DUF1308 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1308), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC76_LEIDO

TriTrypDb:

LdBPK_250360.1 , LdCL_250008700 , LDHU3_25.0430

Length:

753

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IC76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.555
CLV_C14_Caspase3-7	645	649	PF00656	0.569
CLV_C14_Caspase3-7	694	698	PF00656	0.174
CLV_NRD_NRD_1	175	177	PF00675	0.413
CLV_NRD_NRD_1	183	185	PF00675	0.426
CLV_NRD_NRD_1	338	340	PF00675	0.461
CLV_NRD_NRD_1	380	382	PF00675	0.743
CLV_NRD_NRD_1	449	451	PF00675	0.399
CLV_NRD_NRD_1	741	743	PF00675	0.479
CLV_NRD_NRD_1	745	747	PF00675	0.498
CLV_PCSK_FUR_1	329	333	PF00082	0.490
CLV_PCSK_FUR_1	738	742	PF00082	0.437
CLV_PCSK_KEX2_1	183	185	PF00082	0.462
CLV_PCSK_KEX2_1	331	333	PF00082	0.489
CLV_PCSK_KEX2_1	338	340	PF00082	0.424
CLV_PCSK_KEX2_1	379	381	PF00082	0.746
CLV_PCSK_KEX2_1	740	742	PF00082	0.478
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.508
CLV_PCSK_SKI1_1	240	244	PF00082	0.473
CLV_PCSK_SKI1_1	292	296	PF00082	0.391
CLV_PCSK_SKI1_1	393	397	PF00082	0.602
CLV_PCSK_SKI1_1	476	480	PF00082	0.547
CLV_PCSK_SKI1_1	484	488	PF00082	0.432
CLV_PCSK_SKI1_1	604	608	PF00082	0.404
CLV_PCSK_SKI1_1	690	694	PF00082	0.294
CLV_PCSK_SKI1_1	729	733	PF00082	0.385
DEG_APCC_DBOX_1	475	483	PF00400	0.393
DEG_Nend_UBRbox_2	1	3	PF02207	0.600
DEG_SPOP_SBC_1	197	201	PF00917	0.561
DEG_SPOP_SBC_1	285	289	PF00917	0.402
DEG_SPOP_SBC_1	296	300	PF00917	0.320
DEG_SPOP_SBC_1	88	92	PF00917	0.569
DOC_ANK_TNKS_1	182	189	PF00023	0.458
DOC_CYCLIN_RxL_1	297	309	PF00134	0.492
DOC_CYCLIN_RxL_1	618	627	PF00134	0.430
DOC_CYCLIN_yClb3_PxF_3	667	673	PF00134	0.487
DOC_MAPK_gen_1	238	247	PF00069	0.470
DOC_MAPK_gen_1	338	345	PF00069	0.404
DOC_MAPK_gen_1	618	628	PF00069	0.346
DOC_MAPK_MEF2A_6	240	249	PF00069	0.486
DOC_MAPK_MEF2A_6	338	347	PF00069	0.435
DOC_MIT_MIM_1	110	119	PF04212	0.402
DOC_PP1_RVXF_1	688	694	PF00149	0.303
DOC_PP2B_LxvP_1	207	210	PF13499	0.500
DOC_PP2B_LxvP_1	348	351	PF13499	0.474
DOC_PP2B_LxvP_1	515	518	PF13499	0.446
DOC_USP7_MATH_1	125	129	PF00917	0.619
DOC_USP7_MATH_1	198	202	PF00917	0.664
DOC_USP7_MATH_1	367	371	PF00917	0.511
DOC_USP7_MATH_1	391	395	PF00917	0.790
DOC_USP7_MATH_1	466	470	PF00917	0.407
DOC_USP7_MATH_1	498	502	PF00917	0.657
DOC_USP7_MATH_1	50	54	PF00917	0.650
DOC_USP7_MATH_1	555	559	PF00917	0.608
DOC_USP7_MATH_1	579	583	PF00917	0.563
DOC_USP7_MATH_1	727	731	PF00917	0.385
