Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IC56_LEIDO

TriTrypDb:

LdBPK_100730.1 , LdCL_100014100 , LDHU3_10.1060

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IC56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.594
CLV_NRD_NRD_1	1	3	PF00675	0.621
CLV_NRD_NRD_1	175	177	PF00675	0.559
CLV_NRD_NRD_1	18	20	PF00675	0.608
CLV_NRD_NRD_1	266	268	PF00675	0.636
CLV_NRD_NRD_1	322	324	PF00675	0.683
CLV_NRD_NRD_1	469	471	PF00675	0.607
CLV_NRD_NRD_1	503	505	PF00675	0.588
CLV_NRD_NRD_1	64	66	PF00675	0.562
CLV_PCSK_FUR_1	501	505	PF00082	0.582
CLV_PCSK_KEX2_1	175	177	PF00082	0.584
CLV_PCSK_KEX2_1	266	268	PF00082	0.636
CLV_PCSK_KEX2_1	322	324	PF00082	0.683
CLV_PCSK_KEX2_1	468	470	PF00082	0.606
CLV_PCSK_KEX2_1	503	505	PF00082	0.588
CLV_PCSK_KEX2_1	54	56	PF00082	0.558
CLV_PCSK_KEX2_1	64	66	PF00082	0.512
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.588
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.594
CLV_PCSK_SKI1_1	168	172	PF00082	0.552
CLV_PCSK_SKI1_1	218	222	PF00082	0.545
CLV_PCSK_SKI1_1	68	72	PF00082	0.573
CLV_PCSK_SKI1_1	7	11	PF00082	0.556
DEG_APCC_DBOX_1	167	175	PF00400	0.625
DEG_APCC_DBOX_1	35	43	PF00400	0.571
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DEG_SPOP_SBC_1	110	114	PF00917	0.564
DEG_SPOP_SBC_1	342	346	PF00917	0.660
DOC_CKS1_1	360	365	PF01111	0.615
DOC_CKS1_1	413	418	PF01111	0.620
DOC_CYCLIN_RxL_1	215	224	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	220	223	PF00134	0.508
DOC_MAPK_gen_1	162	172	PF00069	0.546
DOC_MAPK_gen_1	2	10	PF00069	0.554
DOC_MAPK_gen_1	64	72	PF00069	0.599
DOC_MAPK_MEF2A_6	165	174	PF00069	0.463
DOC_MAPK_MEF2A_6	32	39	PF00069	0.583
DOC_MAPK_RevD_3	6	20	PF00069	0.552
DOC_PP2B_LxvP_1	220	223	PF13499	0.508
DOC_PP2B_LxvP_1	275	278	PF13499	0.653
DOC_PP2B_LxvP_1	28	31	PF13499	0.652
DOC_PP2B_LxvP_1	8	11	PF13499	0.575
DOC_USP7_MATH_1	103	107	PF00917	0.654
DOC_USP7_MATH_1	110	114	PF00917	0.595
DOC_USP7_MATH_1	141	145	PF00917	0.619
DOC_USP7_MATH_1	180	184	PF00917	0.600
DOC_USP7_MATH_1	187	191	PF00917	0.555
DOC_USP7_MATH_1	278	282	PF00917	0.805
DOC_USP7_MATH_1	324	328	PF00917	0.650
DOC_USP7_MATH_1	342	346	PF00917	0.662
DOC_USP7_MATH_1	435	439	PF00917	0.630
DOC_WW_Pin1_4	176	181	PF00397	0.572
DOC_WW_Pin1_4	276	281	PF00397	0.644
DOC_WW_Pin1_4	313	318	PF00397	0.644
DOC_WW_Pin1_4	353	358	PF00397	0.662
DOC_WW_Pin1_4	359	364	PF00397	0.625
