CRAL/TRIO domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC92_LEIDO

TriTrypDb:

LdBPK_150640.1 , LdCL_150011500 , LDHU3_15.0790

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IC92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.327
CLV_C14_Caspase3-7	392	396	PF00656	0.692
CLV_C14_Caspase3-7	440	444	PF00656	0.421
CLV_NRD_NRD_1	114	116	PF00675	0.461
CLV_NRD_NRD_1	255	257	PF00675	0.329
CLV_NRD_NRD_1	35	37	PF00675	0.389
CLV_NRD_NRD_1	510	512	PF00675	0.576
CLV_PCSK_KEX2_1	114	116	PF00082	0.461
CLV_PCSK_KEX2_1	196	198	PF00082	0.379
CLV_PCSK_KEX2_1	216	218	PF00082	0.180
CLV_PCSK_KEX2_1	255	257	PF00082	0.329
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.379
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.180
CLV_PCSK_SKI1_1	180	184	PF00082	0.509
CLV_PCSK_SKI1_1	314	318	PF00082	0.307
CLV_PCSK_SKI1_1	36	40	PF00082	0.386
CLV_PCSK_SKI1_1	365	369	PF00082	0.330
CLV_PCSK_SKI1_1	415	419	PF00082	0.622
CLV_PCSK_SKI1_1	507	511	PF00082	0.561
CLV_PCSK_SKI1_1	87	91	PF00082	0.446
DEG_APCC_DBOX_1	244	252	PF00400	0.307
DEG_APCC_DBOX_1	373	381	PF00400	0.304
DEG_SCF_FBW7_1	235	240	PF00400	0.307
DOC_CYCLIN_RxL_1	315	329	PF00134	0.379
DOC_MAPK_gen_1	114	120	PF00069	0.452
DOC_MAPK_gen_1	196	202	PF00069	0.379
DOC_MAPK_gen_1	314	325	PF00069	0.379
DOC_MAPK_gen_1	36	42	PF00069	0.378
DOC_MAPK_gen_1	87	95	PF00069	0.416
DOC_PP2B_LxvP_1	93	96	PF13499	0.457
DOC_SPAK_OSR1_1	109	113	PF12202	0.345
DOC_USP7_UBL2_3	314	318	PF12436	0.307
DOC_WW_Pin1_4	168	173	PF00397	0.534
DOC_WW_Pin1_4	233	238	PF00397	0.343
DOC_WW_Pin1_4	441	446	PF00397	0.491
DOC_WW_Pin1_4	448	453	PF00397	0.555
LIG_14-3-3_CanoR_1	321	326	PF00244	0.379
LIG_14-3-3_CanoR_1	374	378	PF00244	0.304
LIG_14-3-3_CanoR_1	438	442	PF00244	0.398
LIG_Actin_RPEL_3	107	126	PF02755	0.355
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_BRCT_BRCA1_1	443	447	PF00533	0.515
LIG_CtBP_PxDLS_1	332	336	PF00389	0.317
LIG_CtBP_PxDLS_1	78	82	PF00389	0.482
LIG_deltaCOP1_diTrp_1	496	501	PF00928	0.523
LIG_FHA_1	120	126	PF00498	0.420
LIG_FHA_1	177	183	PF00498	0.548
LIG_FHA_1	293	299	PF00498	0.307
LIG_FHA_2	280	286	PF00498	0.310
LIG_FHA_2	374	380	PF00498	0.360
LIG_FHA_2	438	444	PF00498	0.412
LIG_FHA_2	80	86	PF00498	0.533
LIG_LIR_Gen_1	231	239	PF02991	0.329
LIG_LIR_Gen_1	496	504	PF02991	0.498
LIG_LIR_Nem_3	105	111	PF02991	0.332
LIG_LIR_Nem_3	147	153	PF02991	0.433
LIG_LIR_Nem_3	215	221	PF02991	0.307
LIG_LIR_Nem_3	231	235	PF02991	0.307
LIG_LIR_Nem_3	236	242	PF02991	0.304
LIG_LIR_Nem_3	496	501	PF02991	0.548
LIG_MYND_1	356	360	PF01753	0.307
LIG_MYND_1	475	479	PF01753	0.482
LIG_Pex14_2	347	351	PF04695	0.307
LIG_Pex14_2	430	434	PF04695	0.387
LIG_PTB_Apo_2	226	233	PF02174	0.285
LIG_PTB_Apo_2	339	346	PF02174	0.307
LIG_PTB_Apo_2	456	463	PF02174	0.518
LIG_PTB_Phospho_1	456	462	PF10480	0.490
LIG_REV1ctd_RIR_1	348	355	PF16727	0.267
LIG_SH2_CRK	108	112	PF00017	0.335
LIG_SH2_CRK	203	207	PF00017	0.307
LIG_SH2_CRK	239	243	PF00017	0.384
LIG_SH2_GRB2like	239	242	PF00017	0.307
