Mitochondrial chaperone, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IC95_LEIDO

TriTrypDb:

LdBPK_220760.1 , LdBPK_366120.1 , LdCL_220014900 , LDHU3_22.1220

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3Q8IC95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC95

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016462	pyrophosphatase activity	5	18
GO:0016787	hydrolase activity	2	18
GO:0016817	hydrolase activity, acting on acid anhydrides	3	18
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	18
GO:0016887	ATP hydrolysis activity	7	18
GO:0017076	purine nucleotide binding	4	18
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.588
CLV_C14_Caspase3-7	397	401	PF00656	0.407
CLV_C14_Caspase3-7	471	475	PF00656	0.697
CLV_C14_Caspase3-7	9	13	PF00656	0.374
CLV_NRD_NRD_1	225	227	PF00675	0.386
CLV_NRD_NRD_1	313	315	PF00675	0.409
CLV_NRD_NRD_1	412	414	PF00675	0.288
CLV_NRD_NRD_1	417	419	PF00675	0.296
CLV_NRD_NRD_1	490	492	PF00675	0.526
CLV_NRD_NRD_1	597	599	PF00675	0.454
CLV_PCSK_KEX2_1	225	227	PF00082	0.378
CLV_PCSK_KEX2_1	313	315	PF00082	0.473
CLV_PCSK_KEX2_1	412	414	PF00082	0.304
CLV_PCSK_KEX2_1	417	419	PF00082	0.308
CLV_PCSK_KEX2_1	490	492	PF00082	0.629
CLV_PCSK_KEX2_1	597	599	PF00082	0.454
CLV_PCSK_KEX2_1	92	94	PF00082	0.269
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.242
CLV_PCSK_PC7_1	413	419	PF00082	0.317
CLV_PCSK_SKI1_1	135	139	PF00082	0.395
CLV_PCSK_SKI1_1	188	192	PF00082	0.371
CLV_PCSK_SKI1_1	266	270	PF00082	0.328
CLV_PCSK_SKI1_1	278	282	PF00082	0.390
CLV_PCSK_SKI1_1	300	304	PF00082	0.374
CLV_PCSK_SKI1_1	338	342	PF00082	0.302
CLV_PCSK_SKI1_1	68	72	PF00082	0.412
DEG_APCC_DBOX_1	185	193	PF00400	0.532
DEG_APCC_DBOX_1	570	578	PF00400	0.543
DOC_ANK_TNKS_1	315	322	PF00023	0.570
DOC_CKS1_1	689	694	PF01111	0.632
DOC_CYCLIN_RxL_1	65	73	PF00134	0.625
DOC_CYCLIN_yClb1_LxF_4	323	328	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.560
DOC_MAPK_gen_1	287	297	PF00069	0.663
DOC_MAPK_gen_1	386	395	PF00069	0.510
DOC_MAPK_gen_1	564	574	PF00069	0.565
DOC_MAPK_gen_1	92	99	PF00069	0.488
DOC_MAPK_MEF2A_6	351	358	PF00069	0.479
DOC_MAPK_MEF2A_6	567	574	PF00069	0.564
DOC_MAPK_MEF2A_6	92	99	PF00069	0.444
DOC_PP1_RVXF_1	276	282	PF00149	0.580
DOC_PP1_RVXF_1	323	329	PF00149	0.521
DOC_SPAK_OSR1_1	316	320	PF12202	0.576
DOC_SPAK_OSR1_1	567	571	PF12202	0.610
DOC_SPAK_OSR1_1	687	691	PF12202	0.558
DOC_USP7_MATH_1	13	17	PF00917	0.425
DOC_USP7_MATH_1	131	135	PF00917	0.570
DOC_USP7_MATH_1	193	197	PF00917	0.480
DOC_USP7_MATH_1	199	203	PF00917	0.499
DOC_USP7_MATH_1	401	405	PF00917	0.495
DOC_USP7_MATH_1	627	631	PF00917	0.609
DOC_USP7_MATH_1	669	673	PF00917	0.604
DOC_USP7_UBL2_3	191	195	PF12436	0.491
DOC_WW_Pin1_4	158	163	PF00397	0.611
DOC_WW_Pin1_4	195	200	PF00397	0.467
DOC_WW_Pin1_4	688	693	PF00397	0.542
