Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IC86_LEIDO

TriTrypDb:

LdBPK_220160.1 , LdCL_220007700 , LDHU3_22.0430

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IC86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	530	534	PF00656	0.586
CLV_C14_Caspase3-7	540	544	PF00656	0.489
CLV_C14_Caspase3-7	720	724	PF00656	0.555
CLV_C14_Caspase3-7	809	813	PF00656	0.656
CLV_C14_Caspase3-7	825	829	PF00656	0.491
CLV_NRD_NRD_1	389	391	PF00675	0.462
CLV_NRD_NRD_1	58	60	PF00675	0.606
CLV_NRD_NRD_1	650	652	PF00675	0.657
CLV_NRD_NRD_1	658	660	PF00675	0.566
CLV_NRD_NRD_1	662	664	PF00675	0.434
CLV_NRD_NRD_1	795	797	PF00675	0.741
CLV_PCSK_FUR_1	648	652	PF00082	0.556
CLV_PCSK_FUR_1	668	672	PF00082	0.413
CLV_PCSK_KEX2_1	232	234	PF00082	0.549
CLV_PCSK_KEX2_1	58	60	PF00082	0.606
CLV_PCSK_KEX2_1	648	650	PF00082	0.679
CLV_PCSK_KEX2_1	658	660	PF00082	0.551
CLV_PCSK_KEX2_1	662	664	PF00082	0.409
CLV_PCSK_KEX2_1	670	672	PF00082	0.445
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.383
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.363
CLV_PCSK_PC7_1	645	651	PF00082	0.486
CLV_PCSK_PC7_1	658	664	PF00082	0.424
CLV_PCSK_SKI1_1	108	112	PF00082	0.387
CLV_PCSK_SKI1_1	232	236	PF00082	0.378
CLV_PCSK_SKI1_1	254	258	PF00082	0.591
CLV_PCSK_SKI1_1	327	331	PF00082	0.536
CLV_PCSK_SKI1_1	390	394	PF00082	0.464
CLV_PCSK_SKI1_1	640	644	PF00082	0.524
CLV_PCSK_SKI1_1	663	667	PF00082	0.437
CLV_PCSK_SKI1_1	670	674	PF00082	0.423
CLV_PCSK_SKI1_1	735	739	PF00082	0.543
DEG_APCC_DBOX_1	734	742	PF00400	0.483
DEG_SPOP_SBC_1	536	540	PF00917	0.657
DOC_AGCK_PIF_2	673	678	PF00069	0.384
DOC_CKS1_1	563	568	PF01111	0.441
DOC_CYCLIN_RxL_1	102	114	PF00134	0.545
DOC_CYCLIN_RxL_1	667	677	PF00134	0.418
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.534
DOC_MAPK_DCC_7	221	231	PF00069	0.405
DOC_MAPK_DCC_7	353	362	PF00069	0.529
DOC_MAPK_gen_1	353	362	PF00069	0.488
DOC_MAPK_gen_1	452	461	PF00069	0.456
DOC_MAPK_gen_1	58	65	PF00069	0.601
DOC_MAPK_MEF2A_6	58	65	PF00069	0.506
DOC_MAPK_MEF2A_6	606	615	PF00069	0.560
DOC_PP1_RVXF_1	250	256	PF00149	0.401
DOC_PP1_RVXF_1	69	75	PF00149	0.495
DOC_PP2B_LxvP_1	786	789	PF13499	0.668
DOC_USP7_MATH_1	172	176	PF00917	0.524
DOC_USP7_MATH_1	18	22	PF00917	0.629
DOC_USP7_MATH_1	278	282	PF00917	0.524
DOC_USP7_MATH_1	544	548	PF00917	0.460
DOC_USP7_MATH_1	638	642	PF00917	0.624
DOC_USP7_MATH_1	740	744	PF00917	0.527
DOC_USP7_MATH_1	8	12	PF00917	0.665
DOC_USP7_UBL2_3	670	674	PF12436	0.392
DOC_WW_Pin1_4	207	212	PF00397	0.463
DOC_WW_Pin1_4	224	229	PF00397	0.267
DOC_WW_Pin1_4	258	263	PF00397	0.597
DOC_WW_Pin1_4	26	31	PF00397	0.607
DOC_WW_Pin1_4	267	272	PF00397	0.601
DOC_WW_Pin1_4	343	348	PF00397	0.461
DOC_WW_Pin1_4	45	50	PF00397	0.789
