60S_ribosomal_protein_L37a/GeneDB:LmjF.36.1925

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L37a, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC65_LEIDO

TriTrypDb:

LdBPK_212190.1 , LdCL_210027600 , LdCL_360025700 , LDHU3_21.2600 , LDHU3_36.2630

Length:

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L37a

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 35

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 35

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005730	nucleolus	5	1

Expansion

Sequence features

A0A3Q8IC65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC65

PDB structure(s): 6az3_o

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.368
CLV_NRD_NRD_1	48	50	PF00675	0.368
CLV_NRD_NRD_1	84	86	PF00675	0.377
CLV_PCSK_KEX2_1	24	26	PF00082	0.368
CLV_PCSK_KEX2_1	3	5	PF00082	0.368
CLV_PCSK_KEX2_1	48	50	PF00082	0.368
CLV_PCSK_KEX2_1	84	86	PF00082	0.368
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.368
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.368
CLV_PCSK_PC7_1	80	86	PF00082	0.368
CLV_PCSK_SKI1_1	24	28	PF00082	0.223
CLV_PCSK_SKI1_1	4	8	PF00082	0.368
CLV_PCSK_SKI1_1	44	48	PF00082	0.300
DEG_SCF_FBW7_1	71	77	PF00400	0.368
DOC_CKS1_1	71	76	PF01111	0.368
DOC_MAPK_gen_1	23	31	PF00069	0.223
DOC_MAPK_gen_1	3	10	PF00069	0.372
DOC_MAPK_gen_1	48	54	PF00069	0.368
DOC_USP7_MATH_1	74	78	PF00917	0.400
DOC_USP7_UBL2_3	24	28	PF12436	0.368
DOC_USP7_UBL2_3	3	7	PF12436	0.386
DOC_WW_Pin1_4	70	75	PF00397	0.370
LIG_14-3-3_CanoR_1	80	84	PF00244	0.368
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_Pex14_2	41	45	PF04695	0.368
LIG_SH2_STAT5	69	72	PF00017	0.373
LIG_WRC_WIRS_1	38	43	PF05994	0.368
MOD_GSK3_1	70	77	PF00069	0.369
MOD_N-GLC_1	74	79	PF02516	0.368
MOD_NEK2_1	29	34	PF00069	0.393
MOD_NEK2_2	2	7	PF00069	0.393
MOD_PIKK_1	29	35	PF00454	0.368
MOD_PKA_2	79	85	PF00069	0.368
MOD_Plk_1	74	80	PF00069	0.368
MOD_ProDKin_1	70	76	PF00069	0.370
TRG_ER_diArg_1	22	25	PF00400	0.368
TRG_ER_diArg_1	47	49	PF00400	0.368
TRG_ER_diArg_1	83	85	PF00400	0.368
TRG_NLS_MonoExtC_3	22	27	PF00514	0.368
TRG_NLS_MonoExtN_4	22	28	PF00514	0.368
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.368
TRG_PTS1	89	92	PF00515	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYR6	Leptomonas seymouri	98%	100%
A0A0S4IY08	Bodo saltans	92%	100%
A0A1D8PP14	Candida albicans (strain SC5314 / ATCC MYA-2876)	63%	100%
A1RSS8	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	39%	91%
A4FZT8	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	37%	96%
A4HLC4	Leishmania braziliensis	100%	100%
A4HP58	Leishmania braziliensis	100%	100%
A4HZI8	Leishmania infantum	100%	100%
A4S6Z4	Ostreococcus lucimarinus (strain CCE9901)	68%	100%
A5UNQ7	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	36%	100%
A6NKH3	Homo sapiens	49%	99%
A6URN7	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	38%	96%
A6UTE9	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	38%	96%
A6VIN8	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	38%	96%
A9A848	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	38%	96%
B0R2Y1	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	39%	97%
B1Y976	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	45%	91%
B6YTZ8	Thermococcus onnurineus (strain NA1)	44%	100%
B8D6B7	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	36%	100%
C5A4Z4	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	45%	100%
C6A452	Thermococcus sibiricus (strain DSM 12597 / MM 739)	48%	100%
D0A344	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	97%	99%
D4AAZ6	Rattus norvegicus	67%	100%
E9ASW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O17307	Schistosoma mansoni	58%	100%
O26777	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	37%	100%
O30179	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	40%	100%
O61462	Cryptochiton stelleri	62%	100%
O61598	Ostertagia ostertagi	64%	100%
O74106	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	42%	100%
O94686	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	98%
O96184	Plasmodium falciparum (isolate 3D7)	52%	96%
P0CX25	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	100%
P0CX26	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	100%
P0DKK1	Oryza sativa subsp. japonica	67%	100%
P0DKK2	Oryza sativa subsp. japonica	67%	100%
P32046	Gallus gallus	64%	100%
P43209	Brassica rapa subsp. rapa	65%	99%
P54051	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	38%	100%
P60619	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	38%	100%
P61513	Homo sapiens	63%	100%
P61514	Mus musculus	63%	100%
P61515	Rattus norvegicus	63%	100%
Q00VK4	Ostreococcus tauri	67%	100%
Q23G98	Tetrahymena thermophila (strain SB210)	56%	89%
Q2NEX3	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	36%	100%
Q3MIC0	Bos taurus	63%	100%
Q4QC01	Leishmania major	100%	100%
Q54UG4	Dictyostelium discoideum	65%	100%
Q5JDM6	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	48%	100%
Q5RBF9	Pongo abelii	63%	100%
Q6FRG6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	62%	100%
Q6L225	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	49%	100%
Q6M0M1	Methanococcus maripaludis (strain S2 / LL)	37%	96%
Q74N55	Nanoarchaeum equitans (strain Kin4-M)	48%	100%
Q751L1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	64%	100%
Q7SZB4	Xenopus laevis	62%	100%
Q8RXU5	Arabidopsis thaliana	66%	100%
Q8TYC3	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	42%	100%
Q8TZI4	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	45%	100%
Q8ZVN1	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	46%	91%
Q90YT0	Ictalurus punctatus	61%	100%
Q975H0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	40%	100%
Q97BZ3	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	43%	100%
Q97ZQ3	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	42%	100%
Q9HGL8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	98%
Q9HIP0	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	46%	100%
Q9HSG8	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	39%	97%
Q9SRK6	Arabidopsis thaliana	62%	100%
Q9U2A8	Caenorhabditis elegans	65%	100%
Q9V202	Pyrococcus abyssi (strain GE5 / Orsay)	42%	100%
Q9VMU4	Drosophila melanogaster	60%	100%
Q9XHE4	Gossypium hirsutum	67%	100%
Q9Y0H7	Myxine glutinosa	57%	100%
Q9YC06	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	46%	100%
Q9ZRS8	Pseudotsuga menziesii	69%	100%
V5BU68	Trypanosoma cruzi	97%	100%