LIG_SH2_SRC	220	223	PF00017	0.379
LIG_SH2_STAP1	11	15	PF00017	0.473
LIG_SH2_STAP1	239	243	PF00017	0.307
LIG_SH2_STAT3	263	266	PF00017	0.285
LIG_SH2_STAT5	128	131	PF00017	0.348
LIG_SH2_STAT5	220	223	PF00017	0.307
LIG_SH2_STAT5	247	250	PF00017	0.307
LIG_SH2_STAT5	267	270	PF00017	0.229
LIG_SH2_STAT5	425	428	PF00017	0.396
LIG_SH3_3	232	238	PF00018	0.379
LIG_SH3_3	439	445	PF00018	0.551
LIG_SH3_3	53	59	PF00018	0.482
LIG_SH3_3	72	78	PF00018	0.418
LIG_SUMO_SIM_par_1	295	302	PF11976	0.307
LIG_SUMO_SIM_par_1	321	326	PF11976	0.329
LIG_SUMO_SIM_par_1	365	370	PF11976	0.323
LIG_TYR_ITIM	106	111	PF00017	0.404
LIG_UBA3_1	125	134	PF00899	0.360
LIG_UBA3_1	92	100	PF00899	0.459
MOD_CDC14_SPxK_1	451	454	PF00782	0.549
MOD_CDK_SPxK_1	448	454	PF00069	0.521
MOD_CDK_SPxxK_3	168	175	PF00069	0.541
MOD_CK1_1	136	142	PF00069	0.407
MOD_CK1_1	283	289	PF00069	0.358
MOD_CK1_1	306	312	PF00069	0.385
MOD_CK1_1	381	387	PF00069	0.610
MOD_CK1_1	390	396	PF00069	0.608
MOD_CK2_1	373	379	PF00069	0.403
MOD_CK2_1	452	458	PF00069	0.537
MOD_CMANNOS	187	190	PF00535	0.388
MOD_Cter_Amidation	253	256	PF01082	0.307
MOD_GlcNHglycan	369	372	PF01048	0.296
MOD_GlcNHglycan	71	74	PF01048	0.644
MOD_GSK3_1	233	240	PF00069	0.307
MOD_GSK3_1	279	286	PF00069	0.362
MOD_GSK3_1	299	306	PF00069	0.265
MOD_GSK3_1	381	388	PF00069	0.595
MOD_GSK3_1	437	444	PF00069	0.468
MOD_GSK3_1	448	455	PF00069	0.500
MOD_GSK3_1	65	72	PF00069	0.589
MOD_N-GLC_1	16	21	PF02516	0.463
MOD_N-GLC_1	333	338	PF02516	0.317
MOD_N-GLC_1	393	398	PF02516	0.666
MOD_N-GLC_1	79	84	PF02516	0.468
MOD_NEK2_1	308	313	PF00069	0.287
MOD_NEK2_1	323	328	PF00069	0.346
MOD_PIKK_1	359	365	PF00454	0.319
MOD_PIKK_1	385	391	PF00454	0.615
MOD_PKA_1	255	261	PF00069	0.316
MOD_PKA_2	255	261	PF00069	0.316
MOD_PKA_2	373	379	PF00069	0.321
MOD_PKA_2	437	443	PF00069	0.397
MOD_Plk_1	333	339	PF00069	0.317
MOD_Plk_1	505	511	PF00069	0.550
MOD_Plk_1	79	85	PF00069	0.461
MOD_Plk_2-3	133	139	PF00069	0.389
MOD_Plk_2-3	79	85	PF00069	0.556
MOD_Plk_4	136	142	PF00069	0.450
MOD_Plk_4	283	289	PF00069	0.329
MOD_Plk_4	326	332	PF00069	0.362
MOD_Plk_4	430	436	PF00069	0.415
MOD_Plk_4	437	443	PF00069	0.457
MOD_ProDKin_1	168	174	PF00069	0.538
MOD_ProDKin_1	233	239	PF00069	0.343
MOD_ProDKin_1	441	447	PF00069	0.500
MOD_ProDKin_1	448	454	PF00069	0.556
MOD_SUMO_rev_2	25	34	PF00179	0.405
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.465
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.307
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.363
TRG_ENDOCYTIC_2	108	111	PF00928	0.331
TRG_ENDOCYTIC_2	128	131	PF00928	0.221
TRG_ENDOCYTIC_2	239	242	PF00928	0.307
TRG_ER_diArg_1	114	116	PF00400	0.461
TRG_ER_diArg_1	255	257	PF00400	0.307
TRG_ER_diArg_1	469	472	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.712
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ3	Leptomonas seymouri	67%	100%
A4H834	Leishmania braziliensis	79%	100%
E9AQ59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFC4	Leishmania major	96%	100%