DOC_WW_Pin1_4	412	417	PF00397	0.617
DOC_WW_Pin1_4	96	101	PF00397	0.649
LIG_14-3-3_CanoR_1	122	129	PF00244	0.653
LIG_14-3-3_CanoR_1	175	179	PF00244	0.562
LIG_14-3-3_CanoR_1	188	193	PF00244	0.556
LIG_14-3-3_CanoR_1	2	10	PF00244	0.652
LIG_14-3-3_CanoR_1	266	275	PF00244	0.758
LIG_14-3-3_CanoR_1	292	298	PF00244	0.592
LIG_14-3-3_CanoR_1	347	355	PF00244	0.671
LIG_14-3-3_CanoR_1	36	40	PF00244	0.585
LIG_14-3-3_CanoR_1	480	489	PF00244	0.624
LIG_14-3-3_CanoR_1	87	96	PF00244	0.657
LIG_Actin_WH2_2	108	124	PF00022	0.575
LIG_Actin_WH2_2	389	406	PF00022	0.581
LIG_Actin_WH2_2	49	66	PF00022	0.550
LIG_APCC_ABBA_1	491	496	PF00400	0.609
LIG_BIR_III_2	126	130	PF00653	0.613
LIG_Clathr_ClatBox_1	249	253	PF01394	0.438
LIG_EVH1_1	30	34	PF00568	0.644
LIG_FHA_1	10	16	PF00498	0.553
LIG_FHA_1	116	122	PF00498	0.584
LIG_FHA_1	245	251	PF00498	0.442
LIG_FHA_2	193	199	PF00498	0.658
LIG_FHA_2	423	429	PF00498	0.635
LIG_Integrin_isoDGR_2	320	322	PF01839	0.587
LIG_LIR_Apic_2	147	151	PF02991	0.567
LIG_LIR_Gen_1	99	109	PF02991	0.628
LIG_LIR_LC3C_4	169	173	PF02991	0.492
LIG_LIR_Nem_3	99	104	PF02991	0.628
LIG_NRBOX	251	257	PF00104	0.535
LIG_SH2_NCK_1	312	316	PF00017	0.590
LIG_SH2_SRC	21	24	PF00017	0.613
LIG_SH2_STAT5	312	315	PF00017	0.691
LIG_SH2_STAT5	463	466	PF00017	0.596
LIG_SH3_2	31	36	PF14604	0.645
LIG_SH3_3	220	226	PF00018	0.527
LIG_SH3_3	28	34	PF00018	0.648
LIG_SH3_3	349	355	PF00018	0.811
LIG_SH3_3	357	363	PF00018	0.682
LIG_SH3_3	415	421	PF00018	0.630
LIG_SH3_3	79	85	PF00018	0.755
LIG_SH3_CIN85_PxpxPR_1	31	36	PF14604	0.645
LIG_SUMO_SIM_anti_2	169	175	PF11976	0.630
LIG_TRAF2_1	195	198	PF00917	0.569
LIG_TRAF2_1	237	240	PF00917	0.539
LIG_WW_3	33	37	PF00397	0.643
MOD_CDC14_SPxK_1	316	319	PF00782	0.637
MOD_CDK_SPK_2	359	364	PF00069	0.611
MOD_CDK_SPxK_1	313	319	PF00069	0.643
MOD_CK1_1	114	120	PF00069	0.630
MOD_CK1_1	144	150	PF00069	0.571
MOD_CK1_1	179	185	PF00069	0.622
MOD_CK1_1	302	308	PF00069	0.642
MOD_CK1_1	346	352	PF00069	0.774
MOD_CK1_1	353	359	PF00069	0.654
MOD_CK1_1	492	498	PF00069	0.602
MOD_CK2_1	110	116	PF00069	0.664
MOD_CK2_1	179	185	PF00069	0.581
MOD_CK2_1	192	198	PF00069	0.591
MOD_CK2_1	435	441	PF00069	0.629
MOD_CK2_1	77	83	PF00069	0.597
MOD_Cter_Amidation	320	323	PF01082	0.589
MOD_DYRK1A_RPxSP_1	176	180	PF00069	0.563
MOD_GlcNHglycan	105	108	PF01048	0.610
MOD_GlcNHglycan	280	283	PF01048	0.596
MOD_GlcNHglycan	328	331	PF01048	0.656