DOC_WW_Pin1_4	483	488	PF00397	0.398
DOC_WW_Pin1_4	532	537	PF00397	0.663
DOC_WW_Pin1_4	562	567	PF00397	0.426
DOC_WW_Pin1_4	601	606	PF00397	0.637
DOC_WW_Pin1_4	690	695	PF00397	0.554
DOC_WW_Pin1_4	835	840	PF00397	0.613
LIG_14-3-3_CanoR_1	221	226	PF00244	0.426
LIG_14-3-3_CanoR_1	367	376	PF00244	0.683
LIG_14-3-3_CanoR_1	444	448	PF00244	0.448
LIG_14-3-3_CanoR_1	71	81	PF00244	0.632
LIG_14-3-3_CanoR_1	86	91	PF00244	0.624
LIG_Actin_WH2_2	430	446	PF00022	0.498
LIG_Actin_WH2_2	723	741	PF00022	0.478
LIG_AP2alpha_2	801	803	PF02296	0.623
LIG_APCC_Cbox_2	101	107	PF00515	0.391
LIG_BIR_III_2	372	376	PF00653	0.503
LIG_BIR_III_2	533	537	PF00653	0.572
LIG_BIR_III_2	626	630	PF00653	0.484
LIG_BRCT_BRCA1_1	202	206	PF00533	0.469
LIG_BRCT_BRCA1_1	552	556	PF00533	0.532
LIG_FHA_1	112	118	PF00498	0.465
LIG_FHA_1	178	184	PF00498	0.457
LIG_FHA_1	208	214	PF00498	0.575
LIG_FHA_1	391	397	PF00498	0.502
LIG_FHA_1	4	10	PF00498	0.604
LIG_FHA_1	46	52	PF00498	0.783
LIG_FHA_1	483	489	PF00498	0.439
LIG_FHA_1	549	555	PF00498	0.454
LIG_FHA_1	563	569	PF00498	0.351
LIG_FHA_1	725	731	PF00498	0.534
LIG_FHA_1	781	787	PF00498	0.725
LIG_FHA_1	793	799	PF00498	0.684
LIG_FHA_2	210	216	PF00498	0.462
LIG_FHA_2	538	544	PF00498	0.513
LIG_FHA_2	96	102	PF00498	0.445
LIG_HCF-1_HBM_1	561	564	PF13415	0.398
LIG_LIR_Apic_2	240	246	PF02991	0.436
LIG_LIR_Apic_2	293	298	PF02991	0.347
LIG_LIR_Gen_1	11	19	PF02991	0.578
LIG_LIR_Gen_1	150	158	PF02991	0.434
LIG_LIR_Gen_1	248	258	PF02991	0.598
LIG_LIR_Gen_1	509	518	PF02991	0.455
LIG_LIR_Gen_1	801	811	PF02991	0.673
LIG_LIR_Nem_3	100	106	PF02991	0.498
LIG_LIR_Nem_3	11	17	PF02991	0.581
LIG_LIR_Nem_3	150	155	PF02991	0.477
LIG_LIR_Nem_3	248	253	PF02991	0.543
LIG_LIR_Nem_3	432	438	PF02991	0.536
LIG_LIR_Nem_3	509	514	PF02991	0.453
LIG_LIR_Nem_3	525	529	PF02991	0.575
LIG_LIR_Nem_3	677	681	PF02991	0.403
LIG_LIR_Nem_3	801	806	PF02991	0.650
LIG_MLH1_MIPbox_1	552	556	PF16413	0.501
LIG_NRBOX	106	112	PF00104	0.459
LIG_OCRL_FandH_1	664	676	PF00620	0.383
LIG_PTB_Apo_2	797	804	PF02174	0.662
LIG_REV1ctd_RIR_1	553	562	PF16727	0.527
LIG_REV1ctd_RIR_1	663	672	PF16727	0.382
LIG_SH2_CRK	14	18	PF00017	0.583
LIG_SH2_CRK	295	299	PF00017	0.483
LIG_SH2_CRK	511	515	PF00017	0.424
LIG_SH2_CRK	681	685	PF00017	0.419
LIG_SH2_NCK_1	238	242	PF00017	0.373
LIG_SH2_PTP2	250	253	PF00017	0.324
LIG_SH2_PTP2	771	774	PF00017	0.556
LIG_SH2_SRC	238	241	PF00017	0.435
LIG_SH2_STAP1	238	242	PF00017	0.373
LIG_SH2_STAP1	369	373	PF00017	0.537
LIG_SH2_STAP1	676	680	PF00017	0.479
LIG_SH2_STAP1	681	685	PF00017	0.523
LIG_SH2_STAT5	106	109	PF00017	0.461
LIG_SH2_STAT5	250	253	PF00017	0.372
LIG_SH2_STAT5	26	29	PF00017	0.516
LIG_SH2_STAT5	301	304	PF00017	0.401
