50S ribosome-binding GTPase/Dynamin family/Elongation factor Tu GTP binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC70_LEIDO

TriTrypDb:

LdBPK_220640.1 , LdCL_220013700 , LDHU3_22.0950

Length:

977

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IC70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC70

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003676	nucleic acid binding	3	3
GO:0003746	translation elongation factor activity	4	3
GO:0005488	binding	1	13
GO:0005525	GTP binding	5	13
GO:0008135	translation factor activity, RNA binding	3	3
GO:0017076	purine nucleotide binding	4	13
GO:0019001	guanyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032561	guanyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.521
CLV_C14_Caspase3-7	399	403	PF00656	0.419
CLV_C14_Caspase3-7	446	450	PF00656	0.555
CLV_C14_Caspase3-7	562	566	PF00656	0.683
CLV_C14_Caspase3-7	645	649	PF00656	0.649
CLV_NRD_NRD_1	23	25	PF00675	0.805
CLV_NRD_NRD_1	253	255	PF00675	0.321
CLV_NRD_NRD_1	321	323	PF00675	0.278
CLV_NRD_NRD_1	388	390	PF00675	0.455
CLV_NRD_NRD_1	491	493	PF00675	0.763
CLV_NRD_NRD_1	538	540	PF00675	0.715
CLV_NRD_NRD_1	588	590	PF00675	0.557
CLV_NRD_NRD_1	591	593	PF00675	0.545
CLV_NRD_NRD_1	599	601	PF00675	0.544
CLV_NRD_NRD_1	720	722	PF00675	0.643
CLV_NRD_NRD_1	76	78	PF00675	0.576
CLV_NRD_NRD_1	787	789	PF00675	0.632
CLV_NRD_NRD_1	793	795	PF00675	0.626
CLV_NRD_NRD_1	842	844	PF00675	0.558
CLV_NRD_NRD_1	872	874	PF00675	0.527
CLV_NRD_NRD_1	887	889	PF00675	0.532
CLV_PCSK_FUR_1	589	593	PF00082	0.634
CLV_PCSK_FUR_1	791	795	PF00082	0.701
CLV_PCSK_KEX2_1	23	25	PF00082	0.827
CLV_PCSK_KEX2_1	321	323	PF00082	0.278
CLV_PCSK_KEX2_1	491	493	PF00082	0.787
CLV_PCSK_KEX2_1	538	540	PF00082	0.688
CLV_PCSK_KEX2_1	588	590	PF00082	0.553
CLV_PCSK_KEX2_1	591	593	PF00082	0.548
CLV_PCSK_KEX2_1	599	601	PF00082	0.550
CLV_PCSK_KEX2_1	720	722	PF00082	0.643
CLV_PCSK_KEX2_1	75	77	PF00082	0.575
CLV_PCSK_KEX2_1	786	788	PF00082	0.603
CLV_PCSK_KEX2_1	793	795	PF00082	0.604
CLV_PCSK_KEX2_1	842	844	PF00082	0.555
CLV_PCSK_KEX2_1	872	874	PF00082	0.552
CLV_PCSK_KEX2_1	953	955	PF00082	0.610
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.639
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.603
CLV_PCSK_PC1ET2_1	953	955	PF00082	0.610
CLV_PCSK_PC7_1	487	493	PF00082	0.672
CLV_PCSK_SKI1_1	118	122	PF00082	0.476
CLV_PCSK_SKI1_1	181	185	PF00082	0.745
CLV_PCSK_SKI1_1	335	339	PF00082	0.278
CLV_PCSK_SKI1_1	389	393	PF00082	0.462
CLV_PCSK_SKI1_1	426	430	PF00082	0.538
CLV_PCSK_SKI1_1	433	437	PF00082	0.517
