Mitochondrial carrier protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC61_LEIDO

TriTrypDb:

LdBPK_220170.1 , LdCL_220007800 , LDHU3_22.0440

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IC61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.377
CLV_NRD_NRD_1	241	243	PF00675	0.510
CLV_NRD_NRD_1	374	376	PF00675	0.739
CLV_NRD_NRD_1	459	461	PF00675	0.373
CLV_NRD_NRD_1	63	65	PF00675	0.410
CLV_PCSK_KEX2_1	196	198	PF00082	0.377
CLV_PCSK_KEX2_1	202	204	PF00082	0.441
CLV_PCSK_KEX2_1	241	243	PF00082	0.510
CLV_PCSK_KEX2_1	374	376	PF00082	0.709
CLV_PCSK_KEX2_1	63	65	PF00082	0.410
CLV_PCSK_KEX2_1	70	72	PF00082	0.394
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.428
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.520
CLV_PCSK_PC7_1	59	65	PF00082	0.387
CLV_PCSK_PC7_1	66	72	PF00082	0.392
CLV_PCSK_SKI1_1	154	158	PF00082	0.372
CLV_PCSK_SKI1_1	160	164	PF00082	0.357
CLV_PCSK_SKI1_1	202	206	PF00082	0.448
CLV_PCSK_SKI1_1	254	258	PF00082	0.757
DEG_COP1_1	342	352	PF00400	0.578
DEG_SPOP_SBC_1	363	367	PF00917	0.723
DOC_CDC14_PxL_1	320	328	PF14671	0.432
DOC_CKS1_1	216	221	PF01111	0.629
DOC_CKS1_1	311	316	PF01111	0.529
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.395
DOC_MAPK_MEF2A_6	54	62	PF00069	0.382
DOC_PP1_RVXF_1	152	159	PF00149	0.415
DOC_PP1_RVXF_1	438	444	PF00149	0.374
DOC_PP1_RVXF_1	57	63	PF00149	0.402
DOC_PP4_FxxP_1	216	219	PF00568	0.500
DOC_PP4_FxxP_1	73	76	PF00568	0.400
DOC_USP7_MATH_1	129	133	PF00917	0.306
DOC_USP7_MATH_1	361	365	PF00917	0.624
DOC_USP7_MATH_1	396	400	PF00917	0.618
DOC_WW_Pin1_4	115	120	PF00397	0.423
DOC_WW_Pin1_4	215	220	PF00397	0.636
DOC_WW_Pin1_4	222	227	PF00397	0.655
DOC_WW_Pin1_4	298	303	PF00397	0.336
DOC_WW_Pin1_4	310	315	PF00397	0.442
DOC_WW_Pin1_4	398	403	PF00397	0.498
LIG_14-3-3_CanoR_1	154	159	PF00244	0.480
LIG_14-3-3_CanoR_1	196	205	PF00244	0.494
LIG_14-3-3_CanoR_1	217	226	PF00244	0.501
LIG_14-3-3_CanoR_1	338	344	PF00244	0.606
LIG_14-3-3_CanoR_1	409	414	PF00244	0.453
LIG_APCC_ABBA_1	163	168	PF00400	0.343
LIG_BRCT_BRCA1_1	299	303	PF00533	0.373
LIG_BRCT_BRCA1_1	92	96	PF00533	0.354
LIG_deltaCOP1_diTrp_1	373	383	PF00928	0.495
LIG_FHA_1	178	184	PF00498	0.365
LIG_FHA_1	263	269	PF00498	0.602
LIG_FHA_1	6	12	PF00498	0.590
LIG_FHA_2	382	388	PF00498	0.666
LIG_FHA_2	410	416	PF00498	0.381
