Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IC57_LEIDO

TriTrypDb:

LdBPK_250070.1 , LdCL_250005700 , LDHU3_25.0090

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IC57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.750
CLV_NRD_NRD_1	261	263	PF00675	0.415
CLV_PCSK_KEX2_1	2	4	PF00082	0.669
CLV_PCSK_KEX2_1	260	262	PF00082	0.463
CLV_PCSK_SKI1_1	108	112	PF00082	0.528
DEG_COP1_1	38	45	PF00400	0.617
DEG_Nend_UBRbox_1	1	4	PF02207	0.673
DOC_MAPK_FxFP_2	79	82	PF00069	0.494
DOC_MAPK_gen_1	124	132	PF00069	0.481
DOC_MAPK_gen_1	2	9	PF00069	0.601
DOC_MAPK_MEF2A_6	124	132	PF00069	0.429
DOC_MAPK_MEF2A_6	2	9	PF00069	0.599
DOC_PP1_RVXF_1	115	121	PF00149	0.478
DOC_PP1_RVXF_1	259	266	PF00149	0.404
DOC_PP2B_LxvP_1	159	162	PF13499	0.454
DOC_PP4_FxxP_1	79	82	PF00568	0.473
DOC_USP7_MATH_1	287	291	PF00917	0.717
DOC_WW_Pin1_4	103	108	PF00397	0.523
DOC_WW_Pin1_4	142	147	PF00397	0.529
DOC_WW_Pin1_4	237	242	PF00397	0.635
DOC_WW_Pin1_4	285	290	PF00397	0.731
DOC_WW_Pin1_4	48	53	PF00397	0.688
LIG_14-3-3_CanoR_1	207	212	PF00244	0.546
LIG_AP2alpha_2	70	72	PF02296	0.471
LIG_BRCT_BRCA1_1	14	18	PF00533	0.656
LIG_BRCT_BRCA1_1	225	229	PF00533	0.515
LIG_CaM_IQ_9	21	37	PF13499	0.501
LIG_eIF4E_1	183	189	PF01652	0.475
LIG_FHA_1	113	119	PF00498	0.589
LIG_FHA_1	195	201	PF00498	0.468
LIG_FHA_1	228	234	PF00498	0.537
LIG_FHA_1	37	43	PF00498	0.584
LIG_FHA_1	61	67	PF00498	0.361
LIG_GBD_Chelix_1	128	136	PF00786	0.463
LIG_LIR_Gen_1	75	84	PF02991	0.426
LIG_LIR_Nem_3	226	232	PF02991	0.432
LIG_LIR_Nem_3	68	72	PF02991	0.431
LIG_LIR_Nem_3	75	79	PF02991	0.387
LIG_LIR_Nem_3	80	84	PF02991	0.401
LIG_MYND_1	158	162	PF01753	0.445
LIG_NRBOX	131	137	PF00104	0.396
LIG_PCNA_yPIPBox_3	207	215	PF02747	0.307
LIG_Pex14_2	65	69	PF04695	0.473
LIG_Rb_LxCxE_1	93	109	PF01857	0.354
LIG_RPA_C_Fungi	265	277	PF08784	0.461
LIG_SH2_SRC	199	202	PF00017	0.522
LIG_SH2_STAT5	183	186	PF00017	0.437
LIG_SH2_STAT5	199	202	PF00017	0.444
LIG_SH2_STAT5	204	207	PF00017	0.461
LIG_SH2_STAT5	76	79	PF00017	0.375
LIG_SH3_3	152	158	PF00018	0.492
LIG_SH3_3	173	179	PF00018	0.425
LIG_WRC_WIRS_1	66	71	PF05994	0.433
MOD_CDK_SPK_2	103	108	PF00069	0.525
MOD_CK1_1	106	112	PF00069	0.497
MOD_CK1_1	142	148	PF00069	0.527
MOD_CK1_1	290	296	PF00069	0.662
MOD_CK2_1	237	243	PF00069	0.564
MOD_GlcNHglycan	14	17	PF01048	0.653
MOD_GlcNHglycan	190	193	PF01048	0.497
MOD_GlcNHglycan	225	228	PF01048	0.479
MOD_GSK3_1	12	19	PF00069	0.635
MOD_GSK3_1	188	195	PF00069	0.537
MOD_GSK3_1	223	230	PF00069	0.437
MOD_GSK3_1	281	288	PF00069	0.648
MOD_GSK3_1	99	106	PF00069	0.525
MOD_N-GLC_1	207	212	PF02516	0.394
MOD_NEK2_1	188	193	PF00069	0.423
MOD_NEK2_1	291	296	PF00069	0.660
MOD_NEK2_1	72	77	PF00069	0.379
MOD_PIKK_1	170	176	PF00454	0.471
MOD_PKA_2	12	18	PF00069	0.625
MOD_PKB_1	117	125	PF00069	0.361
MOD_Plk_1	207	213	PF00069	0.485
MOD_Plk_4	131	137	PF00069	0.499
MOD_Plk_4	194	200	PF00069	0.544
MOD_Plk_4	287	293	PF00069	0.639
MOD_Plk_4	41	47	PF00069	0.591
MOD_Plk_4	60	66	PF00069	0.420
MOD_Plk_4	99	105	PF00069	0.402
MOD_ProDKin_1	103	109	PF00069	0.524
MOD_ProDKin_1	142	148	PF00069	0.526
MOD_ProDKin_1	237	243	PF00069	0.628
MOD_ProDKin_1	285	291	PF00069	0.732
MOD_ProDKin_1	48	54	PF00069	0.683
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.454
TRG_ENDOCYTIC_2	76	79	PF00928	0.349
TRG_ER_diArg_1	1	3	PF00400	0.690
TRG_ER_diArg_1	11	14	PF00400	0.503
TRG_ER_diArg_1	117	120	PF00400	0.402
TRG_ER_diArg_1	260	262	PF00400	0.463
TRG_ER_diArg_1	273	276	PF00400	0.652
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM27	Leptomonas seymouri	51%	100%
A0A1X0NV12	Trypanosomatidae	30%	100%
A0A422N5J2	Trypanosoma rangeli	30%	100%
A4HDV4	Leishmania braziliensis	72%	100%
A4I149	Leishmania infantum	100%	100%
D0A975	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	80%
E9AX83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QA89	Leishmania major	89%	100%