Flagellar_protofilament_ribbon_protein-like_prote in/GeneDB:LmjF.10.1190

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar protofilament ribbon protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IC89_LEIDO

TriTrypDb:

LdBPK_101280.1 , LdCL_100019800 , LDHU3_10.1640

Length:

397

Annotations

Annotations by Jardim et al.

Flagella, Flagellar protofilament ribbon -like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3Q8IC89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.715
CLV_C14_Caspase3-7	65	69	PF00656	0.383
CLV_NRD_NRD_1	141	143	PF00675	0.311
CLV_NRD_NRD_1	174	176	PF00675	0.240
CLV_NRD_NRD_1	229	231	PF00675	0.286
CLV_NRD_NRD_1	248	250	PF00675	0.238
CLV_NRD_NRD_1	319	321	PF00675	0.267
CLV_NRD_NRD_1	352	354	PF00675	0.253
CLV_NRD_NRD_1	372	374	PF00675	0.117
CLV_NRD_NRD_1	57	59	PF00675	0.371
CLV_NRD_NRD_1	78	80	PF00675	0.249
CLV_PCSK_FUR_1	317	321	PF00082	0.272
CLV_PCSK_FUR_1	350	354	PF00082	0.253
CLV_PCSK_KEX2_1	141	143	PF00082	0.311
CLV_PCSK_KEX2_1	174	176	PF00082	0.238
CLV_PCSK_KEX2_1	229	231	PF00082	0.286
CLV_PCSK_KEX2_1	248	250	PF00082	0.238
CLV_PCSK_KEX2_1	317	319	PF00082	0.264
CLV_PCSK_KEX2_1	352	354	PF00082	0.253
CLV_PCSK_KEX2_1	372	374	PF00082	0.117
CLV_PCSK_KEX2_1	78	80	PF00082	0.249
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.182
CLV_PCSK_PC7_1	314	320	PF00082	0.301
CLV_PCSK_PC7_1	348	354	PF00082	0.253
CLV_PCSK_SKI1_1	193	197	PF00082	0.238
CLV_PCSK_SKI1_1	302	306	PF00082	0.305
CLV_PCSK_SKI1_1	319	323	PF00082	0.151
CLV_PCSK_SKI1_1	41	45	PF00082	0.253
CLV_PCSK_SKI1_1	64	68	PF00082	0.300
CLV_PCSK_SKI1_1	74	78	PF00082	0.306
CLV_PCSK_SKI1_1	90	94	PF00082	0.253
DEG_APCC_DBOX_1	259	267	PF00400	0.253
DEG_APCC_DBOX_1	317	325	PF00400	0.272
DOC_CYCLIN_RxL_1	314	326	PF00134	0.261
DOC_MAPK_gen_1	314	324	PF00069	0.268
DOC_MAPK_gen_1	53	62	PF00069	0.253
DOC_USP7_MATH_1	20	24	PF00917	0.555
DOC_USP7_MATH_1	29	33	PF00917	0.539
DOC_USP7_UBL2_3	193	197	PF12436	0.238
LIG_14-3-3_CanoR_1	121	125	PF00244	0.332
LIG_14-3-3_CanoR_1	328	333	PF00244	0.237
LIG_Clathr_ClatBox_1	321	325	PF01394	0.272
LIG_eIF4E_1	88	94	PF01652	0.332
LIG_Integrin_isoDGR_2	15	17	PF01839	0.464
LIG_LIR_Nem_3	386	392	PF02991	0.272
LIG_SH2_STAP1	88	92	PF00017	0.332
LIG_SH2_STAT3	88	91	PF00017	0.332
LIG_SH2_STAT5	389	392	PF00017	0.272
LIG_SUMO_SIM_par_1	320	326	PF11976	0.272
LIG_TRAF2_1	254	257	PF00917	0.324
LIG_TRAF2_1	331	334	PF00917	0.332
LIG_TRAF2_1	4	7	PF00917	0.469
MOD_CK2_1	328	334	PF00069	0.303
MOD_GlcNHglycan	11	14	PF01048	0.603
MOD_GlcNHglycan	2	5	PF01048	0.564
MOD_GlcNHglycan	29	32	PF01048	0.700
MOD_NEK2_1	285	290	PF00069	0.366
MOD_NEK2_1	359	364	PF00069	0.383
MOD_PKA_2	120	126	PF00069	0.246
MOD_PKA_2	277	283	PF00069	0.383
MOD_Plk_1	256	262	PF00069	0.303
MOD_Plk_4	277	283	PF00069	0.253
MOD_Plk_4	285	291	PF00069	0.253
MOD_Plk_4	300	306	PF00069	0.147
MOD_SUMO_for_1	254	257	PF00179	0.365
MOD_SUMO_rev_2	220	226	PF00179	0.303
MOD_SUMO_rev_2	50	57	PF00179	0.272
TRG_DiLeu_BaEn_1	227	232	PF01217	0.383
TRG_DiLeu_BaEn_4	256	262	PF01217	0.383
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.272
TRG_ENDOCYTIC_2	294	297	PF00928	0.253
TRG_ER_diArg_1	229	231	PF00400	0.286
TRG_ER_diArg_1	316	319	PF00400	0.239
TRG_ER_diArg_1	77	79	PF00400	0.249
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.203
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL07	Leptomonas seymouri	80%	100%
A0A0S4INL6	Bodo saltans	53%	100%
A0A1X0NQD2	Trypanosomatidae	69%	100%
A0A3R7KAZ0	Trypanosoma rangeli	68%	100%
A4H6A7	Leishmania braziliensis	91%	100%
A4HUN1	Leishmania infantum	100%	100%
C9ZVR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ANC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q0VC09	Bos taurus	28%	100%
Q32LJ7	Bos taurus	28%	100%
Q4QH95	Leishmania major	97%	100%
Q6AXN9	Rattus norvegicus	30%	100%
Q6AYL4	Rattus norvegicus	29%	100%
Q9D0B8	Mus musculus	30%	100%
Q9D4Q1	Mus musculus	31%	100%
Q9H4K1	Homo sapiens	30%	100%
V5BPA3	Trypanosoma cruzi	67%	100%