RNA pseudouridylate synthase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC63_LEIDO

TriTrypDb:

LdBPK_261140.1 , LdCL_260017000 , LDHU3_26.1420

Length:

976

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IC63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC63

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0009982	pseudouridine synthase activity	4	7
GO:0016853	isomerase activity	2	7
GO:0016866	intramolecular transferase activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.629
CLV_C14_Caspase3-7	441	445	PF00656	0.676
CLV_NRD_NRD_1	129	131	PF00675	0.592
CLV_NRD_NRD_1	177	179	PF00675	0.622
CLV_NRD_NRD_1	182	184	PF00675	0.594
CLV_NRD_NRD_1	390	392	PF00675	0.311
CLV_NRD_NRD_1	397	399	PF00675	0.521
CLV_NRD_NRD_1	414	416	PF00675	0.585
CLV_NRD_NRD_1	5	7	PF00675	0.598
CLV_NRD_NRD_1	66	68	PF00675	0.381
CLV_NRD_NRD_1	773	775	PF00675	0.828
CLV_NRD_NRD_1	87	89	PF00675	0.374
CLV_NRD_NRD_1	955	957	PF00675	0.427
CLV_PCSK_KEX2_1	129	131	PF00082	0.621
CLV_PCSK_KEX2_1	133	135	PF00082	0.629
CLV_PCSK_KEX2_1	176	178	PF00082	0.624
CLV_PCSK_KEX2_1	182	184	PF00082	0.592
CLV_PCSK_KEX2_1	271	273	PF00082	0.275
CLV_PCSK_KEX2_1	390	392	PF00082	0.275
CLV_PCSK_KEX2_1	413	415	PF00082	0.577
CLV_PCSK_KEX2_1	5	7	PF00082	0.598
CLV_PCSK_KEX2_1	66	68	PF00082	0.381
CLV_PCSK_KEX2_1	773	775	PF00082	0.779
CLV_PCSK_KEX2_1	795	797	PF00082	0.614
CLV_PCSK_KEX2_1	87	89	PF00082	0.425
CLV_PCSK_KEX2_1	955	957	PF00082	0.427
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.546
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.329
CLV_PCSK_PC1ET2_1	795	797	PF00082	0.614
CLV_PCSK_PC7_1	129	135	PF00082	0.654
CLV_PCSK_PC7_1	178	184	PF00082	0.619
CLV_PCSK_PC7_1	83	89	PF00082	0.430
CLV_PCSK_SKI1_1	119	123	PF00082	0.495
CLV_PCSK_SKI1_1	129	133	PF00082	0.581
CLV_PCSK_SKI1_1	398	402	PF00082	0.503
CLV_PCSK_SKI1_1	51	55	PF00082	0.573
CLV_PCSK_SKI1_1	778	782	PF00082	0.662
CLV_PCSK_SKI1_1	792	796	PF00082	0.523
CLV_PCSK_SKI1_1	87	91	PF00082	0.377
CLV_PCSK_SKI1_1	890	894	PF00082	0.611
CLV_Separin_Metazoa	410	414	PF03568	0.556
DEG_APCC_DBOX_1	651	659	PF00400	0.442
DEG_ODPH_VHL_1	268	279	PF01847	0.529
DEG_SCF_FBW7_1	159	166	PF00400	0.518
DEG_SCF_FBW7_2	430	435	PF00400	0.712
DEG_SPOP_SBC_1	678	682	PF00917	0.584
DEG_SPOP_SBC_1	930	934	PF00917	0.576
DOC_ANK_TNKS_1	955	962	PF00023	0.416
DOC_CDC14_PxL_1	608	616	PF14671	0.517
DOC_CKS1_1	160	165	PF01111	0.541
DOC_CKS1_1	506	511	PF01111	0.676
DOC_CKS1_1	640	645	PF01111	0.463