CLV_PCSK_SKI1_1	438	442	PF00082	0.494
CLV_PCSK_SKI1_1	511	515	PF00082	0.679
CLV_PCSK_SKI1_1	539	543	PF00082	0.592
CLV_PCSK_SKI1_1	77	81	PF00082	0.548
CLV_PCSK_SKI1_1	853	857	PF00082	0.630
CLV_Separin_Metazoa	407	411	PF03568	0.444
DEG_APCC_DBOX_1	76	84	PF00400	0.559
DEG_APCC_KENBOX_2	857	861	PF00400	0.596
DEG_SPOP_SBC_1	244	248	PF00917	0.478
DOC_ANK_TNKS_1	720	727	PF00023	0.727
DOC_ANK_TNKS_1	944	951	PF00023	0.675
DOC_CDC14_PxL_1	922	930	PF14671	0.614
DOC_CKS1_1	962	967	PF01111	0.617
DOC_CYCLIN_RxL_1	848	859	PF00134	0.620
DOC_CYCLIN_yCln2_LP_2	97	100	PF00134	0.556
DOC_MAPK_DCC_7	96	105	PF00069	0.581
DOC_MAPK_gen_1	305	313	PF00069	0.530
DOC_MAPK_gen_1	538	544	PF00069	0.672
DOC_MAPK_gen_1	720	727	PF00069	0.680
DOC_MAPK_MEF2A_6	96	105	PF00069	0.556
DOC_PP1_RVXF_1	252	259	PF00149	0.478
DOC_PP1_RVXF_1	341	348	PF00149	0.569
DOC_PP1_RVXF_1	458	464	PF00149	0.414
DOC_PP1_RVXF_1	592	599	PF00149	0.544
DOC_PP2B_LxvP_1	171	174	PF13499	0.727
DOC_PP2B_LxvP_1	97	100	PF13499	0.567
DOC_PP4_FxxP_1	394	397	PF00568	0.395
DOC_SPAK_OSR1_1	721	725	PF12202	0.645
DOC_USP7_MATH_1	163	167	PF00917	0.734
DOC_USP7_MATH_1	194	198	PF00917	0.681
DOC_USP7_MATH_1	229	233	PF00917	0.478
DOC_USP7_MATH_1	244	248	PF00917	0.478
DOC_USP7_MATH_1	40	44	PF00917	0.741
DOC_USP7_MATH_1	443	447	PF00917	0.556
DOC_USP7_MATH_1	482	486	PF00917	0.691
DOC_USP7_MATH_1	526	530	PF00917	0.734
DOC_USP7_MATH_1	532	536	PF00917	0.761
DOC_USP7_MATH_1	575	579	PF00917	0.778
DOC_USP7_MATH_1	6	10	PF00917	0.713
DOC_USP7_MATH_1	663	667	PF00917	0.791
DOC_USP7_MATH_1	689	693	PF00917	0.756
DOC_USP7_MATH_1	696	700	PF00917	0.773
DOC_USP7_MATH_1	740	744	PF00917	0.731
DOC_USP7_MATH_1	832	836	PF00917	0.629
DOC_USP7_UBL2_3	339	343	PF12436	0.557
DOC_USP7_UBL2_3	383	387	PF12436	0.459
DOC_WW_Pin1_4	159	164	PF00397	0.709
DOC_WW_Pin1_4	246	251	PF00397	0.498
DOC_WW_Pin1_4	260	265	PF00397	0.470
DOC_WW_Pin1_4	524	529	PF00397	0.774
DOC_WW_Pin1_4	605	610	PF00397	0.716
DOC_WW_Pin1_4	703	708	PF00397	0.737
DOC_WW_Pin1_4	961	966	PF00397	0.612
LIG_14-3-3_CanoR_1	134	142	PF00244	0.711
LIG_14-3-3_CanoR_1	254	259	PF00244	0.478
LIG_14-3-3_CanoR_1	321	325	PF00244	0.478
LIG_14-3-3_CanoR_1	369	374	PF00244	0.389
LIG_14-3-3_CanoR_1	4	11	PF00244	0.764
LIG_14-3-3_CanoR_1	410	420	PF00244	0.548
LIG_14-3-3_CanoR_1	511	516	PF00244	0.669
LIG_14-3-3_CanoR_1	599	605	PF00244	0.447
LIG_14-3-3_CanoR_1	720	725	PF00244	0.727
LIG_14-3-3_CanoR_1	756	763	PF00244	0.785
LIG_14-3-3_CanoR_1	901	907	PF00244	0.671
LIG_APCC_Cbox_1	593	599	PF00515	0.602
