BSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IC68_LEIDO

TriTrypDb:

LdBPK_302890.1 , LdCL_300034500 , LDHU3_30.3840

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IC68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.480
CLV_C14_Caspase3-7	358	362	PF00656	0.297
CLV_NRD_NRD_1	228	230	PF00675	0.425
CLV_NRD_NRD_1	298	300	PF00675	0.413
CLV_NRD_NRD_1	317	319	PF00675	0.292
CLV_PCSK_SKI1_1	379	383	PF00082	0.379
DEG_COP1_1	54	62	PF00400	0.322
DEG_Nend_Nbox_1	1	3	PF02207	0.428
DOC_MAPK_gen_1	297	304	PF00069	0.370
DOC_PP2B_LxvP_1	115	118	PF13499	0.574
DOC_PP2B_LxvP_1	126	129	PF13499	0.545
DOC_PP2B_LxvP_1	57	60	PF13499	0.375
DOC_PP4_MxPP_1	63	66	PF00568	0.408
DOC_USP7_MATH_1	15	19	PF00917	0.405
DOC_USP7_MATH_1	238	242	PF00917	0.473
DOC_USP7_MATH_1	35	39	PF00917	0.409
DOC_USP7_MATH_1	352	356	PF00917	0.332
DOC_USP7_MATH_1	390	394	PF00917	0.535
DOC_USP7_MATH_1	440	444	PF00917	0.692
DOC_USP7_MATH_1	452	456	PF00917	0.483
DOC_USP7_MATH_1	99	103	PF00917	0.295
DOC_USP7_UBL2_3	268	272	PF12436	0.544
DOC_WW_Pin1_4	127	132	PF00397	0.598
DOC_WW_Pin1_4	152	157	PF00397	0.377
DOC_WW_Pin1_4	392	397	PF00397	0.686
DOC_WW_Pin1_4	399	404	PF00397	0.585
DOC_WW_Pin1_4	412	417	PF00397	0.564
DOC_WW_Pin1_4	429	434	PF00397	0.641
DOC_WW_Pin1_4	90	95	PF00397	0.340
LIG_14-3-3_CanoR_1	180	189	PF00244	0.399
LIG_14-3-3_CanoR_1	437	445	PF00244	0.703
LIG_CtBP_PxDLS_1	433	437	PF00389	0.510
LIG_deltaCOP1_diTrp_1	184	193	PF00928	0.248
LIG_deltaCOP1_diTrp_1	73	78	PF00928	0.341
LIG_FHA_1	28	34	PF00498	0.424
LIG_FHA_1	54	60	PF00498	0.352
LIG_FHA_1	87	93	PF00498	0.460
LIG_FHA_2	180	186	PF00498	0.393
LIG_FHA_2	356	362	PF00498	0.469
LIG_LIR_Apic_2	175	179	PF02991	0.395
LIG_LIR_Gen_1	185	195	PF02991	0.252
LIG_LIR_Gen_1	286	295	PF02991	0.365
LIG_LIR_Gen_1	332	343	PF02991	0.362
LIG_LIR_Gen_1	366	372	PF02991	0.267
LIG_LIR_Nem_3	166	171	PF02991	0.431
LIG_LIR_Nem_3	185	191	PF02991	0.256
LIG_LIR_Nem_3	286	291	PF02991	0.345
LIG_LIR_Nem_3	332	338	PF02991	0.364
LIG_LIR_Nem_3	366	371	PF02991	0.267
LIG_SH2_CRK	335	339	PF00017	0.367
LIG_SH2_NCK_1	154	158	PF00017	0.301
LIG_SH2_NCK_1	281	285	PF00017	0.418
LIG_SH2_PTP2	176	179	PF00017	0.391
LIG_SH2_STAT5	154	157	PF00017	0.391
LIG_SH2_STAT5	163	166	PF00017	0.384
LIG_SH2_STAT5	176	179	PF00017	0.410
LIG_SH2_STAT5	377	380	PF00017	0.333
LIG_SH3_2	118	123	PF14604	0.474
LIG_SH3_3	115	121	PF00018	0.497
LIG_SH3_3	228	234	PF00018	0.429
LIG_SH3_3	397	403	PF00018	0.637
LIG_SUMO_SIM_par_1	54	61	PF11976	0.348
LIG_TRAF2_1	455	458	PF00917	0.498
LIG_TRAF2_1	51	54	PF00917	0.525
LIG_TRAF2_1	72	75	PF00917	0.321
