LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IC62_LEIDO
TriTrypDb:
LdBPK_150190.1 , LdCL_150006800 , LDHU3_15.0270
Length:
585

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IC62
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC62

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 280 284 PF00656 0.645
CLV_C14_Caspase3-7 547 551 PF00656 0.578
CLV_MEL_PAP_1 405 411 PF00089 0.570
CLV_NRD_NRD_1 275 277 PF00675 0.737
CLV_NRD_NRD_1 320 322 PF00675 0.658
CLV_NRD_NRD_1 367 369 PF00675 0.656
CLV_NRD_NRD_1 393 395 PF00675 0.594
CLV_NRD_NRD_1 476 478 PF00675 0.655
CLV_NRD_NRD_1 580 582 PF00675 0.687
CLV_PCSK_KEX2_1 275 277 PF00082 0.737
CLV_PCSK_KEX2_1 320 322 PF00082 0.681
CLV_PCSK_KEX2_1 367 369 PF00082 0.656
CLV_PCSK_KEX2_1 393 395 PF00082 0.554
CLV_PCSK_KEX2_1 476 478 PF00082 0.655
CLV_PCSK_KEX2_1 580 582 PF00082 0.687
CLV_PCSK_PC1ET2_1 393 395 PF00082 0.531
CLV_PCSK_SKI1_1 404 408 PF00082 0.546
CLV_PCSK_SKI1_1 499 503 PF00082 0.534
DEG_Nend_UBRbox_2 1 3 PF02207 0.584
DEG_ODPH_VHL_1 233 246 PF01847 0.589
DEG_SCF_FBW7_1 196 203 PF00400 0.630
DEG_SCF_FBW7_1 84 90 PF00400 0.563
DEG_SCF_FBW7_2 33 38 PF00400 0.544
DEG_SPOP_SBC_1 466 470 PF00917 0.531
DOC_CKS1_1 289 294 PF01111 0.586
DOC_CKS1_1 84 89 PF01111 0.565
DOC_CYCLIN_RxL_1 401 411 PF00134 0.562
DOC_MAPK_gen_1 402 409 PF00069 0.540
DOC_MAPK_MEF2A_6 102 111 PF00069 0.614
DOC_MAPK_MEF2A_6 402 409 PF00069 0.556
DOC_MAPK_NFAT4_5 402 410 PF00069 0.568
DOC_PP2B_LxvP_1 519 522 PF13499 0.685
DOC_PP2B_LxvP_1 557 560 PF13499 0.608
DOC_USP7_MATH_1 101 105 PF00917 0.540
DOC_USP7_MATH_1 132 136 PF00917 0.605
DOC_USP7_MATH_1 142 146 PF00917 0.531
DOC_USP7_MATH_1 175 179 PF00917 0.646
DOC_USP7_MATH_1 21 25 PF00917 0.644
DOC_USP7_MATH_1 325 329 PF00917 0.614
DOC_USP7_MATH_1 345 349 PF00917 0.726
DOC_USP7_MATH_1 355 359 PF00917 0.608
DOC_USP7_MATH_1 456 460 PF00917 0.553
DOC_USP7_MATH_1 466 470 PF00917 0.494
DOC_USP7_MATH_1 529 533 PF00917 0.650
DOC_USP7_MATH_1 80 84 PF00917 0.664
DOC_USP7_MATH_1 87 91 PF00917 0.602
DOC_WW_Pin1_4 164 169 PF00397 0.647
DOC_WW_Pin1_4 196 201 PF00397 0.702
DOC_WW_Pin1_4 224 229 PF00397 0.752
DOC_WW_Pin1_4 236 241 PF00397 0.546
DOC_WW_Pin1_4 288 293 PF00397 0.679
DOC_WW_Pin1_4 31 36 PF00397 0.545
DOC_WW_Pin1_4 508 513 PF00397 0.629
DOC_WW_Pin1_4 522 527 PF00397 0.625
DOC_WW_Pin1_4 58 63 PF00397 0.671
DOC_WW_Pin1_4 83 88 PF00397 0.657
LIG_14-3-3_CanoR_1 138 146 PF00244 0.589
LIG_14-3-3_CanoR_1 171 175 PF00244 0.627
LIG_14-3-3_CanoR_1 333 337 PF00244 0.600
LIG_14-3-3_CanoR_1 455 465 PF00244 0.527
