DNA repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA repair protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IC77_LEIDO

TriTrypDb:

LdBPK_220008.1 , LdCL_220005700 , LDHU3_22.0120

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0000109	nucleotide-excision repair complex	3	1
GO:0000110	nucleotide-excision repair factor 1 complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070522	ERCC4-ERCC1 complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IC77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC77

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0000710	meiotic mismatch repair	4	1
GO:0006296	obsolete nucleotide-excision repair, DNA incision, 5'-to lesion	7	1
GO:0006298	mismatch repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0009314	response to radiation	3	1
GO:0009411	response to UV	5	1
GO:0009416	response to light stimulus	4	1
GO:0009628	response to abiotic stimulus	2	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0033683	obsolete nucleotide-excision repair, DNA incision	6	1
GO:0034644	cellular response to UV	6	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0070914	UV-damage excision repair	6	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071478	cellular response to radiation	4	1
GO:0071482	cellular response to light stimulus	5	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0104004	cellular response to environmental stimulus	3	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003684	damaged DNA binding	5	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.518
CLV_NRD_NRD_1	175	177	PF00675	0.559
CLV_NRD_NRD_1	24	26	PF00675	0.617
CLV_NRD_NRD_1	270	272	PF00675	0.687
CLV_NRD_NRD_1	278	280	PF00675	0.581
CLV_PCSK_FUR_1	22	26	PF00082	0.569
CLV_PCSK_KEX2_1	24	26	PF00082	0.566
CLV_PCSK_KEX2_1	269	271	PF00082	0.701
CLV_PCSK_KEX2_1	278	280	PF00082	0.581
DEG_SCF_FBW7_1	208	215	PF00400	0.636
DEG_SCF_TRCP1_1	87	93	PF00400	0.432
DOC_CKS1_1	209	214	PF01111	0.632
DOC_MAPK_gen_1	22	31	PF00069	0.600
DOC_MAPK_HePTP_8	82	94	PF00069	0.401
DOC_MAPK_MEF2A_6	22	31	PF00069	0.600
DOC_MAPK_MEF2A_6	59	68	PF00069	0.594
DOC_MAPK_MEF2A_6	74	83	PF00069	0.481
DOC_MAPK_MEF2A_6	85	94	PF00069	0.416
DOC_PP1_RVXF_1	94	100	PF00149	0.498
DOC_PP4_FxxP_1	209	212	PF00568	0.615
DOC_USP7_MATH_1	129	133	PF00917	0.509
DOC_USP7_MATH_1	183	187	PF00917	0.512
DOC_USP7_MATH_1	238	242	PF00917	0.706
DOC_WW_Pin1_4	158	163	PF00397	0.485
DOC_WW_Pin1_4	208	213	PF00397	0.623
LIG_14-3-3_CanoR_1	176	184	PF00244	0.607
LIG_14-3-3_CanoR_1	253	260	PF00244	0.729
LIG_14-3-3_CanoR_1	270	280	PF00244	0.602
LIG_14-3-3_CanoR_1	96	100	PF00244	0.522
LIG_BIR_II_1	1	5	PF00653	0.469
LIG_BRCT_BRCA1_1	134	138	PF00533	0.639
LIG_FHA_1	159	165	PF00498	0.473
LIG_FHA_1	16	22	PF00498	0.519
LIG_FHA_1	209	215	PF00498	0.562
LIG_FHA_1	253	259	PF00498	0.780
LIG_FHA_1	75	81	PF00498	0.471
LIG_FHA_2	132	138	PF00498	0.609
LIG_FHA_2	164	170	PF00498	0.451
LIG_LIR_Gen_1	98	107	PF02991	0.462
LIG_LIR_Nem_3	189	194	PF02991	0.548
LIG_LIR_Nem_3	98	102	PF02991	0.459
LIG_PCNA_yPIPBox_3	210	224	PF02747	0.612
LIG_Pex14_2	209	213	PF04695	0.572
LIG_SH2_STAT5	124	127	PF00017	0.439
LIG_SH2_STAT5	49	52	PF00017	0.449
LIG_SUMO_SIM_par_1	111	117	PF11976	0.546
LIG_SUMO_SIM_par_1	4	10	PF11976	0.495
LIG_WRC_WIRS_1	220	225	PF05994	0.660
MOD_CK1_1	131	137	PF00069	0.496
MOD_CK1_1	186	192	PF00069	0.590
MOD_CK1_1	227	233	PF00069	0.752
MOD_CK1_1	259	265	PF00069	0.692
MOD_CK1_1	42	48	PF00069	0.460
MOD_CK1_1	7	13	PF00069	0.485
MOD_CK2_1	131	137	PF00069	0.591
MOD_CK2_1	186	192	PF00069	0.519
MOD_CK2_1	85	91	PF00069	0.619
MOD_Cter_Amidation	267	270	PF01082	0.701
MOD_GlcNHglycan	226	229	PF01048	0.669
MOD_GlcNHglycan	273	276	PF01048	0.643
MOD_GlcNHglycan	41	44	PF01048	0.490
MOD_GlcNHglycan	53	56	PF01048	0.574
MOD_GlcNHglycan	87	90	PF01048	0.446
MOD_GSK3_1	124	131	PF00069	0.464
MOD_GSK3_1	132	139	PF00069	0.576
MOD_GSK3_1	208	215	PF00069	0.519
MOD_GSK3_1	224	231	PF00069	0.526
MOD_GSK3_1	252	259	PF00069	0.689
MOD_GSK3_1	39	46	PF00069	0.486
MOD_NEK2_1	128	133	PF00069	0.522
MOD_NEK2_1	136	141	PF00069	0.632
MOD_NEK2_1	213	218	PF00069	0.597
MOD_PIKK_1	15	21	PF00454	0.432
MOD_PIKK_1	156	162	PF00454	0.482
MOD_PIKK_1	213	219	PF00454	0.620
MOD_PIKK_1	74	80	PF00454	0.566
MOD_PK_1	176	182	PF00069	0.489
MOD_PKA_1	176	182	PF00069	0.531
MOD_PKA_2	175	181	PF00069	0.617
MOD_PKA_2	252	258	PF00069	0.715
MOD_PKA_2	95	101	PF00069	0.537
MOD_PKB_1	269	277	PF00069	0.602
MOD_PKB_1	72	80	PF00069	0.544
MOD_Plk_1	228	234	PF00069	0.661
MOD_Plk_1	260	266	PF00069	0.744
MOD_Plk_1	90	96	PF00069	0.584
MOD_Plk_2-3	256	262	PF00069	0.682
MOD_Plk_4	219	225	PF00069	0.669
MOD_Plk_4	247	253	PF00069	0.503
MOD_Plk_4	43	49	PF00069	0.530
MOD_Plk_4	60	66	PF00069	0.401
MOD_Plk_4	95	101	PF00069	0.490
MOD_ProDKin_1	158	164	PF00069	0.476
MOD_ProDKin_1	208	214	PF00069	0.629
TRG_ER_diArg_1	21	24	PF00400	0.530
TRG_ER_diArg_1	269	271	PF00400	0.696
TRG_ER_diArg_1	278	280	PF00400	0.576
TRG_NES_CRM1_1	249	261	PF08389	0.552
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V1	Leptomonas seymouri	59%	100%
A0A3S5IQI3	Trypanosoma rangeli	33%	100%
A4HC59	Leishmania braziliensis	76%	100%
E9AGY7	Leishmania infantum	99%	100%
E9AVJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBY7	Leishmania major	92%	100%
V5DBV7	Trypanosoma cruzi	33%	100%