Inhibitor_of_cysteine_peptidase/GeneDB:LmjF.24.17 70

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inhibitor of cysteine peptidase

Species:

Leishmania donovani

UniProt:

A0A3Q8IC64_LEIDO

TriTrypDb:

LdBPK_241840.1 , LdCL_240024000 , LDHU3_24.2250

Length:

117

Annotations

Annotations by Jardim et al.

Proteases, Inhibitor of cysteine peptidase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IC64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC64

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002020	protease binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.483
CLV_NRD_NRD_1	85	87	PF00675	0.508
CLV_PCSK_SKI1_1	48	52	PF00082	0.386
DOC_MAPK_gen_1	2	11	PF00069	0.711
DOC_MAPK_gen_1	86	94	PF00069	0.392
DOC_MAPK_MEF2A_6	109	116	PF00069	0.425
DOC_MAPK_NFAT4_5	109	117	PF00069	0.386
DOC_USP7_UBL2_3	12	16	PF12436	0.564
DOC_USP7_UBL2_3	83	87	PF12436	0.355
DOC_WW_Pin1_4	60	65	PF00397	0.444
LIG_14-3-3_CanoR_1	109	113	PF00244	0.425
LIG_14-3-3_CanoR_1	2	8	PF00244	0.509
LIG_APCC_ABBAyCdc20_2	109	115	PF00400	0.362
LIG_FHA_1	109	115	PF00498	0.331
LIG_FHA_1	23	29	PF00498	0.353
LIG_FHA_1	4	10	PF00498	0.564
LIG_FHA_1	77	83	PF00498	0.401
LIG_FHA_1	89	95	PF00498	0.409
LIG_FHA_2	8	14	PF00498	0.447
LIG_LIR_Apic_2	93	99	PF02991	0.297
LIG_LIR_Gen_1	77	85	PF02991	0.367
LIG_LIR_Nem_3	77	81	PF02991	0.367
LIG_SH2_CRK	78	82	PF00017	0.504
LIG_SH2_CRK	96	100	PF00017	0.409
LIG_SH2_STAP1	110	114	PF00017	0.490
LIG_SH2_STAP1	78	82	PF00017	0.405
LIG_SH2_STAT5	110	113	PF00017	0.412
LIG_SH2_STAT5	62	65	PF00017	0.418
LIG_SH2_STAT5	78	81	PF00017	0.393
LIG_SH3_3	64	70	PF00018	0.275
LIG_SH3_4	83	90	PF00018	0.355
LIG_SUMO_SIM_anti_2	52	60	PF11976	0.307
LIG_SUMO_SIM_par_1	6	13	PF11976	0.586
MOD_CK1_1	60	66	PF00069	0.418
MOD_CK2_1	21	27	PF00069	0.358
MOD_GlcNHglycan	67	70	PF01048	0.461
MOD_GSK3_1	3	10	PF00069	0.511
MOD_N-GLC_2	15	17	PF02516	0.469
MOD_PKA_2	108	114	PF00069	0.425
MOD_Plk_2-3	49	55	PF00069	0.450
MOD_Plk_4	76	82	PF00069	0.408
MOD_ProDKin_1	60	66	PF00069	0.444
MOD_SUMO_for_1	103	106	PF00179	0.307
TRG_ENDOCYTIC_2	78	81	PF00928	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR0	Leptomonas seymouri	48%	100%
A0A1X0NX79	Trypanosomatidae	31%	100%
A0A1X0NXG1	Trypanosomatidae	32%	90%
A0A3R7MAP9	Trypanosoma rangeli	35%	100%
A4HDN8	Leishmania braziliensis	60%	100%
C9ZWC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	97%
E9AH84	Leishmania infantum	100%	100%
E9AX22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q6KCA4	Entamoeba histolytica	31%	100%
Q868G9	Leishmania major	81%	100%
Q966X9	Trypanosoma cruzi	38%	100%