LIG_SH2_STAT5	369	372	PF00017	0.561
LIG_SH2_STAT5	564	567	PF00017	0.478
LIG_SH2_STAT5	594	597	PF00017	0.655
LIG_SH2_STAT5	771	774	PF00017	0.449
LIG_SH3_1	796	802	PF00018	0.680
LIG_SH3_2	262	267	PF14604	0.561
LIG_SH3_2	605	610	PF14604	0.624
LIG_SH3_3	152	158	PF00018	0.471
LIG_SH3_3	259	265	PF00018	0.587
LIG_SH3_3	27	33	PF00018	0.768
LIG_SH3_3	46	52	PF00018	0.657
LIG_SH3_3	501	507	PF00018	0.470
LIG_SH3_3	592	598	PF00018	0.765
LIG_SH3_3	602	608	PF00018	0.676
LIG_SH3_3	627	633	PF00018	0.437
LIG_SH3_3	689	695	PF00018	0.557
LIG_SH3_3	796	802	PF00018	0.680
LIG_SUMO_SIM_anti_2	446	451	PF11976	0.387
LIG_SUMO_SIM_par_1	446	451	PF11976	0.428
LIG_SUMO_SIM_par_1	632	637	PF11976	0.476
LIG_TRAF2_1	528	531	PF00917	0.539
LIG_TRAF2_1	569	572	PF00917	0.539
LIG_TRAF2_2	334	339	PF00917	0.485
LIG_TYR_ITIM	12	17	PF00017	0.522
LIG_TYR_ITIM	433	438	PF00017	0.432
LIG_WRC_WIRS_1	545	550	PF05994	0.491
MOD_CDK_SPK_2	562	567	PF00069	0.487
MOD_CDK_SPK_2	601	606	PF00069	0.599
MOD_CDK_SPxxK_3	483	490	PF00069	0.507
MOD_CK1_1	207	213	PF00069	0.498
MOD_CK1_1	224	230	PF00069	0.376
MOD_CK1_1	368	374	PF00069	0.518
MOD_CK1_1	378	384	PF00069	0.367
MOD_CK1_1	479	485	PF00069	0.426
MOD_CK1_1	717	723	PF00069	0.533
MOD_CK2_1	209	215	PF00069	0.454
MOD_CK2_1	544	550	PF00069	0.378
MOD_CK2_1	613	619	PF00069	0.518
MOD_Cter_Amidation	388	391	PF01082	0.458
MOD_GlcNHglycan	207	210	PF01048	0.614
MOD_GlcNHglycan	287	290	PF01048	0.547
MOD_GlcNHglycan	311	314	PF01048	0.512
MOD_GlcNHglycan	377	380	PF01048	0.574
MOD_GlcNHglycan	640	643	PF01048	0.565
MOD_GlcNHglycan	652	655	PF01048	0.404
MOD_GlcNHglycan	67	70	PF01048	0.673
MOD_GlcNHglycan	719	722	PF01048	0.544
MOD_GlcNHglycan	742	745	PF01048	0.587
MOD_GlcNHglycan	790	793	PF01048	0.599
MOD_GSK3_1	106	113	PF00069	0.507
MOD_GSK3_1	117	124	PF00069	0.380
MOD_GSK3_1	18	25	PF00069	0.687
MOD_GSK3_1	195	202	PF00069	0.578
MOD_GSK3_1	205	212	PF00069	0.444
MOD_GSK3_1	472	479	PF00069	0.466
MOD_GSK3_1	532	539	PF00069	0.658
MOD_GSK3_1	544	551	PF00069	0.508
MOD_GSK3_1	715	722	PF00069	0.608
MOD_GSK3_1	775	782	PF00069	0.685
MOD_GSK3_1	788	795	PF00069	0.725
MOD_GSK3_1	86	93	PF00069	0.705
MOD_N-GLC_1	309	314	PF02516	0.463
MOD_N-GLC_1	762	767	PF02516	0.529
MOD_NEK2_1	110	115	PF00069	0.584
MOD_NEK2_1	195	200	PF00069	0.454
MOD_NEK2_1	204	209	PF00069	0.382
MOD_NEK2_1	285	290	PF00069	0.539
MOD_NEK2_1	311	316	PF00069	0.487
MOD_NEK2_1	44	49	PF00069	0.588
MOD_NEK2_1	443	448	PF00069	0.442
MOD_NEK2_1	461	466	PF00069	0.255
MOD_NEK2_1	522	527	PF00069	0.570
MOD_NEK2_1	548	553	PF00069	0.497
MOD_NEK2_1	65	70	PF00069	0.599
MOD_NEK2_1	715	720	PF00069	0.486
MOD_NEK2_1	72	77	PF00069	0.494
MOD_NEK2_1	764	769	PF00069	0.554
MOD_NEK2_1	81	86	PF00069	0.575