LIG_14-3-3_CanoR_1	225	231	PF00244	0.577
LIG_14-3-3_CanoR_1	351	357	PF00244	0.486
LIG_14-3-3_CanoR_1	422	429	PF00244	0.522
LIG_14-3-3_CanoR_1	567	571	PF00244	0.566
LIG_APCC_ABBA_1	250	255	PF00400	0.587
LIG_APCC_ABBA_1	393	398	PF00400	0.487
LIG_BIR_III_4	660	664	PF00653	0.511
LIG_BRCT_BRCA1_1	133	137	PF00533	0.505
LIG_EVH1_2	100	104	PF00568	0.522
LIG_FHA_1	225	231	PF00498	0.474
LIG_FHA_1	301	307	PF00498	0.583
LIG_FHA_1	433	439	PF00498	0.686
LIG_FHA_1	454	460	PF00498	0.641
LIG_FHA_2	180	186	PF00498	0.629
LIG_FHA_2	4	10	PF00498	0.377
LIG_FHA_2	689	695	PF00498	0.602
LIG_LIR_Apic_2	161	167	PF02991	0.637
LIG_LIR_Apic_2	556	560	PF02991	0.571
LIG_LIR_Gen_1	12	22	PF02991	0.392
LIG_LIR_Gen_1	575	583	PF02991	0.528
LIG_LIR_Nem_3	12	17	PF02991	0.388
LIG_LIR_Nem_3	196	200	PF02991	0.541
LIG_MLH1_MIPbox_1	133	137	PF16413	0.505
LIG_NRBOX	142	148	PF00104	0.468
LIG_NRBOX	529	535	PF00104	0.548
LIG_PCNA_PIPBox_1	702	711	PF02747	0.556
LIG_PDZ_Class_2	717	722	PF00595	0.588
LIG_Pex14_1	267	271	PF04695	0.537
LIG_Pex14_2	292	296	PF04695	0.517
LIG_Rb_pABgroove_1	390	398	PF01858	0.487
LIG_REV1ctd_RIR_1	369	378	PF16727	0.466
LIG_RPA_C_Fungi	407	419	PF08784	0.311
LIG_SH2_CRK	331	335	PF00017	0.313
LIG_SH2_GRB2like	156	159	PF00017	0.388
LIG_SH2_NCK_1	625	629	PF00017	0.455
LIG_SH2_PTP2	164	167	PF00017	0.456
LIG_SH2_SRC	156	159	PF00017	0.490
LIG_SH2_STAP1	29	33	PF00017	0.422
LIG_SH2_STAP1	368	372	PF00017	0.323
LIG_SH2_STAT3	29	32	PF00017	0.564
LIG_SH2_STAT3	686	689	PF00017	0.497
LIG_SH2_STAT5	121	124	PF00017	0.372
LIG_SH2_STAT5	156	159	PF00017	0.427
LIG_SH2_STAT5	164	167	PF00017	0.463
LIG_SH2_STAT5	208	211	PF00017	0.571
LIG_SH2_STAT5	284	287	PF00017	0.449
LIG_SH2_STAT5	33	36	PF00017	0.436
LIG_SH2_STAT5	51	54	PF00017	0.218
LIG_SH2_STAT5	90	93	PF00017	0.428
LIG_SH3_3	102	108	PF00018	0.413
LIG_SH3_3	146	152	PF00018	0.413
LIG_SH3_3	327	333	PF00018	0.364
LIG_SH3_3	351	357	PF00018	0.455
LIG_SH3_3	538	544	PF00018	0.426
LIG_SH3_3	63	69	PF00018	0.421
LIG_SH3_3	83	89	PF00018	0.408
LIG_SH3_3	94	100	PF00018	0.316
LIG_SUMO_SIM_anti_2	303	308	PF11976	0.401
LIG_SUMO_SIM_par_1	142	148	PF11976	0.381
LIG_SUMO_SIM_par_1	547	553	PF11976	0.389
LIG_TYR_ITIM	588	593	PF00017	0.590
LIG_UBA3_1	189	195	PF00899	0.346
LIG_WRPW_2	150	153	PF00400	0.371
MOD_CK1_1	3	9	PF00069	0.494
MOD_CK1_1	468	474	PF00069	0.600
MOD_CK1_1	672	678	PF00069	0.628
MOD_CK1_1	681	687	PF00069	0.682
MOD_CK2_1	179	185	PF00069	0.448
MOD_CK2_1	688	694	PF00069	0.395
MOD_Cter_Amidation	488	491	PF01082	0.811
MOD_GlcNHglycan	139	142	PF01048	0.439
MOD_GlcNHglycan	237	240	PF01048	0.522
MOD_GlcNHglycan	476	479	PF01048	0.783
MOD_GlcNHglycan	529	533	PF01048	0.381
MOD_GlcNHglycan	599	602	PF01048	0.632
MOD_GlcNHglycan	625	628	PF01048	0.618
MOD_GlcNHglycan	629	632	PF01048	0.603
MOD_GlcNHglycan	666	670	PF01048	0.676
