CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC75_LEIDO

TriTrypDb:

LdBPK_303070.1 , LdCL_300036300 , LDHU3_30.4080

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IC75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC75

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	11
GO:0042592	homeostatic process	3	11
GO:0048878	chemical homeostasis	4	11
GO:0050801	monoatomic ion homeostasis	5	11
GO:0055065	obsolete metal ion homeostasis	7	11
GO:0055080	monoatomic cation homeostasis	6	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0072507	obsolete divalent inorganic cation homeostasis	7	11
GO:0098771	inorganic ion homeostasis	6	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.477
CLV_NRD_NRD_1	287	289	PF00675	0.574
CLV_NRD_NRD_1	384	386	PF00675	0.591
CLV_PCSK_KEX2_1	287	289	PF00082	0.536
CLV_PCSK_KEX2_1	384	386	PF00082	0.592
CLV_PCSK_KEX2_1	403	405	PF00082	0.648
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.690
CLV_PCSK_SKI1_1	319	323	PF00082	0.573
CLV_PCSK_SKI1_1	48	52	PF00082	0.284
CLV_PCSK_SKI1_1	494	498	PF00082	0.625
CLV_PCSK_SKI1_1	67	71	PF00082	0.135
CLV_Separin_Metazoa	320	324	PF03568	0.310
DEG_APCC_DBOX_1	172	180	PF00400	0.270
DEG_APCC_DBOX_1	47	55	PF00400	0.487
DEG_Nend_UBRbox_2	1	3	PF02207	0.580
DEG_SPOP_SBC_1	53	57	PF00917	0.536
DOC_CYCLIN_yCln2_LP_2	438	444	PF00134	0.396
DOC_MAPK_gen_1	287	295	PF00069	0.343
DOC_MAPK_gen_1	384	392	PF00069	0.372
DOC_MAPK_gen_1	403	410	PF00069	0.521
DOC_MAPK_MEF2A_6	287	295	PF00069	0.387
DOC_MAPK_MEF2A_6	403	410	PF00069	0.505
DOC_PP4_FxxP_1	304	307	PF00568	0.371
DOC_USP7_MATH_1	133	137	PF00917	0.352
DOC_USP7_MATH_1	311	315	PF00917	0.408
DOC_USP7_MATH_1	478	482	PF00917	0.443
DOC_WW_Pin1_4	217	222	PF00397	0.544
DOC_WW_Pin1_4	449	454	PF00397	0.533
DOC_WW_Pin1_4	467	472	PF00397	0.431
DOC_WW_Pin1_4	474	479	PF00397	0.498
DOC_WW_Pin1_4	56	61	PF00397	0.508
LIG_14-3-3_CanoR_1	323	331	PF00244	0.292
LIG_14-3-3_CanoR_1	443	449	PF00244	0.502
LIG_14-3-3_CanoR_1	494	499	PF00244	0.424
LIG_14-3-3_CanoR_1	52	60	PF00244	0.487
LIG_BRCT_BRCA1_1	300	304	PF00533	0.433
LIG_BRCT_BRCA1_1	31	35	PF00533	0.428
LIG_BRCT_BRCA1_1	468	472	PF00533	0.544
LIG_Clathr_ClatBox_1	43	47	PF01394	0.456
LIG_CtBP_PxDLS_1	445	450	PF00389	0.416
LIG_EH1_1	288	296	PF00400	0.372
LIG_FHA_1	104	110	PF00498	0.202
LIG_FHA_1	111	117	PF00498	0.124
LIG_FHA_1	147	153	PF00498	0.304
LIG_FHA_1	238	244	PF00498	0.355
LIG_FHA_1	400	406	PF00498	0.507
LIG_FHA_1	410	416	PF00498	0.541
LIG_FHA_1	430	436	PF00498	0.510
LIG_FHA_1	468	474	PF00498	0.557
LIG_FHA_1	91	97	PF00498	0.368
LIG_FHA_2	191	197	PF00498	0.556
LIG_FHA_2	212	218	PF00498	0.463
LIG_FHA_2	247	253	PF00498	0.339
LIG_FHA_2	357	363	PF00498	0.292
LIG_FHA_2	375	381	PF00498	0.403
LIG_FHA_2	57	63	PF00498	0.536
LIG_FHA_2	98	104	PF00498	0.327
LIG_LIR_Apic_2	301	307	PF02991	0.420
LIG_LIR_Gen_1	273	283	PF02991	0.389
LIG_LIR_Gen_1	332	341	PF02991	0.379
LIG_LIR_Gen_1	47	54	PF02991	0.487
LIG_LIR_Gen_1	99	110	PF02991	0.260
LIG_LIR_Nem_3	273	279	PF02991	0.397
LIG_LIR_Nem_3	329	334	PF02991	0.315
LIG_LIR_Nem_3	457	461	PF02991	0.437
LIG_LIR_Nem_3	47	53	PF02991	0.470
LIG_LIR_Nem_3	99	105	PF02991	0.260
LIG_MAD2	162	170	PF02301	0.276
LIG_MAD2	52	60	PF02301	0.508
LIG_NBox_RRM_1	138	148	PF00076	0.454
LIG_PCNA_yPIPBox_3	384	393	PF02747	0.366
LIG_PTB_Apo_2	84	91	PF02174	0.421
LIG_Rb_pABgroove_1	96	104	PF01858	0.404
LIG_SH2_CRK	276	280	PF00017	0.304
LIG_SH2_NCK_1	22	26	PF00017	0.415
LIG_SH2_NCK_1	276	280	PF00017	0.304
LIG_SH2_SRC	348	351	PF00017	0.372
LIG_SH2_STAP1	22	26	PF00017	0.415
LIG_SH2_STAP1	331	335	PF00017	0.366
LIG_SH2_STAT5	137	140	PF00017	0.384
LIG_SH2_STAT5	282	285	PF00017	0.307
LIG_SH2_STAT5	334	337	PF00017	0.335
LIG_SH2_STAT5	382	385	PF00017	0.451
LIG_SH3_3	145	151	PF00018	0.333
LIG_SH3_3	304	310	PF00018	0.370
LIG_SH3_3	369	375	PF00018	0.429
LIG_SH3_CIN85_PxpxPR_1	451	456	PF14604	0.443
LIG_SUMO_SIM_anti_2	362	368	PF11976	0.254
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.495
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.262
LIG_SUMO_SIM_par_1	108	113	PF11976	0.264
LIG_SUMO_SIM_par_1	292	298	PF11976	0.330
LIG_SUMO_SIM_par_1	356	362	PF11976	0.343
LIG_SUMO_SIM_par_1	388	394	PF11976	0.445
LIG_SUMO_SIM_par_1	406	413	PF11976	0.511
LIG_SUMO_SIM_par_1	93	100	PF11976	0.326
LIG_SxIP_EBH_1	432	443	PF03271	0.414
LIG_TRAF2_2	221	226	PF00917	0.465
LIG_TYR_ITSM	272	279	PF00017	0.458
LIG_UBA3_1	69	74	PF00899	0.382
MOD_CDC14_SPxK_1	477	480	PF00782	0.548
MOD_CDK_SPK_2	56	61	PF00069	0.421
MOD_CDK_SPxK_1	474	480	PF00069	0.546
MOD_CDK_SPxxK_3	449	456	PF00069	0.572
MOD_CDK_SPxxK_3	56	63	PF00069	0.382
MOD_CK1_1	13	19	PF00069	0.460
MOD_CK1_1	211	217	PF00069	0.710
MOD_CK1_1	239	245	PF00069	0.487
MOD_CK1_1	259	265	PF00069	0.210
MOD_CK1_1	298	304	PF00069	0.512
MOD_CK1_1	3	9	PF00069	0.688
MOD_CK1_1	314	320	PF00069	0.470
MOD_CK1_1	409	415	PF00069	0.657
MOD_CK1_1	474	480	PF00069	0.703
MOD_CK1_1	481	487	PF00069	0.724
MOD_CK2_1	190	196	PF00069	0.691
MOD_CK2_1	211	217	PF00069	0.600
MOD_CK2_1	246	252	PF00069	0.498
MOD_CK2_1	314	320	PF00069	0.568
MOD_CK2_1	374	380	PF00069	0.572
MOD_CK2_1	56	62	PF00069	0.352
MOD_GlcNHglycan	210	213	PF01048	0.777
MOD_GlcNHglycan	31	34	PF01048	0.397
MOD_GlcNHglycan	349	353	PF01048	0.543
MOD_GlcNHglycan	480	483	PF01048	0.737
MOD_GSK3_1	10	17	PF00069	0.583
MOD_GSK3_1	146	153	PF00069	0.293
MOD_GSK3_1	255	262	PF00069	0.480
MOD_GSK3_1	270	277	PF00069	0.470
MOD_GSK3_1	298	305	PF00069	0.519
MOD_GSK3_1	322	329	PF00069	0.382
MOD_GSK3_1	406	413	PF00069	0.731
MOD_GSK3_1	467	474	PF00069	0.685
MOD_GSK3_1	52	59	PF00069	0.329
MOD_NEK2_1	1	6	PF00069	0.766
MOD_NEK2_1	108	113	PF00069	0.166
MOD_NEK2_1	14	19	PF00069	0.438
MOD_NEK2_1	195	200	PF00069	0.676
MOD_NEK2_1	20	25	PF00069	0.155
MOD_NEK2_1	255	260	PF00069	0.494
MOD_NEK2_1	302	307	PF00069	0.435
MOD_NEK2_1	399	404	PF00069	0.585
MOD_NEK2_1	466	471	PF00069	0.564
MOD_NEK2_1	472	477	PF00069	0.537
MOD_NEK2_1	54	59	PF00069	0.329
MOD_NEK2_1	90	95	PF00069	0.351
MOD_NEK2_1	97	102	PF00069	0.350
MOD_PIKK_1	14	20	PF00454	0.484
MOD_PIKK_1	322	328	PF00454	0.402
MOD_PKA_2	224	230	PF00069	0.533
MOD_PKA_2	264	270	PF00069	0.527
MOD_PKA_2	322	328	PF00069	0.420
MOD_Plk_1	10	16	PF00069	0.606
MOD_Plk_1	103	109	PF00069	0.396
MOD_Plk_1	189	195	PF00069	0.695
MOD_Plk_1	314	320	PF00069	0.546
MOD_Plk_1	326	332	PF00069	0.402
MOD_Plk_2-3	190	196	PF00069	0.670
MOD_Plk_4	133	139	PF00069	0.356
MOD_Plk_4	190	196	PF00069	0.712
MOD_Plk_4	264	270	PF00069	0.452
MOD_Plk_4	295	301	PF00069	0.372
MOD_Plk_4	326	332	PF00069	0.374
MOD_Plk_4	434	440	PF00069	0.666
MOD_Plk_4	65	71	PF00069	0.402
MOD_Plk_4	97	103	PF00069	0.408
MOD_ProDKin_1	217	223	PF00069	0.708
MOD_ProDKin_1	449	455	PF00069	0.696
MOD_ProDKin_1	467	473	PF00069	0.555
MOD_ProDKin_1	474	480	PF00069	0.652
MOD_ProDKin_1	56	62	PF00069	0.382
MOD_SUMO_rev_2	226	232	PF00179	0.543
MOD_SUMO_rev_2	477	486	PF00179	0.591
TRG_DiLeu_BaEn_1	104	109	PF01217	0.382
TRG_DiLeu_BaEn_3	189	195	PF01217	0.625
TRG_ENDOCYTIC_2	276	279	PF00928	0.386
TRG_ENDOCYTIC_2	334	337	PF00928	0.415
TRG_ER_diArg_1	383	385	PF00400	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M9	Leptomonas seymouri	26%	100%
A0A0N1I470	Leptomonas seymouri	66%	98%
A0A0N1PDI6	Leptomonas seymouri	24%	83%
A0A0S4IPA6	Bodo saltans	42%	100%
A0A0S4JSF9	Bodo saltans	25%	93%
A0A1X0NRR8	Trypanosomatidae	23%	100%
A0A1X0P1F1	Trypanosomatidae	46%	100%
A0A1X0PAL3	Trypanosomatidae	27%	88%
A0A3Q8IL77	Leishmania donovani	24%	82%
A0A3Q8ITK0	Leishmania donovani	25%	100%
A0A3R7LBY6	Trypanosoma rangeli	45%	100%
A0A3R7M693	Trypanosoma rangeli	21%	74%
A0A422NS01	Trypanosoma rangeli	25%	88%
A4HAY2	Leishmania braziliensis	25%	85%
A4HIN7	Leishmania braziliensis	80%	99%
A4I5Y4	Leishmania infantum	100%	100%
A4I8C4	Leishmania infantum	25%	100%
A4IA41	Leishmania infantum	24%	82%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	89%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	68%
E9B177	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B383	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B555	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	82%
Q12296	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	71%
Q4Q2T0	Leishmania major	24%	82%
Q4Q6Y7	Leishmania major	97%	100%
Q4V3C7	Arabidopsis thaliana	32%	100%
Q67XQ0	Arabidopsis thaliana	33%	100%
Q8VZI2	Arabidopsis thaliana	28%	100%
Q9USJ3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	73%
Q9ZQR4	Arabidopsis thaliana	29%	100%
V5BKR5	Trypanosoma cruzi	23%	87%
V5DM70	Trypanosoma cruzi	25%	100%
V5DNW3	Trypanosoma cruzi	46%	100%