Mitochondrial chaperone, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IC80_LEIDO

TriTrypDb:

LdBPK_021560.1 , LdCL_220015000 , LDHU3_22.1230

Length:

735

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8IC80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC80

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016462	pyrophosphatase activity	5	18
GO:0016787	hydrolase activity	2	18
GO:0016817	hydrolase activity, acting on acid anhydrides	3	18
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	18
GO:0016887	ATP hydrolysis activity	7	18
GO:0017076	purine nucleotide binding	4	18
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.721
CLV_C14_Caspase3-7	392	396	PF00656	0.585
CLV_C14_Caspase3-7	410	414	PF00656	0.404
CLV_C14_Caspase3-7	484	488	PF00656	0.663
CLV_NRD_NRD_1	326	328	PF00675	0.427
CLV_NRD_NRD_1	425	427	PF00675	0.281
CLV_NRD_NRD_1	430	432	PF00675	0.290
CLV_NRD_NRD_1	503	505	PF00675	0.509
CLV_NRD_NRD_1	610	612	PF00675	0.575
CLV_PCSK_KEX2_1	26	28	PF00082	0.594
CLV_PCSK_KEX2_1	326	328	PF00082	0.425
CLV_PCSK_KEX2_1	425	427	PF00082	0.298
CLV_PCSK_KEX2_1	430	432	PF00082	0.302
CLV_PCSK_KEX2_1	503	505	PF00082	0.622
CLV_PCSK_KEX2_1	610	612	PF00082	0.575
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.594
CLV_PCSK_PC7_1	426	432	PF00082	0.310
CLV_PCSK_SKI1_1	158	162	PF00082	0.364
CLV_PCSK_SKI1_1	201	205	PF00082	0.360
CLV_PCSK_SKI1_1	279	283	PF00082	0.292
CLV_PCSK_SKI1_1	291	295	PF00082	0.383
CLV_PCSK_SKI1_1	313	317	PF00082	0.351
CLV_PCSK_SKI1_1	351	355	PF00082	0.335
DEG_APCC_DBOX_1	583	591	PF00400	0.536
DEG_Nend_UBRbox_3	1	3	PF02207	0.411
DOC_ANK_TNKS_1	328	335	PF00023	0.556
DOC_CKS1_1	702	707	PF01111	0.629
DOC_CYCLIN_yClb1_LxF_4	336	341	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.350
DOC_MAPK_gen_1	199	207	PF00069	0.578
DOC_MAPK_gen_1	235	243	PF00069	0.603
DOC_MAPK_gen_1	300	310	PF00069	0.655
DOC_MAPK_gen_1	399	408	PF00069	0.496
DOC_MAPK_gen_1	577	587	PF00069	0.548
DOC_MAPK_MEF2A_6	199	207	PF00069	0.529
DOC_MAPK_MEF2A_6	364	371	PF00069	0.473
DOC_MAPK_MEF2A_6	580	587	PF00069	0.556
DOC_PIKK_1	120	128	PF02985	0.534
DOC_PP1_RVXF_1	289	295	PF00149	0.573
DOC_PP1_RVXF_1	336	342	PF00149	0.514
DOC_SPAK_OSR1_1	329	333	PF12202	0.562
DOC_SPAK_OSR1_1	580	584	PF12202	0.601
DOC_SPAK_OSR1_1	700	704	PF12202	0.551
DOC_USP7_MATH_1	15	19	PF00917	0.468
DOC_USP7_MATH_1	414	418	PF00917	0.483
DOC_USP7_MATH_1	640	644	PF00917	0.589
DOC_USP7_MATH_1	682	686	PF00917	0.595
DOC_WW_Pin1_4	172	177	PF00397	0.615
DOC_WW_Pin1_4	701	706	PF00397	0.538
LIG_14-3-3_CanoR_1	166	176	PF00244	0.583
LIG_14-3-3_CanoR_1	238	244	PF00244	0.588
LIG_14-3-3_CanoR_1	364	370	PF00244	0.461
LIG_14-3-3_CanoR_1	435	442	PF00244	0.507
LIG_14-3-3_CanoR_1	580	584	PF00244	0.546
LIG_14-3-3_CanoR_1	93	97	PF00244	0.592
LIG_APCC_ABBA_1	116	121	PF00400	0.567
LIG_APCC_ABBA_1	263	268	PF00400	0.565
LIG_APCC_ABBA_1	406	411	PF00400	0.476
LIG_BIR_III_4	673	677	PF00653	0.502
