Heat shock protein DNAJ, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein DNAJ, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC51_LEIDO

TriTrypDb:

LdBPK_220009.1 , LdCL_220005800 , LDHU3_22.0130

Length:

331

Annotations

LeishMANIAdb annotations

An extensive family in kinetoplastids, these chaperone proteins are likely also involved in the folding of secreted proteins as well.. This group contains both cytoplasmic and secreted (likely ER) proteins.. Localization: Cytoplasmic (by homology) / ER (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8IC51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC51

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0042026	protein refolding	3	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051082	unfolded protein binding	3	12
GO:0051087	protein-folding chaperone binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.313
CLV_NRD_NRD_1	33	35	PF00675	0.413
CLV_NRD_NRD_1	58	60	PF00675	0.401
CLV_NRD_NRD_1	75	77	PF00675	0.237
CLV_PCSK_FUR_1	31	35	PF00082	0.487
CLV_PCSK_KEX2_1	33	35	PF00082	0.417
CLV_PCSK_KEX2_1	60	62	PF00082	0.369
CLV_PCSK_KEX2_1	74	76	PF00082	0.214
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.380
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.284

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E7	Leptomonas seymouri	70%	93%
A0A0N1I257	Leptomonas seymouri	29%	71%
A0A0N1I2U4	Leptomonas seymouri	34%	83%
A0A0N1IMD5	Leptomonas seymouri	32%	74%
A0A0N1P953	Leptomonas seymouri	26%	70%
A0A0N1PCG8	Leptomonas seymouri	32%	83%
A0A0N1PCJ3	Leptomonas seymouri	29%	68%
A0A0S4IL02	Bodo saltans	33%	80%
A0A0S4IM72	Bodo saltans	30%	72%
A0A0S4J3S5	Bodo saltans	35%	83%

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