LIG_BIR_II_1	1	5	PF00653	0.625
LIG_BIR_III_4	565	569	PF00653	0.638
LIG_BIR_III_4	815	819	PF00653	0.649
LIG_DLG_GKlike_1	254	262	PF00625	0.478
LIG_EVH1_2	101	105	PF00568	0.569
LIG_FHA_1	122	128	PF00498	0.596
LIG_FHA_1	251	257	PF00498	0.478
LIG_FHA_1	414	420	PF00498	0.491
LIG_FHA_1	437	443	PF00498	0.589
LIG_FHA_1	6	12	PF00498	0.705
LIG_FHA_1	621	627	PF00498	0.711
LIG_FHA_1	758	764	PF00498	0.580
LIG_FHA_1	937	943	PF00498	0.575
LIG_FHA_1	962	968	PF00498	0.612
LIG_FHA_2	288	294	PF00498	0.478
LIG_FHA_2	336	342	PF00498	0.484
LIG_FHA_2	358	364	PF00498	0.493
LIG_FHA_2	402	408	PF00498	0.436
LIG_FHA_2	505	511	PF00498	0.729
LIG_FHA_2	643	649	PF00498	0.628
LIG_FHA_2	834	840	PF00498	0.651
LIG_HCF-1_HBM_1	207	210	PF13415	0.642
LIG_LIR_Apic_2	959	965	PF02991	0.600
LIG_LIR_Gen_1	124	131	PF02991	0.606
LIG_LIR_Gen_1	138	147	PF02991	0.535
LIG_LIR_Gen_1	216	224	PF02991	0.325
LIG_LIR_Gen_1	257	267	PF02991	0.478
LIG_LIR_Gen_1	290	299	PF02991	0.481
LIG_LIR_Gen_1	608	618	PF02991	0.698
LIG_LIR_Gen_1	764	773	PF02991	0.647
LIG_LIR_Gen_1	862	871	PF02991	0.505
LIG_LIR_Gen_1	903	913	PF02991	0.555
LIG_LIR_Nem_3	104	108	PF02991	0.580
LIG_LIR_Nem_3	124	128	PF02991	0.317
LIG_LIR_Nem_3	138	143	PF02991	0.539
LIG_LIR_Nem_3	216	221	PF02991	0.454
LIG_LIR_Nem_3	257	262	PF02991	0.478
LIG_LIR_Nem_3	290	294	PF02991	0.499
LIG_LIR_Nem_3	314	320	PF02991	0.482
LIG_LIR_Nem_3	608	614	PF02991	0.625
LIG_LIR_Nem_3	764	769	PF02991	0.576
LIG_LIR_Nem_3	862	868	PF02991	0.529
LIG_LIR_Nem_3	903	909	PF02991	0.560
LIG_NRBOX	234	240	PF00104	0.478
LIG_NRBOX	424	430	PF00104	0.594
LIG_NRBOX	851	857	PF00104	0.612
LIG_SH2_CRK	125	129	PF00017	0.497
LIG_SH2_CRK	259	263	PF00017	0.478
LIG_SH2_CRK	378	382	PF00017	0.398
LIG_SH2_CRK	388	392	PF00017	0.444
LIG_SH2_CRK	611	615	PF00017	0.701
LIG_SH2_GRB2like	918	921	PF00017	0.536
LIG_SH2_NCK_1	378	382	PF00017	0.398
LIG_SH2_PTP2	540	543	PF00017	0.713
LIG_SH2_SRC	218	221	PF00017	0.451
LIG_SH2_STAT3	773	776	PF00017	0.668
LIG_SH2_STAT5	210	213	PF00017	0.587
LIG_SH2_STAT5	317	320	PF00017	0.478
LIG_SH2_STAT5	329	332	PF00017	0.478
LIG_SH2_STAT5	344	347	PF00017	0.416
LIG_SH2_STAT5	462	465	PF00017	0.597
LIG_SH2_STAT5	540	543	PF00017	0.628
LIG_SH2_STAT5	895	898	PF00017	0.535
LIG_SH2_STAT5	91	94	PF00017	0.549
LIG_SH3_1	858	864	PF00018	0.612
LIG_SH3_1	96	102	PF00018	0.538
LIG_SH3_2	37	42	PF14604	0.639
LIG_SH3_3	277	283	PF00018	0.478
LIG_SH3_3	289	295	PF00018	0.478
LIG_SH3_3	34	40	PF00018	0.682
LIG_SH3_3	706	712	PF00018	0.666
LIG_SH3_3	746	752	PF00018	0.778
LIG_SH3_3	825	831	PF00018	0.680