LIG_GBD_Chelix_1	291	299	PF00786	0.394
LIG_LIR_Apic_2	308	314	PF02991	0.365
LIG_LIR_Gen_1	300	311	PF02991	0.394
LIG_LIR_Gen_1	328	337	PF02991	0.469
LIG_LIR_Gen_1	412	421	PF02991	0.527
LIG_LIR_Nem_3	13	19	PF02991	0.561
LIG_LIR_Nem_3	185	191	PF02991	0.276
LIG_LIR_Nem_3	199	204	PF02991	0.413
LIG_LIR_Nem_3	300	306	PF02991	0.368
LIG_LIR_Nem_3	328	333	PF02991	0.413
LIG_LIR_Nem_3	412	416	PF02991	0.478
LIG_LIR_Nem_3	74	80	PF02991	0.408
LIG_NRP_CendR_1	461	464	PF00754	0.428
LIG_Pex14_1	201	205	PF04695	0.553
LIG_Pex14_2	175	179	PF04695	0.332
LIG_Pex14_2	329	333	PF04695	0.469
LIG_Pex14_2	73	77	PF04695	0.402
LIG_REV1ctd_RIR_1	172	180	PF16727	0.281
LIG_REV1ctd_RIR_1	202	212	PF16727	0.471
LIG_SH2_CRK	311	315	PF00017	0.373
LIG_SH2_CRK	86	90	PF00017	0.344
LIG_SH2_PTP2	322	325	PF00017	0.497
LIG_SH2_PTP2	57	60	PF00017	0.360
LIG_SH2_STAP1	330	334	PF00017	0.478
LIG_SH2_STAT3	453	456	PF00017	0.541
LIG_SH2_STAT5	305	308	PF00017	0.363
LIG_SH2_STAT5	322	325	PF00017	0.358
LIG_SH2_STAT5	330	333	PF00017	0.386
LIG_SH2_STAT5	335	338	PF00017	0.357
LIG_SH2_STAT5	343	346	PF00017	0.497
LIG_SH2_STAT5	453	456	PF00017	0.541
LIG_SH2_STAT5	458	461	PF00017	0.554
LIG_SH2_STAT5	57	60	PF00017	0.381
LIG_SH2_STAT5	94	97	PF00017	0.446
LIG_TYR_ITIM	320	325	PF00017	0.460
LIG_TYR_ITIM	84	89	PF00017	0.425
LIG_WRC_WIRS_1	326	331	PF05994	0.381
MOD_CDK_SPxxK_3	398	405	PF00069	0.488
MOD_CK1_1	221	227	PF00069	0.687
MOD_CK1_1	240	246	PF00069	0.578
MOD_CK1_1	297	303	PF00069	0.351
MOD_CK1_1	328	334	PF00069	0.467
MOD_CK1_1	362	368	PF00069	0.670
MOD_CK1_1	381	387	PF00069	0.655
MOD_CK1_1	401	407	PF00069	0.541
MOD_CK1_1	41	47	PF00069	0.476
MOD_CK1_1	5	11	PF00069	0.635
MOD_CK2_1	247	253	PF00069	0.558
MOD_CK2_1	367	373	PF00069	0.770
MOD_CK2_1	381	387	PF00069	0.666
MOD_CK2_1	409	415	PF00069	0.379
MOD_CK2_1	7	13	PF00069	0.558
MOD_GlcNHglycan	198	201	PF01048	0.544
MOD_GlcNHglycan	220	223	PF01048	0.705
MOD_GlcNHglycan	232	235	PF01048	0.574
MOD_GlcNHglycan	283	286	PF01048	0.435
MOD_GlcNHglycan	33	36	PF01048	0.442
MOD_GlcNHglycan	359	362	PF01048	0.687
MOD_GlcNHglycan	369	372	PF01048	0.708
MOD_GlcNHglycan	4	7	PF01048	0.678
MOD_GlcNHglycan	40	43	PF01048	0.351
MOD_GSK3_1	1	8	PF00069	0.629
MOD_GSK3_1	154	161	PF00069	0.393
MOD_GSK3_1	192	199	PF00069	0.470
MOD_GSK3_1	217	224	PF00069	0.584