DOC_USP7_MATH_1	9	13	PF00917	0.659
DOC_USP7_UBL2_3	166	170	PF12436	0.526
DOC_WW_Pin1_4	153	158	PF00397	0.536
DOC_WW_Pin1_4	314	319	PF00397	0.515
DOC_WW_Pin1_4	403	408	PF00397	0.492
DOC_WW_Pin1_4	46	51	PF00397	0.627
DOC_WW_Pin1_4	91	96	PF00397	0.521
LIG_14-3-3_CanoR_1	159	168	PF00244	0.501
LIG_14-3-3_CanoR_1	272	276	PF00244	0.508
LIG_14-3-3_CanoR_1	393	403	PF00244	0.693
LIG_14-3-3_CanoR_1	468	473	PF00244	0.462
LIG_14-3-3_CanoR_1	578	587	PF00244	0.434
LIG_14-3-3_CanoR_1	624	629	PF00244	0.385
LIG_14-3-3_CanoR_1	729	737	PF00244	0.405
LIG_BIR_III_2	497	501	PF00653	0.587
LIG_BIR_III_4	54	58	PF00653	0.644
LIG_CSL_BTD_1	398	401	PF09270	0.520
LIG_CSL_BTD_1	665	668	PF09270	0.546
LIG_EVH1_2	210	214	PF00568	0.471
LIG_FHA_1	177	183	PF00498	0.426
LIG_FHA_1	318	324	PF00498	0.409
LIG_FHA_1	372	378	PF00498	0.569
LIG_FHA_1	395	401	PF00498	0.534
LIG_FHA_1	412	418	PF00498	0.344
LIG_FHA_1	46	52	PF00498	0.628
LIG_FHA_1	565	571	PF00498	0.451
LIG_FHA_1	629	635	PF00498	0.486
LIG_FHA_2	200	206	PF00498	0.556
LIG_FHA_2	232	238	PF00498	0.368
LIG_FHA_2	517	523	PF00498	0.490
LIG_FHA_2	597	603	PF00498	0.333
LIG_FHA_2	672	678	PF00498	0.469
LIG_FHA_2	703	709	PF00498	0.363
LIG_GBD_Chelix_1	108	116	PF00786	0.457
LIG_LIR_Apic_2	396	402	PF02991	0.507
LIG_LIR_Apic_2	520	526	PF02991	0.493
LIG_LIR_Apic_2	663	669	PF02991	0.530
LIG_LIR_Gen_1	2	11	PF02991	0.645
LIG_LIR_Gen_1	227	236	PF02991	0.286
LIG_LIR_Gen_1	290	301	PF02991	0.435
LIG_LIR_Gen_1	317	327	PF02991	0.463
LIG_LIR_Gen_1	597	607	PF02991	0.431
LIG_LIR_Gen_1	675	685	PF02991	0.392
LIG_LIR_LC3C_4	205	209	PF02991	0.497
LIG_LIR_Nem_3	162	168	PF02991	0.538
LIG_LIR_Nem_3	227	232	PF02991	0.436
LIG_LIR_Nem_3	243	249	PF02991	0.508
LIG_LIR_Nem_3	290	296	PF02991	0.426
LIG_LIR_Nem_3	597	603	PF02991	0.349
LIG_LIR_Nem_3	675	681	PF02991	0.392
LIG_MYND_1	401	405	PF01753	0.515
LIG_NRBOX	101	107	PF00104	0.439
LIG_NRBOX	115	121	PF00104	0.321
LIG_NRBOX	322	328	PF00104	0.332
LIG_Rb_LxCxE_1	230	250	PF01857	0.416
LIG_SH2_CRK	165	169	PF00017	0.502
LIG_SH2_CRK	229	233	PF00017	0.531
LIG_SH2_PTP2	246	249	PF00017	0.561
LIG_SH2_SRC	246	249	PF00017	0.516
LIG_SH2_SRC	426	429	PF00017	0.527
LIG_SH2_STAP1	229	233	PF00017	0.343
LIG_SH2_STAP1	474	478	PF00017	0.440
LIG_SH2_STAP1	572	576	PF00017	0.318
LIG_SH2_STAT3	72	75	PF00017	0.638
LIG_SH2_STAT5	246	249	PF00017	0.552
LIG_SH2_STAT5	258	261	PF00017	0.630
LIG_SH2_STAT5	474	477	PF00017	0.445
LIG_SH2_STAT5	678	681	PF00017	0.388