LIG_SH3_3	858	864	PF00018	0.502
LIG_SH3_3	95	101	PF00018	0.548
LIG_SUMO_SIM_anti_2	404	410	PF11976	0.520
LIG_SUMO_SIM_anti_2	56	63	PF11976	0.543
LIG_SUMO_SIM_par_1	56	63	PF11976	0.543
LIG_TRAF2_1	629	632	PF00917	0.609
LIG_TRAF2_1	877	880	PF00917	0.609
LIG_WRC_WIRS_1	175	180	PF05994	0.676
MOD_CK1_1	145	151	PF00069	0.664
MOD_CK1_1	162	168	PF00069	0.587
MOD_CK1_1	176	182	PF00069	0.717
MOD_CK1_1	323	329	PF00069	0.478
MOD_CK1_1	603	609	PF00069	0.749
MOD_CK1_1	692	698	PF00069	0.751
MOD_CK1_1	703	709	PF00069	0.756
MOD_CK1_1	754	760	PF00069	0.755
MOD_CK1_1	835	841	PF00069	0.602
MOD_CK2_1	162	168	PF00069	0.741
MOD_CK2_1	4	10	PF00069	0.741
MOD_CK2_1	401	407	PF00069	0.440
MOD_CK2_1	504	510	PF00069	0.741
MOD_CK2_1	626	632	PF00069	0.726
MOD_CK2_1	663	669	PF00069	0.725
MOD_CK2_1	696	702	PF00069	0.644
MOD_CK2_1	968	974	PF00069	0.738
MOD_Cter_Amidation	586	589	PF01082	0.593
MOD_Cter_Amidation	718	721	PF01082	0.641
MOD_GlcNHglycan	135	138	PF01048	0.647
MOD_GlcNHglycan	145	148	PF01048	0.583
MOD_GlcNHglycan	24	27	PF01048	0.694
MOD_GlcNHglycan	398	401	PF01048	0.394
MOD_GlcNHglycan	470	473	PF01048	0.716
MOD_GlcNHglycan	495	499	PF01048	0.815
MOD_GlcNHglycan	500	503	PF01048	0.669
MOD_GlcNHglycan	507	510	PF01048	0.626
MOD_GlcNHglycan	557	560	PF01048	0.677
MOD_GlcNHglycan	611	614	PF01048	0.667
MOD_GlcNHglycan	637	640	PF01048	0.765
MOD_GlcNHglycan	698	701	PF01048	0.781
MOD_GlcNHglycan	742	745	PF01048	0.646
MOD_GlcNHglycan	756	759	PF01048	0.567
MOD_GlcNHglycan	781	784	PF01048	0.691
MOD_GlcNHglycan	814	819	PF01048	0.656
MOD_GlcNHglycan	820	823	PF01048	0.667
MOD_GSK3_1	142	149	PF00069	0.616
MOD_GSK3_1	159	166	PF00069	0.705
MOD_GSK3_1	173	180	PF00069	0.750
MOD_GSK3_1	245	252	PF00069	0.497
MOD_GSK3_1	254	261	PF00069	0.498
MOD_GSK3_1	357	364	PF00069	0.481
MOD_GSK3_1	365	372	PF00069	0.418
MOD_GSK3_1	463	470	PF00069	0.635
MOD_GSK3_1	494	501	PF00069	0.799
MOD_GSK3_1	555	562	PF00069	0.725
MOD_GSK3_1	59	66	PF00069	0.651
MOD_GSK3_1	603	610	PF00069	0.688
MOD_GSK3_1	692	699	PF00069	0.699
MOD_GSK3_1	725	732	PF00069	0.745
MOD_GSK3_1	750	757	PF00069	0.622
MOD_GSK3_1	814	821	PF00069	0.622
MOD_GSK3_1	957	964	PF00069	0.587
MOD_GSK3_1	968	975	PF00069	0.612
MOD_LATS_1	367	373	PF00433	0.411
MOD_LATS_1	718	724	PF00433	0.597
MOD_N-GLC_1	250	255	PF02516	0.278
MOD_N-GLC_1	936	941	PF02516	0.558
MOD_NEK2_1	121	126	PF00069	0.585
MOD_NEK2_1	258	263	PF00069	0.495
MOD_NEK2_1	287	292	PF00069	0.521
MOD_NEK2_1	357	362	PF00069	0.546
MOD_NEK2_1	436	441	PF00069	0.568
MOD_NEK2_1	463	468	PF00069	0.500
MOD_NEK2_1	833	838	PF00069	0.576
