Carrier protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carrier protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC78_LEIDO

TriTrypDb:

LdBPK_101100.1 , LdCL_100017900 , LDHU3_10.1450

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 28
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	29
GO:0110165	cellular anatomical entity	1	29
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IC78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC78

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006862	nucleotide transport	6	2
GO:0009987	cellular process	1	2
GO:0015748	organophosphate ester transport	5	2
GO:0015931	nucleobase-containing compound transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0035352	NAD transmembrane transport	4	1
GO:0043132	NAD transport	7	1
GO:1901679	nucleotide transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0051724	NAD transmembrane transporter activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.457
CLV_NRD_NRD_1	114	116	PF00675	0.296
CLV_NRD_NRD_1	214	216	PF00675	0.182
CLV_NRD_NRD_1	351	353	PF00675	0.275
CLV_PCSK_KEX2_1	214	216	PF00082	0.182
CLV_PCSK_KEX2_1	350	352	PF00082	0.267
CLV_PCSK_PC7_1	346	352	PF00082	0.306
CLV_PCSK_SKI1_1	102	106	PF00082	0.283
CLV_PCSK_SKI1_1	142	146	PF00082	0.287
CLV_PCSK_SKI1_1	206	210	PF00082	0.225
CLV_PCSK_SKI1_1	232	236	PF00082	0.205
CLV_PCSK_SKI1_1	260	264	PF00082	0.479
DEG_APCC_DBOX_1	141	149	PF00400	0.574
DEG_Nend_Nbox_1	1	3	PF02207	0.713
DEG_SCF_FBW7_1	333	340	PF00400	0.470
DOC_CKS1_1	334	339	PF01111	0.428
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.309
DOC_MAPK_HePTP_8	348	365	PF00069	0.345
DOC_MAPK_MEF2A_6	194	202	PF00069	0.429
DOC_USP7_MATH_1	20	24	PF00917	0.762
DOC_USP7_MATH_1	210	214	PF00917	0.471
DOC_USP7_MATH_1	287	291	PF00917	0.426
DOC_USP7_MATH_1	375	379	PF00917	0.302
DOC_WW_Pin1_4	208	213	PF00397	0.506
DOC_WW_Pin1_4	333	338	PF00397	0.455
DOC_WW_Pin1_4	54	59	PF00397	0.730
LIG_14-3-3_CanoR_1	115	125	PF00244	0.502
LIG_14-3-3_CanoR_1	214	220	PF00244	0.448
LIG_14-3-3_CanoR_1	229	235	PF00244	0.500
LIG_14-3-3_CanoR_1	258	263	PF00244	0.352
LIG_Actin_WH2_2	218	234	PF00022	0.525
LIG_BRCT_BRCA1_1	131	135	PF00533	0.475
LIG_CtBP_PxDLS_1	108	112	PF00389	0.472
LIG_deltaCOP1_diTrp_1	289	297	PF00928	0.415
LIG_FHA_1	125	131	PF00498	0.508
LIG_FHA_1	238	244	PF00498	0.290
LIG_FHA_1	317	323	PF00498	0.275
LIG_FHA_1	343	349	PF00498	0.436
LIG_FHA_1	61	67	PF00498	0.644
LIG_FHA_1	74	80	PF00498	0.599
LIG_FHA_2	375	381	PF00498	0.257
LIG_IBAR_NPY_1	324	326	PF08397	0.439
LIG_LIR_Apic_2	289	295	PF02991	0.457
LIG_LIR_Gen_1	159	166	PF02991	0.457
LIG_LIR_Gen_1	378	386	PF02991	0.249
LIG_LIR_Gen_1	82	91	PF02991	0.510
LIG_LIR_LC3C_4	240	244	PF02991	0.434
LIG_LIR_Nem_3	126	131	PF02991	0.518
LIG_LIR_Nem_3	138	144	PF02991	0.598
LIG_LIR_Nem_3	159	165	PF02991	0.473
LIG_LIR_Nem_3	218	222	PF02991	0.451
LIG_LIR_Nem_3	233	238	PF02991	0.312
LIG_LIR_Nem_3	378	384	PF02991	0.232
LIG_LIR_Nem_3	82	86	PF02991	0.514
LIG_LYPXL_SIV_4	325	333	PF13949	0.463
LIG_Pex14_1	252	256	PF04695	0.275
LIG_SH2_CRK	256	260	PF00017	0.341
LIG_SH2_CRK	358	362	PF00017	0.330
LIG_SH2_SRC	15	18	PF00017	0.617
LIG_SH2_SRC	379	382	PF00017	0.218
LIG_SH2_STAP1	187	191	PF00017	0.509
LIG_SH2_STAP1	381	385	PF00017	0.227
LIG_SH2_STAT5	162	165	PF00017	0.475
LIG_SH2_STAT5	326	329	PF00017	0.446
LIG_SH3_3	11	17	PF00018	0.721
LIG_SH3_3	193	199	PF00018	0.483
LIG_SH3_3	23	29	PF00018	0.778