DOC_CYCLIN_RxL_1	123	135	PF00134	0.553
DOC_CYCLIN_RxL_1	81	91	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	523	529	PF00134	0.648
DOC_MAPK_gen_1	271	279	PF00069	0.529
DOC_MAPK_gen_1	371	381	PF00069	0.475
DOC_MAPK_gen_1	729	737	PF00069	0.570
DOC_MAPK_MEF2A_6	211	220	PF00069	0.425
DOC_PP2B_LxvP_1	521	524	PF13499	0.635
DOC_PP4_FxxP_1	609	612	PF00568	0.574
DOC_PP4_FxxP_1	966	969	PF00568	0.420
DOC_USP7_MATH_1	136	140	PF00917	0.462
DOC_USP7_MATH_1	189	193	PF00917	0.563
DOC_USP7_MATH_1	344	348	PF00917	0.460
DOC_USP7_MATH_1	418	422	PF00917	0.655
DOC_USP7_MATH_1	440	444	PF00917	0.623
DOC_USP7_MATH_1	544	548	PF00917	0.535
DOC_USP7_MATH_1	593	597	PF00917	0.580
DOC_USP7_MATH_1	626	630	PF00917	0.605
DOC_USP7_MATH_1	669	673	PF00917	0.581
DOC_USP7_MATH_1	678	682	PF00917	0.642
DOC_USP7_MATH_1	769	773	PF00917	0.827
DOC_USP7_MATH_1	799	803	PF00917	0.600
DOC_USP7_MATH_1	824	828	PF00917	0.618
DOC_USP7_MATH_1	842	846	PF00917	0.538
DOC_USP7_MATH_1	919	923	PF00917	0.715
DOC_USP7_MATH_1	928	932	PF00917	0.701
DOC_WW_Pin1_4	159	164	PF00397	0.754
DOC_WW_Pin1_4	183	188	PF00397	0.607
DOC_WW_Pin1_4	20	25	PF00397	0.505
DOC_WW_Pin1_4	291	296	PF00397	0.533
DOC_WW_Pin1_4	428	433	PF00397	0.783
DOC_WW_Pin1_4	436	441	PF00397	0.832
DOC_WW_Pin1_4	455	460	PF00397	0.593
DOC_WW_Pin1_4	505	510	PF00397	0.714
DOC_WW_Pin1_4	513	518	PF00397	0.659
DOC_WW_Pin1_4	594	599	PF00397	0.599
DOC_WW_Pin1_4	639	644	PF00397	0.453
DOC_WW_Pin1_4	704	709	PF00397	0.676
DOC_WW_Pin1_4	767	772	PF00397	0.701
DOC_WW_Pin1_4	904	909	PF00397	0.746
DOC_WW_Pin1_4	921	926	PF00397	0.557
DOC_WW_Pin1_4	98	103	PF00397	0.445
LIG_14-3-3_CanoR_1	123	132	PF00244	0.557
LIG_14-3-3_CanoR_1	313	319	PF00244	0.483
LIG_14-3-3_CanoR_1	468	476	PF00244	0.448
LIG_14-3-3_CanoR_1	548	556	PF00244	0.566
LIG_14-3-3_CanoR_1	652	662	PF00244	0.424
LIG_14-3-3_CanoR_1	748	754	PF00244	0.640
LIG_14-3-3_CanoR_1	778	783	PF00244	0.661
LIG_APCC_ABBA_1	90	95	PF00400	0.363
LIG_APCC_ABBAyCdc20_2	732	738	PF00400	0.590
LIG_BIR_III_4	783	787	PF00653	0.642
LIG_FHA_1	215	221	PF00498	0.387
LIG_FHA_1	259	265	PF00498	0.475
LIG_FHA_1	288	294	PF00498	0.475
LIG_FHA_1	30	36	PF00498	0.511
LIG_FHA_1	374	380	PF00498	0.475
LIG_FHA_1	406	412	PF00498	0.507
LIG_FHA_1	471	477	PF00498	0.453
LIG_FHA_1	583	589	PF00498	0.574
LIG_FHA_1	60	66	PF00498	0.578
LIG_FHA_1	643	649	PF00498	0.551
LIG_FHA_1	75	81	PF00498	0.328
LIG_FHA_1	789	795	PF00498	0.584
LIG_FHA_1	826	832	PF00498	0.629
LIG_FHA_1	875	881	PF00498	0.571