MOD_NEK2_1	94	99	PF00069	0.536
MOD_PIKK_1	195	201	PF00454	0.447
MOD_PIKK_1	290	296	PF00454	0.441
MOD_PIKK_1	715	721	PF00454	0.458
MOD_PK_1	86	92	PF00069	0.586
MOD_PKA_1	390	396	PF00069	0.459
MOD_PKA_1	650	656	PF00069	0.431
MOD_PKA_2	111	117	PF00069	0.427
MOD_PKA_2	44	50	PF00069	0.601
MOD_PKA_2	443	449	PF00069	0.411
MOD_PKA_2	650	656	PF00069	0.453
MOD_PKA_2	701	707	PF00069	0.520
MOD_PKA_2	90	96	PF00069	0.679
MOD_PKB_1	648	656	PF00069	0.490
MOD_Plk_1	177	183	PF00069	0.395
MOD_Plk_1	461	467	PF00069	0.397
MOD_Plk_1	579	585	PF00069	0.563
MOD_Plk_2-3	319	325	PF00069	0.514
MOD_Plk_4	121	127	PF00069	0.627
MOD_Plk_4	245	251	PF00069	0.476
MOD_Plk_4	297	303	PF00069	0.340
MOD_Plk_4	311	317	PF00069	0.419
MOD_Plk_4	443	449	PF00069	0.396
MOD_Plk_4	544	550	PF00069	0.421
MOD_Plk_4	579	585	PF00069	0.515
MOD_Plk_4	764	770	PF00069	0.548
MOD_ProDKin_1	207	213	PF00069	0.454
MOD_ProDKin_1	224	230	PF00069	0.268
MOD_ProDKin_1	258	264	PF00069	0.598
MOD_ProDKin_1	26	32	PF00069	0.605
MOD_ProDKin_1	267	273	PF00069	0.597
MOD_ProDKin_1	343	349	PF00069	0.457
MOD_ProDKin_1	45	51	PF00069	0.791
MOD_ProDKin_1	483	489	PF00069	0.394
MOD_ProDKin_1	532	538	PF00069	0.658
MOD_ProDKin_1	562	568	PF00069	0.430
MOD_ProDKin_1	601	607	PF00069	0.636
MOD_ProDKin_1	690	696	PF00069	0.564
MOD_ProDKin_1	835	841	PF00069	0.615
MOD_SUMO_for_1	609	612	PF00179	0.629
MOD_SUMO_rev_2	175	181	PF00179	0.411
MOD_SUMO_rev_2	808	816	PF00179	0.658
MOD_SUMO_rev_2	824	834	PF00179	0.497
TRG_DiLeu_BaEn_2	618	624	PF01217	0.414
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.488
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.502
TRG_ENDOCYTIC_2	14	17	PF00928	0.586
TRG_ENDOCYTIC_2	238	241	PF00928	0.450
TRG_ENDOCYTIC_2	244	247	PF00928	0.484
TRG_ENDOCYTIC_2	250	253	PF00928	0.452
TRG_ENDOCYTIC_2	435	438	PF00928	0.555
TRG_ENDOCYTIC_2	511	514	PF00928	0.509
TRG_ENDOCYTIC_2	526	529	PF00928	0.462
TRG_ENDOCYTIC_2	676	679	PF00928	0.370
TRG_ENDOCYTIC_2	681	684	PF00928	0.415
TRG_ER_diArg_1	251	254	PF00400	0.517
TRG_ER_diArg_1	465	468	PF00400	0.382
TRG_ER_diArg_1	648	651	PF00400	0.680
TRG_ER_diArg_1	658	660	PF00400	0.543
TRG_ER_diArg_1	661	663	PF00400	0.412
TRG_NES_CRM1_1	451	462	PF08389	0.420
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	650	655	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	728	733	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S2	Leptomonas seymouri	42%	94%
A0A422NSI7	Trypanosoma rangeli	27%	100%
A4HC78	Leishmania braziliensis	73%	100%
A4HZQ6	Leishmania infantum	99%	100%
C9ZSE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AVL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QBW7	Leishmania major	91%	100%
V5BB53	Trypanosoma cruzi	27%	100%