LIG_TYR_ITIM	160	165	PF00017	0.513
LIG_WRC_WIRS_1	259	264	PF05994	0.330
MOD_CDC14_SPxK_1	211	214	PF00782	0.382
MOD_CDK_SPxK_1	208	214	PF00069	0.382
MOD_CDK_SPxxK_3	208	215	PF00069	0.391
MOD_CK1_1	218	224	PF00069	0.486
MOD_CK1_1	275	281	PF00069	0.404
MOD_CK1_1	312	318	PF00069	0.263
MOD_CK1_1	49	55	PF00069	0.748
MOD_CK2_1	3	9	PF00069	0.739
MOD_CK2_1	374	380	PF00069	0.243
MOD_GlcNHglycan	118	121	PF01048	0.378
MOD_GlcNHglycan	16	20	PF01048	0.489
MOD_GlcNHglycan	184	187	PF01048	0.227
MOD_GlcNHglycan	265	269	PF01048	0.573
MOD_GlcNHglycan	289	292	PF01048	0.610
MOD_GlcNHglycan	315	318	PF01048	0.250
MOD_GlcNHglycan	358	361	PF01048	0.327
MOD_GlcNHglycan	49	52	PF01048	0.562
MOD_GSK3_1	206	213	PF00069	0.484
MOD_GSK3_1	293	300	PF00069	0.335
MOD_GSK3_1	309	316	PF00069	0.261
MOD_GSK3_1	32	39	PF00069	0.723
MOD_GSK3_1	333	340	PF00069	0.473
MOD_GSK3_1	49	56	PF00069	0.709
MOD_GSK3_1	75	82	PF00069	0.597
MOD_N-GLC_1	79	84	PF02516	0.357
MOD_N-GLC_2	366	368	PF02516	0.407
MOD_NEK2_1	192	197	PF00069	0.533
MOD_NEK2_1	2	7	PF00069	0.708
MOD_NEK2_1	238	243	PF00069	0.321
MOD_NEK2_1	263	268	PF00069	0.292
MOD_NEK2_1	361	366	PF00069	0.305
MOD_NEK2_1	374	379	PF00069	0.213
MOD_NEK2_2	22	27	PF00069	0.608
MOD_NEK2_2	230	235	PF00069	0.414
MOD_PIKK_1	278	284	PF00454	0.498
MOD_PKA_1	115	121	PF00069	0.536
MOD_PKA_2	272	278	PF00069	0.466
MOD_Plk_1	3	9	PF00069	0.709
MOD_Plk_1	79	85	PF00069	0.516
MOD_Plk_4	198	204	PF00069	0.412
MOD_Plk_4	238	244	PF00069	0.301
MOD_Plk_4	258	264	PF00069	0.199
MOD_Plk_4	3	9	PF00069	0.721
MOD_Plk_4	337	343	PF00069	0.510
MOD_ProDKin_1	208	214	PF00069	0.506
MOD_ProDKin_1	333	339	PF00069	0.455
MOD_ProDKin_1	54	60	PF00069	0.726
TRG_DiLeu_BaEn_4	67	73	PF01217	0.723
TRG_ENDOCYTIC_2	162	165	PF00928	0.474
TRG_ENDOCYTIC_2	205	208	PF00928	0.509
TRG_ENDOCYTIC_2	256	259	PF00928	0.241
TRG_ENDOCYTIC_2	326	329	PF00928	0.453
TRG_ENDOCYTIC_2	358	361	PF00928	0.286
TRG_ENDOCYTIC_2	381	384	PF00928	0.227
TRG_ENDOCYTIC_2	83	86	PF00928	0.492
TRG_ER_diArg_1	214	216	PF00400	0.382
TRG_ER_diArg_1	350	352	PF00400	0.399
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V4	Leptomonas seymouri	24%	100%
A0A0N1I8S5	Leptomonas seymouri	29%	100%
A0A0N1IBB8	Leptomonas seymouri	23%	82%
A0A0N1IHK9	Leptomonas seymouri	65%	100%
A0A0S4JF45	Bodo saltans	30%	96%
A0A0S4JH99	Bodo saltans	44%	78%
A0A0S4JIT1	Bodo saltans	32%	100%
A0A1X0NN16	Trypanosomatidae	31%	100%
A0A1X0NQB5	Trypanosomatidae	54%	100%
A0A1X0P6Z0	Trypanosomatidae	26%	99%
A0A3Q8IS12	Leishmania donovani	29%	100%
A0A3R7L1P3	Trypanosoma rangeli	29%	100%
A0A3S7WUZ5	Leishmania donovani	26%	88%
A0A422NGL1	Trypanosoma rangeli	53%	100%
A0A422P0Q3	Trypanosoma rangeli	29%	100%
A4H690	Leishmania braziliensis	80%	100%
A4H9K7	Leishmania braziliensis	26%	100%
A4HQI4	Leishmania braziliensis	30%	100%
A4HUL3	Leishmania infantum	100%	100%
A4HXX3	Leishmania infantum	26%	100%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	99%
E9AHZ3	Leishmania infantum	29%	100%
E9ANB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9ARN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q1DRJ3	Coccidioides immitis (strain RS)	26%	100%
Q1LZB3	Bos taurus	23%	100%
Q4Q094	Leishmania major	29%	100%
Q4QDU2	Leishmania major	27%	100%
Q4QHB2	Leishmania major	90%	99%
Q54VX4	Dictyostelium discoideum	23%	100%
Q9BSK2	Homo sapiens	22%	100%
V5BTU3	Trypanosoma cruzi	52%	100%
V5DDT9	Trypanosoma cruzi	30%	100%
V5DN72	Trypanosoma cruzi	29%	100%