LIG_SH3_1	154	160	PF00018	0.533
LIG_SH3_1	742	748	PF00018	0.516
LIG_SH3_2	388	393	PF14604	0.525
LIG_SH3_3	154	160	PF00018	0.664
LIG_SH3_3	205	211	PF00018	0.482
LIG_SH3_3	242	248	PF00018	0.495
LIG_SH3_3	250	256	PF00018	0.621
LIG_SH3_3	347	353	PF00018	0.450
LIG_SH3_3	385	391	PF00018	0.615
LIG_SH3_3	399	405	PF00018	0.540
LIG_SH3_3	459	465	PF00018	0.407
LIG_SH3_3	501	507	PF00018	0.673
LIG_SH3_3	662	668	PF00018	0.689
LIG_SH3_3	742	748	PF00018	0.521
LIG_SUMO_SIM_anti_2	282	290	PF11976	0.418
LIG_SUMO_SIM_par_1	320	328	PF11976	0.437
LIG_SUMO_SIM_par_1	413	422	PF11976	0.311
LIG_SUMO_SIM_par_1	565	571	PF11976	0.482
LIG_SUMO_SIM_par_1	624	632	PF11976	0.443
LIG_TRAF2_1	599	602	PF00917	0.430
LIG_TYR_ITIM	676	681	PF00017	0.385
LIG_UBA3_1	322	331	PF00899	0.565
LIG_WW_1	255	258	PF00397	0.505
LIG_WW_2	668	671	PF00397	0.417
MOD_CDC14_SPxK_1	156	159	PF00782	0.532
MOD_CDK_SPxK_1	153	159	PF00069	0.536
MOD_CK1_1	126	132	PF00069	0.667
MOD_CK1_1	134	140	PF00069	0.696
MOD_CK1_1	28	34	PF00069	0.605
MOD_CK1_1	317	323	PF00069	0.320
MOD_CK1_1	35	41	PF00069	0.584
MOD_CK1_1	394	400	PF00069	0.595
MOD_CK1_1	49	55	PF00069	0.679
MOD_CK2_1	111	117	PF00069	0.444
MOD_CK2_1	134	140	PF00069	0.643
MOD_CK2_1	231	237	PF00069	0.376
MOD_CK2_1	271	277	PF00069	0.683
MOD_CK2_1	284	290	PF00069	0.417
MOD_CK2_1	421	427	PF00069	0.424
MOD_CK2_1	535	541	PF00069	0.643
MOD_CK2_1	596	602	PF00069	0.374
MOD_CK2_1	671	677	PF00069	0.504
MOD_CK2_1	702	708	PF00069	0.363
MOD_CK2_1	727	733	PF00069	0.351
MOD_GlcNHglycan	12	15	PF01048	0.678
MOD_GlcNHglycan	149	152	PF01048	0.817
MOD_GlcNHglycan	161	164	PF01048	0.673
MOD_GlcNHglycan	189	192	PF01048	0.483
MOD_GlcNHglycan	249	252	PF01048	0.580
MOD_GlcNHglycan	260	263	PF01048	0.654
MOD_GlcNHglycan	31	34	PF01048	0.640
MOD_GlcNHglycan	393	396	PF01048	0.628
MOD_GlcNHglycan	43	46	PF01048	0.792
MOD_GlcNHglycan	537	540	PF01048	0.559
MOD_GlcNHglycan	557	560	PF01048	0.428
MOD_GlcNHglycan	581	584	PF01048	0.460
MOD_GlcNHglycan	639	642	PF01048	0.518
MOD_GlcNHglycan	681	684	PF01048	0.488
MOD_GSK3_1	134	141	PF00069	0.679
MOD_GSK3_1	192	199	PF00069	0.509
MOD_GSK3_1	25	32	PF00069	0.605
MOD_GSK3_1	260	267	PF00069	0.681
MOD_GSK3_1	33	40	PF00069	0.576
MOD_GSK3_1	367	374	PF00069	0.464
MOD_GSK3_1	389	396	PF00069	0.595
MOD_GSK3_1	41	48	PF00069	0.693
MOD_GSK3_1	412	419	PF00069	0.434
MOD_GSK3_1	468	475	PF00069	0.477
MOD_GSK3_1	544	551	PF00069	0.782
MOD_GSK3_1	579	586	PF00069	0.614