LIG_14-3-3_CanoR_1 530 535 PF00244 0.719
LIG_14-3-3_CanoR_1 562 567 PF00244 0.709
LIG_Actin_WH2_2 393 410 PF00022 0.575
LIG_BRCT_BRCA1_1 365 369 PF00533 0.558
LIG_BRCT_BRCA1_1 54 58 PF00533 0.602
LIG_CtBP_PxDLS_1 487 491 PF00389 0.487
LIG_FHA_1 154 160 PF00498 0.678
LIG_FHA_1 181 187 PF00498 0.536
LIG_FHA_1 201 207 PF00498 0.595
LIG_FHA_1 23 29 PF00498 0.674
LIG_FHA_1 280 286 PF00498 0.840
LIG_FHA_1 302 308 PF00498 0.615
LIG_FHA_1 325 331 PF00498 0.602
LIG_FHA_1 383 389 PF00498 0.630
LIG_FHA_1 92 98 PF00498 0.629
LIG_FHA_2 278 284 PF00498 0.717
LIG_FHA_2 289 295 PF00498 0.614
LIG_FHA_2 35 41 PF00498 0.557
LIG_GBD_Chelix_1 494 502 PF00786 0.494
LIG_HP1_1 242 246 PF01393 0.601
LIG_Integrin_RGD_1 450 452 PF01839 0.521
LIG_LIR_Gen_1 366 375 PF02991 0.597
LIG_LIR_Nem_3 237 241 PF02991 0.645
LIG_LIR_Nem_3 366 372 PF02991 0.601
LIG_MYND_3 70 74 PF01753 0.595
LIG_NRBOX 402 408 PF00104 0.568
LIG_NRBOX 493 499 PF00104 0.505
LIG_SH2_SRC 15 18 PF00017 0.595
LIG_SH2_STAT3 41 44 PF00017 0.646
LIG_SH2_STAT5 15 18 PF00017 0.558
LIG_SH2_STAT5 296 299 PF00017 0.578
LIG_SH2_STAT5 500 503 PF00017 0.656
LIG_SH3_1 553 559 PF00018 0.708
LIG_SH3_3 147 153 PF00018 0.634
LIG_SH3_3 199 205 PF00018 0.633
LIG_SH3_3 225 231 PF00018 0.665
LIG_SH3_3 286 292 PF00018 0.595
LIG_SH3_3 521 527 PF00018 0.682
LIG_SH3_3 553 559 PF00018 0.698
LIG_SH3_3 57 63 PF00018 0.641
LIG_SH3_3 65 71 PF00018 0.592
LIG_SH3_3 81 87 PF00018 0.527
LIG_SUMO_SIM_anti_2 120 126 PF11976 0.562
LIG_SUMO_SIM_par_1 241 247 PF11976 0.665
MOD_CDC14_SPxK_1 525 528 PF00782 0.654
MOD_CDK_SPxK_1 522 528 PF00069 0.658
MOD_CDK_SPxxK_3 164 171 PF00069 0.648
MOD_CDK_SPxxK_3 288 295 PF00069 0.650
MOD_CK1_1 204 210 PF00069 0.696
MOD_CK1_1 229 235 PF00069 0.657
MOD_CK1_1 250 256 PF00069 0.673
MOD_CK1_1 269 275 PF00069 0.705
MOD_CK1_1 277 283 PF00069 0.650
MOD_CK1_1 284 290 PF00069 0.608
MOD_CK1_1 301 307 PF00069 0.590
MOD_CK1_1 363 369 PF00069 0.652
MOD_CK1_1 469 475 PF00069 0.664
MOD_CK1_1 480 486 PF00069 0.617
MOD_CK1_1 533 539 PF00069 0.659
MOD_CK1_1 61 67 PF00069 0.703
MOD_CK1_1 83 89 PF00069 0.767
MOD_CK1_1 92 98 PF00069 0.613
MOD_CK2_1 175 181 PF00069 0.660
MOD_CK2_1 207 213 PF00069 0.694
MOD_CK2_1 345 351 PF00069 0.744
MOD_CK2_1 456 462 PF00069 0.546
MOD_GlcNHglycan 134 137 PF01048 0.610
MOD_GlcNHglycan 172 175 PF01048 0.645
MOD_GlcNHglycan 183 186 PF01048 0.510
MOD_GlcNHglycan 29 32 PF01048 0.624
MOD_GlcNHglycan 300 303 PF01048 0.651
MOD_GlcNHglycan 362 365 PF01048 0.689
MOD_GlcNHglycan 430 433 PF01048 0.597
MOD_GlcNHglycan 469 472 PF01048 0.592
MOD_GlcNHglycan 512 515 PF01048 0.630
