCSK_SKI1_1 256 260 PF00082 0.667
CLV_PCSK_SKI1_1 274 278 PF00082 0.728
DOC_ANK_TNKS_1 181 188 PF00023 0.604
DOC_CKS1_1 143 148 PF01111 0.607
DOC_CYCLIN_yCln2_LP_2 166 172 PF00134 0.566
DOC_MAPK_MEF2A_6 157 166 PF00069 0.517
DOC_MAPK_MEF2A_6 27 35 PF00069 0.478
DOC_PP1_RVXF_1 127 134 PF00149 0.534
DOC_PP2B_LxvP_1 166 169 PF13499 0.476
DOC_USP7_MATH_1 221 225 PF00917 0.658
DOC_USP7_MATH_1 269 273 PF00917 0.615
DOC_USP7_UBL2_3 232 236 PF12436 0.623
DOC_USP7_UBL2_3 262 266 PF12436 0.623
DOC_USP7_UBL2_3 271 275 PF12436 0.729
DOC_WW_Pin1_4 142 147 PF00397 0.599
LIG_14-3-3_CanoR_1 127 132 PF00244 0.502
LIG_14-3-3_CanoR_1 240 247 PF00244 0.568
LIG_FHA_1 196 202 PF00498 0.639
LIG_FHA_2 150 156 PF00498 0.678
LIG_FHA_2 265 271 PF00498 0.519
LIG_HP1_1 255 259 PF01393 0.499
LIG_LIR_Apic_2 224 228 PF02991 0.636
LIG_LIR_Gen_1 110 119 PF02991 0.486
LIG_LIR_Gen_1 120 128 PF02991 0.472
LIG_LIR_Gen_1 15 25 PF02991 0.735
LIG_LIR_Gen_1 186 194 PF02991 0.518
LIG_LIR_Gen_1 73 83 PF02991 0.485
LIG_LIR_Nem_3 110 115 PF02991 0.466
LIG_LIR_Nem_3 186 192 PF02991 0.521
LIG_LIR_Nem_3 73 79 PF02991 0.482
LIG_PTB_Apo_2 188 195 PF02174 0.625
LIG_PTB_Phospho_1 188 194 PF10480 0.623
LIG_SH2_CRK 189 193 PF00017 0.538
LIG_SH2_CRK 225 229 PF00017 0.669
LIG_SH2_CRK 76 80 PF00017 0.518
LIG_SH2_GRB2like 189 192 PF00017 0.623
LIG_SH2_PTP2 159 162 PF00017 0.592
LIG_SH2_SRC 159 162 PF00017 0.592
LIG_SH2_STAT5 118 121 PF00017 0.461
LIG_SH2_STAT5 159 162 PF00017 0.592
LIG_SH2_STAT5 229 232 PF00017 0.660
LIG_SH3_1 159 165 PF00018 0.585
LIG_SH3_2 146 151 PF14604 0.601
LIG_SH3_3 143 149 PF00018 0.649
LIG_SH3_3 159 165 PF00018 0.395
LIG_SH3_3 197 203 PF00018 0.468
LIG_SH3_3 227 233 PF00018 0.632
LIG_SH3_3 23 29 PF00018 0.565
LIG_SH3_3 249 255 PF00018 0.548
LIG_SH3_3 8 14 PF00018 0.644
LIG_SH3_4 232 239 PF00018 0.545
LIG_SH3_4 262 269 PF00018 0.670
LIG_TRAF2_1 152 155 PF00917 0.621
LIG_TRAF2_1 19 22 PF00917 0.659
LIG_TRAF2_1 39 42 PF00917 0.717
LIG_WW_3 148 152 PF00397 0.597
MOD_CK1_1 110 116 PF00069 0.527
MOD_CK1_1 117 123 PF00069 0.502
MOD_CK2_1 149 155 PF00069 0.589
MOD_CK2_1 245 251 PF00069 0.619
MOD_CK2_1 264 270 PF00069 0.515
MOD_CK2_1 43 49 PF00069 0.655
MOD_GlcNHglycan 204 207 PF01048 0.649
MOD_GlcNHglycan 45 48 PF01048 0.646
MOD_GlcNHglycan 83 86 PF01048 0.508
MOD_GSK3_1 110 117 PF00069 0.501
MOD_N-GLC_1 264 269 PF02516 0.719
MOD_NEK2_1 107 112 PF00069 0.523
MOD_PIKK_1 195 201 PF00454 0.653
MOD_PIKK_1 269 275 PF00454 0.655
MOD_Plk_1 107 113 PF00069 0.530
MOD_Plk_4 107 113 PF00069 0.498
MOD_Plk_4 114 120 PF00069 0.488
MOD_Plk_4 127 133 PF00069 0.250
MOD_Plk_4 13 19 PF00069 0.734
MOD_Plk_4 31 37 PF00069 0.500
MOD_Plk_4 75 81 PF00069 0.500
MOD_ProDKin_1 142 148 PF00069 0.595
MOD_SUMO_for_1 175 178 PF00179 0.601
TRG_ENDOCYTIC_2 122 125 PF00928 0.543
TRG_ENDOCYTIC_2 189 192 PF00928 0.482
TRG_ENDOCYTIC_2 76 79 PF00928 0.518
TRG_ER_diArg_1 254 257 PF00400 0.589
TRG_NLS_MonoExtC_3 208 214 PF00514 0.608
TRG_Pf-PMV_PEXEL_1 182 186 PF00026 0.574

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P685 Leptomonas seymouri 54% 94%
A0A422NX50 Trypanosoma rangeli 33% 100%
A4HE03 Leishmania braziliensis 71% 100%
A4I1B3 Leishmania infantum 100% 100%
D0A5K5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AXE9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QA23 Leishmania major 94% 100%
V5BN56 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS