Serine/threonine protein kinase sos2, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC87_LEIDO

TriTrypDb:

LdBPK_220630.1 , LdCL_220013600 , LDHU3_22.1060

Length:

371

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IC87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC87

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.486
CLV_NRD_NRD_1	279	281	PF00675	0.604
CLV_NRD_NRD_1	312	314	PF00675	0.747
CLV_NRD_NRD_1	57	59	PF00675	0.301
CLV_PCSK_KEX2_1	2	4	PF00082	0.488
CLV_PCSK_KEX2_1	22	24	PF00082	0.117
CLV_PCSK_KEX2_1	266	268	PF00082	0.467
CLV_PCSK_KEX2_1	312	314	PF00082	0.680
CLV_PCSK_KEX2_1	57	59	PF00082	0.316
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.334
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.467
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.737
CLV_PCSK_SKI1_1	127	131	PF00082	0.300
CLV_PCSK_SKI1_1	243	247	PF00082	0.316
CLV_PCSK_SKI1_1	57	61	PF00082	0.341
DEG_APCC_DBOX_1	252	260	PF00400	0.300
DEG_Nend_UBRbox_1	1	4	PF02207	0.484
DEG_SPOP_SBC_1	336	340	PF00917	0.768
DOC_CYCLIN_RxL_1	239	247	PF00134	0.421
DOC_CYCLIN_yClb5_NLxxxL_5	239	245	PF00134	0.446
DOC_MAPK_gen_1	127	136	PF00069	0.300
DOC_MAPK_gen_1	221	229	PF00069	0.446
DOC_MAPK_gen_1	57	67	PF00069	0.288
DOC_MAPK_JIP1_4	130	136	PF00069	0.316
DOC_PP1_SILK_1	53	58	PF00149	0.282
DOC_USP7_MATH_1	208	212	PF00917	0.365
DOC_USP7_MATH_1	328	332	PF00917	0.769
DOC_USP7_MATH_1	336	340	PF00917	0.750
DOC_USP7_UBL2_3	239	243	PF12436	0.421
DOC_USP7_UBL2_3	36	40	PF12436	0.300
DOC_WW_Pin1_4	244	249	PF00397	0.455
DOC_WW_Pin1_4	279	284	PF00397	0.661
DOC_WW_Pin1_4	302	307	PF00397	0.716
DOC_WW_Pin1_4	324	329	PF00397	0.759
LIG_14-3-3_CanoR_1	275	283	PF00244	0.653
LIG_Actin_WH2_2	262	277	PF00022	0.551
LIG_FHA_1	136	142	PF00498	0.427
LIG_FHA_1	168	174	PF00498	0.300
LIG_FHA_2	356	362	PF00498	0.735
LIG_IRF3_LxIS_1	49	54	PF10401	0.385
LIG_LIR_Apic_2	172	178	PF02991	0.297
LIG_LIR_Gen_1	15	24	PF02991	0.289
LIG_LIR_Gen_1	184	192	PF02991	0.339
LIG_LIR_Gen_1	272	278	PF02991	0.565
LIG_LIR_Gen_1	6	13	PF02991	0.306
LIG_LIR_Nem_3	15	21	PF02991	0.289
LIG_LIR_Nem_3	184	188	PF02991	0.339
LIG_LIR_Nem_3	263	268	PF02991	0.511
LIG_LIR_Nem_3	6	10	PF02991	0.306
LIG_LIR_Nem_3	74	80	PF02991	0.360
LIG_REV1ctd_RIR_1	262	269	PF16727	0.456
LIG_SH2_CRK	18	22	PF00017	0.385
LIG_SH2_PTP2	200	203	PF00017	0.316
LIG_SH2_PTP2	78	81	PF00017	0.286
LIG_SH2_SRC	268	271	PF00017	0.545
LIG_SH2_STAP1	165	169	PF00017	0.316
LIG_SH2_STAT5	175	178	PF00017	0.297
LIG_SH2_STAT5	200	203	PF00017	0.300
LIG_SH2_STAT5	268	271	PF00017	0.492
LIG_SH2_STAT5	273	276	PF00017	0.513
LIG_SH2_STAT5	367	370	PF00017	0.691
LIG_SH2_STAT5	78	81	PF00017	0.286
LIG_SUMO_SIM_anti_2	226	233	PF11976	0.446
LIG_SUMO_SIM_anti_2	52	57	PF11976	0.300
LIG_SUMO_SIM_anti_2	8	15	PF11976	0.421
LIG_SUMO_SIM_par_1	66	74	PF11976	0.298
LIG_TYR_ITIM	198	203	PF00017	0.300
LIG_UBA3_1	55	62	PF00899	0.327
MOD_CDK_SPK_2	244	249	PF00069	0.384
MOD_CK1_1	232	238	PF00069	0.446
MOD_CK1_1	305	311	PF00069	0.722
MOD_CK1_1	340	346	PF00069	0.702
MOD_CK1_1	355	361	PF00069	0.728
MOD_CK2_1	158	164	PF00069	0.421
MOD_CK2_1	355	361	PF00069	0.756
MOD_GlcNHglycan	234	237	PF01048	0.394
MOD_GlcNHglycan	309	312	PF01048	0.760
MOD_GlcNHglycan	319	322	PF01048	0.737
MOD_GlcNHglycan	328	331	PF01048	0.589
MOD_GlcNHglycan	345	348	PF01048	0.583
MOD_GlcNHglycan	360	364	PF01048	0.541
MOD_GSK3_1	165	172	PF00069	0.300
MOD_GSK3_1	225	232	PF00069	0.446
MOD_GSK3_1	300	307	PF00069	0.657
MOD_GSK3_1	319	326	PF00069	0.750
MOD_GSK3_1	336	343	PF00069	0.686
MOD_GSK3_1	355	362	PF00069	0.492
MOD_LATS_1	317	323	PF00433	0.673
MOD_N-GLC_1	340	345	PF02516	0.767
MOD_N-GLC_2	240	242	PF02516	0.446
MOD_NEK2_1	147	152	PF00069	0.300
MOD_NEK2_1	158	163	PF00069	0.300
MOD_NEK2_1	169	174	PF00069	0.243
MOD_NEK2_1	274	279	PF00069	0.512
MOD_NEK2_1	51	56	PF00069	0.357
MOD_NEK2_1	71	76	PF00069	0.117
MOD_PIKK_1	201	207	PF00454	0.421
MOD_PIKK_1	292	298	PF00454	0.660
MOD_PIKK_1	355	361	PF00454	0.739
MOD_PKA_2	153	159	PF00069	0.385
MOD_PKA_2	252	258	PF00069	0.300
MOD_PKA_2	274	280	PF00069	0.614
MOD_PKA_2	341	347	PF00069	0.781
MOD_Plk_1	225	231	PF00069	0.456
MOD_Plk_1	51	57	PF00069	0.289
MOD_Plk_2-3	252	258	PF00069	0.334
MOD_Plk_4	225	231	PF00069	0.456
MOD_ProDKin_1	244	250	PF00069	0.455
MOD_ProDKin_1	279	285	PF00069	0.666
MOD_ProDKin_1	302	308	PF00069	0.719
MOD_ProDKin_1	324	330	PF00069	0.759
MOD_SUMO_for_1	129	132	PF00179	0.316
MOD_SUMO_rev_2	232	241	PF00179	0.358
TRG_ENDOCYTIC_2	18	21	PF00928	0.316
TRG_ENDOCYTIC_2	185	188	PF00928	0.300
TRG_ENDOCYTIC_2	200	203	PF00928	0.295
TRG_ENDOCYTIC_2	273	276	PF00928	0.535
TRG_ENDOCYTIC_2	7	10	PF00928	0.316
TRG_ENDOCYTIC_2	77	80	PF00928	0.287
TRG_ER_diArg_1	1	3	PF00400	0.535
TRG_ER_diArg_1	220	223	PF00400	0.378
TRG_ER_diArg_1	56	58	PF00400	0.316
TRG_NLS_MonoExtN_4	20	26	PF00514	0.357
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N5	Leptomonas seymouri	28%	86%
A0A0N0P6T0	Leptomonas seymouri	27%	68%
A0A0N0P787	Leptomonas seymouri	27%	96%
A0A0N0P8H5	Leptomonas seymouri	32%	100%
A0A0N1HY86	Leptomonas seymouri	28%	71%
A0A0N1I6T8	Leptomonas seymouri	38%	100%
A0A0N1IIF9	Leptomonas seymouri	40%	100%
A0A0N1IM47	Leptomonas seymouri	31%	100%
A0A0N1PC31	Leptomonas seymouri	29%	95%
A0A0N1PC32	Leptomonas seymouri	33%	95%
A0A0N1PD05	Leptomonas seymouri	29%	83%
A0A0N1PDW7	Leptomonas seymouri	80%	94%
A0A0N1PEV2	Leptomonas seymouri	29%	69%
A0A0S4IKH2	Bodo saltans	28%	75%
A0A0S4IMB7	Bodo saltans	29%	84%
A0A0S4IQ75	Bodo saltans	31%	74%
A0A0S4IRZ7	Bodo saltans	28%	75%
A0A0S4IV16	Bodo saltans	30%	97%
A0A0S4IX86	Bodo saltans	28%	86%
A0A0S4IYA6	Bodo saltans	28%	100%
A0A0S4IZY3	Bodo saltans	30%	100%
A0A0S4J3Y5	Bodo saltans	33%	86%
A0A0S4J4B3	Bodo saltans	36%	83%
A0A0S4J4X4	Bodo saltans	32%	100%
A0A0S4J6L4	Bodo saltans	31%	97%
A0A0S4J7K4	Bodo saltans	30%	76%
A0A0S4J842	Bodo saltans	27%	69%
A0A0S4J8J4	Bodo saltans	28%	100%
A0A0S4JA09	Bodo saltans	30%	90%
A0A0S4JBR3	Bodo saltans	29%	100%
A0A0S4JCG2	Bodo saltans	36%	83%
A0A0S4JER5	Bodo saltans	30%	82%
A0A0S4JI67	Bodo saltans	26%	81%
A0A0S4JK24	Bodo saltans	26%	85%
A0A0S4JNA1	Bodo saltans	28%	75%
A0A0S4JPZ1	Bodo saltans	29%	83%
A0A0S4JTJ8	Bodo saltans	30%	81%
A0A0S4JUJ2	Bodo saltans	31%	100%
A0A0S4JWD5	Bodo saltans	31%	95%
A0A0S4KFT7	Bodo saltans	31%	100%
A0A0S4KHR9	Bodo saltans	27%	100%
A0A0S4KMV7	Bodo saltans	62%	100%
A0A0S4KN74	Bodo saltans	28%	100%
A0A1X0NF53	Trypanosomatidae	27%	80%
A0A1X0NIA0	Trypanosomatidae	26%	86%
A0A1X0NIX2	Trypanosomatidae	30%	85%
A0A1X0NJV4	Trypanosomatidae	29%	72%
A0A1X0NKA1	Trypanosomatidae	30%	84%
A0A1X0NLC8	Trypanosomatidae	30%	78%
A0A1X0NM94	Trypanosomatidae	29%	73%
A0A1X0NQ63	Trypanosomatidae	40%	100%
A0A1X0NRF6	Trypanosomatidae	32%	68%
A0A1X0NTR6	Trypanosomatidae	66%	100%
A0A1X0NUQ4	Trypanosomatidae	27%	98%
A0A1X0NW24	Trypanosomatidae	27%	100%
A0A1X0NY93	Trypanosomatidae	29%	95%
A0A1X0NYK8	Trypanosomatidae	30%	100%
A0A1X0P1A2	Trypanosomatidae	29%	80%
A0A1X0P4Z7	Trypanosomatidae	27%	67%
A0A1X0P527	Trypanosomatidae	30%	84%
A0A1X0P549	Trypanosomatidae	28%	78%
A0A1X0P5B1	Trypanosomatidae	31%	100%
A0A1X0P5F2	Trypanosomatidae	30%	100%
A0A1X0P5U3	Trypanosomatidae	26%	72%
A0A1X0P692	Trypanosomatidae	30%	100%
A0A1X0P6E7	Trypanosomatidae	28%	95%
A0A1X0P6V1	Trypanosomatidae	39%	100%
A0A1X0P735	Trypanosomatidae	40%	100%
A0A1X0P7V0	Trypanosomatidae	32%	100%
A0A1X0P8F7	Trypanosomatidae	24%	85%
A0A1X0P9C4	Trypanosomatidae	29%	74%
A0A2I0BVG8	Plasmodium falciparum (isolate NF54)	31%	71%
A0A3Q8IAQ1	Leishmania donovani	30%	100%
A0A3Q8IB30	Leishmania donovani	32%	100%
A0A3Q8IDK8	Leishmania donovani	33%	66%
A0A3Q8IFK8	Leishmania donovani	31%	84%
A0A3Q8IFW0	Leishmania donovani	27%	86%
A0A3Q8IHH8	Leishmania donovani	27%	74%
A0A3Q8IIG1	Leishmania donovani	30%	100%
A0A3Q8IIH5	Leishmania donovani	30%	67%
A0A3Q8IJ66	Leishmania donovani	23%	99%
A0A3Q8IJM9	Leishmania donovani	30%	78%
A0A3Q8INQ4	Leishmania donovani	28%	95%
A0A3Q8INS5	Leishmania donovani	29%	100%
A0A3Q8IPR6	Leishmania donovani	28%	100%
A0A3Q8IRT6	Leishmania donovani	28%	73%
A0A3R7K5P9	Trypanosoma rangeli	65%	99%
A0A3R7KCZ4	Trypanosoma rangeli	28%	92%
A0A3R7KRP1	Trypanosoma rangeli	30%	78%
A0A3R7LT21	Trypanosoma rangeli	32%	67%
A0A3R7M5C7	Trypanosoma rangeli	38%	100%
A0A3R7MHW5	Trypanosoma rangeli	28%	93%
A0A3R7MKG5	Trypanosoma rangeli	29%	84%
A0A3R7N4D8	Trypanosoma rangeli	29%	92%
A0A3R7N5S4	Trypanosoma rangeli	28%	98%
A0A3R7NKI8	Trypanosoma rangeli	28%	100%
A0A3R7RIN5	Trypanosoma rangeli	28%	74%
A0A3S5H5G0	Leishmania donovani	27%	100%
A0A3S5H5U5	Leishmania donovani	26%	100%
A0A3S5H606	Leishmania donovani	38%	100%
A0A3S5H7M0	Leishmania donovani	29%	71%
A0A3S5IRC3	Trypanosoma rangeli	29%	99%
A0A3S7WTN9	Leishmania donovani	25%	96%
A0A3S7WUX5	Leishmania donovani	39%	100%
A0A3S7WVE9	Leishmania donovani	29%	100%
A0A3S7WWE7	Leishmania donovani	24%	100%
A0A3S7WYP4	Leishmania donovani	26%	100%
A0A3S7X2W9	Leishmania donovani	26%	100%
A0A3S7X6T8	Leishmania donovani	29%	83%
A0A3S7X7D5	Leishmania donovani	25%	100%
A0A3S7X9R4	Leishmania donovani	30%	100%
A0A3S7X9S2	Leishmania donovani	30%	100%
A0A3S7XA45	Leishmania donovani	32%	95%
A0A3S7XAX0	Leishmania donovani	29%	78%
A0A422N701	Trypanosoma rangeli	31%	83%
A0A422NUF0	Trypanosoma rangeli	27%	93%
A0A422P0J2	Trypanosoma rangeli	33%	100%
A0A422P0N6	Trypanosoma rangeli	28%	100%
A0A422P1R5	Trypanosoma rangeli	30%	100%
A0A509AHB6	Plasmodium berghei (strain Anka)	29%	71%
A0A509AQE6	Plasmodium berghei (strain Anka)	30%	66%
A0A8I3S724	Canis lupus familiaris	33%	92%
A0AUV4	Mus musculus	32%	73%
A2BD05	Sus scrofa	29%	100%
A2KF29	Mus musculus	30%	77%
A2XFF4	Oryza sativa subsp. indica	34%	73%
A2YNT8	Oryza sativa subsp. indica	33%	100%
A2ZAB5	Oryza sativa subsp. indica	32%	100%
A2ZVI7	Oryza sativa subsp. japonica	34%	72%
A3B529	Oryza sativa subsp. japonica	34%	85%
A4H459	Leishmania braziliensis	26%	100%
A4H4S9	Leishmania braziliensis	25%	100%
A4H539	Leishmania braziliensis	38%	100%
A4H7W1	Leishmania braziliensis	30%	68%
A4H8C4	Leishmania braziliensis	26%	100%
A4H9H4	Leishmania braziliensis	40%	100%
A4H9L8	Leishmania braziliensis	32%	100%
A4H9X2	Leishmania braziliensis	28%	100%
A4HA94	Leishmania braziliensis	26%	100%
A4HAC8	Leishmania braziliensis	25%	100%
A4HBL4	Leishmania braziliensis	22%	100%
A4HCD7	Leishmania braziliensis	92%	100%
A4HCE6	Leishmania braziliensis	31%	100%
A4HED7	Leishmania braziliensis	28%	100%
A4HEL2	Leishmania braziliensis	29%	100%
A4HFF3	Leishmania braziliensis	29%	74%
A4HFI2	Leishmania braziliensis	28%	100%
A4HG27	Leishmania braziliensis	33%	68%
A4HHQ5	Leishmania braziliensis	28%	73%
A4HHR5	Leishmania braziliensis	30%	72%
A4HI35	Leishmania braziliensis	28%	100%
A4HJT5	Leishmania braziliensis	30%	84%
A4HJW2	Leishmania braziliensis	26%	86%
A4HLR0	Leishmania braziliensis	30%	83%
A4HMD1	Leishmania braziliensis	23%	99%
A4HNG3	Leishmania braziliensis	31%	100%
A4HNI1	Leishmania braziliensis	32%	78%
A4HP12	Leishmania braziliensis	26%	73%
A4HSE2	Leishmania infantum	27%	100%
A4HTB4	Leishmania infantum	38%	100%
A4HW88	Leishmania infantum	30%	67%
A4HWP5	Leishmania infantum	25%	100%
A4HXU0	Leishmania infantum	39%	100%
A4HXY2	Leishmania infantum	32%	100%
A4HZA2	Leishmania infantum	24%	100%
A4HZV1	Leishmania infantum	100%	100%
A4HZW8	Leishmania infantum	30%	100%
A4I140	Leishmania infantum	26%	100%
A4I1T4	Leishmania infantum	28%	100%
A4I1U3	Leishmania infantum	29%	100%
A4I435	Leishmania infantum	30%	100%
A4I4X0	Leishmania infantum	27%	100%
A4I4X5	Leishmania infantum	29%	71%
A4I4Y0	Leishmania infantum	26%	100%
A4I5B1	Leishmania infantum	28%	100%
A4I7A1	Leishmania infantum	31%	84%
A4I7C4	Leishmania infantum	27%	100%
A4I960	Leishmania infantum	30%	83%
A4I9H1	Leishmania infantum	25%	100%
A4IAZ8	Leishmania infantum	23%	99%
A4IBT4	Leishmania infantum	31%	97%
A4IBT9	Leishmania infantum	31%	100%
A4IC37	Leishmania infantum	30%	78%
A4IC54	Leishmania infantum	32%	100%
A4IDC1	Leishmania infantum	26%	73%
A4IDK3	Leishmania infantum	29%	78%
A4IGM9	Xenopus tropicalis	31%	100%
A5GFW1	Sus scrofa	33%	92%
A8WXF6	Caenorhabditis briggsae	35%	70%
A8X6H4	Caenorhabditis briggsae	37%	100%
A9TF79	Physcomitrium patens	31%	100%
B8BBT7	Oryza sativa subsp. indica	34%	73%
C0HKC8	Mus musculus	32%	74%
C0HKC9	Mus musculus	32%	74%
C6K3W8	Leptomonas seymouri	31%	70%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	91%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	88%
C9ZMH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	84%
C9ZN29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	76%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	86%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	84%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	95%
C9ZYF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZYS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	93%
C9ZZX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZZX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A2M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A5Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A879	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	67%
D3ZBE5	Rattus norvegicus	30%	100%
D4AE59	Rattus norvegicus	31%	85%
E9ACW7	Leishmania major	31%	66%
E9AD33	Leishmania major	28%	100%
E9AEB9	Leishmania major	28%	74%
E9AEC9	Leishmania major	29%	71%
E9AED4	Leishmania major	26%	100%
E9AET0	Leishmania major	28%	100%
E9AFM1	Leishmania major	31%	100%
E9AFX4	Leishmania major	33%	100%
E9AG71	Leishmania infantum	26%	100%
E9AGR7	Leishmania infantum	29%	100%
E9AHC6	Leishmania infantum	28%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9ALF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ALF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	71%
E9ALG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	74%
E9APY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	67%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ARC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	67%
E9ARK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9ARW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	76%
E9ASS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	73%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AYV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AZF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	68%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	84%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	83%
E9B4G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B5Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	99%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B727	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B745	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	78%
G5EFM9	Caenorhabditis elegans	28%	100%
O01427	Caenorhabditis elegans	30%	100%
O08875	Rattus norvegicus	34%	86%
O13945	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	70%
O14408	Metarhizium anisopliae	33%	97%
O14965	Homo sapiens	33%	92%
O15865	Plasmodium falciparum (isolate K1 / Thailand)	35%	72%
O22932	Arabidopsis thaliana	38%	85%
O22971	Arabidopsis thaliana	36%	74%
O35942	Mus musculus	33%	84%
O43293	Homo sapiens	31%	82%
O54784	Mus musculus	30%	83%
O55099	Rattus norvegicus	34%	100%
O59697	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	88%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O61267	Drosophila melanogaster	34%	78%
O61661	Drosophila melanogaster	32%	72%
O64629	Arabidopsis thaliana	32%	100%
O65554	Arabidopsis thaliana	36%	84%
O70126	Mus musculus	35%	100%
O70150	Rattus norvegicus	34%	100%
O77708	Oryctolagus cuniculus	34%	70%
O80902	Arabidopsis thaliana	34%	86%
O88445	Mus musculus	33%	100%
O88764	Rattus norvegicus	30%	83%
O95747	Homo sapiens	29%	70%
O96017	Homo sapiens	33%	68%
P08413	Rattus norvegicus	34%	68%
P08414	Mus musculus	37%	79%
P0C5D6	Oryza sativa subsp. japonica	32%	100%
P11275	Rattus norvegicus	33%	78%
P11730	Rattus norvegicus	33%	70%
P11798	Mus musculus	33%	78%
P11801	Homo sapiens	33%	88%
P13234	Rattus norvegicus	37%	78%
P15735	Homo sapiens	32%	91%
P15791	Rattus norvegicus	34%	70%
P23443	Homo sapiens	29%	71%
P28178	Dictyostelium discoideum	30%	77%
P28652	Mus musculus	34%	68%
P42818	Arabidopsis thaliana	31%	80%
P43292	Arabidopsis thaliana	31%	100%
P51955	Homo sapiens	28%	83%
P51956	Homo sapiens	34%	73%
P53682	Oryza sativa subsp. japonica	34%	69%
P54644	Dictyostelium discoideum	32%	84%
P54645	Rattus norvegicus	32%	66%
P54646	Homo sapiens	34%	67%
P54666	Trypanosoma brucei brucei	31%	100%
P59241	Rattus norvegicus	32%	93%
P59895	Rattus norvegicus	29%	100%
P62343	Plasmodium falciparum (isolate K1 / Thailand)	31%	71%
P62344	Plasmodium falciparum (isolate 3D7)	31%	71%
P62345	Plasmodium berghei (strain Anka)	32%	70%
P67998	Oryctolagus cuniculus	29%	71%
P67999	Rattus norvegicus	29%	71%
P92937	Arabidopsis thaliana	39%	88%
P92958	Arabidopsis thaliana	37%	72%
P97477	Mus musculus	32%	94%
Q00168	Drosophila melanogaster	35%	70%
Q02066	Triticum aestivum	32%	100%
Q02723	Secale cereale	31%	74%
Q09137	Rattus norvegicus	34%	67%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	81%
Q0D4B2	Oryza sativa subsp. japonica	38%	71%
Q0D4J7	Oryza sativa subsp. japonica	33%	100%
Q0GGW5	Gallus gallus	31%	84%
Q0JI49	Oryza sativa subsp. japonica	36%	74%
Q0V7M1	Bos taurus	33%	88%
Q10LQ2	Oryza sativa subsp. japonica	35%	82%
Q10SC8	Oryza sativa subsp. japonica	39%	81%
Q13131	Homo sapiens	32%	66%
Q13555	Homo sapiens	33%	66%
Q13557	Homo sapiens	34%	74%
Q14012	Homo sapiens	35%	100%
Q15831	Homo sapiens	29%	86%
Q16566	Homo sapiens	36%	78%
Q27687	Leishmania major	32%	100%
Q28948	Sus scrofa	34%	67%
Q2HJF7	Bos taurus	34%	76%
Q2QMI0	Oryza sativa subsp. japonica	36%	82%
Q2QY37	Oryza sativa subsp. japonica	34%	69%
Q2QY53	Oryza sativa subsp. japonica	40%	85%
Q2QYM3	Oryza sativa subsp. japonica	36%	85%
Q2RAV0	Oryza sativa subsp. japonica	34%	69%
Q2RAX3	Oryza sativa subsp. japonica	40%	82%
Q2RBF0	Oryza sativa subsp. japonica	36%	85%
Q2TA06	Bos taurus	33%	92%
Q2V452	Arabidopsis thaliana	41%	84%
Q38997	Arabidopsis thaliana	36%	72%
Q39030	Arabidopsis thaliana	32%	79%
Q3MHJ9	Bos taurus	33%	68%
Q42396	Arabidopsis thaliana	34%	76%
Q42438	Arabidopsis thaliana	31%	70%
Q4KTY1	Pinctada fucata	32%	89%
Q4Q1J2	Leishmania major	29%	78%
Q4Q1S4	Leishmania major	27%	73%
Q4Q3K6	Leishmania major	25%	100%
Q4Q3Y9	Leishmania major	30%	83%
Q4Q5T9	Leishmania major	26%	86%
Q4Q5W2	Leishmania major	31%	84%
Q4Q7M5	Leishmania major	29%	100%
Q4Q7W2	Leishmania major	30%	100%
Q4Q9I7	Leishmania major	29%	100%
Q4Q9K2	Leishmania major	27%	100%
Q4QBQ2	Leishmania major	30%	100%
Q4QBR6	Leishmania major	98%	100%
Q4QCK0	Leishmania major	24%	100%
Q4QDK6	Leishmania major	28%	100%
Q4QDX7	Leishmania major	39%	100%
Q4QF23	Leishmania major	26%	100%