MOD_GSK3_1	624	631	PF00069	0.479
MOD_GSK3_1	651	658	PF00069	0.648
MOD_GSK3_1	679	686	PF00069	0.284
MOD_GSK3_1	725	732	PF00069	0.367
MOD_GSK3_1	87	94	PF00069	0.616
MOD_N-GLC_1	264	269	PF02516	0.540
MOD_NEK2_1	20	25	PF00069	0.709
MOD_NEK2_1	37	42	PF00069	0.552
MOD_NEK2_1	375	380	PF00069	0.499
MOD_NEK2_1	412	417	PF00069	0.320
MOD_NEK2_1	563	568	PF00069	0.413
MOD_NEK2_1	679	684	PF00069	0.273
MOD_NEK2_1	89	94	PF00069	0.537
MOD_NEK2_2	421	426	PF00069	0.476
MOD_NEK2_2	683	688	PF00069	0.385
MOD_PIKK_1	131	137	PF00454	0.705
MOD_PIKK_1	419	425	PF00454	0.454
MOD_PK_1	123	129	PF00069	0.478
MOD_PK_1	624	630	PF00069	0.393
MOD_PKA_1	176	182	PF00069	0.453
MOD_PKA_2	158	164	PF00069	0.746
MOD_PKA_2	271	277	PF00069	0.608
MOD_PKA_2	533	539	PF00069	0.558
MOD_PKA_2	679	685	PF00069	0.363
MOD_PKB_1	174	182	PF00069	0.411
MOD_PKB_1	238	246	PF00069	0.464
MOD_Plk_1	20	26	PF00069	0.671
MOD_Plk_1	371	377	PF00069	0.652
MOD_Plk_1	412	418	PF00069	0.320
MOD_Plk_1	564	570	PF00069	0.434
MOD_Plk_1	596	602	PF00069	0.374
MOD_Plk_1	629	635	PF00069	0.503
MOD_Plk_4	203	209	PF00069	0.632
MOD_Plk_4	395	401	PF00069	0.664
MOD_Plk_4	468	474	PF00069	0.448
MOD_Plk_4	564	570	PF00069	0.420
MOD_Plk_4	624	630	PF00069	0.394
MOD_ProDKin_1	153	159	PF00069	0.536
MOD_ProDKin_1	314	320	PF00069	0.508
MOD_ProDKin_1	403	409	PF00069	0.479
MOD_ProDKin_1	46	52	PF00069	0.628
MOD_ProDKin_1	91	97	PF00069	0.516
MOD_SUMO_rev_2	597	606	PF00179	0.414
MOD_SUMO_rev_2	728	736	PF00179	0.383
TRG_DiLeu_BaEn_1	565	570	PF01217	0.473
TRG_DiLeu_BaEn_3	601	607	PF01217	0.437
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.431
TRG_ENDOCYTIC_2	165	168	PF00928	0.457
TRG_ENDOCYTIC_2	229	232	PF00928	0.420
TRG_ENDOCYTIC_2	246	249	PF00928	0.376
TRG_ENDOCYTIC_2	5	8	PF00928	0.656
TRG_ENDOCYTIC_2	600	603	PF00928	0.431
TRG_ENDOCYTIC_2	678	681	PF00928	0.363
TRG_ER_diArg_1	171	174	PF00400	0.406
TRG_ER_diArg_1	182	184	PF00400	0.393
TRG_ER_diArg_1	379	381	PF00400	0.735
TRG_ER_diArg_1	737	740	PF00400	0.508
TRG_NES_CRM1_1	477	490	PF08389	0.456
TRG_Pf-PMV_PEXEL_1	302	307	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	729	733	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW5	Leptomonas seymouri	46%	98%
A0A1X0P4J1	Trypanosomatidae	28%	100%
A4H4A7	Leishmania braziliensis	67%	99%
A4I178	Leishmania infantum	99%	100%
D0A5G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AXB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QA60	Leishmania major	91%	100%