LIG_FHA_2	40	46	PF00498	0.513
LIG_FHA_2	7	13	PF00498	0.580
LIG_LIR_Apic_2	157	163	PF02991	0.649
LIG_LIR_Apic_2	18	24	PF02991	0.485
LIG_LIR_Gen_1	203	214	PF02991	0.394
LIG_LIR_Gen_1	73	80	PF02991	0.382
LIG_LIR_Gen_1	733	742	PF02991	0.580
LIG_LIR_Nem_3	203	209	PF02991	0.378
LIG_LIR_Nem_3	300	305	PF02991	0.474
LIG_LIR_Nem_3	73	79	PF02991	0.388
LIG_LIR_Nem_3	733	737	PF02991	0.602
LIG_NRBOX	259	265	PF00104	0.529
LIG_NRBOX	603	609	PF00104	0.580
LIG_NRP_CendR_1	975	976	PF00754	0.580
LIG_PTAP_UEV_1	307	312	PF05743	0.434
LIG_SH2_CRK	160	164	PF00017	0.649
LIG_SH2_CRK	206	210	PF00017	0.392
LIG_SH2_CRK	236	240	PF00017	0.312
LIG_SH2_CRK	257	261	PF00017	0.475
LIG_SH2_CRK	305	309	PF00017	0.460
LIG_SH2_GRB2like	256	259	PF00017	0.529
LIG_SH2_NCK_1	160	164	PF00017	0.649
LIG_SH2_NCK_1	305	309	PF00017	0.495
LIG_SH2_NCK_1	859	863	PF00017	0.536
LIG_SH2_SRC	305	308	PF00017	0.529
LIG_SH2_STAP1	105	109	PF00017	0.374
LIG_SH2_STAP1	302	306	PF00017	0.529
LIG_SH2_STAP1	72	76	PF00017	0.448
LIG_SH2_STAP1	93	97	PF00017	0.399
LIG_SH2_STAT3	115	118	PF00017	0.455
LIG_SH2_STAT3	41	44	PF00017	0.448
LIG_SH2_STAT3	474	477	PF00017	0.435
LIG_SH2_STAT5	115	118	PF00017	0.455
LIG_SH2_STAT5	160	163	PF00017	0.649
LIG_SH2_STAT5	266	269	PF00017	0.524
LIG_SH2_STAT5	342	345	PF00017	0.495
LIG_SH2_STAT5	41	44	PF00017	0.462
LIG_SH2_STAT5	480	483	PF00017	0.427
LIG_SH2_STAT5	545	548	PF00017	0.590
LIG_SH2_STAT5	644	647	PF00017	0.483
LIG_SH2_STAT5	749	752	PF00017	0.567
LIG_SH3_1	305	311	PF00018	0.495
LIG_SH3_1	33	39	PF00018	0.556
LIG_SH3_2	308	313	PF14604	0.495
LIG_SH3_3	181	187	PF00018	0.528
LIG_SH3_3	238	244	PF00018	0.529
LIG_SH3_3	264	270	PF00018	0.475
LIG_SH3_3	276	282	PF00018	0.475
LIG_SH3_3	305	311	PF00018	0.543
LIG_SH3_3	315	321	PF00018	0.494
LIG_SH3_3	33	39	PF00018	0.485
LIG_SH3_3	362	368	PF00018	0.529
LIG_SH3_3	43	49	PF00018	0.541
LIG_SH3_3	449	455	PF00018	0.683
LIG_SH3_3	456	462	PF00018	0.595
LIG_SH3_3	506	512	PF00018	0.679
LIG_SH3_3	514	520	PF00018	0.682
LIG_SH3_3	583	589	PF00018	0.652
LIG_SH3_3	684	690	PF00018	0.635
LIG_SH3_3	832	838	PF00018	0.554
LIG_SH3_3	922	928	PF00018	0.701
LIG_Sin3_3	223	230	PF02671	0.410
LIG_SUMO_SIM_anti_2	376	383	PF11976	0.485
LIG_TRAF2_1	42	45	PF00917	0.506
LIG_TRAF2_1	633	636	PF00917	0.507
LIG_TRAF2_1	756	759	PF00917	0.487
LIG_TRFH_1	266	270	PF08558	0.312
LIG_TYR_ITIM	204	209	PF00017	0.378
LIG_WW_3	313	317	PF00397	0.255
MOD_CDC14_SPxK_1	707	710	PF00782	0.579
MOD_CDC14_SPxK_1	770	773	PF00782	0.667