Q4QFJ2	Leishmania major	30%	67%
Q4QIJ7	Leishmania major	38%	100%
Q4QIV8	Leishmania major	26%	100%
Q4QJJ0	Leishmania major	27%	100%
Q4V3C8	Arabidopsis thaliana	34%	76%
Q501V0	Danio rerio	31%	88%
Q54CY9	Dictyostelium discoideum	33%	100%
Q54PB4	Dictyostelium discoideum	34%	77%
Q54PX0	Dictyostelium discoideum	32%	75%
Q54SJ5	Dictyostelium discoideum	36%	100%
Q54WX4	Dictyostelium discoideum	33%	97%
Q55BN8	Dictyostelium discoideum	31%	89%
Q59S66	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	70%
Q5EG47	Mus musculus	32%	66%
Q5JLD8	Oryza sativa subsp. japonica	39%	83%
Q5JLQ9	Oryza sativa subsp. japonica	35%	78%
Q5JLS2	Oryza sativa subsp. japonica	38%	69%
Q5KQF5	Oryza sativa subsp. japonica	31%	82%
Q5N942	Oryza sativa subsp. japonica	31%	100%
Q5QNM6	Oryza sativa subsp. japonica	35%	73%
Q5R495	Pongo abelii	29%	70%
Q5RCC4	Pongo abelii	33%	78%
Q5RD00	Pongo abelii	34%	67%
Q5RDH5	Pongo abelii	33%	67%
Q5VQQ5	Oryza sativa subsp. japonica	34%	72%
Q5W736	Oryza sativa subsp. japonica	34%	81%
Q5Z6X0	Oryza sativa subsp. japonica	35%	72%
Q5ZKI0	Gallus gallus	33%	77%
Q60EY8	Oryza sativa subsp. japonica	35%	80%
Q61XD3	Caenorhabditis briggsae	30%	100%
Q63450	Rattus norvegicus	35%	99%
Q68Y49	Oryza sativa subsp. japonica	35%	73%
Q69Q47	Oryza sativa subsp. japonica	38%	82%
Q6AVM3	Oryza sativa subsp. japonica	31%	72%
Q6BVA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	32%	90%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	32%	100%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	100%
Q6DE08	Xenopus laevis	32%	100%
Q6DE87	Xenopus laevis	33%	78%
Q6DEH3	Danio rerio	33%	76%
Q6DGS3	Danio rerio	33%	67%
Q6ERS0	Oryza sativa subsp. japonica	37%	92%
Q6ERS4	Oryza sativa subsp. japonica	37%	81%
Q6GPL3	Xenopus laevis	31%	100%
Q6H7U5	Oryza sativa subsp. japonica	37%	75%
Q6NW76	Danio rerio	32%	100%
Q6P2M8	Homo sapiens	34%	100%
Q6PHZ2	Mus musculus	34%	74%
Q6SA08	Homo sapiens	30%	100%
Q6TJY3	Bos taurus	29%	70%
Q6X4A2	Oryza sativa subsp. japonica	39%	83%
Q6Z9F4	Oryza sativa subsp. japonica	36%	82%
Q6ZI44	Oryza sativa subsp. japonica	30%	100%
Q6ZLP5	Oryza sativa subsp. japonica	38%	82%
Q755C4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	100%
Q75GK4	Oryza sativa subsp. japonica	35%	83%
Q75H77	Oryza sativa subsp. japonica	30%	100%
Q75L42	Oryza sativa subsp. japonica	37%	82%
Q75LR7	Oryza sativa subsp. japonica	33%	100%
Q75V57	Oryza sativa subsp. japonica	32%	100%
Q7RAH3	Plasmodium yoelii yoelii	29%	69%
Q7RJG2	Plasmodium yoelii yoelii	32%	70%
Q7TNJ7	Rattus norvegicus	35%	78%
Q7X996	Oryza sativa subsp. japonica	34%	84%
Q7XIW5	Oryza sativa subsp. japonica	32%	84%
Q7XQP4	Oryza sativa subsp. japonica	32%	100%
Q7Y0B9	Oryza sativa subsp. japonica	31%	100%
Q7YRC6	Bos taurus	33%	100%
Q84VQ3	Arabidopsis thaliana	40%	85%
Q852Q0	Oryza sativa subsp. japonica	34%	73%
Q852Q1	Oryza sativa subsp. japonica	34%	73%
Q852Q2	Oryza sativa subsp. japonica	36%	73%
Q863I2	Sus scrofa	29%	70%
Q869W6	Dictyostelium discoideum	35%	100%
Q86AD7	Dictyostelium discoideum	36%	95%
Q8BHI9	Mus musculus	30%	85%
Q8BRK8	Mus musculus	34%	67%
Q8BSK8	Mus musculus	29%	71%