MOD_GSK3_1	230	237	PF00069	0.564
MOD_GSK3_1	281	288	PF00069	0.422
MOD_GSK3_1	294	301	PF00069	0.312
MOD_GSK3_1	357	364	PF00069	0.652
MOD_GSK3_1	392	399	PF00069	0.706
MOD_GSK3_1	423	430	PF00069	0.396
MOD_GSK3_1	97	104	PF00069	0.314
MOD_LATS_1	339	345	PF00433	0.570
MOD_N-GLC_1	237	242	PF02516	0.569
MOD_N-GLC_1	262	267	PF02516	0.606
MOD_N-GLC_2	30	32	PF02516	0.472
MOD_NEK2_1	1	6	PF00069	0.634
MOD_NEK2_1	158	163	PF00069	0.342
MOD_NEK2_1	31	36	PF00069	0.419
MOD_NEK2_1	325	330	PF00069	0.368
MOD_NEK2_1	333	338	PF00069	0.376
MOD_NEK2_1	447	452	PF00069	0.447
MOD_NEK2_1	7	12	PF00069	0.595
MOD_NEK2_2	435	440	PF00069	0.381
MOD_NEK2_2	97	102	PF00069	0.370
MOD_NMyristoyl	1	7	PF02799	0.466
MOD_PIKK_1	328	334	PF00454	0.492
MOD_PIKK_1	41	47	PF00454	0.476
MOD_PKA_1	196	202	PF00069	0.458
MOD_PKA_2	101	107	PF00069	0.301
MOD_PKA_2	183	189	PF00069	0.302
MOD_PKA_2	196	202	PF00069	0.353
MOD_PKA_2	234	240	PF00069	0.656
MOD_PKA_2	396	402	PF00069	0.617
MOD_Plk_1	262	268	PF00069	0.738
MOD_Plk_4	120	126	PF00069	0.383
MOD_Plk_4	154	160	PF00069	0.331
MOD_Plk_4	178	184	PF00069	0.358
MOD_Plk_4	294	300	PF00069	0.350
MOD_Plk_4	325	331	PF00069	0.393
MOD_Plk_4	447	453	PF00069	0.394
MOD_Plk_4	90	96	PF00069	0.355
MOD_ProDKin_1	115	121	PF00069	0.420
MOD_ProDKin_1	215	221	PF00069	0.639
MOD_ProDKin_1	222	228	PF00069	0.657
MOD_ProDKin_1	298	304	PF00069	0.340
MOD_ProDKin_1	310	316	PF00069	0.454
MOD_ProDKin_1	398	404	PF00069	0.490
MOD_SUMO_rev_2	253	262	PF00179	0.575
TRG_DiLeu_BaEn_1	168	173	PF01217	0.297
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.423
TRG_ENDOCYTIC_2	213	216	PF00928	0.552
TRG_ENDOCYTIC_2	322	325	PF00928	0.432
TRG_ENDOCYTIC_2	330	333	PF00928	0.442
TRG_ENDOCYTIC_2	57	60	PF00928	0.345
TRG_ENDOCYTIC_2	86	89	PF00928	0.346
TRG_ER_diArg_1	241	244	PF00400	0.666
TRG_ER_diArg_1	374	376	PF00400	0.734
TRG_ER_diArg_1	62	64	PF00400	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I563	Leptomonas seymouri	60%	100%
A0A0S4JRQ8	Bodo saltans	42%	100%
A0A1X0NUU2	Trypanosomatidae	46%	100%
A0A3R7L681	Trypanosoma rangeli	45%	100%
A4HC79	Leishmania braziliensis	76%	99%
A4HZQ7	Leishmania infantum	100%	100%
C9ZSF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AVL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBW6	Leishmania major	92%	100%
V5BK78	Trypanosoma cruzi	46%	100%