MOD_GlcNHglycan	672	675	PF01048	0.733
MOD_GlcNHglycan	676	679	PF01048	0.723
MOD_GlcNHglycan	680	683	PF01048	0.660
MOD_GSK3_1	195	202	PF00069	0.520
MOD_GSK3_1	217	224	PF00069	0.529
MOD_GSK3_1	352	359	PF00069	0.436
MOD_GSK3_1	37	44	PF00069	0.577
MOD_GSK3_1	593	600	PF00069	0.660
MOD_GSK3_1	623	630	PF00069	0.544
MOD_GSK3_1	665	672	PF00069	0.686
MOD_GSK3_1	674	681	PF00069	0.758
MOD_LATS_1	595	601	PF00433	0.562
MOD_N-GLC_1	170	175	PF02516	0.506
MOD_NEK2_1	137	142	PF00069	0.419
MOD_NEK2_1	179	184	PF00069	0.709
MOD_NEK2_1	41	46	PF00069	0.535
MOD_NEK2_1	441	446	PF00069	0.736
MOD_NEK2_1	494	499	PF00069	0.600
MOD_NEK2_1	528	533	PF00069	0.484
MOD_NEK2_1	70	75	PF00069	0.486
MOD_NEK2_1	76	81	PF00069	0.418
MOD_NEK2_2	291	296	PF00069	0.412
MOD_NEK2_2	566	571	PF00069	0.420
MOD_PIKK_1	179	185	PF00454	0.498
MOD_PIKK_1	707	713	PF00454	0.408
MOD_PKA_1	597	603	PF00069	0.581
MOD_PKA_2	224	230	PF00069	0.450
MOD_PKA_2	421	427	PF00069	0.373
MOD_PKA_2	484	490	PF00069	0.561
MOD_PKA_2	566	572	PF00069	0.441
MOD_PKA_2	597	603	PF00069	0.686
MOD_PKA_2	716	722	PF00069	0.529
MOD_Plk_1	300	306	PF00069	0.479
MOD_Plk_1	453	459	PF00069	0.517
MOD_Plk_2-3	375	381	PF00069	0.274
MOD_Plk_4	291	297	PF00069	0.394
MOD_Plk_4	302	308	PF00069	0.394
MOD_Plk_4	37	43	PF00069	0.500
MOD_Plk_4	401	407	PF00069	0.481
MOD_Plk_4	578	584	PF00069	0.357
MOD_Plk_4	70	76	PF00069	0.595
MOD_Plk_4	81	87	PF00069	0.518
MOD_ProDKin_1	158	164	PF00069	0.507
MOD_ProDKin_1	195	201	PF00069	0.314
MOD_ProDKin_1	688	694	PF00069	0.411
MOD_SUMO_for_1	209	212	PF00179	0.311
MOD_SUMO_rev_2	274	280	PF00179	0.546
TRG_DiLeu_BaEn_1	185	190	PF01217	0.402
TRG_DiLeu_BaEn_1	578	583	PF01217	0.516
TRG_DiLeu_BaEn_2	389	395	PF01217	0.323
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.523
TRG_DiLeu_LyEn_5	185	190	PF01217	0.387
TRG_ENDOCYTIC_2	368	371	PF00928	0.299
TRG_ENDOCYTIC_2	51	54	PF00928	0.432
TRG_ENDOCYTIC_2	57	60	PF00928	0.246
TRG_ENDOCYTIC_2	576	579	PF00928	0.389
TRG_ENDOCYTIC_2	590	593	PF00928	0.436
TRG_ER_diArg_1	186	189	PF00400	0.526
TRG_ER_diArg_1	230	233	PF00400	0.490
TRG_ER_diArg_1	313	316	PF00400	0.528
TRG_ER_diArg_1	412	414	PF00400	0.351
TRG_ER_diArg_1	570	573	PF00400	0.475
TRG_NES_CRM1_1	578	592	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P906	Leptomonas seymouri	31%	98%
A0A1X0NTT2	Trypanosomatidae	35%	100%
A0A3Q8IC80	Leishmania donovani	80%	100%
A0A3Q8IHZ0	Leishmania donovani	28%	100%
A0A422NUH1	Trypanosoma rangeli	32%	100%
A4HCE5	Leishmania braziliensis	64%	100%
A4HZW7	Leishmania infantum	99%	99%
A4IDZ9	Leishmania infantum	28%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
E9AVS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q0H4	Leishmania major	28%	100%
Q4QBQ3	Leishmania major	75%	100%
Q4QBQ4	Leishmania major	90%	99%
V5DMJ8	Trypanosoma cruzi	33%	100%