MOD_CDK_SPK_2	908	913	PF00069	0.570
MOD_CDK_SPxK_1	704	710	PF00069	0.583
MOD_CDK_SPxK_1	767	773	PF00069	0.657
MOD_CDK_SPxxK_3	20	27	PF00069	0.490
MOD_CDK_SPxxK_3	291	298	PF00069	0.340
MOD_CDK_SPxxK_3	767	774	PF00069	0.707
MOD_CK1_1	158	164	PF00069	0.711
MOD_CK1_1	259	265	PF00069	0.340
MOD_CK1_1	286	292	PF00069	0.302
MOD_CK1_1	335	341	PF00069	0.401
MOD_CK1_1	347	353	PF00069	0.336
MOD_CK1_1	495	501	PF00069	0.698
MOD_CK1_1	629	635	PF00069	0.558
MOD_CK1_1	903	909	PF00069	0.681
MOD_CK1_1	931	937	PF00069	0.602
MOD_CK2_1	189	195	PF00069	0.579
MOD_CK2_1	259	265	PF00069	0.340
MOD_CK2_1	291	297	PF00069	0.312
MOD_CK2_1	347	353	PF00069	0.255
MOD_CK2_1	39	45	PF00069	0.490
MOD_CK2_1	469	475	PF00069	0.530
MOD_CK2_1	6	12	PF00069	0.583
MOD_CK2_1	629	635	PF00069	0.629
MOD_CK2_1	929	935	PF00069	0.637
MOD_Cter_Amidation	85	88	PF01082	0.390
MOD_DYRK1A_RPxSP_1	183	187	PF00069	0.609
MOD_GlcNHglycan	134	137	PF01048	0.534
MOD_GlcNHglycan	138	141	PF01048	0.566
MOD_GlcNHglycan	150	153	PF01048	0.557
MOD_GlcNHglycan	169	172	PF01048	0.543
MOD_GlcNHglycan	308	311	PF01048	0.286
MOD_GlcNHglycan	335	338	PF01048	0.408
MOD_GlcNHglycan	348	352	PF01048	0.338
MOD_GlcNHglycan	376	379	PF01048	0.312
MOD_GlcNHglycan	487	490	PF01048	0.578
MOD_GlcNHglycan	494	497	PF01048	0.620
MOD_GlcNHglycan	551	554	PF01048	0.762
MOD_GlcNHglycan	571	574	PF01048	0.768
MOD_GlcNHglycan	615	618	PF01048	0.688
MOD_GlcNHglycan	62	65	PF01048	0.469
MOD_GlcNHglycan	631	634	PF01048	0.539
MOD_GlcNHglycan	671	674	PF01048	0.653
MOD_GlcNHglycan	698	701	PF01048	0.605
MOD_GlcNHglycan	718	722	PF01048	0.612
MOD_GlcNHglycan	877	880	PF01048	0.496
MOD_GlcNHglycan	938	941	PF01048	0.664
MOD_GSK3_1	132	139	PF00069	0.516
MOD_GSK3_1	144	151	PF00069	0.595
MOD_GSK3_1	154	161	PF00069	0.615
MOD_GSK3_1	162	169	PF00069	0.539
MOD_GSK3_1	242	249	PF00069	0.312
MOD_GSK3_1	283	290	PF00069	0.331
MOD_GSK3_1	329	336	PF00069	0.417
MOD_GSK3_1	343	350	PF00069	0.276
MOD_GSK3_1	436	443	PF00069	0.749
MOD_GSK3_1	454	461	PF00069	0.564
MOD_GSK3_1	51	58	PF00069	0.590
MOD_GSK3_1	544	551	PF00069	0.559
MOD_GSK3_1	625	632	PF00069	0.682
MOD_GSK3_1	694	701	PF00069	0.768
MOD_GSK3_1	900	907	PF00069	0.732
MOD_GSK3_1	917	924	PF00069	0.563
MOD_N-GLC_1	166	171	PF02516	0.536
MOD_N-GLC_1	418	423	PF02516	0.544
MOD_N-GLC_1	55	60	PF02516	0.535
MOD_N-GLC_1	944	949	PF02516	0.623
MOD_NEK2_1	132	137	PF00069	0.539
MOD_NEK2_1	148	153	PF00069	0.573
MOD_NEK2_1	155	160	PF00069	0.559
MOD_NEK2_1	283	288	PF00069	0.302