LIG_deltaCOP1_diTrp_1	62	71	PF00928	0.457
LIG_eIF4E_1	105	111	PF01652	0.486
LIG_EVH1_1	65	69	PF00568	0.335
LIG_FHA_1	155	161	PF00498	0.552
LIG_FHA_1	192	198	PF00498	0.709
LIG_FHA_1	314	320	PF00498	0.558
LIG_FHA_1	446	452	PF00498	0.689
LIG_FHA_1	467	473	PF00498	0.633
LIG_FHA_1	9	15	PF00498	0.598
LIG_FHA_2	702	708	PF00498	0.597
LIG_LIR_Apic_2	170	176	PF02991	0.622
LIG_LIR_Apic_2	569	573	PF02991	0.560
LIG_LIR_Apic_2	62	66	PF02991	0.453
LIG_LIR_Gen_1	127	137	PF02991	0.587
LIG_LIR_Gen_1	29	36	PF02991	0.495
LIG_LIR_Gen_1	588	596	PF02991	0.527
LIG_LIR_Gen_1	70	79	PF02991	0.327
LIG_LIR_Nem_3	127	133	PF02991	0.611
LIG_LIR_Nem_3	163	168	PF02991	0.577
LIG_LIR_Nem_3	208	213	PF02991	0.548
LIG_LIR_Nem_3	29	35	PF02991	0.485
LIG_LIR_Nem_3	62	67	PF02991	0.484
LIG_LIR_Nem_3	70	74	PF02991	0.332
LIG_NRBOX	542	548	PF00104	0.540
LIG_PCNA_PIPBox_1	715	724	PF02747	0.542
LIG_PCNA_TLS_4	204	211	PF02747	0.475
LIG_PDZ_Class_2	730	735	PF00595	0.570
LIG_Pex14_1	280	284	PF04695	0.522
LIG_Pex14_2	305	309	PF04695	0.512
LIG_Pex14_2	67	71	PF04695	0.434
LIG_Pex14_2	78	82	PF04695	0.296
LIG_Rb_pABgroove_1	403	411	PF01858	0.476
LIG_REV1ctd_RIR_1	382	391	PF16727	0.457
LIG_RPA_C_Fungi	420	432	PF08784	0.298
LIG_SH2_CRK	173	177	PF00017	0.509
LIG_SH2_CRK	344	348	PF00017	0.291
LIG_SH2_NCK_1	119	123	PF00017	0.448
LIG_SH2_NCK_1	638	642	PF00017	0.477
LIG_SH2_SRC	119	122	PF00017	0.544
LIG_SH2_SRC	210	213	PF00017	0.311
LIG_SH2_STAP1	105	109	PF00017	0.348
LIG_SH2_STAP1	381	385	PF00017	0.315
LIG_SH2_STAT3	699	702	PF00017	0.492
LIG_SH2_STAT5	136	139	PF00017	0.349
LIG_SH2_STAT5	210	213	PF00017	0.461
LIG_SH2_STAT5	222	225	PF00017	0.583
LIG_SH2_STAT5	297	300	PF00017	0.425
LIG_SH3_1	63	69	PF00018	0.424
LIG_SH3_3	200	206	PF00018	0.385
LIG_SH3_3	340	346	PF00018	0.318
LIG_SH3_3	364	370	PF00018	0.446
LIG_SH3_3	551	557	PF00018	0.416
LIG_SH3_3	63	69	PF00018	0.424
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.305
LIG_SUMO_SIM_anti_2	316	321	PF11976	0.382
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.313
LIG_SUMO_SIM_par_1	560	566	PF11976	0.379
LIG_TRAF2_1	180	183	PF00917	0.550
LIG_TRAF2_2	212	217	PF00917	0.296
LIG_TYR_ITIM	601	606	PF00017	0.587
MOD_CDC14_SPxK_1	175	178	PF00782	0.483
MOD_CDK_SPxK_1	172	178	PF00069	0.477
MOD_CK1_1	10	16	PF00069	0.708
MOD_CK1_1	169	175	PF00069	0.554
MOD_CK1_1	20	26	PF00069	0.589
MOD_CK1_1	481	487	PF00069	0.583
MOD_CK1_1	685	691	PF00069	0.603
MOD_CK1_1	694	700	PF00069	0.679
MOD_CK1_1	92	98	PF00069	0.496
MOD_CK2_1	121	127	PF00069	0.381
MOD_CK2_1	701	707	PF00069	0.388
MOD_Cter_Amidation	24	27	PF01082	0.451
MOD_Cter_Amidation	501	504	PF01082	0.802
MOD_GlcNHglycan	229	232	PF01048	0.673
MOD_GlcNHglycan	489	492	PF01048	0.758
MOD_GlcNHglycan	54	57	PF01048	0.438
MOD_GlcNHglycan	542	546	PF01048	0.352
MOD_GlcNHglycan	612	615	PF01048	0.628
MOD_GlcNHglycan	638	641	PF01048	0.611
MOD_GlcNHglycan	642	645	PF01048	0.579
MOD_GlcNHglycan	679	683	PF01048	0.656
MOD_GlcNHglycan	685	688	PF01048	0.716
