DUF5353 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IC90_LEIDO

TriTrypDb:

LdBPK_220900.1 , LdCL_220016400 , LDHU3_22.1410

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	3

Expansion

Sequence features

A0A3Q8IC90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.493
CLV_NRD_NRD_1	121	123	PF00675	0.454
CLV_NRD_NRD_1	196	198	PF00675	0.598
CLV_NRD_NRD_1	74	76	PF00675	0.619
CLV_PCSK_KEX2_1	222	224	PF00082	0.488
CLV_PCSK_KEX2_1	74	76	PF00082	0.638
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.513
CLV_PCSK_SKI1_1	144	148	PF00082	0.536
CLV_PCSK_SKI1_1	197	201	PF00082	0.452
CLV_PCSK_SKI1_1	222	226	PF00082	0.524
DOC_CYCLIN_RxL_1	139	149	PF00134	0.485
DOC_PP1_RVXF_1	220	227	PF00149	0.606
DOC_USP7_MATH_1	173	177	PF00917	0.610
DOC_USP7_MATH_1	204	208	PF00917	0.501
DOC_WW_Pin1_4	153	158	PF00397	0.546
DOC_WW_Pin1_4	36	41	PF00397	0.586
LIG_14-3-3_CanoR_1	74	79	PF00244	0.523
LIG_FHA_1	111	117	PF00498	0.436
LIG_FHA_1	136	142	PF00498	0.719
LIG_FHA_1	200	206	PF00498	0.555
LIG_FHA_1	241	247	PF00498	0.545
LIG_FHA_2	170	176	PF00498	0.516
LIG_FHA_2	42	48	PF00498	0.631
LIG_FHA_2	75	81	PF00498	0.399
LIG_LIR_Gen_1	172	181	PF02991	0.445
LIG_LIR_Gen_1	207	215	PF02991	0.424
LIG_LIR_Nem_3	172	177	PF02991	0.438
LIG_LIR_Nem_3	214	218	PF02991	0.526
LIG_LIR_Nem_3	230	235	PF02991	0.382
LIG_LIR_Nem_3	89	93	PF02991	0.459
LIG_NRBOX	245	251	PF00104	0.480
LIG_SH2_CRK	174	178	PF00017	0.438
LIG_SH2_CRK	247	251	PF00017	0.433
LIG_SH2_CRK	30	34	PF00017	0.474
LIG_SH2_SRC	78	81	PF00017	0.568
LIG_SH2_STAP1	229	233	PF00017	0.486
LIG_SH2_STAT5	124	127	PF00017	0.573
LIG_SH2_STAT5	241	244	PF00017	0.487
LIG_SH2_STAT5	88	91	PF00017	0.457
LIG_SH3_3	165	171	PF00018	0.503
LIG_SUMO_SIM_anti_2	100	107	PF11976	0.457
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.610
LIG_SUMO_SIM_par_1	113	121	PF11976	0.507
LIG_SUMO_SIM_par_1	143	149	PF11976	0.544
LIG_ULM_U2AF65_1	222	227	PF00076	0.612
LIG_WRC_WIRS_1	212	217	PF05994	0.558
MOD_CDK_SPxK_1	157	163	PF00069	0.533
MOD_CK1_1	101	107	PF00069	0.580
MOD_CK1_1	128	134	PF00069	0.689
MOD_CK1_1	176	182	PF00069	0.670
MOD_CK1_1	6	12	PF00069	0.616
MOD_CK2_1	137	143	PF00069	0.574
MOD_CK2_1	41	47	PF00069	0.587
MOD_GlcNHglycan	100	103	PF01048	0.492
MOD_GlcNHglycan	178	181	PF01048	0.679
MOD_GlcNHglycan	183	186	PF01048	0.696
MOD_GlcNHglycan	6	9	PF01048	0.674
MOD_GlcNHglycan	90	93	PF01048	0.466
MOD_GSK3_1	107	114	PF00069	0.421
MOD_GSK3_1	125	132	PF00069	0.552
MOD_GSK3_1	133	140	PF00069	0.502
MOD_GSK3_1	153	160	PF00069	0.692
MOD_GSK3_1	169	176	PF00069	0.504
MOD_GSK3_1	97	104	PF00069	0.495
MOD_N-GLC_1	153	158	PF02516	0.648
MOD_NEK2_1	125	130	PF00069	0.659
MOD_NEK2_1	133	138	PF00069	0.502
MOD_NEK2_1	211	216	PF00069	0.446
MOD_NEK2_1	4	9	PF00069	0.583
MOD_NEK2_1	69	74	PF00069	0.504
MOD_PIKK_1	133	139	PF00454	0.459
MOD_PIKK_1	199	205	PF00454	0.551
MOD_PKA_1	74	80	PF00069	0.514
MOD_PKA_2	4	10	PF00069	0.574
MOD_PKA_2	74	80	PF00069	0.514
MOD_Plk_4	101	107	PF00069	0.468
MOD_Plk_4	111	117	PF00069	0.419
MOD_Plk_4	204	210	PF00069	0.409
MOD_Plk_4	228	234	PF00069	0.468
MOD_ProDKin_1	153	159	PF00069	0.545
MOD_ProDKin_1	36	42	PF00069	0.583
MOD_SUMO_rev_2	118	125	PF00179	0.515
TRG_DiLeu_BaEn_1	143	148	PF01217	0.541
TRG_DiLeu_BaEn_1	47	52	PF01217	0.607
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.494
TRG_ENDOCYTIC_2	174	177	PF00928	0.432
TRG_ENDOCYTIC_2	247	250	PF00928	0.478
TRG_NLS_MonoExtN_4	219	226	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E4	Leptomonas seymouri	57%	100%
A0A1X0NTC5	Trypanosomatidae	38%	100%
A0A3R7NDY8	Trypanosoma rangeli	36%	100%
A4HCE9	Leishmania braziliensis	81%	100%
A4HZY0	Leishmania infantum	99%	100%
C9ZSL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AVU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QBN9	Leishmania major	92%	100%
V5BVV8	Trypanosoma cruzi	35%	100%