LIG_UBA3_1	311	319	PF00899	0.295
LIG_UBA3_1	367	373	PF00899	0.290
MOD_CDK_SPK_2	392	397	PF00069	0.487
MOD_CK1_1	127	133	PF00069	0.491
MOD_CK1_1	18	24	PF00069	0.540
MOD_CK1_1	355	361	PF00069	0.428
MOD_CK1_1	401	407	PF00069	0.590
MOD_CK1_1	441	447	PF00069	0.694
MOD_CK2_1	179	185	PF00069	0.347
MOD_CK2_1	429	435	PF00069	0.588
MOD_CK2_1	452	458	PF00069	0.551
MOD_CK2_1	69	75	PF00069	0.316
MOD_CK2_1	99	105	PF00069	0.430
MOD_GlcNHglycan	10	13	PF01048	0.444
MOD_GlcNHglycan	125	129	PF01048	0.498
MOD_GlcNHglycan	240	243	PF01048	0.490
MOD_GlcNHglycan	363	366	PF01048	0.408
MOD_GlcNHglycan	390	393	PF01048	0.478
MOD_GlcNHglycan	404	407	PF01048	0.522
MOD_GlcNHglycan	409	412	PF01048	0.776
MOD_GlcNHglycan	438	441	PF01048	0.582
MOD_GlcNHglycan	44	47	PF01048	0.563
MOD_GSK3_1	129	136	PF00069	0.655
MOD_GSK3_1	325	332	PF00069	0.280
MOD_GSK3_1	355	362	PF00069	0.313
MOD_GSK3_1	388	395	PF00069	0.456
MOD_GSK3_1	398	405	PF00069	0.503
MOD_GSK3_1	421	428	PF00069	0.562
MOD_GSK3_1	436	443	PF00069	0.675
MOD_GSK3_1	65	72	PF00069	0.493
MOD_GSK3_1	86	93	PF00069	0.325
MOD_N-GLC_1	133	138	PF02516	0.428
MOD_N-GLC_2	276	278	PF02516	0.256
MOD_N-GLC_2	88	90	PF02516	0.283
MOD_NEK2_1	210	215	PF00069	0.414
MOD_NEK2_1	311	316	PF00069	0.286
MOD_NEK2_1	325	330	PF00069	0.244
MOD_NEK2_1	359	364	PF00069	0.374
MOD_NEK2_1	436	441	PF00069	0.498
MOD_PK_1	55	61	PF00069	0.338
MOD_PKA_2	179	185	PF00069	0.337
MOD_PKA_2	27	33	PF00069	0.491
MOD_PKA_2	436	442	PF00069	0.667
MOD_Plk_1	53	59	PF00069	0.443
MOD_Plk_1	99	105	PF00069	0.395
MOD_Plk_4	311	317	PF00069	0.360
MOD_Plk_4	325	331	PF00069	0.280
MOD_Plk_4	355	361	PF00069	0.314
MOD_Plk_4	363	369	PF00069	0.271
MOD_Plk_4	99	105	PF00069	0.464
MOD_ProDKin_1	127	133	PF00069	0.594
MOD_ProDKin_1	152	158	PF00069	0.383
MOD_ProDKin_1	392	398	PF00069	0.688
MOD_ProDKin_1	399	405	PF00069	0.586
MOD_ProDKin_1	412	418	PF00069	0.566
MOD_ProDKin_1	429	435	PF00069	0.640
MOD_ProDKin_1	90	96	PF00069	0.343
MOD_SUMO_for_1	234	237	PF00179	0.608
MOD_SUMO_rev_2	100	110	PF00179	0.440
MOD_SUMO_rev_2	455	465	PF00179	0.574
TRG_DiLeu_BaEn_4	262	268	PF01217	0.362
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.302
TRG_ENDOCYTIC_2	281	284	PF00928	0.299
TRG_ENDOCYTIC_2	335	338	PF00928	0.367
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q4	Leptomonas seymouri	46%	97%
A0A1X0P2L0	Trypanosomatidae	30%	100%
A0A422N306	Trypanosoma rangeli	28%	100%
A4HIM1	Leishmania braziliensis	69%	100%
A4I5W6	Leishmania infantum	99%	100%
C9ZR88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4Q705	Leishmania major	88%	100%
V5DNX2	Trypanosoma cruzi	27%	100%