MOD_NEK2_1	29	34	PF00069	0.492
MOD_NEK2_1	549	554	PF00069	0.565
MOD_NEK2_1	60	65	PF00069	0.516
MOD_NEK2_1	653	658	PF00069	0.505
MOD_NEK2_1	74	79	PF00069	0.353
MOD_NEK2_1	825	830	PF00069	0.662
MOD_NEK2_1	917	922	PF00069	0.655
MOD_NEK2_2	749	754	PF00069	0.564
MOD_PIKK_1	124	130	PF00454	0.553
MOD_PIKK_1	680	686	PF00454	0.660
MOD_PK_1	391	397	PF00069	0.340
MOD_PKA_2	725	731	PF00069	0.617
MOD_PKB_1	483	491	PF00069	0.606
MOD_Plk_1	44	50	PF00069	0.497
MOD_Plk_1	55	61	PF00069	0.527
MOD_Plk_1	72	78	PF00069	0.371
MOD_Plk_4	155	161	PF00069	0.517
MOD_Plk_4	259	265	PF00069	0.340
MOD_Plk_4	283	289	PF00069	0.302
MOD_Plk_4	391	397	PF00069	0.291
MOD_ProDKin_1	159	165	PF00069	0.753
MOD_ProDKin_1	183	189	PF00069	0.606
MOD_ProDKin_1	20	26	PF00069	0.507
MOD_ProDKin_1	291	297	PF00069	0.392
MOD_ProDKin_1	428	434	PF00069	0.782
MOD_ProDKin_1	436	442	PF00069	0.832
MOD_ProDKin_1	455	461	PF00069	0.586
MOD_ProDKin_1	505	511	PF00069	0.707
MOD_ProDKin_1	513	519	PF00069	0.658
MOD_ProDKin_1	594	600	PF00069	0.592
MOD_ProDKin_1	639	645	PF00069	0.454
MOD_ProDKin_1	704	710	PF00069	0.676
MOD_ProDKin_1	767	773	PF00069	0.705
MOD_ProDKin_1	904	910	PF00069	0.745
MOD_ProDKin_1	921	927	PF00069	0.577
MOD_ProDKin_1	98	104	PF00069	0.435
MOD_SUMO_rev_2	813	823	PF00179	0.620
TRG_AP2beta_CARGO_1	73	83	PF09066	0.387
TRG_DiLeu_BaEn_4	635	641	PF01217	0.533
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.547
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.312
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.434
TRG_ENDOCYTIC_2	206	209	PF00928	0.385
TRG_ENDOCYTIC_2	236	239	PF00928	0.342
TRG_ENDOCYTIC_2	257	260	PF00928	0.312
TRG_ER_diArg_1	129	131	PF00400	0.563
TRG_ER_diArg_1	175	178	PF00400	0.588
TRG_ER_diArg_1	182	184	PF00400	0.556
TRG_ER_diArg_1	390	392	PF00400	0.315
TRG_ER_diArg_1	412	415	PF00400	0.576
TRG_ER_diArg_1	483	486	PF00400	0.547
TRG_ER_diArg_1	5	7	PF00400	0.596
TRG_ER_diArg_1	562	565	PF00400	0.606
TRG_ER_diArg_1	65	67	PF00400	0.395
TRG_ER_diArg_1	690	693	PF00400	0.578
TRG_ER_diArg_1	87	89	PF00400	0.425
TRG_ER_diArg_1	955	957	PF00400	0.467
TRG_ER_diArg_1	974	976	PF00400	0.565
TRG_NLS_MonoExtN_4	792	799	PF00514	0.635
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	955	960	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN9	Leptomonas seymouri	43%	100%
A4HEX1	Leishmania braziliensis	70%	98%
A4I245	Leishmania infantum	100%	100%
E9AY95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q978	Leishmania major	88%	100%