MOD_GlcNHglycan	689	692	PF01048	0.706
MOD_GlcNHglycan	693	696	PF01048	0.650
MOD_GlcNHglycan	98	101	PF01048	0.616
MOD_GSK3_1	13	20	PF00069	0.653
MOD_GSK3_1	168	175	PF00069	0.602
MOD_GSK3_1	191	198	PF00069	0.448
MOD_GSK3_1	223	230	PF00069	0.443
MOD_GSK3_1	365	372	PF00069	0.484
MOD_GSK3_1	4	11	PF00069	0.707
MOD_GSK3_1	606	613	PF00069	0.638
MOD_GSK3_1	636	643	PF00069	0.550
MOD_GSK3_1	678	685	PF00069	0.668
MOD_GSK3_1	687	694	PF00069	0.744
MOD_GSK3_1	88	95	PF00069	0.618
MOD_LATS_1	608	614	PF00433	0.544
MOD_N-GLC_1	239	244	PF02516	0.306
MOD_N-GLC_1	246	251	PF02516	0.349
MOD_NEK2_1	227	232	PF00069	0.361
MOD_NEK2_1	454	459	PF00069	0.745
MOD_NEK2_1	49	54	PF00069	0.601
MOD_NEK2_1	507	512	PF00069	0.594
MOD_NEK2_1	541	546	PF00069	0.456
MOD_NEK2_2	304	309	PF00069	0.396
MOD_NEK2_2	579	584	PF00069	0.409
MOD_PIKK_1	720	726	PF00454	0.389
MOD_PKA_1	610	616	PF00069	0.565
MOD_PKA_2	234	240	PF00069	0.468
MOD_PKA_2	434	440	PF00069	0.350
MOD_PKA_2	497	503	PF00069	0.552
MOD_PKA_2	579	585	PF00069	0.429
MOD_PKA_2	610	616	PF00069	0.675
MOD_PKA_2	729	735	PF00069	0.513
MOD_PKA_2	92	98	PF00069	0.560
MOD_Plk_1	223	229	PF00069	0.399
MOD_Plk_1	239	245	PF00069	0.279
MOD_Plk_1	313	319	PF00069	0.467
MOD_Plk_1	466	472	PF00069	0.499
MOD_Plk_2-3	121	127	PF00069	0.381
MOD_Plk_2-3	388	394	PF00069	0.264
MOD_Plk_4	137	143	PF00069	0.383
MOD_Plk_4	17	23	PF00069	0.691
MOD_Plk_4	304	310	PF00069	0.403
MOD_Plk_4	315	321	PF00069	0.384
MOD_Plk_4	414	420	PF00069	0.477
MOD_Plk_4	591	597	PF00069	0.350
MOD_Plk_4	92	98	PF00069	0.651
MOD_ProDKin_1	172	178	PF00069	0.519
MOD_ProDKin_1	701	707	PF00069	0.404
MOD_SUMO_for_1	192	195	PF00179	0.483
MOD_SUMO_rev_2	287	293	PF00179	0.540
TRG_DiLeu_BaEn_1	591	596	PF01217	0.516
TRG_DiLeu_BaEn_1	70	75	PF01217	0.322
TRG_DiLeu_BaEn_2	402	408	PF01217	0.315
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.370
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.437
TRG_ENDOCYTIC_2	119	122	PF00928	0.630
TRG_ENDOCYTIC_2	210	213	PF00928	0.409
TRG_ENDOCYTIC_2	381	384	PF00928	0.291
TRG_ENDOCYTIC_2	589	592	PF00928	0.398
TRG_ENDOCYTIC_2	603	606	PF00928	0.424
TRG_ER_diArg_1	199	202	PF00400	0.528
TRG_ER_diArg_1	326	329	PF00400	0.526
TRG_ER_diArg_1	425	427	PF00400	0.342
TRG_ER_diArg_1	583	586	PF00400	0.402
TRG_NES_CRM1_1	591	605	PF08389	0.398
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	651	655	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P906	Leptomonas seymouri	29%	100%
A0A1X0NTT2	Trypanosomatidae	34%	100%
A0A3Q8IC95	Leishmania donovani	80%	100%
A0A3Q8IHZ0	Leishmania donovani	28%	100%
A0A422NUH1	Trypanosoma rangeli	33%	100%
A4HCE5	Leishmania braziliensis	75%	100%
A4HZW7	Leishmania infantum	79%	100%
A4IDZ9	Leishmania infantum	28%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
E9AVS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4Q0H4	Leishmania major	29%	100%
Q4QBQ3	Leishmania major	91%	99%
Q4QBQ4	Leishmania major	74%	100%
V5DMJ8	Trypanosoma cruzi	34%	100%