MOD_NEK2_1	936	941	PF00069	0.558
MOD_NEK2_2	532	537	PF00069	0.552
MOD_PIKK_1	927	933	PF00454	0.567
MOD_PK_1	361	367	PF00069	0.412
MOD_PK_1	369	375	PF00069	0.393
MOD_PK_1	720	726	PF00069	0.643
MOD_PKA_1	254	260	PF00069	0.521
MOD_PKA_1	720	726	PF00069	0.643
MOD_PKA_2	133	139	PF00069	0.700
MOD_PKA_2	22	28	PF00069	0.794
MOD_PKA_2	320	326	PF00069	0.478
MOD_PKA_2	482	488	PF00069	0.714
MOD_PKA_2	689	695	PF00069	0.766
MOD_PKA_2	720	726	PF00069	0.722
MOD_PKA_2	818	824	PF00069	0.652
MOD_PKA_2	900	906	PF00069	0.627
MOD_PKB_1	492	500	PF00069	0.789
MOD_PKB_1	640	648	PF00069	0.750
MOD_Plk_1	443	449	PF00069	0.576
MOD_Plk_1	576	582	PF00069	0.708
MOD_Plk_1	879	885	PF00069	0.666
MOD_Plk_1	89	95	PF00069	0.554
MOD_Plk_4	123	129	PF00069	0.494
MOD_Plk_4	156	162	PF00069	0.661
MOD_Plk_4	230	236	PF00069	0.478
MOD_Plk_4	287	293	PF00069	0.478
MOD_Plk_4	323	329	PF00069	0.480
MOD_Plk_4	369	375	PF00069	0.416
MOD_Plk_4	851	857	PF00069	0.605
MOD_Plk_4	957	963	PF00069	0.584
MOD_ProDKin_1	159	165	PF00069	0.707
MOD_ProDKin_1	246	252	PF00069	0.498
MOD_ProDKin_1	260	266	PF00069	0.470
MOD_ProDKin_1	524	530	PF00069	0.774
MOD_ProDKin_1	605	611	PF00069	0.720
MOD_ProDKin_1	703	709	PF00069	0.738
MOD_ProDKin_1	961	967	PF00069	0.613
TRG_DiLeu_BaEn_1	552	557	PF01217	0.694
TRG_DiLeu_BaEn_4	110	116	PF01217	0.520
TRG_DiLeu_BaEn_4	879	885	PF01217	0.611
TRG_ENDOCYTIC_2	125	128	PF00928	0.491
TRG_ENDOCYTIC_2	218	221	PF00928	0.407
TRG_ENDOCYTIC_2	259	262	PF00928	0.478
TRG_ENDOCYTIC_2	317	320	PF00928	0.487
TRG_ENDOCYTIC_2	378	381	PF00928	0.387
TRG_ENDOCYTIC_2	388	391	PF00928	0.439
TRG_ENDOCYTIC_2	462	465	PF00928	0.633
TRG_ENDOCYTIC_2	611	614	PF00928	0.626
TRG_ENDOCYTIC_2	944	947	PF00928	0.568
TRG_ER_diArg_1	195	198	PF00400	0.627
TRG_ER_diArg_1	320	322	PF00400	0.478
TRG_ER_diArg_1	538	540	PF00400	0.675
TRG_ER_diArg_1	598	600	PF00400	0.586
TRG_ER_diArg_1	720	722	PF00400	0.595
TRG_ER_diArg_1	792	794	PF00400	0.653
TRG_ER_diArg_1	871	873	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	452	457	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH8	Leptomonas seymouri	57%	83%
A0A3R7NJM0	Trypanosoma rangeli	43%	100%
A0A3S7WX68	Leishmania donovani	100%	84%
A4HCB6	Leishmania braziliensis	81%	100%
A4HZV0	Leishmania infantum	100%	100%
C9ZSF9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AVQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AVR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	96%
Q4QBR5	Leishmania major	94%	100%
Q4QBS5	Leishmania major	94%	100%
V5BVT0	Trypanosoma cruzi	44%	100%