MOD_GlcNHglycan 568 571 PF01048 0.685
MOD_GlcNHglycan 91 94 PF01048 0.630
MOD_GSK3_1 132 139 PF00069 0.596
MOD_GSK3_1 192 199 PF00069 0.736
MOD_GSK3_1 200 207 PF00069 0.627
MOD_GSK3_1 222 229 PF00069 0.709
MOD_GSK3_1 246 253 PF00069 0.648
MOD_GSK3_1 266 273 PF00069 0.774
MOD_GSK3_1 27 34 PF00069 0.605
MOD_GSK3_1 275 282 PF00069 0.642
MOD_GSK3_1 284 291 PF00069 0.553
MOD_GSK3_1 297 304 PF00069 0.580
MOD_GSK3_1 321 328 PF00069 0.750
MOD_GSK3_1 456 463 PF00069 0.614
MOD_GSK3_1 465 472 PF00069 0.642
MOD_GSK3_1 529 536 PF00069 0.584
MOD_GSK3_1 558 565 PF00069 0.812
MOD_GSK3_1 83 90 PF00069 0.652
MOD_GSK3_1 91 98 PF00069 0.568
MOD_NEK2_1 125 130 PF00069 0.571
MOD_NEK2_1 246 251 PF00069 0.691
MOD_NEK2_1 339 344 PF00069 0.563
MOD_NEK2_1 426 431 PF00069 0.627
MOD_NEK2_1 465 470 PF00069 0.581
MOD_NEK2_1 91 96 PF00069 0.649
MOD_OFUCOSY 453 460 PF10250 0.557
MOD_PIKK_1 277 283 PF00454 0.728
MOD_PIKK_1 445 451 PF00454 0.530
MOD_PK_1 368 374 PF00069 0.642
MOD_PK_1 530 536 PF00069 0.578
MOD_PKA_1 275 281 PF00069 0.731
MOD_PKA_1 413 419 PF00069 0.597
MOD_PKA_2 101 107 PF00069 0.654
MOD_PKA_2 137 143 PF00069 0.531
MOD_PKA_2 170 176 PF00069 0.646
MOD_PKA_2 254 260 PF00069 0.637
MOD_PKA_2 274 280 PF00069 0.743
MOD_PKA_2 332 338 PF00069 0.645
MOD_PKA_2 407 413 PF00069 0.575
MOD_PKA_2 426 432 PF00069 0.435
MOD_PKA_2 529 535 PF00069 0.651
MOD_Plk_1 16 22 PF00069 0.591
MOD_Plk_1 246 252 PF00069 0.660
MOD_Plk_1 325 331 PF00069 0.576
MOD_Plk_1 461 467 PF00069 0.546
MOD_Plk_4 247 253 PF00069 0.688
MOD_Plk_4 325 331 PF00069 0.602
MOD_Plk_4 332 338 PF00069 0.533
MOD_Plk_4 493 499 PF00069 0.539
MOD_ProDKin_1 164 170 PF00069 0.646
MOD_ProDKin_1 196 202 PF00069 0.701
MOD_ProDKin_1 224 230 PF00069 0.750
MOD_ProDKin_1 236 242 PF00069 0.542
MOD_ProDKin_1 288 294 PF00069 0.676
MOD_ProDKin_1 31 37 PF00069 0.545
MOD_ProDKin_1 508 514 PF00069 0.634
MOD_ProDKin_1 522 528 PF00069 0.626
MOD_ProDKin_1 58 64 PF00069 0.670
MOD_ProDKin_1 83 89 PF00069 0.655
TRG_DiLeu_BaEn_4 398 404 PF01217 0.506
TRG_DiLeu_BaLyEn_6 401 406 PF01217 0.573
TRG_ER_diArg_1 320 322 PF00400 0.655
TRG_ER_diArg_1 367 369 PF00400 0.620
TRG_ER_diArg_1 402 405 PF00400 0.565
TRG_ER_diArg_1 434 437 PF00400 0.570
TRG_NES_CRM1_1 492 507 PF08389 0.505
TRG_Pf-PMV_PEXEL_1 305 309 PF00026 0.597

Homologs

Protein Taxonomy Sequence identity Coverage
A4H7Y8 Leishmania braziliensis 64% 100%
A4HWB6 Leishmania infantum 100% 100%
E9AQ16 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QFG5 Leishmania major 90% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS