Prefoldin subunit 3

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin subunit 3

Gene product:

prefoldin-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IC74_LEIDO

TriTrypDb:

LdBPK_261360.1 , LdCL_260019200 , LDHU3_26.1670

Length:

194

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Prefoldin-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 6
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016272	prefoldin complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005737	cytoplasm	2	1
GO:0005844	polysome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IC74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC74

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.529
CLV_MEL_PAP_1	43	49	PF00089	0.487
CLV_NRD_NRD_1	184	186	PF00675	0.452
CLV_PCSK_KEX2_1	184	186	PF00082	0.408
CLV_PCSK_KEX2_1	45	47	PF00082	0.453
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.453
CLV_PCSK_SKI1_1	143	147	PF00082	0.266
CLV_PCSK_SKI1_1	22	26	PF00082	0.489
CLV_PCSK_SKI1_1	96	100	PF00082	0.281
DEG_Nend_UBRbox_3	1	3	PF02207	0.498
DOC_MAPK_MEF2A_6	18	25	PF00069	0.450
DOC_PP1_RVXF_1	20	26	PF00149	0.436
DOC_USP7_UBL2_3	7	11	PF12436	0.537
DOC_WW_Pin1_4	13	18	PF00397	0.535
LIG_14-3-3_CanoR_1	143	152	PF00244	0.481
LIG_14-3-3_CanoR_1	46	54	PF00244	0.440
LIG_14-3-3_CanoR_1	60	68	PF00244	0.419
LIG_Actin_WH2_2	72	88	PF00022	0.521
LIG_eIF4E_1	84	90	PF01652	0.507
LIG_FHA_1	103	109	PF00498	0.427
LIG_FHA_1	117	123	PF00498	0.427
LIG_FHA_1	136	142	PF00498	0.427
LIG_FHA_1	147	153	PF00498	0.532
LIG_FHA_1	171	177	PF00498	0.483
LIG_FHA_1	63	69	PF00498	0.542
LIG_FHA_2	131	137	PF00498	0.452
LIG_FHA_2	153	159	PF00498	0.444
LIG_FHA_2	165	171	PF00498	0.426
LIG_FHA_2	7	13	PF00498	0.544
LIG_LIR_Apic_2	12	17	PF02991	0.411
LIG_LIR_Nem_3	48	54	PF02991	0.482
LIG_SH2_NCK_1	179	183	PF00017	0.443
LIG_SH2_PTP2	14	17	PF00017	0.418
LIG_SH2_STAT5	132	135	PF00017	0.440
LIG_SH2_STAT5	14	17	PF00017	0.392
LIG_SH2_STAT5	8	11	PF00017	0.529
LIG_SH2_STAT5	84	87	PF00017	0.500
LIG_SUMO_SIM_par_1	167	174	PF11976	0.483
LIG_TRAF2_1	133	136	PF00917	0.521
LIG_TRAF2_1	154	157	PF00917	0.483
LIG_TRAF2_1	188	191	PF00917	0.503
MOD_CDK_SPK_2	13	18	PF00069	0.521
MOD_CK1_1	36	42	PF00069	0.522
MOD_CK2_1	130	136	PF00069	0.438
MOD_CK2_1	144	150	PF00069	0.491
MOD_CK2_1	164	170	PF00069	0.483
MOD_CK2_1	185	191	PF00069	0.558
MOD_GlcNHglycan	146	149	PF01048	0.284
MOD_GlcNHglycan	35	38	PF01048	0.558
MOD_GSK3_1	32	39	PF00069	0.503
MOD_GSK3_1	45	52	PF00069	0.444
MOD_N-GLC_1	171	176	PF02516	0.240
MOD_NEK2_1	104	109	PF00069	0.466
MOD_NEK2_1	32	37	PF00069	0.505
MOD_NEK2_1	61	66	PF00069	0.495
MOD_NEK2_1	85	90	PF00069	0.538
MOD_NEK2_2	116	121	PF00069	0.427
MOD_PIKK_1	135	141	PF00454	0.487
MOD_PIKK_1	152	158	PF00454	0.445
MOD_PKA_1	185	191	PF00069	0.479
MOD_PKA_1	45	51	PF00069	0.489
MOD_PKA_2	45	51	PF00069	0.489
MOD_PKA_2	62	68	PF00069	0.569
MOD_Plk_1	130	136	PF00069	0.440
MOD_Plk_1	171	177	PF00069	0.453
MOD_Plk_2-3	164	170	PF00069	0.521
MOD_Plk_2-3	6	12	PF00069	0.492
MOD_Plk_4	104	110	PF00069	0.440
MOD_Plk_4	164	170	PF00069	0.539
MOD_Plk_4	39	45	PF00069	0.403
MOD_Plk_4	85	91	PF00069	0.491
MOD_ProDKin_1	13	19	PF00069	0.536
MOD_SUMO_rev_2	69	78	PF00179	0.453
TRG_DiLeu_BaEn_1	136	141	PF01217	0.427
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.540
TRG_ENDOCYTIC_2	179	182	PF00928	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB38	Leptomonas seymouri	90%	100%
A0A0S4KIH2	Bodo saltans	61%	100%
A0A1X0NS72	Trypanosomatidae	52%	100%
A0A422NIQ5	Trypanosoma rangeli	52%	99%
A4HEZ3	Leishmania braziliensis	94%	100%
A4I267	Leishmania infantum	100%	100%
B0ZT47	Elsinoe fawcettii	42%	98%
C9ZRT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9AYB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O18054	Caenorhabditis elegans	34%	100%
P48363	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	97%
P57741	Arabidopsis thaliana	36%	99%
P61758	Homo sapiens	45%	98%
P61759	Mus musculus	45%	99%
Q10143	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
Q2TBX2	Bos taurus	44%	98%
Q4Q956	Leishmania major	99%	100%
Q54LS2	Dictyostelium discoideum	36%	99%
Q5RCG9	Pongo abelii	45%	98%
Q9VGP6	Drosophila melanogaster	35%	100%