Q8BW96	Mus musculus	35%	96%
Q8C0N0	Mus musculus	31%	75%
Q8C0V7	Mus musculus	32%	74%
Q8C1R0	Mus musculus	33%	100%
Q8IBS5	Plasmodium falciparum (isolate 3D7)	33%	70%
Q8ICR0	Plasmodium falciparum (isolate 3D7)	35%	72%
Q8IU85	Homo sapiens	35%	96%
Q8IY84	Homo sapiens	30%	85%
Q8LIG4	Oryza sativa subsp. japonica	39%	83%
Q8RWC9	Arabidopsis thaliana	38%	84%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	29%	100%
Q8TDX7	Homo sapiens	30%	100%
Q8W1D5	Arabidopsis thaliana	37%	76%
Q8W490	Arabidopsis thaliana	31%	79%
Q91604	Xenopus laevis	32%	86%
Q91819	Xenopus laevis	35%	91%
Q91820	Xenopus laevis	34%	91%
Q91VB2	Mus musculus	35%	78%
Q91YA2	Mus musculus	33%	88%
Q91YS8	Mus musculus	35%	99%
Q923T9	Mus musculus	33%	70%
Q93VD3	Arabidopsis thaliana	38%	77%
Q940H6	Arabidopsis thaliana	31%	100%
Q94C40	Arabidopsis thaliana	42%	86%
Q94CG0	Arabidopsis thaliana	35%	89%
Q95266	Sus scrofa	34%	74%
Q96NX5	Homo sapiens	34%	78%
Q96PN8	Homo sapiens	37%	100%
Q9C562	Arabidopsis thaliana	31%	77%
Q9D2E1	Mus musculus	37%	100%
Q9D411	Mus musculus	30%	100%
Q9DG02	Xenopus laevis	33%	78%
Q9ES70	Mus musculus	29%	100%
Q9ES74	Mus musculus	30%	100%
Q9FFP9	Arabidopsis thaliana	31%	100%
Q9FJ54	Arabidopsis thaliana	38%	85%
Q9FJ55	Arabidopsis thaliana	36%	77%
Q9FLZ3	Arabidopsis thaliana	36%	75%
Q9FMP5	Arabidopsis thaliana	33%	70%
Q9GNR4	Leishmania major	31%	100%
Q9HC98	Homo sapiens	29%	100%
Q9LDI3	Arabidopsis thaliana	43%	83%
Q9LEU7	Arabidopsis thaliana	36%	83%
Q9LGV5	Oryza sativa subsp. japonica	38%	80%
Q9LP51	Arabidopsis thaliana	36%	71%
Q9LWM4	Oryza sativa subsp. japonica	37%	80%
Q9LYQ8	Arabidopsis thaliana	34%	81%
Q9LZW4	Arabidopsis thaliana	37%	84%
Q9M9E9	Arabidopsis thaliana	33%	100%
Q9MAM1	Arabidopsis thaliana	38%	83%
Q9N0X0	Sus scrofa	34%	100%
Q9NAH6	Caenorhabditis elegans	31%	67%
Q9NHE1	Leishmania major	23%	99%
Q9P7I2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q9QYK9	Mus musculus	34%	100%
Q9QYZ3	Mus musculus	32%	77%
Q9QYZ4	Mus musculus	30%	77%
Q9QYZ6	Mus musculus	31%	74%
Q9R0A5	Mus musculus	29%	73%
Q9SEZ7	Arabidopsis thaliana	35%	79%
Q9SN43	Arabidopsis thaliana	37%	76%
Q9STV4	Arabidopsis thaliana	40%	83%
Q9SUL7	Arabidopsis thaliana	36%	87%
Q9TXJ0	Caenorhabditis elegans	37%	100%
Q9UBS0	Homo sapiens	29%	77%
Q9UQB9	Homo sapiens	33%	100%
Q9UQM7	Homo sapiens	33%	78%
Q9WTK7	Mus musculus	31%	85%
Q9XF67	Arabidopsis thaliana	31%	76%
Q9XIW0	Arabidopsis thaliana	35%	86%
Q9Y899	Emericella nidulans	35%	92%
Q9Z265	Mus musculus	31%	68%
V5B871	Trypanosoma cruzi	32%	87%
V5BAZ8	Trypanosoma cruzi	27%	97%
V5BC28	Trypanosoma cruzi	29%	74%
V5BCH2	Trypanosoma cruzi	30%	95%
V5BEK5	Trypanosoma cruzi	32%	100%
V5BH88	Trypanosoma cruzi	29%	68%
V5BI43	Trypanosoma cruzi	31%	74%
V5BNV8	Trypanosoma cruzi	39%	100%
V5BP88	Trypanosoma cruzi	31%	80%
V5BPE2	Trypanosoma cruzi	31%	100%
V5BQF4	Trypanosoma cruzi	27%	100%
V5BWC2	Trypanosoma cruzi	39%	100%
V5C224	Trypanosoma cruzi	29%	74%
V5D579	Trypanosoma cruzi	27%	86%
V5D9M1	Trypanosoma cruzi	31%	100%
V5DI55	Trypanosoma cruzi	27%	89%
V5DMJ4	Trypanosoma cruzi	67%	100%
V5DUH0	Trypanosoma cruzi	27%	68%
W0LYS5	Macrobrachium nipponense	36%	100%