MOD_GlcNHglycan	352	355	PF01048	0.664
MOD_GlcNHglycan	435	438	PF01048	0.629
MOD_GlcNHglycan	447	450	PF01048	0.552
MOD_GlcNHglycan	484	487	PF01048	0.632
MOD_GSK3_1	105	112	PF00069	0.587
MOD_GSK3_1	128	135	PF00069	0.655
MOD_GSK3_1	140	147	PF00069	0.520
MOD_GSK3_1	176	183	PF00069	0.603
MOD_GSK3_1	188	195	PF00069	0.549
MOD_GSK3_1	261	268	PF00069	0.618
MOD_GSK3_1	293	300	PF00069	0.813
MOD_GSK3_1	302	309	PF00069	0.712
MOD_GSK3_1	342	349	PF00069	0.802
MOD_GSK3_1	370	377	PF00069	0.696
MOD_GSK3_1	435	442	PF00069	0.645
MOD_GSK3_1	472	479	PF00069	0.619
MOD_GSK3_1	495	502	PF00069	0.579
MOD_N-GLC_1	302	307	PF02516	0.638
MOD_N-GLC_1	422	427	PF02516	0.634
MOD_NEK2_1	132	137	PF00069	0.603
MOD_NEK2_1	15	20	PF00069	0.676
MOD_NEK2_1	241	246	PF00069	0.505
MOD_NEK2_1	256	261	PF00069	0.510
MOD_NEK2_1	310	315	PF00069	0.679
MOD_NEK2_1	403	408	PF00069	0.514
MOD_NEK2_1	422	427	PF00069	0.664
MOD_NEK2_1	439	444	PF00069	0.555
MOD_NEK2_1	77	82	PF00069	0.667
MOD_NEK2_2	293	298	PF00069	0.591
MOD_NEK2_2	435	440	PF00069	0.629
MOD_NEK2_2	489	494	PF00069	0.580
MOD_PIKK_1	141	147	PF00454	0.607
MOD_PIKK_1	21	27	PF00454	0.642
MOD_PIKK_1	241	247	PF00454	0.510
MOD_PIKK_1	405	411	PF00454	0.529
MOD_PIKK_1	441	447	PF00454	0.616
MOD_PKA_1	266	272	PF00069	0.636
MOD_PKA_2	1	7	PF00069	0.672
MOD_PKA_2	121	127	PF00069	0.657
MOD_PKA_2	132	138	PF00069	0.571
MOD_PKA_2	174	180	PF00069	0.578
MOD_PKA_2	187	193	PF00069	0.537
MOD_PKA_2	265	271	PF00069	0.658
MOD_PKA_2	346	352	PF00069	0.672
MOD_PKA_2	35	41	PF00069	0.587
MOD_PKA_2	403	409	PF00069	0.646
MOD_PKA_2	439	445	PF00069	0.620
MOD_Plk_1	302	308	PF00069	0.667
MOD_Plk_1	495	501	PF00069	0.581
MOD_Plk_4	144	150	PF00069	0.571
MOD_Plk_4	188	194	PF00069	0.647
MOD_Plk_4	231	237	PF00069	0.489
MOD_Plk_4	256	262	PF00069	0.595
MOD_Plk_4	302	308	PF00069	0.805
MOD_Plk_4	495	501	PF00069	0.581
MOD_ProDKin_1	176	182	PF00069	0.574
MOD_ProDKin_1	276	282	PF00069	0.642
MOD_ProDKin_1	313	319	PF00069	0.643
MOD_ProDKin_1	353	359	PF00069	0.663
MOD_ProDKin_1	412	418	PF00069	0.620
MOD_ProDKin_1	96	102	PF00069	0.649
TRG_ER_diArg_1	174	176	PF00400	0.484
TRG_ER_diArg_1	468	470	PF00400	0.582
TRG_ER_diArg_1	63	65	PF00400	0.564
TRG_NES_CRM1_1	62	73	PF08389	0.545
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HUI0	Leishmania infantum	100%	100%
E9AN78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QHE7	Leishmania major	83%	100%